Energy Metabolism- how your body makes energy and where the energy comes from ATP ADP + P + energy ATP- CP (0-10 seconds) creatine phosphate (CP) CP C + P ATP ADP + P + energy Non-Oxidative/Anaerobic (10-90 seconds) Glucose G-6-P glycogen ATP ATP PA LA NADH + H NAD+ CA+ phosphorylase a phosphorylase b Acetyl CoA citric acid CO 2 H + H + H + H + H + 32 ATP H + H + H + O + H + = H 2 O hexokinase PFK Oxidative (90+ seconds)
Factor Inhibits Stimulates Explain why do your answer(s) in the previous columns “make sense?” ADP PFK If ADP is being used or is building up, it means that the body is in need of energy (ATP –> ADP+P). ADP will stimulate or “tell” PFK to act on G-^P, thus beginning non-oxidative metabolism (glycolysis) G-6-P HK and Phos. A If there is an excess of G-6-P in your body it will inhibit hexokinase which normally signals glucose to be broken down into G-6-P and also will inhibit Phosphorylase A which signals glycogen to be broken down into G-6-P Ca + Phos. A If there is an excess of Ca phosphorylase b will stimulate phosphorylase a which signals glycogen to be converted into G-6-P ATP-CP PFK If there is an excess of ATP-CP lactic acid builds up in your body leading to PFK being inhibited. Citric Acid PFK If there is an excess of Citric Acid there is no need for Acetyl CoA or pyruvic acid so the PFK would be inhibited. O 2 PFK If there is an excess of oxygen there would be no need for oxidative metabolism which is initiated by pyruvic acid so PFK would be inhibited since pyruvic acid isn’t needed. Epinephrine Synthase Phos. A If there is an excess of epinephrine the enzyme, phosphorylase a would be stimulated to produce G-6-P from glycogen and synthase would be inhibited so G-6-P wouldn’t turn into glycogen. Insulin HK and PFK If there is an excess of insulin, hexokinase(HK) and PFK would be stimulated so that glucose could be broken down into G-6-P and then into pyruvic acid. Glucagon Phos. A If there is an excess of glucagon, phosphorylase a would be stimulated to help glycogen turn into G-6-P.
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