Types of iron with examples
Absorption, transport & storage
Factors affecting iron absorption
Dietary sources & RDA
Minerals are inorganic compound which are essential
for the normal growth and maintenance of the body.
Major elements/Macro minerals :
e.g : Ca, Mg, P, Na, K, Cl, S
Trace elements/ Micro minerals:
e.g: Fe, I, Cu, Co, Se, Mn, Zn, Se, Mo.
Body iron content : 3-4 g
Types of iron :
• Functional iron(Heme):
Heme proteins 7 enzymes:
Hb, Mb, cytochromes
xanthine oxidase, typtophen pyrrolase.
Storge iron(non heme containing protin):
Absorption, transport & storage:
duodenum & jejunum
Only Fe+2 form is absorbed
Iron metabolism is maintained by regulation at the level of
absorption & not by excretion.
Iron store in the body depleted absorption increased.
When adequate amount of iron present in the body
absorption is decreased this is called “mucosal block
Regulation of absorption:
1. Mucosal regulation: absorption required DMT-I,
ferroportin, both are synthesised by down regulation of
HEPCIDIN. In anemia hepacidin synthesis decreased so
ferroportin synthesis increased.
2. Store regulation
3. Erythropoeric regulation
1 molecule bind with 2 iron molecule
Iron deficiency transferrin level increased.
Present in intestine, mucosal cell, liver, spleen, bone
Form by partial deproteinization of ferritin
Present in liver, spleen, bone marrow
Iron is one way element.
It is very efficiently utilized and reutilized,not
excreted in urine.
1mg of iron is loss through bile, sweat, feces.
Any type of bleeding will cause loss of iron.
Functions of iron:
Fuctions are exerts through the compound in which it
Hb & myoglobin: transport of o2 & co2
Cytochrome : for ETC& oxidative phosphorylation
Hookworm infection, 1-0.3 ml of blood loss
Piles, peptic ulcer, menorrhagia
Repeated pregnancies- 1gm loss
Nephrosis-loss of heptoglobin, hemopexin,
Microcytic hypochromatic anemia
Hb <10gm – apathy
Derangment in cellular respiration
• Serum iron leve:l- decreased in iron deficiency,
kwashikor, acute and chronic infection
• TIBC: - increased in hypochromatic anemia,
• TfR:- increased in iron deficiency anemia,
Oral iron supplementation:
Pregnancy: 100mg of iron + 500microgram folic acid
Children: 20mg of iron + 100microgram folic acid
Iron tablet gives along with vitaminC & E
Excess of iron
brown granules) seen in
spleen & liver
Causes: repeated blood
Hereditary due to
abnormal gene on
Total ironis is 25-30gm
deposited in liver cell n
leads to cell death &
Deposited in skin leads
to brown yellow
Deposited in pancreas
leads to diabetes
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