DIURETICS How do they work? WHAT DO THEY DO? When do I use them? How do I use them?
Na-K-2Cl SYMPORT INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>Loop Diuretics </li></ul></ul><ul><ul><li>High Ceil...
THERAPEUTIC EFFECTS Increase Na Excretion to 25% of Filtered Load Treatment for Oliguric ARF Increase Ca Excretion Treatme...
ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia Profound ECFV Depletion Hyperglycemia Hyperuricemia Ototoxi...
OTHER EFFECTS Increase & Redistribute RBF Increase Renin Release Release PGs Block TGF
Na-Cl SYMPORT INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>Thiazide Diuretics </li></ul></ul><ul><ul><li>Thiazide...
THERAPEUTIC EFFECTS Increase Na Excretion to 5% of Filtered Load Treatment for Hypertension Decrease Ca Excretion Treatmen...
ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia ECFV Depletion Hyperglycemia Hyperuricemia Hyponatremia Hyp...
Na CHANNEL INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>K-Sparing Diuretics </li></ul></ul>Amiloride Triamterene
THERAPEUTIC EFFECTS Enhance Natriuresis  Caused by Other Diuretics Block Na Channels Treatment for  Liddle’s Syndrome Prev...
ADVERSE EFFECTS Renal Stones Interstitial Nephritis Megaloblastosis Hyperkalemia Hyperkalemia Amiloride Triamterene
MINERALOCORTICOID RECEPTOR ANTAGONISTS <ul><li>Also Called: </li></ul><ul><ul><li>K-Sparing Diuretics </li></ul></ul><ul><...
THERAPEUTIC EFFECTS Enhances Natriuresis  Caused by Other Diuretics Blocks Aldosterone Treatment for  Primary Hyper-aldost...
ADVERSE EFFECTS Impotence Gynecomastia Metabolic Acidosis Hyperkalemia Hirsutism CNS Side Effects Peptic Ulcers Gastritis ...
Upcoming SlideShare
Loading in …5
×

DIURETICS Part II - What Do They Do

14,206
-1

Published on

Published in: Health & Medicine
0 Comments
5 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
14,206
On Slideshare
0
From Embeds
0
Number of Embeds
4
Actions
Shares
0
Downloads
379
Comments
0
Likes
5
Embeds 0
No embeds

No notes for slide

DIURETICS Part II - What Do They Do

  1. 1. DIURETICS How do they work? WHAT DO THEY DO? When do I use them? How do I use them?
  2. 2. Na-K-2Cl SYMPORT INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>Loop Diuretics </li></ul></ul><ul><ul><li>High Ceiling Diuretics </li></ul></ul>Ethacrynic Acid Torsemide Bumetanide Furosemide
  3. 3. THERAPEUTIC EFFECTS Increase Na Excretion to 25% of Filtered Load Treatment for Oliguric ARF Increase Ca Excretion Treatment for Hypercalcemia Impair Free Water Reabsorption Treatment for Hyponatremia Increase Venous Capacitance Treatment for Pulmonary Edema Increase Urine Volume Treatment for Severe Edema
  4. 4. ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia Profound ECFV Depletion Hyperglycemia Hyperuricemia Ototoxicity Hypocalcemia
  5. 5. OTHER EFFECTS Increase & Redistribute RBF Increase Renin Release Release PGs Block TGF
  6. 6. Na-Cl SYMPORT INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>Thiazide Diuretics </li></ul></ul><ul><ul><li>Thiazide-Like Diuretics </li></ul></ul>Chlorthalidone Metolazone Chlorothiazide Hydrochlorothiazide
  7. 7. THERAPEUTIC EFFECTS Increase Na Excretion to 5% of Filtered Load Treatment for Hypertension Decrease Ca Excretion Treatment for Calcium Nephrolithiasis Treatment for Nephrogenic Diabetes Insipidus Treatment for Mild Edema
  8. 8. ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia ECFV Depletion Hyperglycemia Hyperuricemia Hyponatremia Hypercalcemia Impotence Increased LDL
  9. 9. Na CHANNEL INHIBITORS <ul><li>Also Called: </li></ul><ul><ul><li>K-Sparing Diuretics </li></ul></ul>Amiloride Triamterene
  10. 10. THERAPEUTIC EFFECTS Enhance Natriuresis Caused by Other Diuretics Block Na Channels Treatment for Liddle’s Syndrome Prevent Hypokalemia Used in Combination with Loop & Thiazide Diuretics Treatment for Lithium-Induced Diabetes Insipidus
  11. 11. ADVERSE EFFECTS Renal Stones Interstitial Nephritis Megaloblastosis Hyperkalemia Hyperkalemia Amiloride Triamterene
  12. 12. MINERALOCORTICOID RECEPTOR ANTAGONISTS <ul><li>Also Called: </li></ul><ul><ul><li>K-Sparing Diuretics </li></ul></ul><ul><ul><li>Aldosterone Antagonists </li></ul></ul>Spironolactone Eplerenone
  13. 13. THERAPEUTIC EFFECTS Enhances Natriuresis Caused by Other Diuretics Blocks Aldosterone Treatment for Primary Hyper-aldosteronism Prevents Hypokalemia Used in Combination with Loop & Thiazide Diuretics Treatment for Edema of Liver Cirrhosis Treatment for Hypertension Treatment for Heart Failure
  14. 14. ADVERSE EFFECTS Impotence Gynecomastia Metabolic Acidosis Hyperkalemia Hirsutism CNS Side Effects Peptic Ulcers Gastritis Menstrual Irregularities Deepening of Voice
  1. A particular slide catching your eye?

    Clipping is a handy way to collect important slides you want to go back to later.

×