SustainAgilityHow smart innovation, biotech and agile
leadership will transform human health
Dr Patrick Dixon Chairman Glo...
3
4
Cloud
Nanotech
Mobile
Biotech
Genes + Cells
Digital Connect
Atoms
Converging - Combinations
Read	
  Human	
  Genome	
  in	
  an	
  Hour	
  for	
  $1000
•Fluidics
•Biochemistry
•Semiconductors
•Gene3cs
•Mathema3cs
•...
How will future
life sciences research be funded ?
Strategies	
  o+en	
  overtaken	
  by	
  Events
Need	
  for	
  Agile	
  Leadership	
  
Discoveries Product	
  
Recalls
Gov...
•
•
•
18
WGP	
  1980-­‐2013	
  (%,constant	
  prices)
Diversity	
  to	
  seize
global	
  markets
EU	
  GDP	
  1980-­‐2013	
  
(%,constant	
  prices)	
  
Vietnam	
  GDP	
  1985-­‐2011	
  
>40% WDP by 2015
—IMF - adjusted for Purchasing Power Parity
24
25
26
•
£ 375 bn
$2.3 trillion US + $85bn per month
EMOTION
Europe Dying
4 couples to
produce single
great-grand
child
Stop Ageing
75%	
  of	
  all	
  US	
  and	
  UK	
  wealth	
  owned	
  by	
  those	
  over	
  65
65%	
  health	
  spend	
  is	
  on	
  ...
Chronic	
  CondiTons	
  –	
  MulTple	
  Needs
•100	
  million	
  Americans	
  have	
  chronic	
  condi3ons	
  
•	
  80%	
 ...
AGE
Neuro-degeneration
Cancer / Heart / Stroke / Obesity
Infections / Chronic wounds
Joint replacement / Mobility
Care of ...
Rationing all government
Health competes with ....RESEARCH
Specialties compete
Diseases / Patient groups
Treatment methods...
Irrational Rationing
Pharma Crisis
Patent expiry, pipeline length, lack innovation
Performance
Shift in retail health care from health
treatment to life enhancement
•$15bn spend on cosmetic surgery in US (2012)
•14.6 million procedures - up 5% in 12 months
•6.1 million Botox treatments ...
may be
Want to think better............
•20%	
  students	
  in	
  US	
  use	
  memory-­‐enhancing	
  drugs	
  	
  
Know more than your doctor
90% in US want to view test results
before their doctor
Mayo Clinic
2 million visits
every month
1	
  trillion
pages	
  a	
  month
Future life sciences research will be
funded increasingly by emerging
markets and wealthy individuals
£2.8bn in 2012 - 450 platforms - x2 / year
http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg
http://blog.f1000.com/wp-content/uploads/2012/01...
Future of Med TechHow smart innovation will transform human health
Dr Patrick Dixon Chairman Global Change Ltd
Expect clinical medtech to feed lab medtech
Cloud
Nanotech
Mobile
Biotech
Genes + Cells
Digital Connect
Atoms
Converging - Combinations
coatings and robots
Text
Digital
Control
Human nerve cells growing on an integrated circuit
Imaging and Robotics
Faster	
  healing
•Positron emission tomography
•Magnetic nuclear resonance
Cloud Processing
•$75bn endoscopy market by 2022 ($23bn 2010)
•125,000 stents or carotid surgery a year in US
•non slip tracheal implant
•Dune device detecting
•cancer during operation
Organ support
Print Elastomere
•Harvard	
  Bioscience
•Bioreactor	
  	
  
•Bone	
  marrow	
  stem	
  cells
•Polymer	
  scaffold
Print New Skin (Lexmar)
1.75m	
  in	
  US	
  with	
  Macular	
  degeneraTon
Device or Virus ?
Using high power lasers to transfer fluorophores
into long-lived "off states" – a non-fluorescent
molecule state. Can take...
• Zettabyte = 1024 Exabytes
Exabyte = 1024 Petabytes
Petabyte = 1024 Terabytes
Terabytes = 1024 Gigabytes That's a data ex...
Computer-­‐aided	
  decisions	
  save	
  lives
Ottawa Hospital, Ontario - 3000 ipads
Mayo Clinic - 2000 ipads
Tele-Monitoring
Ecosystem
•Diabetes, congestive heart failure, obstructive pulmonary
•2.2 million at home
•> $22bn by 2015
•Mobile telephony
Smart
	...
Future of BiotechHow biotech will change life on earth and slow ageing
Dr Patrick Dixon Chairman Global Change Ltd
Cloud
Nanotech
Mobile
Biotech
Genes + Cells
Digital Connect
Atoms
Converging - Combinations
Read	
  Human	
  Genome	
  in	
  an	
  Hour	
  for	
  $1000
•Fluidics
•Biochemistry
•Semiconductors
•Gene3cs
•Mathema3cs
•...
Genes for old age, speech, memory, criminality,
depression, obesity and stable relationships
Genetic Prophecy
•Danaher (Beckman Coulter)
Brand
Trusted
Natural
Medicine
Epigenetics
impact on gene
expression from
environment
Obesity epidemic
1 in 3 babies in New York will develop
adult-type diabetes - many as children
Obesity costs US $100bn a y...
—Resveratol
—Broccoli	
  (sulforaphane)
—Flavonoids
—Beta-­‐carotene
—Anthocyanins
—Alpha-­‐linoleic	
  acid
—Gluco...
Can we stop ageing ?
Worn out Mitochondria – Energy Boost
R-alpha-lipoic acid
Acetyl-L-carnitine
Alzheimers: Souvenaid
—Souvenaid clinical trial
—Multi-nutrient drink
—MIT collaboration
Monkeys	
  on	
  diet	
  live	
  longer
•After 20 years
•80% alive v 50% on normal calories
•Less cancer, diabetes,
•Less ...
Metformin story
125
Low blood pressure and total body lift - Alteon
Stem
Cells
•Pigs	
  teeth	
  grown	
  inside	
  rats
•Mice	
  grow	
  new	
  teeth	
  from	
  nerve	
  cells	
  /	
  gumGrow New Teeth
Repair Heart / Brain
Woman with a male brain
- lessons for brain repair
•Adenovirus	
  
•Infected	
  mouse	
  hair	
  cells
•Permanent	
  colour	
  change
Permanent	
  Hair	
  Colour	
  	
  
•Adenovirus	
  contains	
  Math1	
  gene
•Turns	
  young	
  ear	
  cells	
  into	
  hair	
  cells
•Inject	
  virus	
  par3...
Adenoviral human telomerase
reverse transcriptase
Confidential
HSV1	
  causes	
  cold	
  sores.	
  When	
  engineered	
  as	
  Seprehvir	
  
(HSV-­‐1716),	
  it	
  is	
  ha...
Slow or no ageing is a reality
•Rockfish, Turtles, some Whales
•No signs of getting old
Rougheye	
  rockfish	
  (Sebastes	
...
136
1 in 12 in Liberia – UNICEF
1	
  in	
  10	
  women	
  die	
  in	
  childbirth	
  in	
  some	
  
parts	
  of	
  Northern	
 ...
138
1.8	
  million	
  small	
  children	
  die	
  every	
  year	
  because	
  of	
  dirty	
  water	
  supplies
SustainAgilityHow smart innovation, biotech and agile
leadership will transform human health
Dr Patrick Dixon Chairman Glo...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory ...
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Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker

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Future of health care, medical research, life sciences and medical technology - keynote by Futurist and physician Dr Patrick Dixon - http://www.globalchange.com. Diagnostics, imaging, super-resolution microscopy, cancer therapy, oncolytic viruses, future of anti-ageing research, funding of health care, health care in emerging markets, EU and US health trends.

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Future of life sciences, health care, medical technology, biotech, future of the pharma industry, diagnostics, laboratory research and medical imaging / super-resolution microscopy - keynote speaker

  1. 1. SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views
  2. 2. 3
  3. 3. 4
  4. 4. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
  5. 5. Read  Human  Genome  in  an  Hour  for  $1000 •Fluidics •Biochemistry •Semiconductors •Gene3cs •Mathema3cs •Immunology
  6. 6. How will future life sciences research be funded ?
  7. 7. Strategies  o+en  overtaken  by  Events Need  for  Agile  Leadership   Discoveries Product   Recalls Government Policy  changes Economic Crises
  8. 8.
  9. 9.
  10. 10.
  11. 11. 18
  12. 12. WGP  1980-­‐2013  (%,constant  prices) Diversity  to  seize global  markets
  13. 13. EU  GDP  1980-­‐2013   (%,constant  prices)  
  14. 14. Vietnam  GDP  1985-­‐2011  
  15. 15. >40% WDP by 2015 —IMF - adjusted for Purchasing Power Parity
  16. 16. 24
  17. 17. 25
  18. 18. 26
  19. 19. • £ 375 bn $2.3 trillion US + $85bn per month
  20. 20. EMOTION
  21. 21. Europe Dying 4 couples to produce single great-grand child Stop Ageing
  22. 22. 75%  of  all  US  and  UK  wealth  owned  by  those  over  65 65%  health  spend  is  on  over  65s
  23. 23. Chronic  CondiTons  –  MulTple  Needs •100  million  Americans  have  chronic  condi3ons   •  80%  of  health  spending •  88%  of  all  prescrip3ons •  70%  of  physician  visits •  66%  Medicare  cost  =  people  with  5+  condi3ons Almost  all  caused  by  one  single  factor  
  24. 24. AGE Neuro-degeneration Cancer / Heart / Stroke / Obesity Infections / Chronic wounds Joint replacement / Mobility Care of elderly at home
  25. 25. Rationing all government Health competes with ....RESEARCH Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition
  26. 26. Irrational Rationing
  27. 27. Pharma Crisis Patent expiry, pipeline length, lack innovation
  28. 28. Performance Shift in retail health care from health treatment to life enhancement
  29. 29. •$15bn spend on cosmetic surgery in US (2012) •14.6 million procedures - up 5% in 12 months •6.1 million Botox treatments - up by 8% Want to look better $100 for 1.7-ounces
  30. 30. may be Want to think better............ •20%  students  in  US  use  memory-­‐enhancing  drugs    
  31. 31. Know more than your doctor
  32. 32. 90% in US want to view test results before their doctor Mayo Clinic
  33. 33. 2 million visits every month
  34. 34. 1  trillion pages  a  month
  35. 35. Future life sciences research will be funded increasingly by emerging markets and wealthy individuals
  36. 36. £2.8bn in 2012 - 450 platforms - x2 / year
  37. 37. http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg http://blog.f1000.com/wp-content/uploads/2012/01/ResearchForBlog-logo.jpg
  38. 38. Future of Med TechHow smart innovation will transform human health Dr Patrick Dixon Chairman Global Change Ltd
  39. 39. Expect clinical medtech to feed lab medtech
  40. 40. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
  41. 41. coatings and robots
  42. 42. Text
  43. 43. Digital Control
  44. 44. Human nerve cells growing on an integrated circuit
  45. 45. Imaging and Robotics
  46. 46. Faster  healing
  47. 47. •Positron emission tomography •Magnetic nuclear resonance
  48. 48. Cloud Processing
  49. 49. •$75bn endoscopy market by 2022 ($23bn 2010) •125,000 stents or carotid surgery a year in US
  50. 50. •non slip tracheal implant
  51. 51. •Dune device detecting •cancer during operation
  52. 52. Organ support
  53. 53. Print Elastomere
  54. 54. •Harvard  Bioscience •Bioreactor     •Bone  marrow  stem  cells •Polymer  scaffold
  55. 55. Print New Skin (Lexmar)
  56. 56. 1.75m  in  US  with  Macular  degeneraTon
  57. 57. Device or Virus ?
  58. 58. Using high power lasers to transfer fluorophores into long-lived "off states" – a non-fluorescent molecule state. Can take 2-10 minutes to develop the image fully.
  59. 59. • Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in approximately 10 years. Big Data
  60. 60. Computer-­‐aided  decisions  save  lives
  61. 61. Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads
  62. 62. Tele-Monitoring Ecosystem
  63. 63. •Diabetes, congestive heart failure, obstructive pulmonary •2.2 million at home •> $22bn by 2015 •Mobile telephony Smart  Tablet
  64. 64. Future of BiotechHow biotech will change life on earth and slow ageing Dr Patrick Dixon Chairman Global Change Ltd
  65. 65. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
  66. 66. Read  Human  Genome  in  an  Hour  for  $1000 •Fluidics •Biochemistry •Semiconductors •Gene3cs •Mathema3cs •Immunology
  67. 67. Genes for old age, speech, memory, criminality, depression, obesity and stable relationships
  68. 68. Genetic Prophecy
  69. 69. •Danaher (Beckman Coulter)
  70. 70. Brand Trusted Natural Medicine Epigenetics impact on gene expression from environment
  71. 71. Obesity epidemic 1 in 3 babies in New York will develop adult-type diabetes - many as children Obesity costs US $100bn a year
  72. 72. —Resveratol —Broccoli  (sulforaphane) —Flavonoids —Beta-­‐carotene —Anthocyanins —Alpha-­‐linoleic  acid —Glucosamine —Chondroi3n —Ginseng —Garlic  oil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group) Interesting Neutraceuticals
  73. 73. Can we stop ageing ?
  74. 74. Worn out Mitochondria – Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine
  75. 75. Alzheimers: Souvenaid —Souvenaid clinical trial —Multi-nutrient drink —MIT collaboration
  76. 76. Monkeys  on  diet  live  longer •After 20 years •80% alive v 50% on normal calories •Less cancer, diabetes, •Less heart disease, strokes •Less brain decay 124
  77. 77. Metformin story 125
  78. 78. Low blood pressure and total body lift - Alteon
  79. 79. Stem Cells
  80. 80. •Pigs  teeth  grown  inside  rats •Mice  grow  new  teeth  from  nerve  cells  /  gumGrow New Teeth
  81. 81. Repair Heart / Brain
  82. 82. Woman with a male brain - lessons for brain repair
  83. 83. •Adenovirus   •Infected  mouse  hair  cells •Permanent  colour  change Permanent  Hair  Colour    
  84. 84. •Adenovirus  contains  Math1  gene •Turns  young  ear  cells  into  hair  cells •Inject  virus  par3cles  into  inner  ear •New  hair  cells  grow  near  Organ  of  Cor3 •Research  in  Guinea  Pigs Cure for Deafness Or transform cells as part of organ repair
  85. 85. Adenoviral human telomerase reverse transcriptase
  86. 86. Confidential HSV1  causes  cold  sores.  When  engineered  as  Seprehvir   (HSV-­‐1716),  it  is  harmless  to  healthy  @ssue. •Oncoly3c  viruses •Infect  and  kill  cancer  tumour  cells   •No  damage  to  healthy  3ssue •Evidence  of  impact  in  clinical  trials •Able  to  deliver  new  genes  into  cancer  cells •Micro-­‐dose  chemo,  micro-­‐dose  radiotherapy Viruses to cure cancer
  87. 87. Slow or no ageing is a reality •Rockfish, Turtles, some Whales •No signs of getting old Rougheye  rockfish  (Sebastes  aleuFanus)  —  205  years Aldabra  Giant  Tortoise  —  255  years Lobsters  are  believed  to  live  100  or  more  years Ocean  Quahog  clam  —  405  years Some animals do not seem to “age” in normal way
  88. 88. 136
  89. 89. 1 in 12 in Liberia – UNICEF 1  in  10  women  die  in  childbirth  in  some   parts  of  Northern  Mozambique  
  90. 90. 138 1.8  million  small  children  die  every  year  because  of  dirty  water  supplies
  91. 91. SustainAgilityHow smart innovation, biotech and agile leadership will transform human health Dr Patrick Dixon Chairman Global Change Ltd http://www.globalchange.com - 5 million video views
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