Future of health care, life sciences, biotech, medtech and pharma - keynote speaker

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Future of life sciences research, medical technology, super-resolution microscopy, health care, pharma industry, laboratory research, clinical data and medical diagnostics. Oncolytic viruses, gene …

Future of life sciences research, medical technology, super-resolution microscopy, health care, pharma industry, laboratory research, clinical data and medical diagnostics. Oncolytic viruses, gene therapy, negligible senescence, anti ageing, training of health care professionals. Keynote by Dr Patrick Dixon - conference speaker

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  • 1. Dr Patrick Dixon Chairman Global Change Ltd SustainAgility How smart innovation, biotech and agile leadership will transform human health
  • 2. 5 C-Brace
  • 3. Cloud Nanotech Mobile Biotech Genes + Cells Digital Connect Atoms Converging - Combinations
  • 4. Strategies  o+en  overtaken  by  Events Need  for  Agile  Leadership   Discoveries Product   Recalls Government Policy  changes Economic Crises
  • 5. • Click  to  edit  Master  text  styles 19
  • 6. AGILITY means more than one strategy
  • 7. How will future life sciences research be funded ?
  • 8. WGP  1980-­‐2013  (%,constant  prices) Diversity  to  seize global  markets
  • 9. EU  GDP  1980-­‐2013   (%,constant  prices)  
  • 10. Vietnam  GDP  1985-­‐2011  
  • 11. >40% WDP by 2015 — IMF - adjusted for Purchasing Power Parity
  • 12. 27
  • 13. 28
  • 14. 29
  • 15. 32
  • 16. • Click  to  edit  Master  text  styles
  • 17. • Click  to  edit  Master  text  styles
  • 18. • £ 375 bn $2.3 trillion US + $85bn per month
  • 19. Text
  • 20. Digital Control
  • 21. Human nerve cells growing on an integrated circuit
  • 22. The future is about EMOTION
  • 23. 300 million move to cities in China and 475 million to cities in Africa by 2025
  • 24. 1 billion over 60 year olds in 10 years
  • 25. • most are women
  • 26. Europe Dying 4 couples to produce single great-grand child Stop Ageing
  • 27. 75%  of  all  US  and  UK  wealth  owned  by   those  over  65  -­‐  but  many  need  to  work
  • 28. Older                                    Money 65% health budget on those over 65
  • 29. 66% of over 50s in Asia by 2050 —81 million now over 60 in India
  • 30. Chronic Conditions – Multiple Needs • 100 million Americans have chronic conditions • 80% of health spending • 88% of all prescriptions • 70% of physician visits • 66% Medicare cost = people with 5+ conditions Almost all caused by one single factor
  • 31. 65% health spend on those over 65 AGE
  • 32. Health Challenges Neurodegeneration eg Avonex Cancer / Obesity /Chronic wounds Infections eg Ceftolozane/tazobactam Joint replacement long term Care elderly at home
  • 33. Patent Expiry 3000 Canadian Pharma Patents 2003-11
  • 34. • $75bn endoscopy market by 2022 ($23bn 2010)
  • 35. •125,000 stents or carotid surgery a year in US
  • 36. Cloud Processing
  • 37. •Positron emission tomography •Magnetic nuclear resonance
  • 38. Imaging and Robotics
  • 39. • Zettabyte = 1024 Exabytes Exabyte = 1024 Petabytes Petabyte = 1024 Terabytes Terabytes = 1024 Gigabytes That's a data explosion of 44x in Big Data
  • 40. Product scanning means safety Computer-aided decisions save lives and time
  • 41. Ottawa Hospital, Ontario - 3000 ipads Mayo Clinic - 2000 ipads
  • 42. Home Care
  • 43. Tele-Monitoring Ecosystem
  • 44. •Diabetes, congestive heart failure, obstructive pulmonary •2.2 million at home •> $22bn by 2015 •Mobile telephony
  • 45. •swallow smart pill •relays info about gut •sensor-enabled tablets •check if medication taken Smart Tablet Startups
  • 46. EU 8bn in UK alone Independent Living
  • 47. Mobility Comfort Support Safety
  • 48. Faster healing
  • 49. 82 Med Tech most med tech rapidly obsolete
  • 50. Know more than your doctor
  • 51. 90% in US want to view test results before their doctor Mayo Clinic
  • 52. 2 million visits every month
  • 53. 1  trillion pages  a   month
  • 54. Read Human Genome in an Hour • Fluidics • Biochemistry • Semiconductors • Genetics • Mathematics • Immunology • Robotics
  • 55. Home Tele-Monitoring
  • 56. Virtual Medicine
  • 57. Irrational Rationing
  • 58. Rationing all government Health competes with .... Specialties compete Diseases / Patient groups Treatment methods Greatest impact for greatest number Competition
  • 59. Irrational Rationing
  • 60. Transurethral resection Laser destruction Microwave destruction Heat destruction Da Vinci robot Competition
  • 61. Patient campaigns / Google Legal / IT linked decisions Financial incentives Patient experience /quality life Local skills / experience Appropriate infrastructure Impact on rationing
  • 62. Performance Shift in retail health care from health treatment to life enhancement
  • 63. • $15bn spend on cosmetic surgery in US (2012) • 14.6 million procedures - up 5% in 12 months • 6.1 million Botox treatments - up by 8% Want to look better
  • 64. may be Want to think better • 20% students in US use memory-enhancing drugs
  • 65. Can we stop ageing ?
  • 66. Brand Trusted Natural
  • 67. Obesity Epidemic —1 in 3 newborn babies in NewYork will develop diabetes —Obesity costs US $100bn a year
  • 68. Interesting Neutraceuticals —Resveratol —Broccoli (sulforaphane) —Flavonoids —Beta-carotene —Anthocyanins —Alpha-linoleic acid —Glucosamine —Chondroitin —Ginseng —Garlic oil Global Sales Nutraceutical Ingredients $24 Billion by 2015 China will surpass the U.S. and Western Europe as the largest global producer and consumer by 2020. (Freedonia Group)
  • 69. —Click to edit Master text styles 116 $100 for 1.7-ounces
  • 70. Alzheimers: Souvenaid —Souvenaid clinical trial —Multi-nutrient drink —MIT collaboration
  • 71. Worn out Mitochondria – Energy Boost R-alpha-lipoic acid Acetyl-L-carnitine
  • 72. • Adenovirus • Infected mouse hair cells • Permanent colour change Permanent Hair Colour
  • 73. Treatment which restores and maintains the youthful elasticity of hardened arteries – and helps wrinkled skin. Global sales? Low blood pressure and total body lift Alteon
  • 74. • Pigs teeth grown inside rats • Mice grow new teeth from nerve cells / gum tissue Grow New Teeth
  • 75. Repair of heart or brain damage following coronary / stroke using adult stem cells Repair Heart / Brain
  • 76. Stem cells Compete or Co-operate
  • 77. Near-perfect repair of heart or brain damage following coronary / stroke
  • 78. Your Brain Can Repair
  • 79. Monkeys on diet live longer • After 20 years - 80% alive v 50% on normal calories • Less cancer, diabetes, heart disease, strokes, brain decay 126
  • 80. Slow or no ageing is a reality • Rockfish, Turtles, some Whales • No signs of getting old Rougheye rockfish (Sebastes aleutianus) — 205 years Aldabra Giant Tortoise — 255 years Lobsters are believed to live 100 or more years Ocean Quahog clam — 405 years Some animals do not seem to “age” in normal way
  • 81. Summary - Pharma and Ageing —Many new opportunities —See through older eyes —Connect with emotion —Timing is everything —Events + decisions —Performance - wellness —Diagnostics —Home monitoring —Neutraceuticals —Save treatment costs —Improve mobility —Prolong independence Ageing remedies with real evidence will be tomorrow’s blockbusters
  • 82. Genetic Prophecy
  • 83. Genes for old age, speech, memory, criminality, depression, obesity and stable relationships
  • 84. • Danaher (Beckman Coulter)
  • 85. • Fluidics • Biochemistry • Semiconductors • Genetics • Mathematics • Immunology • Robotics Read genome in 2 hours for $5,000
  • 86. •Using sound and microfluidics to separate cells
  • 87. Stem Cells
  • 88. Brain Can Repair Itself Daily
  • 89. •Positron emission tomography •Magnetic nuclear resonance
  • 90. Cloud processing huge investment
  • 91. Imaging and Robotics
  • 92. •$75bn endoscopy market by 2022 ($23bn 2010)
  • 93. • Dune device detecting • cancer during operation
  • 94. • 125,000 stents or carotid surgery a year in US
  • 95. •non slip tracheal implant
  • 96. • 3d print
  • 97. Organ support
  • 98. Print Elastomere
  • 99. • Harvard Bioscience • Bioreactor • Bone marrow stem cells • Polymer scaffold
  • 100. Print New Skin (Lexmar)
  • 101. Negative Pressure Healing
  • 102. • 14 times oxygen levels in wound tissue Hyperbaric Oxygen
  • 103. Adenoviral human telomerase reverse transcriptase
  • 104. coatings and robots
  • 105. Build Nanotech Robots
  • 106. Adenoviral human telomerase reverse transcriptase Heal Old Wounds
  • 107. Mobility Comfort Support Safety
  • 108. • `
  • 109. eSight
  • 110. Device or Virus
  • 111. £2.8bn in 2012 - 450 platforms - x2 / year
  • 112. • Emerging markets Emerging Markets
  • 113. 1 in 10 women die giving birth in parts of Northern Mozambique 1 in 12 in Liberia – UNICEF
  • 114. 179
  • 115. 180
  • 116. • Adenovirus contains Math1 gene • Turns young ear cells into hair cells • Inject virus particles into inner ear • New hair cells grow near Organ of Corti • Research in Guinea Pigs Cure for Deafness ?
  • 117. Confidential HSV1  causes  cold  sores.   When  engineered  as   Seprehvir  (HSV-­‐1716),  it  is   harmless  to  healthy  @ssue. •Oncolytic viruses •Infect and kill cancer tumour cells •No damage to healthy tissue •Evidence of impact in clinical trials •Able to deliver new genes into cancer cells •Micro-dose chemo, micro-dose radiotherapy Viruses to cure cancer ?
  • 118. • Reolysin - 28% improvement in response to chemo in head and neck cancer • Early Phase III 185 Viruses to cure cancer ?
  • 119. • Emerging markets
  • 120. 1 in 12 in Liberia – UNICEF 1 in 10 women die in childbirth in some parts of Northern Mozambique
  • 121. 188 1.8 million small children die every year because of dirty water supplies
  • 122. 189
  • 123. globalchange.com - slides and videos SustainAgility How smart innovation and agile leadership will transform human health