2. Relationships among hypothalamic releasing and inhibiting hormones, the anterior pituitary hormones controlled by hypothalamic hormones, and their respective target organs or tissues .
3. Its 198 amino acid, single chain peptide MW- 23000 Secreted by lactotroph(mammotroph) cells
4.
5. Bromocriptine -Ergot derivative, 2-bromo- α -ergocryptine -potent dopamine agonist Action ↓ Prl release from Pituitary ↓ GI motility ↑ GH release Hypotention Stimulate D2 receptor in CTZ Levodopa like action in CNS
6.
7.
8. Anterior pituitary secrets two Gns FSH & LH Function - promote gametogenesis and secretion of gonadal hormones. FSH- in female in male Induces follicular growth Development of ovam Secretion of estrogens Supports spermatogenesis Ovarian and testicular atrophy
9. LH In Females- In male- Progesteron secretion occurs only under the influence of LH. Induces preovulatory swelling of the ripe graafian follicle and triggers ovulation Stimulates testosterone secretion Disturbances of Gn secretion- Delayed puberty in girls and boys Inadequate Gn secretion – amenorrhoea & sterility in women impotence and infertility in men
10.
11.
12.
13.
14. 39 amino acid single chain peptide MW- 4500 Derived from larger peptide pro-opio melanocortin (MW 30,000) Function- - promotes steriodogenesis in adrenal cortex by stimulating formation in cortical cells - Increase the availability of cholesterol for conversion to pregnenolone
15.
16. Excess production- Cushing’s syndrome USES Diagnosis of disorders of pituitary adrenal axis Injected 25 IU i.v. causes increase in plasma cortisol if adrenals are functional.
