DIURETICS Part II - What Do They Do

DIURETICS How do they work? WHAT DO THEY DO? When do I use them? How do I use them?

Na-K-2Cl SYMPORT INHIBITORS
Also Called:
Loop Diuretics
High Ceiling Diuretics
Ethacrynic Acid Torsemide Bumetanide Furosemide

THERAPEUTIC EFFECTS Increase Na Excretion to 25% of Filtered Load Treatment for Oliguric ARF Increase Ca Excretion Treatment for Hypercalcemia Impair Free Water Reabsorption Treatment for Hyponatremia Increase Venous Capacitance Treatment for Pulmonary Edema Increase Urine Volume Treatment for Severe Edema

ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia Profound ECFV Depletion Hyperglycemia Hyperuricemia Ototoxicity Hypocalcemia

OTHER EFFECTS Increase & Redistribute RBF Increase Renin Release Release PGs Block TGF

Na-Cl SYMPORT INHIBITORS
Also Called:
Thiazide Diuretics
Thiazide-Like Diuretics
Chlorthalidone Metolazone Chlorothiazide Hydrochlorothiazide

THERAPEUTIC EFFECTS Increase Na Excretion to 5% of Filtered Load Treatment for Hypertension Decrease Ca Excretion Treatment for Calcium Nephrolithiasis Treatment for Nephrogenic Diabetes Insipidus Treatment for Mild Edema

ADVERSE EFFECTS Hypomagnesemia Metabolic Alkalosis Hypokalemia ECFV Depletion Hyperglycemia Hyperuricemia Hyponatremia Hypercalcemia Impotence Increased LDL

Na CHANNEL INHIBITORS
Also Called:
K-Sparing Diuretics
Amiloride Triamterene

THERAPEUTIC EFFECTS Enhance Natriuresis Caused by Other Diuretics Block Na Channels Treatment for Liddle’s Syndrome Prevent Hypokalemia Used in Combination with Loop & Thiazide Diuretics Treatment for Lithium-Induced Diabetes Insipidus

ADVERSE EFFECTS Renal Stones Interstitial Nephritis Megaloblastosis Hyperkalemia Hyperkalemia Amiloride Triamterene

MINERALOCORTICOID RECEPTOR ANTAGONISTS
Also Called:
K-Sparing Diuretics
Aldosterone Antagonists
Spironolactone Eplerenone

THERAPEUTIC EFFECTS Enhances Natriuresis Caused by Other Diuretics Blocks Aldosterone Treatment for Primary Hyper-aldosteronism Prevents Hypokalemia Used in Combination with Loop & Thiazide Diuretics Treatment for Edema of Liver Cirrhosis Treatment for Hypertension Treatment for Heart Failure

ADVERSE EFFECTS Impotence Gynecomastia Metabolic Acidosis Hyperkalemia Hirsutism CNS Side Effects Peptic Ulcers Gastritis Menstrual Irregularities Deepening of Voice

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DIURETICS Part II - What Do They Do

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DIURETICS Part II - What Do They Do Presentation Transcript