By :
Payal patel
Outline:
Introduction
Types of iron with examples
Absorption, transport & storage
Factors affecting iron absorption
F...
Minerals
Minerals are inorganic compound which are essential

for the normal growth and maintenance of the body.

 Major...
Iron
Macro mineral
Body iron content : 3-4 g
•
•
•
•

Blood- 75%
Liver
Bone marrow
Muscles

Types of iron :

• Function...
Storge iron(non heme containing protin):
 Transferrin
 Ferritin
 Hemosiderin.

Absorption, transport & storage:
Absorp...
Factors affect iron absorption:
Increased:

Decreased:

 Acidity

 Phytate & oxalate

 Ascorbic acid

 Tea

 cysteine...
 Iron metabolism is maintained by regulation at the level of

absorption & not by excretion.
 Iron store in the body dep...
Transport form:
 Transferrin:
 Glycoprotein
 1 molecule bind with 2 iron molecule
 Iron deficiency transferrin level i...
 Iron is one way element.
 It is very efficiently utilized and reutilized,not

excreted in urine.
 1mg of iron is loss ...
Functions of iron:
 Fuctions are exerts through the compound in which it

is present.
 Hb & myoglobin: transport of o2 &...
Dietary sources:





Plant
Leafy vegetable
Pulses
Cerals
jeggery

Animal
 Liver
 Meat
 Milk-poor
RDA:
Male: 10mg/day
Menstruation:20mg/day
Pregnancy: 40mg/day
Lactation: 40 mg/day
Deficiency:
Causes:
Nutrition deficiency
Hypochlorhydria
Gastrectomy
Hookworm infection, 1-0.3 ml of blood loss
Pile...
Clinical manifestation:

Microcytic hypochromatic anemia
Hb <10gm – apathy
Derangment in cellular respiration
Irritabi...
Tretment:
Oral iron supplementation:
Pregnancy: 100mg of iron + 500microgram folic acid
Children: 20mg of iron + 100mic...
Hemosiderosis:
Excess of iron
Hemosiderin(golden
brown granules) seen in
spleen & liver
Causes: repeated blood
transfus...
Iron
Iron
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Iron metabolism

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Iron

  1. 1. By : Payal patel
  2. 2. Outline: Introduction Types of iron with examples Absorption, transport & storage Factors affecting iron absorption Functions Dietary sources & RDA Deficiency Toxicity
  3. 3. Minerals Minerals are inorganic compound which are essential for the normal growth and maintenance of the body.  Major elements/Macro minerals : • Requirement>100mg/day  e.g : Ca, Mg, P, Na, K, Cl, S  Trace elements/ Micro minerals: • Requirement<100mg/day e.g: Fe, I, Cu, Co, Se, Mn, Zn, Se, Mo.
  4. 4. Iron Macro mineral Body iron content : 3-4 g • • • • Blood- 75% Liver Bone marrow Muscles Types of iron : • Functional iron(Heme):  Heme proteins 7 enzymes:  Hb, Mb, cytochromes  catalases, peroxidases  xanthine oxidase, typtophen pyrrolase.
  5. 5. Storge iron(non heme containing protin):  Transferrin  Ferritin  Hemosiderin. Absorption, transport & storage: Absorption:  duodenum & jejunum  Only Fe+2 form is absorbed
  6. 6. Factors affect iron absorption: Increased: Decreased:  Acidity  Phytate & oxalate  Ascorbic acid  Tea  cysteine  Copper deficiency  Iron deficiency anemia  Calcium, lead, phosphate  Alkaline  gastractomy
  7. 7.  Iron metabolism is maintained by regulation at the level of absorption & not by excretion.  Iron store in the body depleted absorption increased.  When adequate amount of iron present in the body absorption is decreased this is called “mucosal block theory” Regulation of absorption: 1. Mucosal regulation: absorption required DMT-I, ferroportin, both are synthesised by down regulation of HEPCIDIN. In anemia hepacidin synthesis decreased so ferroportin synthesis increased. 2. Store regulation 3. Erythropoeric regulation
  8. 8. Transport form:  Transferrin:  Glycoprotein  1 molecule bind with 2 iron molecule  Iron deficiency transferrin level increased. Storage form:  Ferritin:  Present in intestine, mucosal cell, liver, spleen, bone marrow  Hemosiderin:  Form by partial deproteinization of ferritin  Present in liver, spleen, bone marrow
  9. 9.  Iron is one way element.  It is very efficiently utilized and reutilized,not excreted in urine.  1mg of iron is loss through bile, sweat, feces.  Any type of bleeding will cause loss of iron.
  10. 10. Functions of iron:  Fuctions are exerts through the compound in which it is present.  Hb & myoglobin: transport of o2 & co2  Cytochrome : for ETC& oxidative phosphorylation  Peroxidase: phagocytosis
  11. 11. Dietary sources:     Plant Leafy vegetable Pulses Cerals jeggery Animal  Liver  Meat  Milk-poor
  12. 12. RDA: Male: 10mg/day Menstruation:20mg/day Pregnancy: 40mg/day Lactation: 40 mg/day
  13. 13. Deficiency: Causes: Nutrition deficiency Hypochlorhydria Gastrectomy Hookworm infection, 1-0.3 ml of blood loss Piles, peptic ulcer, menorrhagia Repeated pregnancies- 1gm loss Nephrosis-loss of heptoglobin, hemopexin, transferrin Lead poisoning
  14. 14. Clinical manifestation: Microcytic hypochromatic anemia Hb <10gm – apathy Derangment in cellular respiration Irritability Laboratory diagnosis: • Serum iron leve:l- decreased in iron deficiency, kwashikor, acute and chronic infection • TIBC: - increased in hypochromatic anemia, pregnancy • TfR:- increased in iron deficiency anemia, hemolytic anemia
  15. 15. Tretment: Oral iron supplementation: Pregnancy: 100mg of iron + 500microgram folic acid Children: 20mg of iron + 100microgram folic acid Iron tablet gives along with vitaminC & E Toxicty: Intake>50mg Nausea Abdominal pain
  16. 16. Hemosiderosis: Excess of iron Hemosiderin(golden brown granules) seen in spleen & liver Causes: repeated blood transfusion Primary hemosiderosis: Hereditary due to abnormal gene on chrmosome no.6 Bantu siderosis: Hemochromatosis: Total ironis is 25-30gm Hemosiderin is deposited in liver cell n leads to cell death & cirrhosis Deposited in skin leads to brown yellow discolorition called hemochromatosis Deposited in pancreas leads to diabetes Bronze diabetes
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