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Ignite London - phatmattbaker - Dirty Doner

by Matt Baker on Nov 19, 2009

583 views

The slides from my Ignite! talk at the first Ignite London. I gave a talk where I performed a poem 'about the kebab that broke my heart' talking about different types of bacteria, how they move, how th...

The slides from my Ignite! talk at the first Ignite London. I gave a talk where I performed a poem 'about the kebab that broke my heart' talking about different types of bacteria, how they move, how the motor is assembled, and how enterotoxic E. coli can make us sick. You can see more of me at www.phatmattbaker.com or on twitter @phatmattbaker

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Matt Baker , Researcher at Oxford University my original slides had some movies, and some animation features which aren't shown here, as well the video of the sperm swimming isn't shown. 2 years ago Reply
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Dirty…. The first bite’s tight What a concoction. Unfortunately for me Also an enterotoxin.
What was this that gave me the shits, That destroyed my relationship to meat that loved to bits? It wasn’t flocks of streptococcus, They make you cough and get raucus, Nor shapely shigella, the domain of dysentry, I haven’t been near contaminated water recently,
It wasn’t smarmy salmonella, from uncooked chicken, I’d only had a doner, and that was finger licken, I was starting to wonder where I was up to Don’t fuck with chicken, cause chicken will fuck you,
It wasn’t my drastic sexual activity I’m giving an ignite talk, I don’t have proclivity. I mean it could have been worse let’s face it It was restricted to things that I’d tasted There are bacteria that are plenty heinous They even attack the dear old penis And of these, it’s syphillis that’s the meanest.
my problem was carried by e coli in my uncooked donor ‘beef’ Spread rapidly through my intestinal tract quickly causing grief E coli can swim 80 times its length in a second Driven my a molecular machine, that’s amazing I reckon, The flagellar motor, fastest machine on the planet, Which can build itself, steer itself, yeah I’d have it under the bonnet of my molecular Vauxhall astra cause it’s two anna half times faster than a formula one, and it’s done, solely by evolution.
the motor assembled in the peptidoglycan layer, first the basal body which is the support and the main stayer then FliG, the almighty rotor, which is what turns when the motor she a goer (above needs to be 15s – expand) next in line the stators are slipped in, in mechanical terms this is actin like a piston driven by ion flow across the cell membrane it exerts torque on the rotor in a mechanism unplain
next is the filament or the propellor Which drives bacteria helter and skelter This the god fearing said was intelligence But educationally speaking that’s totally negligent The same assembly is in a viral capsid Good news for me as a christian I’ve lapsed, these filaments all rotate and tangle together which rotating acts the same as a submarine propellor
Returning to those topics of dicks 90% of which are interested in chicks, With sperm within that desperately seeks, The egg, it’s valhalla, with which it can mix
The bacteria had chosen a soft target to attack the so called luminal cells lining the wall of my stomach. It targeted the ribosome, where proteins are made, And with no new proteins these cells will soon fade Cellular death from a gastric grenade. My stomach responded the only way it knew how By cramping and pumping the offending item of chow I couldn’t assist with Imodium pills or antibiotics it would kill the bacteria and release all the shit that is toxic
My stomach responded the only way it knew how By cramping and pumping the offending item of chow I couldn’t assist with Imodium pills or antibiotics it would kill the bacteria and release all the shit that is toxic This wasn’t my chef’s preconceived idea…
Filler slide to lead into ‘science’
I’d vanquished the foe and conquered my toilet Learnt my lesson to thoroughly cook it or boil it. (chg) An easier way without a lot of kerfuffle, Is next time, to just, order the felafel.
It’s not e.coli that’s the toxic bona fide, It’s that it’s inherited toxic genes on it’s evolutionary ride, And sometimes, in some strains, like O157 It will take you to the toilet guessin, But for karen, who had a wrongun burger in Llay, And for Aaron who touched a porker in the hay, O157 caused them to stay On renal support in a coma for days. Aaron Furnell (one of the twins with the pigs) Karen Morrisroe Clutton
It’s not e.coli that’s the toxic bona fide, It’s that it’s inherited toxic genes on it’s evolutionary ride, And sometimes, in some strains, like O157 It will take you to the toilet guessin, But for karen, who had a wrongun burger in Llay, And for Aaron who touched a porker in the hay, O157 caused them to stay On renal support in a coma for days. Aaron Furnell (one of the twins with the pigs) Karen Morrisroe Clutton

Ignite London - phatmattbaker - Dirty Doner — Presentation Transcript

What’s Special About Bacteria? Matthew Baker Diarrhea and Dödgy Döners
1µm
A self assembling motor, composed of 45 proteins, that can rotate at up to 40,000 rpm , and switch direction of rotation in 10ms.
Bacteria
- Everywhere: 10 times as many bacterial cells in the gut as there are human cells
Thanks Animations: Keichi Namba Lab, Osaka Uni Photos: Brett Tully: http://www.flickr.com/photos/brett-tully/ Doners: Bodrum Kebab, 242 Cowley Road Sperm: E. Coli: Howard Berg’s Lab, Harvard. http://www.rowland.org/labs/bacteria/ Human Flora : Bajzer , M and Seeley , R. Nature 444, 1009-1010 Different bacteria TEM: Wikicommons Aaron and Karen: BBC www.phatmattbaker.com