• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
proton pump inhibitors PPT
 

proton pump inhibitors PPT

on

  • 12,342 views

Join PHARMASTUFF UPDATES group on FACEBOOK. follow this link

Join PHARMASTUFF UPDATES group on FACEBOOK. follow this link
https://www.facebook.com/groups/pharmastuff/

Statistics

Views

Total Views
12,342
Views on SlideShare
12,122
Embed Views
220

Actions

Likes
16
Downloads
0
Comments
4

12 Embeds 220

http://pharmastuff.blogspot.com 127
http://pharmastuff.blogspot.in 68
http://pharmastuff.blogspot.ru 10
http://pharmastuff.blogspot.tw 4
http://pharmastuff.blogspot.kr 3
http://www.pharmastuff.blogspot.in 2
http://pharmastuff.blogspot.co.uk 1
http://www.slashdocs.com 1
http://pharmastuff.blogspot.ro 1
http://pharmastuff.blogspot.pt 1
http://pharmastuff.blogspot.com.au 1
http://pharmastuff.blogspot.it 1
More...

Accessibility

Categories

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel

14 of 4 previous next Post a comment

  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
  • Please sir send me at
    rezowan931@gmail.com
    Are you sure you want to
    Your message goes here
    Processing…
  • i like this presentation can you email @ newbiest_garcia@yahoo.com...thank you so much and God bless...
    Are you sure you want to
    Your message goes here
    Processing…
  • Dear Sir/Madam
    i like this presentation can you email @ mahmood2680@aol.com
    Advance thanks
    Mahmood zafar
    Are you sure you want to
    Your message goes here
    Processing…
  • excellent
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    proton pump inhibitors PPT proton pump inhibitors PPT Presentation Transcript

    • SEMINAR ON PROTON PUMP INHIBITORS. SUBMITTED BY AVS.PRAVEEN KUMAR 07P25R0005. UNDER THEGUIDENCE OF Mr. K.SURENDRA Assistant professor,M.Pharm, RAO’S COLLEGE OF PHARMACY
    • PEPTIC ULCER .
      • INTRODUCTION:
      • DEFINITION:
      • Formation of sores or erosions in the lining of stomach and duodenum are referred as peptic ulcers.
      • Ulcers are known to be caused whenever
      • there occurs an imbalance b/n the protective
      • factors.
      • Use of non steroidal anti - inflammatory drugs
      • (NSAIDS).
      • Pathologic hypersecretory disorders.
      • Esophageal ulcers.
      • Gastric Ulcers.
      • Duodenal Ulcers.
      • Stress-induced Ulcers.
      • Marginal or anastomotic
      • Ulcers.
      • Drug or NSAID-induced
      • Ulcers.  
      • The common signs & symptoms of peptic ulcer
        • Pain after 2-3 hours of food consumption.
        • Heart burn and indigestion.
        • Belching (expulsion of gas).
        • Nausea, vomiting, loss of appetite and weight
        • loss.
        • Black tarry stools.
        • Pain in the abdomen with the burning
        • sensation.
        • Blood vomiting and pain during night time.
    •  
      • DIAGNOSIS
        • Endoscopy.
        • X-rays of Upper GI tract.
        • Gastric secretory studies show
          • hyperchlorhydria.
      • Hemorrhage or bleeding.
      • Penetration or spreading.
      • Gastric perforation.
      • Gastric outlet obstruction & Shock.
      • COMPLICATIONS
    •   ANTI ULCER DRUGS
      • DEFINITION
      • Anti ulcer drugs are medicines used to treat ulcers in
      • the stomach and the upper part of small intestine.
      • Anti secretory agents are the drugs that are used to
      • suppress or reduce the gastric acid secretion.
      • 1.Reduction Of gastric acid:
      • H2 Anti Histamines
      • Cimetidine
      • Ranitidine
      • Pantaprazole
      • b) Proton Pump Inhibitors.
      • Omeprazole
      • Lansoprazole
      • Pantoprazole
      • Rabeprazole
      • c) Anti cholinergics
      • Pirenzapine
      • Propantheline
      • Oxyphenonium
      • d) Prostaglandin Analogues
      • Misoprostil
      • Enprostil
      • 2) Neutralization of
      • gastric acid
      • a) Systemic
      • Sodium bicarbonate
      • (NaHCO 3 )
      • b) Non-Systemic
      • Magnesium hydroxide
      • Magnesium trisilicate
      • Aluminum hydroxide gel
      • Magaldrate calcium
      • 3) Ulcer protective
      • Sucralfate
      • Colloidal bismuth
      • sub citrate
      • 4)Ulcer Healing
      • Carbenoxolone
      • sodium
      • 5)Anti-H.pylori drugs
      • Amoxicillin
      • Clarithromycin
      • Metronidazole
      • Tinidazole
      • Tetracycline
    • PROTON PUMP INHIBITORS DRUG OF CHOICE
      • OMEPRAZOLE
      • ESOMEPRAZOLE
      • LANSOPRAZOLE
      • PANTOPRAZOLE
      • RABEPRAZOLE
    • Omeprazole. The proton pump inhibitor OMEPRAZOLE
    • OMEPRAZOLE . Systematic ( IUPAC ) name 6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1 H -benzo[ d ]imidazole Chemical data Formula C 17 H 19 N 3 O 3 S   Mol. mass 345.4 g/mol Pharmacokinetic data Bioavailability 35–60% Metabolism Hepatic ( CYP2C19 , CYP3A4 ) Half life 1 - 1.2 hours Excretion 80% Renal 20% Faecal Therapeutic considerations Routes Oral, IV
    • PHARMACO K INETICS
      • ABSORPTION  
      • The absorption of omeprazole takes place in the
      • small intestine and is usually completed within 3–6
      • hours.
      • The systemic bioavailability of omeprazole after
      • repeated dose is about 60%.Plasma protein binding is
      • about 95%.
      • DISTRIBUTION
      • Distribution of the drug is wide and about 95% of the
      • drug is bound to proteins.
    • METABOLISM
      • Omeprazole. Sulphenic acid.
      • Enzyme inhibitor complex. Sulphenamide.
      • Omeprazole under goes rapid first pass
      • metabolism & systemic hepatic metabolism by
      • cytochrome P450,(CYP2C19 and CYP3A4).
      • The plasma half life of the drug is 0.5 to 1 hour
      • EXCRETION:
      • Urine : 80%
      • Faeces : 20%
    • PHYSIOLOGY OF HCL SECRETION
    • MECHANISM OF ACTION OF OMEPRAZOLE
      • Omeprazole belongs to the category of anti secretory
      • compound that act primarily by suppressing the gastric
      • acid secretion. This action is achieved by inhibiting the
      • H + /K + ATPase enzyme system selectively at the
      • secretory surface of the gastric parietal cells.
      • Adverse reactions
      • CNS Manifestations
      • CVS Manifestations
      • Endocrinal Manifestations
      • Gastrointestinal Manifestations
      •   Drug interactions
      • Omeprazole decreases plasma concentrations of Atazanavir.
      • Omeprazole increases plasma concentrations of
      • Crabamazepine, Tacrolimus, Diazepam.
      • Omeprazole effects are reduced incase of Amino glutethimide.
      • CONTRA INDICATIONS
    • Omeprazole 20 mg, Capsules Omeprazole 10 mg, Capsules OMEZ :10, 20, 40,mg capsules. PROTOLOC :20, 40,mg capsules.
      • MARKETED PRODUCTS
    • OTHER DRUGS
      • PANTOPRAZOLE
      • LANSOPRAZOLE
      • ESOMEPRAZOLE
      • RABEPRAZOLE
      • CONCLUSION
      • Proton pump inhibitors are the first class drugs in
      • the treatment of peptic ulcer and other gastro intestinal
      • disorders.
      • Mainly the drug omeprazole have less side effects when
      • compared to other drugs in this class. So this drug is used
      • very commonly in treating gastric disorders.
      • PPI use is not driven by secondary care admission.
      • Most patients prescribed a therapeutic rather
      • than maintenance dose.
    • REFFERENCE Essentials of medical pharmacology, by KD. Thripathi. Pharmacology & pharmaco therapeutics, by R.S. satoshkar. Text book of medical pharmacology, by Padmaja uday kumar. Pharmacology & clinical pharmaco kinetics, by G. Kutzung. Www. Proton pump inhibitor wikipedia, the free encyclopedia.
    •