Glucose G-6-P Synthease Glycogen Hexokynase Phosphase A Phosphase B Ca + Epinephrine PFK PA LA ATP ATP NADH+H NAD+ Non- Oxidative Oxidative Cytoplasm PA Ca Mitochondria Acetyl CoA Citric Acid Co2 Co2 ATP ATP A TP- C P (Creatine Phosphate) ADP ADP + P+ energy CP C+P ADP
Stimulate / Inhibit Factor Inhibits Stimulates Explain why do your answer(s) in the previous columns “make sense?” ADP PFK If ADP is being used or is building up, it means that the body is in need of energy (ATP –> ADP+P). ADP will stimulate or “tell” PFK to act on G-^P, thus beginning non-oxidative metabolism (glycolysis) G-6-P Hexokinase and Phosphoralase If there is an excess of G-6-P in your body it will inhibit HK and phosporalase, which normally signals glucose to be broken down into G-6-P. Ca + Glycolisis It stimulates muscle contraction, phosphoralase b, it will stimulate phosphoralase a which signals glycogen to be converted into G-6-P. ATP-CP PFK If there is excess in ATP-CP, lactic acid builds up in the body leading to PFK being inhibited. Citric Acid PFK If there is an excess of Citric Acid, there would be no need for Acetyl CoA or pyruvic acid so the PFK would be inhibited. O 2 PFK If there is an excess of O2, there would be no need for oxidative metabolism which is initiated by pyruvic acid so PFK would be inhibited since pyruvic acid is not needed. Epinephrine Synth Phos. If there is an excess of adrenaline, the production of glycogen would increase. Makes ATP production unnecessary. Insulin HK & PK If there is an excess of insulin, hexokinase and PFK would be stimulated so that glucose can be broken down into G-6-P and then into pyruvic acid. Glucagon Phosph If there is an excess of glucagons,phospohalayse- A would be stimulated to help glycogen turn into G-6-P.