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Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker
 

Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker

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Future of health care, medical research, life sciences and medical technology - keynote by Futurist and physician Dr Patrick Dixon - http://www.globalchange.com. Diagnostics, imaging, super-resolution ...

Future of health care, medical research, life sciences and medical technology - keynote by Futurist and physician Dr Patrick Dixon - http://www.globalchange.com. Diagnostics, imaging, super-resolution microscopy, cancer therapy, oncolytic viruses, future of anti-ageing research, funding of health care, health care in emerging markets, EU and US health trends.

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    Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker Presentation Transcript

    • SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views
    • 3
    • 4
    • Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
    • Read  Human  Genome  in  an  Hour  for  $1000 •Fluidics •Biochemistry •Semiconductors •Gene3cs •Mathema3cs •Immunology
    • How will future life sciences research be funded ?
    • Strategies  o+en  overtaken  by  Events Need  for  Agile  Leadership   Discoveries Product   Recalls Government Policy  changes Economic Crises
    • 18
    • WGP  1980-­‐2013  (%,constant  prices) Diversity  to  seize global  markets
    • EU  GDP  1980-­‐2013   (%,constant  prices)  
    • Vietnam  GDP  1985-­‐2011  
    • >40% WDP by 2015 —IMF - adjusted for Purchasing Power Parity
    • 24
    • 25
    • 26
    • • £ 375 bn $2.3 trillion US + $85bn per month
    • EMOTION
    • Europe Dying 4 couples to produce single great-grand child Stop Ageing
    • 75%  of  all  US  and  UK  wealth  owned  by  those  over  65 65%  health  spend  is  on  over  65s
    • Chronic  CondiTons  –  MulTple  Needs •100  million  Americans  have  chronic  condi3ons   •  80%  of  health  spending •  88%  of  all  prescrip3ons •  70%  of  physician  visits •  66%  Medicare  cost  =  people  with  5+  condi3ons Almost  all  caused  by  one  single  factor  
    • AGE Neuro-degeneration Cancer / Heart / Stroke / Obesity Infections / Chronic wounds Joint replacement / Mobility Care of elderly at home
    • Rationing all government Health competes with ....RESEARCH Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition
    • Irrational Rationing
    • Pharma Crisis Patent expiry, pipeline length, lack innovation
    • Performance Shift in retail health care from health treatment to life enhancement
    • •$15bn spend on cosmetic surgery in US (2012) •14.6 million procedures - up 5% in 12 months •6.1 million Botox treatments - up by 8% Want to look better $100 for 1.7-ounces
    • may be Want to think better............ •20%  students  in  US  use  memory-­‐enhancing  drugs    
    • Know more than your doctor
    • 90% in US want to view test results before their doctor Mayo Clinic
    • 2 million visits every month
    • 1  trillion pages  a  month
    • Future life sciences research will be funded increasingly by emerging markets and wealthy individuals
    • £2.8bn in 2012 - 450 platforms - x2 / year
    • http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg
    • Future of Med TechHow smart innovation will transform human health Dr Patrick Dixon Chairman Global Change Ltd
    • Expect clinical medtech to feed lab medtech
    • Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
    • coatings and robots
    • Text
    • Digital Control
    • Human nerve cells growing on an integrated circuit
    • Imaging and Robotics
    • Faster  healing
    • •Positron emission tomography •Magnetic nuclear resonance
    • Cloud Processing
    • •$75bn endoscopy market by 2022 ($23bn 2010) •125,000 stents or carotid surgery a year in US
    • •non slip tracheal implant
    • •Dune device detecting •cancer during operation
    • Organ support
    • Print Elastomere
    • •Harvard  Bioscience •Bioreactor     •Bone  marrow  stem  cells •Polymer  scaffold
    • Print New Skin (Lexmar)
    • 1.75m  in  US  with  Macular  degeneraTon
    • Device or Virus ?
    • Using high power lasers to transfer fluorophores into long-lived "off states" – a non-fluorescent molecule state. Can take 2-10 minutes to develop the image fully.
    • • Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in approximately 10 years. Big Data
    • Computer-­‐aided  decisions  save  lives
    • Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads
    • Tele-Monitoring Ecosystem
    • •Diabetes, congestive heart failure, obstructive pulmonary •2.2 million at home •> $22bn by 2015 •Mobile telephony Smart  Tablet
    • Future of BiotechHow biotech will change life on earth and slow ageing Dr Patrick Dixon Chairman Global Change Ltd
    • Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
    • Read  Human  Genome  in  an  Hour  for  $1000 •Fluidics •Biochemistry •Semiconductors •Gene3cs •Mathema3cs •Immunology
    • Genes for old age, speech, memory, criminality, depression, obesity and stable relationships
    • Genetic Prophecy
    • •Danaher (Beckman Coulter)
    • Brand Trusted Natural Medicine Epigenetics impact on gene expression from environment
    • Obesity epidemic 1 in 3 babies in New York will develop adult-type diabetes - many as children Obesity costs US $100bn a year
    • —Resveratol —Broccoli  (sulforaphane) —Flavonoids —Beta-­‐carotene —Anthocyanins —Alpha-­‐linoleic  acid —Glucosamine —Chondroi3n —Ginseng —Garlic  oil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group) Interesting Neutraceuticals
    • Can we stop ageing ?
    • Worn out Mitochondria – Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine
    • Alzheimers: Souvenaid —Souvenaid clinical trial —Multi-nutrient drink —MIT collaboration
    • Monkeys  on  diet  live  longer •After 20 years •80% alive v 50% on normal calories •Less cancer, diabetes, •Less heart disease, strokes •Less brain decay 124
    • Metformin story 125
    • Low blood pressure and total body lift - Alteon
    • Stem Cells
    • •Pigs  teeth  grown  inside  rats •Mice  grow  new  teeth  from  nerve  cells  /  gumGrow New Teeth
    • Repair Heart / Brain
    • Woman with a male brain - lessons for brain repair
    • •Adenovirus   •Infected  mouse  hair  cells •Permanent  colour  change Permanent  Hair  Colour    
    • •Adenovirus  contains  Math1  gene •Turns  young  ear  cells  into  hair  cells •Inject  virus  par3cles  into  inner  ear •New  hair  cells  grow  near  Organ  of  Cor3 •Research  in  Guinea  Pigs Cure for Deafness Or transform cells as part of organ repair
    • Adenoviral human telomerase reverse transcriptase
    • Confidential HSV1  causes  cold  sores.  When  engineered  as  Seprehvir   (HSV-­‐1716),  it  is  harmless  to  healthy  @ssue. •Oncoly3c  viruses •Infect  and  kill  cancer  tumour  cells   •No  damage  to  healthy  3ssue •Evidence  of  impact  in  clinical  trials •Able  to  deliver  new  genes  into  cancer  cells •Micro-­‐dose  chemo,  micro-­‐dose  radiotherapy Viruses to cure cancer
    • Slow or no ageing is a reality •Rockfish, Turtles, some Whales •No signs of getting old Rougheye  rockfish  (Sebastes  aleuFanus)  —  205  years Aldabra  Giant  Tortoise  —  255  years Lobsters  are  believed  to  live  100  or  more  years Ocean  Quahog  clam  —  405  years Some animals do not seem to “age” in normal way
    • 136
    • 1 in 12 in Liberia – UNICEF 1  in  10  women  die  in  childbirth  in  some   parts  of  Northern  Mozambique  
    • 138 1.8  million  small  children  die  every  year  because  of  dirty  water  supplies
    • SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views