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Dr Patrick Dixon Chairman Global Change Ltd
SustainAgility
How smart innovation, biotech and agile
leadership will transfo...
5
C-Brace
Cloud
Nanotech
Mobile
Biotech
Genes +
Cells
Digital Connect
Atoms
Converging - Combinations
Strategies	
  o+en	
  overtaken	
  by	
  Events
Need	
  for	
  Agile	
  Leadership	
  
Discoveries Product	
  
Recalls
Gov...
• Click	
  to	
  edit	
  Master	
  text	
  styles
19
AGILITY
means
more than
one strategy
How will future
life sciences
research be funded ?
WGP	
  1980-­‐2013	
  (%,constant	
  prices)
Diversity	
  to	
  seize
global	
  markets
EU	
  GDP	
  1980-­‐2013	
  
(%,constant	
  prices)	
  
Vietnam	
  GDP	
  1985-­‐2011	
  
>40% WDP by 2015
— IMF - adjusted for Purchasing Power Parity
27
28
29
32
• Click	
  to	
  edit	
  Master	
  text	
  styles
• Click	
  to	
  edit	
  Master	
  text	
  styles
•
£ 375 bn
$2.3 trillion US + $85bn per month
Text
Digital
Control
Human nerve cells growing on an integrated circuit
The future is about
EMOTION
300 million move to cities in China and
475 million to cities in Africa by 2025
1 billion over 60 year olds in 10 years
• most are women
Europe Dying
4 couples to
produce single
great-grand
child
Stop Ageing
75%	
  of	
  all	
  US	
  and	
  UK	
  wealth	
  owned	
  by	
  
those	
  over	
  65	
  -­‐	
  but	
  many	
  need	
  to	
...
Older	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  Money
65% health budget on those over 65
66% of over 50s in Asia by 2050
—81 million now
over 60 in India
Chronic Conditions – Multiple Needs
• 100 million Americans have chronic conditions
• 80% of health spending
• 88% of all ...
65% health spend on those over 65
AGE
Health
Challenges
Neurodegeneration eg Avonex
Cancer / Obesity /Chronic wounds
Infections eg Ceftolozane/tazobactam
Joint ...
Patent Expiry
3000 Canadian Pharma Patents 2003-11
• $75bn endoscopy market by 2022 ($23bn 2010)
•125,000 stents or carotid surgery a year in US
Cloud Processing
•Positron emission tomography
•Magnetic nuclear resonance
Imaging and Robotics
• Zettabyte = 1024 Exabytes
Exabyte = 1024 Petabytes
Petabyte = 1024 Terabytes
Terabytes = 1024 Gigabytes That's a
data ex...
Product scanning
means safety
Computer-aided
decisions save
lives and time
Ottawa Hospital, Ontario - 3000 ipads
Mayo Clinic - 2000 ipads
Home Care
Tele-Monitoring
Ecosystem
•Diabetes, congestive heart failure,
obstructive pulmonary
•2.2 million at home
•> $22bn by 2015
•Mobile telephony
•swallow smart pill
•relays info about gut
•sensor-enabled tablets
•check if medication taken
Smart Tablet Startups
EU 8bn in UK alone
Independent Living
Mobility
Comfort
Support
Safety
Faster healing
82
Med Tech
most med tech rapidly obsolete
Know more than
your doctor
90% in US want
to view test
results before
their doctor
Mayo Clinic
2 million visits
every month
1	
  trillion
pages	
  a	
  
month
Read Human Genome in an Hour
• Fluidics
• Biochemistry
• Semiconductors
• Genetics
• Mathematics
• Immunology
• Robotics
Home Tele-Monitoring
Virtual Medicine
Irrational
Rationing
Rationing all government
Health competes with ....
Specialties compete
Diseases / Patient groups
Treatment methods
Greates...
Irrational
Rationing
Transurethral resection
Laser destruction
Microwave destruction
Heat destruction
Da Vinci robot
Competition
Patient campaigns / Google
Legal / IT linked decisions
Financial incentives
Patient experience /quality life
Local skills ...
Performance
Shift in retail health care from health
treatment to life enhancement
• $15bn spend on cosmetic surgery in US (2012)
• 14.6 million procedures - up 5% in 12 months
• 6.1 million Botox treatmen...
may be
Want to think better
• 20% students in US use memory-enhancing drugs
Can we stop ageing ?
Brand
Trusted
Natural
Obesity Epidemic
—1 in 3 newborn babies
in NewYork will
develop diabetes
—Obesity costs US
$100bn a year
Interesting Neutraceuticals
—Resveratol
—Broccoli (sulforaphane)
—Flavonoids
—Beta-carotene
—Anthocyanins
—Alpha-lin...
—Click to edit Master text
styles
116
$100 for 1.7-ounces
Alzheimers: Souvenaid
—Souvenaid clinical trial
—Multi-nutrient drink
—MIT collaboration
Worn out Mitochondria – Energy Boost
R-alpha-lipoic acid
Acetyl-L-carnitine
• Adenovirus
• Infected mouse hair cells
• Permanent colour change
Permanent Hair Colour
Treatment which restores and
maintains the youthful elasticity of
hardened arteries – and helps
wrinkled skin. Global sale...
• Pigs teeth grown
inside rats
• Mice grow new
teeth from nerve
cells / gum tissue
Grow New Teeth
Repair of heart or brain
damage following
coronary / stroke
using adult stem cells
Repair Heart / Brain
Stem cells
Compete or
Co-operate
Near-perfect repair of
heart or brain damage
following coronary /
stroke
Your
Brain
Can
Repair
Monkeys on diet live longer
• After 20 years - 80% alive v 50% on normal calories
• Less cancer, diabetes, heart disease, ...
Slow or no ageing is a reality
• Rockfish,
Turtles, some
Whales
• No signs of
getting old
Rougheye rockfish (Sebastes aleu...
Summary - Pharma and Ageing
—Many new opportunities
—See through older eyes
—Connect with emotion
—Timing is everythin...
Genetic Prophecy
Genes for old age, speech, memory, criminality,
depression, obesity and stable relationships
• Danaher (Beckman Coulter)
• Fluidics
• Biochemistry
• Semiconductors
• Genetics
• Mathematics
• Immunology
• Robotics
Read genome in 2 hours for $5,...
•Using sound
and
microfluidics
to separate
cells
Stem
Cells
Brain
Can
Repair
Itself
Daily
•Positron emission tomography
•Magnetic nuclear resonance
Cloud processing huge investment
Imaging and Robotics
•$75bn endoscopy market by 2022 ($23bn 2010)
• Dune device detecting
• cancer during operation
• 125,000 stents or carotid surgery a year in US
•non slip tracheal implant
• 3d print
Organ support
Print Elastomere
• Harvard Bioscience
• Bioreactor
• Bone marrow stem cells
• Polymer scaffold
Print New Skin (Lexmar)
Negative
Pressure
Healing
• 14 times oxygen levels in wound tissue
Hyperbaric
Oxygen
Adenoviral
human
telomerase
reverse
transcriptase
coatings and robots
Build Nanotech Robots
Adenoviral
human
telomerase
reverse
transcriptase
Heal Old Wounds
Mobility
Comfort
Support
Safety
• `
eSight
Device or Virus
£2.8bn in 2012 - 450 platforms - x2 / year
• Emerging markets
Emerging Markets
1 in 10 women die giving birth in
parts of Northern Mozambique
1 in 12 in Liberia – UNICEF
179
180
• Adenovirus contains Math1 gene
• Turns young ear cells into hair cells
• Inject virus particles into inner ear
• New hai...
Confidential
HSV1	
  causes	
  cold	
  sores.	
  
When	
  engineered	
  as	
  
Seprehvir	
  (HSV-­‐1716),	
  it	
  is	
  
...
• Reolysin - 28%
improvement in
response to
chemo in head
and neck cancer
• Early Phase III
185
Viruses to cure cancer ?
• Emerging markets
1 in 12 in Liberia – UNICEF
1 in 10 women die in childbirth in some
parts of Northern Mozambique
188
1.8 million small children die every year
because of dirty water supplies
189
globalchange.com - slides and videos
SustainAgility
How smart innovation and agile
leadership will transform human health
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
Future of health care, life sciences, biotech, medtech and pharma - keynote speaker
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Future of health care, life sciences, biotech, medtech and pharma - keynote speaker

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Future of life sciences research, medical technology, super-resolution microscopy, health care, pharma industry, laboratory research, clinical data and medical diagnostics. Oncolytic viruses, gene therapy, negligible senescence, anti ageing, training of health care professionals. Keynote by Dr Patrick Dixon - conference speaker

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Transcript of "Future of health care, life sciences, biotech, medtech and pharma - keynote speaker"

  1. 1. Dr Patrick Dixon Chairman Global Change Ltd SustainAgility How smart innovation, biotech and agile leadership will transform human health
  2. 2. 5 C-Brace
  3. 3. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
  4. 4. Strategies  o+en  overtaken  by  Events Need  for  Agile  Leadership   Discoveries Product   Recalls Government Policy  changes Economic Crises
  5. 5. • Click  to  edit  Master  text  styles 19
  6. 6. AGILITY means more than one strategy
  7. 7. How will future life sciences research be funded ?
  8. 8. WGP  1980-­‐2013  (%,constant  prices) Diversity  to  seize global  markets
  9. 9. EU  GDP  1980-­‐2013   (%,constant  prices)  
  10. 10. Vietnam  GDP  1985-­‐2011  
  11. 11. >40% WDP by 2015 — IMF - adjusted for Purchasing Power Parity
  12. 12. 27
  13. 13. 28
  14. 14. 29
  15. 15. 32
  16. 16. • Click  to  edit  Master  text  styles
  17. 17. • Click  to  edit  Master  text  styles
  18. 18. • £ 375 bn $2.3 trillion US + $85bn per month
  19. 19. Text
  20. 20. Digital Control
  21. 21. Human nerve cells growing on an integrated circuit
  22. 22. The future is about EMOTION
  23. 23. 300 million move to cities in China and 475 million to cities in Africa by 2025
  24. 24. 1 billion over 60 year olds in 10 years
  25. 25. • most are women
  26. 26. Europe Dying 4 couples to produce single great-grand child Stop Ageing
  27. 27. 75%  of  all  US  and  UK  wealth  owned  by   those  over  65  -­‐  but  many  need  to  work
  28. 28. Older                                    Money 65% health budget on those over 65
  29. 29. 66% of over 50s in Asia by 2050 —81 million now over 60 in India
  30. 30. Chronic Conditions – Multiple Needs • 100 million Americans have chronic conditions • 80% of health spending • 88% of all prescriptions • 70% of physician visits • 66% Medicare cost = people with 5+ conditions Almost all caused by one single factor
  31. 31. 65% health spend on those over 65 AGE
  32. 32. Health Challenges Neurodegeneration eg Avonex Cancer / Obesity /Chronic wounds Infections eg Ceftolozane/tazobactam Joint replacement long term Care elderly at home
  33. 33. Patent Expiry 3000 Canadian Pharma Patents 2003-11
  34. 34. • $75bn endoscopy market by 2022 ($23bn 2010)
  35. 35. •125,000 stents or carotid surgery a year in US
  36. 36. Cloud Processing
  37. 37. •Positron emission tomography •Magnetic nuclear resonance
  38. 38. Imaging and Robotics
  39. 39. • Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in Big Data
  40. 40. Product scanning means safety Computer-aided decisions save lives and time
  41. 41. Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads
  42. 42. Home Care
  43. 43. Tele-Monitoring Ecosystem
  44. 44. •Diabetes, congestive heart failure, obstructive pulmonary •2.2 million at home •> $22bn by 2015 •Mobile telephony
  45. 45. •swallow smart pill •relays info about gut •sensor-enabled tablets •check if medication taken Smart Tablet Startups
  46. 46. EU 8bn in UK alone Independent Living
  47. 47. Mobility Comfort Support Safety
  48. 48. Faster healing
  49. 49. 82 Med Tech most med tech rapidly obsolete
  50. 50. Know more than your doctor
  51. 51. 90% in US want to view test results before their doctor Mayo Clinic
  52. 52. 2 million visits every month
  53. 53. 1  trillion pages  a   month
  54. 54. Read Human Genome in an Hour • Fluidics • Biochemistry • Semiconductors • Genetics • Mathematics • Immunology • Robotics
  55. 55. Home Tele-Monitoring
  56. 56. Virtual Medicine
  57. 57. Irrational Rationing
  58. 58. Rationing all government Health competes with .... Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition
  59. 59. Irrational Rationing
  60. 60. Transurethral resection Laser destruction Microwave destruction Heat destruction Da Vinci robot Competition
  61. 61. Patient campaigns / Google Legal / IT linked decisions Financial incentives Patient experience /quality life Local skills / experience Appropriate infrastructure Impact on rationing
  62. 62. Performance Shift in retail health care from health treatment to life enhancement
  63. 63. • $15bn spend on cosmetic surgery in US (2012) • 14.6 million procedures - up 5% in 12 months • 6.1 million Botox treatments - up by 8% Want to look better
  64. 64. may be Want to think better • 20% students in US use memory-enhancing drugs
  65. 65. Can we stop ageing ?
  66. 66. Brand Trusted Natural
  67. 67. Obesity Epidemic —1 in 3 newborn babies in NewYork will develop diabetes —Obesity costs US $100bn a year
  68. 68. Interesting Neutraceuticals —Resveratol —Broccoli (sulforaphane) —Flavonoids —Beta-carotene —Anthocyanins —Alpha-linoleic acid —Glucosamine —Chondroitin —Ginseng —Garlic oil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group)
  69. 69. —Click to edit Master text styles 116 $100 for 1.7-ounces
  70. 70. Alzheimers: Souvenaid —Souvenaid clinical trial —Multi-nutrient drink —MIT collaboration
  71. 71. Worn out Mitochondria – Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine
  72. 72. • Adenovirus • Infected mouse hair cells • Permanent colour change Permanent Hair Colour
  73. 73. Treatment which restores and maintains the youthful elasticity of hardened arteries – and helps wrinkled skin. Global sales? Low blood pressure and total body lift Alteon
  74. 74. • Pigs teeth grown inside rats • Mice grow new teeth from nerve cells / gum tissue Grow New Teeth
  75. 75. Repair of heart or brain damage following coronary / stroke using adult stem cells Repair Heart / Brain
  76. 76. Stem cells Compete or Co-operate
  77. 77. Near-perfect repair of heart or brain damage following coronary / stroke
  78. 78. Your Brain Can Repair
  79. 79. Monkeys on diet live longer • After 20 years - 80% alive v 50% on normal calories • Less cancer, diabetes, heart disease, strokes, brain decay 126
  80. 80. Slow or no ageing is a reality • Rockfish, Turtles, some Whales • No signs of getting old Rougheye rockfish (Sebastes aleutianus) — 205 years Aldabra Giant Tortoise — 255 years Lobsters are believed to live 100 or more years Ocean Quahog clam — 405 years Some animals do not seem to “age” in normal way
  81. 81. Summary - Pharma and Ageing —Many new opportunities —See through older eyes —Connect with emotion —Timing is everything —Events + decisions —Performance - wellness —Diagnostics —Home monitoring —Neutraceuticals —Save treatment costs —Improve mobility —Prolong independence Ageing remedies with real evidence will be tomorrow’s blockbusters
  82. 82. Genetic Prophecy
  83. 83. Genes for old age, speech, memory, criminality, depression, obesity and stable relationships
  84. 84. • Danaher (Beckman Coulter)
  85. 85. • Fluidics • Biochemistry • Semiconductors • Genetics • Mathematics • Immunology • Robotics Read genome in 2 hours for $5,000
  86. 86. •Using sound and microfluidics to separate cells
  87. 87. Stem Cells
  88. 88. Brain Can Repair Itself Daily
  89. 89. •Positron emission tomography •Magnetic nuclear resonance
  90. 90. Cloud processing huge investment
  91. 91. Imaging and Robotics
  92. 92. •$75bn endoscopy market by 2022 ($23bn 2010)
  93. 93. • Dune device detecting • cancer during operation
  94. 94. • 125,000 stents or carotid surgery a year in US
  95. 95. •non slip tracheal implant
  96. 96. • 3d print
  97. 97. Organ support
  98. 98. Print Elastomere
  99. 99. • Harvard Bioscience • Bioreactor • Bone marrow stem cells • Polymer scaffold
  100. 100. Print New Skin (Lexmar)
  101. 101. Negative Pressure Healing
  102. 102. • 14 times oxygen levels in wound tissue Hyperbaric Oxygen
  103. 103. Adenoviral human telomerase reverse transcriptase
  104. 104. coatings and robots
  105. 105. Build Nanotech Robots
  106. 106. Adenoviral human telomerase reverse transcriptase Heal Old Wounds
  107. 107. Mobility Comfort Support Safety
  108. 108. • `
  109. 109. eSight
  110. 110. Device or Virus
  111. 111. £2.8bn in 2012 - 450 platforms - x2 / year
  112. 112. • Emerging markets Emerging Markets
  113. 113. 1 in 10 women die giving birth in parts of Northern Mozambique 1 in 12 in Liberia – UNICEF
  114. 114. 179
  115. 115. 180
  116. 116. • Adenovirus contains Math1 gene • Turns young ear cells into hair cells • Inject virus particles into inner ear • New hair cells grow near Organ of Corti • Research in Guinea Pigs Cure for Deafness ?
  117. 117. Confidential HSV1  causes  cold  sores.   When  engineered  as   Seprehvir  (HSV-­‐1716),  it  is   harmless  to  healthy  @ssue. •Oncolytic viruses •Infect and kill cancer tumour cells •No damage to healthy tissue •Evidence of impact in clinical trials •Able to deliver new genes into cancer cells •Micro-dose chemo, micro-dose radiotherapy Viruses to cure cancer ?
  118. 118. • Reolysin - 28% improvement in response to chemo in head and neck cancer • Early Phase III 185 Viruses to cure cancer ?
  119. 119. • Emerging markets
  120. 120. 1 in 12 in Liberia – UNICEF 1 in 10 women die in childbirth in some parts of Northern Mozambique
  121. 121. 188 1.8 million small children die every year because of dirty water supplies
  122. 122. 189
  123. 123. globalchange.com - slides and videos SustainAgility How smart innovation and agile leadership will transform human health
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