Renal Demo 1 Renal Metastases Demo TexRAD: Potential predictive imaging biomarker of response to treatment in metastatic renal cancer TexRAD PRE-TREATMENT Case Study | Demo | Evidence Screenshot of the Renal TexRAD highlighting ‘Right lobe liver’ metastases (pre-treatment) on the conventional CT image (top-left), followed by the derived texture maps superimposed on the conventional CT image – fine (red), medium (green) and coarse (blue) texture 5 6 6 7 8 1 2 3 4

Renal Demo 2 Renal Metastases Demo TexRAD: Potential predictive imaging biomarker of response to treatment in metastatic renal cancer TexRAD POST-TREATMENT Case Study | Demo | Evidence Screenshot of the Renal TexRAD highlighting ‘Right lobe liver’ metastases (post-treatment) on the conventional CT image (top-left), followed by the derived texture maps superimposed on the conventional CT image – fine (red), medium (green) and coarse (blue) texture 5 6 6 7 8 1 2 3 4

Renal Evidence 1 Renal Early Evidence Clinical Evidence – Recent findings a ccepted in ECR 2010 [1] Case Study | Demo | Evidence CT Texture significantly predicts patients with poor prognosis (treatment response) 5 6 6 7 8 1 2 3 4 p < 0.005

Renal Evidence 2 Renal Early Evidence Clinical Evidence – Recent findings a ccepted in ECR 2010 [1] Case Study | Demo | Evidence Existing anatomical imaging response criteria (RECIST) did not significantly predict patients with poor prognosis 5 6 6 7 8 1 2 3 4

References - Renal RENAL 1 Ganeshan B, Rajpopat M, Vinayan A, Nathan P, Goh V, Miles KA. CT texture and enhancement: Potential predictive imaging biomarkers of response to treatment in metastatic renal cancer. Accepted as a paper presentation in European Society of Radiology 2010, Vienna, Austria. References - Renal Cancer Colorectal | Lung | Breast | Prostate | Renal | Lung | Brain | DTA

RENAL

1 Ganeshan B, Rajpopat M, Vinayan A, Nathan P, Goh V, Miles KA. CT texture and enhancement: Potential predictive imaging biomarkers of response to treatment in metastatic renal cancer. Accepted as a paper presentation in European Society of Radiology 2010, Vienna, Austria.