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Energy Metabolism
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Energy Metabolism

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  • 1. ATP ADP + P = ENERGY ATPase CP C + P When ATP is depleted Then reuses it ADP stimulates PFK because it will tell PFK to act of G-6-P, thus beginning non-oxidative metabolism (glycolosis). ATP-CP inhibits PFK because if you already have enough energy (ATP-CP) PFK is not needed to produce ATP.
  • 2. Glucose HK G-6-P Synthetase ATP ATP PA LA Glycogen NAD + NADH+H NADH+H NAD + Cycle necessary for energy Epinephrine inhibits, increases fat metabolism G-6-P inhibits HK because you do not need glucose when you have an abundance of G-6-P Non-oxidative/ Anaerobic PFK Phosphorylase a Phosphorylase b Ca + , Epinephrine (adrenaline) Epinephrine stimulates phosphorylase because it is needed to send the epinephrine back to G-6-P and through PFK into the cycle to generate ATP. Ca + stimulates phosphorylase because calcium is needed to produce glycogen, which is needed by phophorylase.
  • 3. CORI CYCLE LA Glucose Glycogen Pasta (carbs)
  • 4. Excessive LA Decrease in pH Enzymes and muscular properties don’t work “ heavy feeling” Slow down Cytoplasm PA LA (OXIDATIVE)
  • 5. Mitochondria Acetyl CoA ATP ATP CO 2 CO 2 Kreb’s Cycle Electron Transport Chain H H H H H H H H H H H H H H 32 ATP molecules O 2 + H H 2 O (OXIDATIVE) Citric Acid inhibits PFK because Kreb’s Cycle produces ATP, therefore PFK is not needed to produce ATP. O 2 inhibits PFK because if you don’t have enough oxygen, then LA builds up, which will cause a “heavy feeling”. Citric Acid
  • 6.
    • Insulin stimulates HK and PFK because insulin gives you energy so you do not need to produce glucose to use HK to go into G-6-P and PFK to produce ATP.
    • Glucagon stimulates phosphorylase because glucagon causes an almost instantaneous release of glucose from the liver. Phosphorylase comes into play because without it the glycogen will not be transferred out of the liver.