Prostate Demo 1 Prostate Demo Case Study | Demo | Evidence Screenshot of the Prostate TexRAD highlighting the conventional CT image of the prostate (top-left), followed by the derived texture maps superimposed on the conventional CT image – fine (red), medium (green) and coarse (blue) texture 5 6 6 7 8 1 2 3 4

Prostate Evidence 1 Prostate Early Evidence Clinical Evidence – Submitted an abstract UKRC 2010 [1] Case Study | Demo | Evidence A medium texture (mean grey-level intensity) below 2.4 predicted the presence of tumour with an area under the ROC curve of 0.909, p = 0.0001, sensitivity = 84% and specificity = 84% Texture was significantly different between tumour & normal prostate tissue 5 6 6 7 8 1 2 3 4

Prostate Evidence 2 Prostate Early Evidence Clinical Evidence – Submitted an abstract UKRC 2010 [1] Case Study | Demo | Evidence Medium mean grey-level intensity correlates inversely with Prognostic risk factors (determined on the basis of gleason score, PSA level and clinical T stage) Texture correlates with prognostic risk factor (adverse tumour biology and/or patient outcome) 5 6 6 7 8 1 2 3 4

References - Prostate PROSTATE 1. Ganeshan B, Rajpopat M, Young RCD, Chatwin CR, Tremlett J, Robinson A, Miles KA. Preliminary evidence of altered texture on CT. Submitted as a paper to UK Radiological Congress 2010, Birmingham, UK. References - Prostate Cancer Colorectal | Lung | Breast | Prostate | Renal | Lung | Brain | DTA

PROSTATE

1. Ganeshan B, Rajpopat M, Young RCD, Chatwin CR, Tremlett J, Robinson A, Miles KA. Preliminary evidence of altered texture on CT. Submitted as a paper to UK Radiological Congress 2010, Birmingham, UK.