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Estrogens
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Transcript

  • 1. Estrogens (female sex hormones)
  • 2.
    • NATURAL ESTROGENS- Estradiol
    • Synthesized-
    • Graafian follicle
    • Corpus luteum
    • Placenta
    • Estradiol estrone estriol
    • Drawbacks
    • Inactive orally
    • Rapid metabolism in liver
    • have short duration of action
    oxidation hydroxylated
  • 3. SYNTHETIC ESTROGENS Steroidal- Ethinylestradiol Mestranol Tibolone Nonsteroidal - Diethylstilbestrol Hexestrol Dienestrol
  • 4. REGULATION OF SECRETION - Daily- 10- 100µg During pregnancy- 30 mg/day Postmenopausal- 2-10 µg/day ACTIONS Pubertal changes Metabolic effects- Anabolic Retard bone resorption Induce nitric oxide synthase in endothelium
  • 5. MAO Nuclear receptors ER α - uterus,hypothalamus,blood vessels ER β - prostate glands in males ovaries in females Trasdermal estradiol- estradiol-TTS 3 sizes-5, 10& 20cm 2 0.025mg,0.05mg& 0.1mg USES Contraceptives Hormone replacement therapy in postmenopausal women
  • 6. ANTIESTROGENS Clomiphene citrate MAO - induces Gn secretion by blocking estrogenic feedback inhibition of pituitary USE - 1.Sterlity due to failure of ovulation 2.Aid in vitro fertilization 3.Male infertility
  • 7.
    • SELECTIVE ESTROGEN RECEPTOR MODULATOR (SERM)
    • Tamoxifen citrate
    • - Potent estrogen antagonist - breast carcinoma cells, blood vessels
    • Partial agonis t- uterus, bone, liver & pituitary.
    • Raloxifene
    • Antagonist – endometrium & breast
    • Partial agonist- bone & cvs
    • Ormeloxifene
    • Antagonist - breast & uterus
  • 8. PROGESTINS Progestin= favouring pregnancy Natural progestin Progesterone Synthetic progestins Progesterone derivatives Medroxyprogesterone acetate Megestrol acetate Dydrogesterone Hydroxyprogesterone caproate
  • 9. 19-Nortestosterone derivatives Older compounds Newer compounds Norethindrone Norethynodrel Ethynodiol diacetate Lynestrenol Allylstrenol Norgestrel Levonorgestrel Desogestrel Norgestimate Gestodene
  • 10. ACTION Prepration of uterus for nidation Maintenance of pregnancy CNS Pituitary Metabolism Body temperature MOA Steroid receptors Female genital tract, breast,CNS and pituitary
  • 11.
    • USES
    • Contraceptives
    • HRT
    • Dysfunctional uterine bleeding
    • Habitual abortion
  • 12.
    • ANTIPROGESTINS
    • Mifepristone
    • 19-norsteroid
    • Potent antiprogestational
    • Antiglucocorticoid
    • Antiandrogenic
    • USES
    • Termination of pregnancy-upto 7 weeks
    • Cervical ripening
    • Induction of labour
    • Cushing syndrome
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