Curriculum Vitae


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Curriculum Vitae

  1. 1. Liu, C CURRICULUM VITAE Date prepared: July, 2010 Chen Liu M. D., Ph. D.OFFICE ADDRESS: University of Florida, College of Medicine Department of Pathology, Immunology & Laboratory Medicine 1600 SW Archer Rd, M646, Gainesville, FL 32610 Tel: 352-273-5413 Fax: 352-392-3053 Email: liu@pathology.ufl.eduCURRENT POSITION Endowed Chair in Gastrointestinal and Liver Research Professor of Pathology (tenured) Director, Gastrointestinal and Liver Pathology Section Director, Gastrointestinal and Liver Pathology Fellowship Program Attending Physician in Shands Hospital of the University of FloridaCLINICAL SPECIALTYSurgical pathology specialized in gastrointestinal and liver pathology,AP/CP Board-Certified, American Board of PathologyCURRENT RESEARCH PROGRAMS Innate and adaptive immune response and immunopathology of hepatitis C Viral infection Liver cancer biomarker discovery and therapy Alpha-1 antitrypsin deficiency and liver disease 1
  2. 2. Liu, C Graft vs. Host Disease (GVHD)EDUCATION Surgical Pathology Fellow, UT MD Anderson Cancer Center, Houston, TX Resident, AP/CP, Medical College of Pennsylvania, Philadelphia, PA Postdoctoral Fellow, Vogt Lab, Scripps Clinic and Research Foundation, La Jolla, CA Ph.D., Mason Lab, University of Pennsylvania School of Medicine, Philadelphia, PA Graduate Training, Peking Union Medical College, Beijing, China M.D., Tong Liao Medical College, Tong Liao, ChinaCLINICAL EXPERIENCES Surgical Pathologist , Shands Hospital at U. Florida 2000--Present Surgical Pathology Fellowship, UT M.D. Anderson Cancer Center 1999--2000 Residency MCP-Hahnemann University Hospitals, Philadelphia, 1996--1999 GI Liver Pathology Chester County Hospital, PA April 1-April 30, 1999 GI Liver Pathology Yale University Department of Pathology Nov. 1-Nov 30, 1998 Dermatopathology University of Pennsylvania Dept. of Dermatology May 1-May 30, 1999 Hematology & Oncology Hahnemann University Hospital Department of Hematology Sept.1, 1998-Oct. 31, 1998RESEARCH EXPERIENCESResidency Medical College of Pennsylvania Projects: Angiogenic activity in prostate cancer, liver cancer and soft tissue tumors Histopathology of HCV infection and apoptosis Beta catenin mutation in HCC using laser capture microdissectionPostdoctoral Fellow The Scripps Research Institute, Peter Vogt”s lab, La Jolla, California, 2
  3. 3. Liu, C Projects: Gene transcription regulation and novel small molecule inhibitors Cloning and characterization of protooncogene qin/BF1 Development of Lox P and Cre knockout systemGraduate Student University of Pennsylvania School of Medicine, Graduate Program in Pathology, Bill Mason’s Lab. Projects: Liver specific transcription regulation of hepatitis B virus Tissue tropism of hepatitis B viral infection Hepatocyte turnover and viral clearanceTEACHING EXPERIENCES Fellowship Director, GI/Liver Pathology 2004-present Pathology Resident Teaching 2000-present Rotation Director, Molecular Pathology 2001-2007 Course Director, Systemic pathology GI-Liver section for 2nd year-medical students 2003-present Mentor, IDP graduate program at UF 2002-present Mentor, NIH-T32 training program in Gastroenterology. 2003-present Graduate student teaching 2000-presentAWARDS Howard Hughes Medical Institute Undergraduate Mentor Award 2010 Mid-career Mentor Award, National Institute of Health 2009 Liver Research Scholar, American Liver Foundation 2002 Clinical Fellow Research Award, M.D. Anderson Cancer Center. 1999 Award from GI Pathology Society, 1998 House Staff Research Award, MCP Hahnemann University 1997 Individual National Research Award, National Cancer Institute, NIH 1994 3
  4. 4. Liu, C Scientific Merit Award, Ministry of Health, China 1988 Honored Outstanding Medical Graduate, TongLiao Medical College 1985RESEARCH GRANTS Active: National Institute of Health, NCRR, K26 (2009-2014), Principal Investigator. "Mouse Immunopathology". National Institute of Health, NCI, R01 (2009-2014), Principal Investigator. "Molecular targets for liver cancer diagnosis and therapy". National Institute of Health, NIAID, R01 (2005-2010) , Co-Principal Investigator (Nelson), “Innate and adaptive immune response in HCV patients.” UF/ Moffitt Cancer Center (2009-2010) Principal Investigator, "Immunotherapy for liver cancer" UF/ Moffitt Cancer Center (2009-2011) Principal Investigator, "Bone marrow transplantation for liver cancer therapy" National Institute of Health, R01 (PI, Ferrara, U. Michigan,) co-investigator, multiple years National Institute of Health (2010-1015), R01 (PI, Yu, Moffitt Cancer Center) co- investigator, "Role of Th17 cells in GVHD". University of Florida Research Foundation (2010-2012) Principal investigator, "Nanozyme in cancer therapy". 4
  5. 5. Liu, C Projects completed: National Institute of Health, NHLBI, R21 (2005-2009), Principal Investigator, “Small molecules to treat alpha-a antitrypsin deficiency.” Alpha- one Foundation, Research grant, (2007-2009), Principal Investigator, “Therapeutic small molecules for alpha-1 antitrypsin deficiency.” Geyer Foundation for Cancer Research, (2008-2009), Principal Investigator, "Liver Cancer Biomarkers". National Institute of Health, NIAID, R21 (2005-2008), Principal Investigator, “Murine model for hepatitis C virus.” National Institute of Health, NIDDK, K08 (2002-2007), Principal Investigator, “ Role of liver cytokine expression in hepatitis C viral infection” Florida Biomedical Research Program, (2007-2008), Co-PI, Biomarker discovery of liver cancer. National Institute of Health, NIDDK, R03 (2005-2008), Principal Investigator, “Role of SOCS3 in Interferon Resistance.” CellzDirect Corporation, (2005-2007), Principal Investigator, “Hepatic Registry Program.” Howard Hughes Medical Institute (2000-2002) Startup Program. Howard Hughes Medical Institute ( 2000-2003) Pilot project. University of Florida Research Foundation (2002-2003) Opportunity research fund. 5
  6. 6. Liu, C American Liver Foundation, (2003-2005), Principal Investigator, “Establishment and characterization of PiZZ liver cell lines.” American Liver Foundation, (2002-2005), Principal Investigator, Liver scholar award Children’s Miracle Network, (2005-2006), Principal Investigator, “Novel treatment for hepatoblastoma.” Wyeth Research. (2003-2007), Investigator (PI, Abdelmalek), A Randomized, Open-Label, Comparative Evaluation of Conversion From Calcineurin Inhibitor Treatment To Sirolimus Treatment VersusPROFESSIONAL CERTIFICATES Board Certification (AP/CP) American Board of Pathology Medical Licensure State of Florida Physician and Surgeon Licensure, Commonwealth of Pennsylvania Valid ECMFG CertificatePROFESSIONAL ACTIVITIES Member of National Institutes of Health Study Section (ad hoc): GMA2 ZRG, 2003, 2005, 2006, 2007, 2008, 2009, 2010 Member of Education Committee, Hans Popper Hepatopathology Society. 2007 to present Member of Basic Science Committee, American Association for the Study of Liver Disease, 2004-2008 Member of Tissue Bank Committee, Alpha-1 Foundation. 2005 to 2008. Editorial Board, Laboratory Investigation, 2005- present Editorial Board, International Journal of Clinical and Experimental Pathology. Editorial Board, World Journal of Gastroenterology. 6
  7. 7. Liu, C Ad Hoc reviewer: J. Virology; Hepatology; Gastroenterology; Oncogene; American J. Pathology; Human Pathology; Lab Investigation; Cancer Research; J. Interferon Research; Human Immunology, FSEB letter. Graduate student mentor, IDP graduate program, University of Florida.PUBLICATIONS ( Total 115)Original Peer- Reviewed Articles:1. Eksioglu, E; Bess, J; Jones, G; Dettloff, J.; Dangmeon, P.; Elyar, J; Liu, C. (2010). Differences in the antiviral activity of antibodies of chronic HCV patients after long term IL-10 therapy. Viral Immunology. In Press2. Pan J, Oh S-H, Soldevila-Pico C, Nelson DR, Liu C. (2010) Low prevalence of HBV DNA in the liver allograft from anti-HBc-positive donors. Clinical Transplantation. In press.3. Ararat MA, Eksioglu E, Cao M, Xu YL, Aktinson M, Liu C, Nelson DR, Cabrera R (2010) Influence of serum and soluble CD25 (sCD25) on regulatory and regulatory and effector T cell function in Hepatocellular Carcinoma. Scand. J. Immunology. In press.4. George T, Nair J, Liu C, Zlotecki,RA, Caridi,JG (2010) Gastroduodenal Ulcerations as a Delayed Complication of Hepatic Metastasis Radioembolization. J. Clin. Onc. in press.5. Eksioglu EA, Bess JR, Zhu H, Xu Y, Dong HJ, Elyar J, Nelson DR, Liu C. (2009) Hepatitis C virus modulates human monocyte-derived dendritic cells. J. Viro. Hepatitis, Dec 29, Epub ahead of print6. Na IK, Lu SX, Yim NL, Goldberg GL, Tsai J, Rao U, Smith OM, King CG, Suh D, Hirschhorn-Cymerman D, Palomba L, Penack O, Holland AM, Jenq RR, Ghosh A, Tran H, Merghoub T, Liu C, Sempowski GD, Ventevogel M, Beauchemin N, van den Brink MR (2010) The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft- versus-host disease. J. Clin. Invest. 120(1):343-57. Toubai T, Malter C, Tawara I, Liu C, Nieves E, Lowler KP, Sun Y, Reddy P.(2010) Immunization with host-type CD8{alpha}+ dendritic cells reduces experimental acute GVHD in an IL-10-dependent manner. Blood. 115(3):724-35 7
  8. 8. Liu, C8. Silva IA, Olkiewicz K, Askew D, Fisher JM, Chaudhary MN, Vannella KM, Deurloo DT, Choi SW, Pierce EM, Clouthier SG, Liu C, Cooke KR.(2010) Secondary lymphoid organs contribute to, but are not required for the induction of graft-versus-host responses following allogeneic bone marrow transplantation: a shifting paradigm for T cell allo-activation. Biol Blood Marrow Transplant .16(5):598-6119. Cardona D, Zhang XK, Liu C (2009) Absence of carbomyl phosphate synthetase I in small intestinal carcinoma. Am. J Clin Path. 132(6):877-8210. Vila L, Liu HY, Al- Quran S, Coco D, Dong HJ, Liu C (2009) Identification of c-kit gene mutations in primary adenoid cystic carcinoma of the salivary gland. Modern Pathology. 2009 Oct;22(10):1296-302.11. Rotolo JA, Stancevic B, Lu, SX, Zhang J, Suh D, King CW, Murphy G, Liu C, van den Brink MRM (2009). Cytotoxic T cells induce ceramide-rich platform in target cell membrane to initiate graft versus host disease. Blood August 7 (Epub ahead of print). 114(17):3693-70612. Stiffler JD, Nguyen M, Sohn JA, Liu C, Kaplan D, Seeger C. (2009) Focal distribution of hepatitis C virus RNA in infected livers. PLoS One. 18;4(8):e666113. Abdelmalek M, Sanderson SO, Angulo P, Liu C, Peter J, Keach J, Cave M, Chen T, McClain CJ, Lindor KD. (2009). Btaine for nonalcoholic fatty liver disease: results of a randomized placebo controlled trial. Hepatology. 50(6):1818-2614. Penack O, Henke E, Suh D, Liu C, Lu T, May C, Scheinberg D, Gao DC, and Van den Brink M (2009) NOD2 regulates hematopoietic cell function during graft-versus-host disease. J. Exp. Med. 2010 Jan;120(1):343-5615. Kenworthy R, Lambert D, Yang F, Wang N, Chen Z, Zhu HZ, Zhu F, Liu C, Li K, Tang H (2009), Short hairpin RNA delived by lentiviral vector transduction trigger RIG-I-mediated IFN activation. Nucleic Acid Res. 37(19):6587-9916. Kwan JC, Eksioglu E, Liu C, Paul V, Luesch (2009) Grassystatins A−C from Marine Cyanobacteria, Potent Cathepsin E Inhibitors that Reduce Antigen Presentation. J Med Chem. 52(18):5732-4717. Glushakova LG, Lisankie MJ, Eruslanov EB, Ojano-Dirain CP, Zolotukhin I, Liu C, Stacpoole, P. (2009) AAV3-mediated Transfer and Expression of the Pyruvate Dehydrogenase E1 alpha Subunit Gene Causes Metabolic Remodeling and Apoptosis of Human Liver Cancer Cells. Molecular Genetics and Metabolism. 98(3):289-99 8
  9. 9. Liu, C18. Jin B, Yao B, Li JL, Fields R, Delmas AL, Liu C and Robertson (2009). DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modification in colon cancer. Cancer Research. 69(18):7412-2119. Cabrera R, Cao ME, Atkinson M, Wasserfall CH, Liu C, Nelson DR, (2009) Hepatocellular Carcinoma Immunopathogenesis: Clinical vvidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25). Dig. Dis. Sci. August 28 (Epub ahead of print) . 55(2):484-9520. Cao M, Cabrera R, Xu YL, Liu C, Nelson DR. (2009) Gamma irradiation alters the phenotype and function of CD4+CD25+ regulatory T cells. Cell Bio Int. 33:565-7121. Olaf Penack, Erik Henke, David Suh, Chris King, Odette Smith, Il-Kang Na, Amanda Holland, Arnab Ghosh, Sydney Lu, Robert Jenq, Chen Liu, George Murphy, Theresa Lu, Chad May, David Scheinberg, Ding Cheng Gao, Vivek Mittal, Glenn Heller, Robert Benezra, and Marcel Van den Brink (2009) Inhibition of Neovascularization Simultaneously Ameliorates Graft-versus-host Disease and Decreases Tumor Growth. J. NCI. 2010 May 12. [Epub ahead of print]22. Kappel LW, Goldberg GL, King CG, Suh D, Smith OM, Ligh C, Holland A, Grubin J, Liu C, Iwakura Y, Mark N, Heller G, and van den Brink MRM (2009) IL-17 contributes to CD4- mediated graft-versus-host disease. Blood. 113:945-952.23. Hildebrandt GC, Olkiewicz KM, Corrion L, Clouthier SG, Pierce EM, Liu C, Cooke KR (2008) A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome. Biol Blood Marrow Transplant 14: 385-39624. Butler SL, Dong HJ, Cardona D, Jia MH, Zheng R, Zhu HZ, Crawford JM and Liu C. (2008) The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1. Lab Invest 88:78-88.25. Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ. (2008) β2 Integrins Separates Graft-versus-host disease and Graft-versus-leukemia effect. Blood 111(2):954-6226. Reddy P, Sun Y, Toubai T, Duran-Struuck R, Clouthier SG, Weisiger E, Maeda Y, Tawara I, Krijanovski O, Gatza E, Liu C, Malter C, Mascagni P, Dinarello CA, Ferrara JL (2008) Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest. 118(7):2562. 9
  10. 10. Liu, C27. Gatza E, Rogers CE, Clouthier SG, Lowler KP, Tawara I, Liu C, Reddy P, Ferrara JL (2008) Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells. Blood. 112(4):1515-2128. Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN.(2008) FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis. 29(6):1096-10729. Tawara I, Maeda Y, Sun Y, Lowler KP, Liu C, Toubai T, McKenzie AN, Reddy P. (2008) Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs- host disease. Exp Hematol. 36(8):988-9630. Liu C, Witek R, Bess, J, Zhu, HZ, Lin, P (2008) Repopulation of human hepatocytes in immunodeficient mice. FASEB J. 2008 22:465.431. Wu H.; Zhu, H; Zhuang, J.; Yang, S.; Liu,C.; Cao, Y.C. (2008) “Water-Soluble Nanocrystals Through Dual-Interaction Ligands.” Angew. Chem., 47: 3730-3734.32. Kim TD, Terwey TH, Zakrzewski JL, Suh D, Kochman AA, Chen ME, King CG, Borsotti C, Grubin J, Smith OM, Heller G, Liu C, Murphy GF, Alpdogan O, van den Brink MR. (2008) Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood. 2008 Mar 1;111(5):2929-4033. Liu W, Grobmyer SR, Liu C, Hochwald SN (2007) Primary presacral neuroendocrine tumor associated with imperforate anus. World J Surg Onc. 5:11534. Zhu HZ, Dong, HJ, Eksioglu E, Cao MD, Hemming, A, Crawford JM, Nelson DR, Liu C. (2007) Hepatitis C virus triggers apoptosis of a novel hepatoma cell line through innate antiviral defense system. Gastroenterology. 133:1649-1659.35. Liu C, Zhu HZ, Nelson DR. (2007) Albuferon exhibits anti-HCV activity in cell culture. Hepatology Research. 2007 Nov;37(11):941-7.36. Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N, Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. (2007) IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. J Immunol. 2007 Aug 1;179(3):1669-8037. Choi SW, Hildebrandt GC, Olkiewicz KM, Hanauer DA, Chaudhary MN, Silva IA, Rogers CE, Deurloo D, Fisher JM, Liu C, Adams D, Chensue SW, Cooke KR (2007) CCR1:CCL5 10
  11. 11. Liu, C (RANTES) receptor ligand interactions modulates allogeneic T cell responses and reduces graft-versus-host disease following stem cell transplantation. Blood. 110(9):3447-5538. Kim T, Grobmyer SR, Liu C, Hochwald SN. (2007) Primary presacral neuroendocrine tumor associated with imperforate anus. World J. Surg. Oncol. 5: 11539. Duran-Struuck R, Tawara I, Lowler K, Clouthier SG, Weisiger E, Rogers C, Luker G, Kumanogoh A, Liu C, Ferrara JL, Reddy P.(2007) A novel role for the semaphorin Sema4D in the induction of allo-responses. 13(11):1294-130340. Cao M, Cabrera R, Xu Y, Zhu, H, Liu C, Nelson DR. (2007) Hepatocellular carcinoma cell supernatants increase expansion and function of CD4(+)CD25(+) regulatory T cells. Lab Invest. 87(6):582-9041. Cardona D, Grobmyer S, Crawford JM, Liu C. (2007) Hepatocellular carcinoma arising from ectopic liver tissue in the pancreas. Virchows Arch. 450(2):225-942. Borsotti, C, Franklin AR, Lu, SX, Kim TD, Smith OM, Suh D, King CG, Chow A, Liu C, Alpdogan O, and van den Brink MR (2007) Absence of donor T cell derived soluble TNF decreases graft-versus-host-disease without impairing graft-versus-tumor activity. Blood 2007 Jul 15;110(2):783-6.43. Abdelmalek MF, Liu C, Valentine JF. (2007) Successful treatment of chronic hepatitis C with pegylated interferon, ribavirin, and infliximab in a patient with Crohns disease. 102:133344. Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR. Am Surg. Presentation and management of gastrointestinal stromal tumors of the duodenum. 2006 Aug;72(8):719-22; discussion 722-3.45. Abdemalek M, Liu C, Nelson D, Shuster J, Asal NR. (2006) Familial aggregation of insulin resistance in first degree relatives of patients with nonalcoholic fatty liver disease. Clinical Gastroenterology and Hepatology, 2006 Sep;4(9):1162-9.46. Firpi RJ, Zhu HZ, Liu C, Nelson DR. (2006) Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of sustained virological response after liver transplantation. Liver Transplantation, 2006 Jan;12 (1):51-7.47. Samara K, Liu C, Soldevila-Pico C, Nelson DR, Abdelmalek MF. (2006) Betaine resolves severe alcohol-induced hepatitis and steatosis following liver transplantation. Dig Dis Sci. 51:1226 11
  12. 12. Liu, C48. Wang B, He J, Liu C, Chang LJ. (2006) An effective cancer vaccine modality: lentiviral modification of dendritic cells expressing multiple cancer-specific antigens. Vaccine 24: 3477-8949. Fujita S, Kushihata F, Herrmann GE, Mergo PJ, Liu C, Nelson DR, Hemming, AW (2006) Combined hepatic resection and radiofrequency ablation for multiple hepatic adenomas. J. Gastro. Hepatology. 21(8):1351-450. Reddy P, Maeda Y, Liu C, Krijanovski O, Korngold R, Ferrara JLM. (2005), A critical role for antigen presenting cells and alloantigen expression in graft-versus-leukemia response after allogeneic bone marrow transplantation. Nature Medicine. Nov;11(11):1244-951. Zhu HZ, Butera M, Nelson DR, Liu C. (2005) Novel Type I interferon IL-28A suppresses hepatitis C virus. Virology J. 2:80.52. Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Kochman AA, Terwey TH, Willis LM, Schiro R. Heller G, Murphy GF, Liu C, Alpdogan O, Van den Brink MR. (2005) Absence of inducible costimulator on alloreactive T cell reduces graft-versus-host disease and induces Th2 deviation. Blood, 2005 Nov 1;106(9):3285-9253. Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MRM. (2005) CC chemokine receptor 2 is required for CD8-induced graft- versus-host disease. Blood. 2005 Nov 1;106(9):3322-3054. Marsh RW, Walker MH, Liu C. (2005) Breast implants as a possible etiology of epithelioid hemangioendothelioma and successful therapy with interferon-alpha2. Breast J. 4: 257-26155. Zhu HZ, Nelson DR, Crawford JM, Liu C. (2005) Defective JAK-STAT pathway is associated with HCV interferon resistance. J. Interferon & Cytokine Res., 25:528-53956. Rufforny I, Wilkinson EJ, Zhu H, Buteral M, Liu C, Massoll NA. (2005) Human papillomavirus infection and p16(INK4a) protein expression in vulvar intraepithelial neoplasia and invasive squamous cell carcinoma J Low Genit Tract Dis. 9(2):108-1357. Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, FerraraJL. (2005) Critical role of host {gamma}{delta} T cells i experimental acute graft-versus-host disease. Blood. 2005 Jul 15;106(2):749-5558. Gerbitz A, Ewing P, Olkiewicz K, Willmarth NE, Williams D, Hildebrandt G, Wilke A, Liu C, Eissner G, AndreesenR, Holler E, Guo R, Ward PA, Cooke KR. (2005) A role for CD54 12
  13. 13. Liu, C (intercellular adhesion molecule-1) in leukocyte recruitment to the lung during the development of experimental idiopathic pneumonia syndrome.Transplantation,79:536-54259. Cresawn KO, Fraites, TJ, Wasserfall C, Atkinson M, Lewis M, Porvasnik S, Liu C, Mah C, Byrne BJ. (2005) Correction of glycogen storage disease type II from intrahepatic delivery of rAAV and rAAV8 vectors is dependent on an inhibitory antibody response. Gene Therapy, 2005 Jan;16(1):68-8060. Hashimoto D, Asakura, S, Miyake S, Yamamura T, Kaer L, Liu C, Tanimoto M, Teshima T. (2005) Stimulation of host natural killer T cells by synthetic glycolipid regulates acute graft- versus host disease by inducing Th2 polarization of donor T cells. J. Immunology, 174:551-55661. Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T, Ferrara JL. (2005) Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Blood. 105:2023-2027.62. Hildebrandt GC, Olkiewicz KM, Choi S, Corrion LA, Clouthier SG, Liu C, Serody JS, Cooke KR. (2005) Donor T cell-production of RANTES significantly contributes to the development of Idiopathic Pneumonia Syndrome after allogeneic stem cell transplantation. Blood, 105:2249-2257.63. Zhu H, Shang X, Terada N, Liu C (2004) STAT3 induces anti-hepatitis C viral activity. Biochem Biophys Res Commun. 343:518-52864. Shang XZ, Zhu HZ, Tu ZK, Nelson DR, Liu C (2004) Stabilized beta catenin promotes hepatocyte proliferation and inhibits TNF-induced apoptosis. Lab Investigation. 84:332-34165. Gerbitz A, Nickoloff BJ, Olkiewicz K, Willmarth NE, Hildebrandt G, Liu C, Kobzik L, Eissner G, Holler E, Ferrara JL, Cooke KR. (2004) A role for tumor necrosis factor-alpha- mediated endothelial apoptosis in the development of experimental idiopathic pneumonia syndrome. Transplantation, 78:494-50266. Li, M; Liu, C. (2004) Cytokeratin 20 confirms Merkel cell metastasis to stomach. Appl Immunohistochem Mol Morphol. 12:346-349.67. Reddy P; Maeda, Y; Hotary, K; Liu, C; Reznikove, LL; Dinarello, CA, Ferrara, JM (2004) Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus leukemia effect. Proc, Natl. Acad. Sci. U. S. A, 101:3921-3926. 13
  14. 14. Liu, C68. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR. (2004) An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology, 40: 1062-71.69. Camp ER, Hochwald SN, Liu C. (2004) FAP with concurrent duodenal adenomatous polyposis and carcinoid tumor. J Surg Oncol. 87(4):187-90.70. Min CK, Maeda Y, Lowler K, Liu C, Clouthier S, Lofthus D, Weisiger E, Ferrara JL, Reddy P. (2004) Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T cell subsets after experimental allogeneic bone marrow transplantation. Blood, 104:3393-3399.71. Duffner, UA; Maeda, Y; Cooke, KR; Reddy, P; Ordemann, R; Liu, C; Ferrara, JL. (2004) Host dendritic cells alone are sufficient to initiate acute graft-versus-host-disease. J. Immunology. 172:7393-739872. Hildebrandt GC, Corrion, LA, Olkiewicz, KM, Lowler, K, Moore, BB, Kuziel, WA, Liu, C and Cooke, KR. (2004) Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome J. Immunology, 173:2050-973. Abdelmalek MF, Firpi RJ, Soldevila-Pico C, Reed AI, Hemming AW, Liu C, Crawford JM, Davis GL, Nelson DR (2004) Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C. Liver Transpl. 10(2):199-20774. Persad, R; Liu, C; Wu, TT; Houlihan, PS; Hamilton, SR; Diehl, AM, Rashid, A (2004) Overexpression of caspase 3 in hepatocellular carcinoma. Modern Pathology, 17(8) 1026.75. Hildebrandt, GC; Olkiewicz, KM; Chang, Y; Liu, C; Cooke, KR (2004) Donor-dreived TNF regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogenic bone marraow transplantation. Blood, 104:586-9376. Friedman JS, Alpdogan O, van den Brink MR, Liu C, Hurwitz D, Boyd A, Kupper TS, Burakoff SJ. (2004) Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant.10:448-60.77. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Cabrera R, Shuster JJ, Theriaque D, Reed AI, Hemming AW, Liu C, Crawford JM, and Nelson DR.(2004) One-year Protocol Liver Biopsy Can Stratify Fibrosis Progression In Liver Transplant Recipients With Recurrent Hepatitis C Infection. Liver Transpl . 40:1062-71 14
  15. 15. Liu, C78. Liu, C; Zhu, HZ; Xu, YL; Nelson, DR. (2003) CD8+ T cell interaction with HCV replicon cells: evidence for both cytokine- and cell-mediated antiviral activity. Hepatology, 37:1335-134279. Hassanein A, Glanz S, Kessler H, Eskin T, Liu C (2003) Beta catenin is aberrantly expressed in tumors expression shadow cells: pilomatricoma, craniopharyngioma, and calcifying odontogenic tumor. Am J Clinical Pathology. 120(5):732-6.80. Zhu, H.Z; Zhao, HS; Collins, CD; Eckenrode, SE; Run, Q; McIndoe, RA; Crawford, JM; Nelson, DR; She, JX; Liu, C. Gene expression associated with IFN alpha antiviral activity in an HCV replicon cell line. (2003) Hepatology, 37:1180-1188. EDITORIAL: on page 97581. Zhu, HZ; Liu, C. (2003) Interleukin 1 inhibits hepatitis C viral RNA replication by activation of extracellular regulated kinase pathway. J. Virology. 77:5493-549882. Petrovic, A; Alpdogan, O; Willis, LM; Eng, JM; Greenberg, AS; Kappel, BJ; Liu, C; Murphy, G; Heller, G and van den Brink, MR (2004) LPAM ( α/β integrin) is an important homing integrin on alloreactive T cells in the development of intestinal Graft-Versus-Host Disease. Blood.103: 1542-1547.83. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y, Maeda Y, Reddy P, Williams DL, Hanash S, Ferrara JL. (2003) Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotid microarrays. Blood 102(2):763-7184. Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JL. (2003) Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood 102(2):429-3585. Reddy P, Teshima T, Hildebrandt G, Williams DL, Liu C, Cooke KR, Ferrara JL. (2003) Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effects. Blood 101(7):2877-85.86. Clouthier S, Cooke KR, Teshima T, Lowler KP, Liu C, Connolly K, Ferrara JL (2003) Repifermin (Keratinocyte Growth Factor-2), delays onset of graft-versus-host disease while preserving a graft-versus-leukemia effect. Biology of Bone marrow, Blood and Transplantation. (9):592-60387. Nelson DR, Tu Z, Soldevila-Pico C, Abdelmalek M, Zhu H, Xu YL, Liu, C, Davis GL (2003) Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect. Hepatology, 38(4):859-68 15
  16. 16. Liu, C88. Duffner, U., Lu, B., Teshima, T., Williams, D.L., Hildebrandt, G., Reddy, P., Ordemann, R., Lowler, K., Liu, C., Cooke, K.R., and Ferrara J.L.M. (2003) Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol. (10):897-902 ,89. Hildebrandt, G.C., Duffner, U.A., Olkiewicz, K.M., Willmarth, N.E., Corrion, L.A., Clouthier, S., Williams, D.L., Reddy, P.R., Moore, B.B., Liu, C., and K.R. Cooke. (2003). A Critical Role for CCR2 in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood, 2004 103:2417-2426.90. Takanori Teshima1, Rainer Ordemann1, Pavan Reddy, Svetlana Gagin, Chen Liu, Kenneth R. Cooke & James L. M. Ferrara (2002) Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nature Medicine 8:575-581. ( Cover article)91. Firpi RJ, Abdelmalek MF, Soldevila-Pico C, Reed A, Hemming A, Howard R, Van Der Werf W, Lauwers G, Liu C, Crawford JM, Davis GL, Nelson DR. Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C. Liver Transpl 2002 Nov;8(11):1000-100692. Ordemann R, Hutchinson R, Friedman J, Burakoff SJ, Reddy P, Duffner U, Braun TM, Liu C, Teshima T, Ferrara JL. (2002) Enhanced allostimulatory activity of host antigen- presenting cells in old mice intensifies acute graft-versus-host disease J. Clin Invest. 109:1249-5693. Teshima, T; Reddy, P; Lowler, K; Kukuruga, M; Liu, C; Cooke, K; Ferrara, J (2002) Flt3 ligand modulates immune responses through expansion of CD8α+ dentritic cells. Blood. 99:1825-1832.94. Teshima, T; Liu, C; Lowler, KP; Dranoff, G; Ferrara J. (2002) Donor leukocyte infusion from immunized donors increases tumor vaccine efficiency after allogenic bone marrow transplantation. Cancer Research. 62:796-800.95. Reddy, P; Teshima, T; Lowler, K; Kukuruga, M; Liu, C; Cooke, K; Ferrara, J (2001) Interleukin-18 regulates acute graft versus host disease by enhancing Fas mediated donor T cell apoptosis. J. Experimental Medicine. 194:1433-1440.96. Guo, JT; Zhou, H; Liu, C; Aldrich, C; Saputelli, J; Whitaker, T; Barrasa, I; Mason, WS; Seeger, C. (2000) Viral clearance and hepatocyte turnover during hepatitis B infection in woodchucks. J. Virology 74:1495-150597. Ayala, G; Liu, C; Nicosia, R (2000) Microvasculature and VEGF expression in cartilaginous tumors. Human Pathology, 31:341-346 16
  17. 17. Liu, C98. Guo, JT; Liu,C; Mason, WS; Pugh, JC (1998) Cloning and expression of a cDNA encoding the large subunit of duck replication factor C Biochimica et Biophysica Acta 1395:293-30099. Liu, C; Smith, BC; Nicolaou, BM, Vogt, P (1996) Sequence selective carbohydrate DNA interaction: Dimeric and monomeric forms of the calicheamicin aryltetrasacchride interfere with transcription factor function. Proc, Natl. Acad. Sci. U. S. A 93:940-944100. Liu, C; Mason, WS; Burch, JBE (1994) Identification of factor binding sites in duck hepatitis B virus and in vivo effects of enhancer mutations J Virology. 68:2286-2296101. Mason, WS;Cullen, J; Saputelli, J; Wu, TT; Liu, C; London, WT; Lusterbader, E; Shaffer, P: O’connell, Aldrich, CE; Jilbert, AR (1994) Characterization of the antiviral effects of 2’carbodeoxyguanosine in duck chronically infected with duck hepatitis B virus Hepatology 19:398-411102. Liu, C; Condreay, LD; Burch,JB; Mason, WS (1991) Characterization of the core promoter and enhancer of duck hepatits B virus Virology 184:242-252103. Wu, TT; Condreay, LD; Liu, C; Mason, WS and Jibert, JR (1991) Hepadnavirus DNA synthesis. In: 1990 international symposium on viral hepatitis and liver disease ed. Hollinger, B; Margolis H; William and Wilkins. 114-121104. Mason, WS; Summers, J; Liu, C; Condreay, LD;Wu, TT (1991) Chronic hepadnavirus infection. In: international symposium on hepatitis delta virus, ed. Gerin, J; Purcell; Rizetto, M Wiley-Liss, Inc. 235-242105. Liu, C; Chen, HS (1988) Application of duck hepatocyte culture system in antiviral research Proc. Chinese Acad. Med. Sci. 4:455-457Reviews and Chapters106. Liu C; Crawford JM. (2004) Chapter 17, Pathology of gastrointestinal tract. In “ Robbins Pathologic Basis of Disease”. 7 th edn. pp. 410-474107. Liu C; Crawford JM. (2003) Liver anatomy. In: Madara ed. “ Encyclopedia of Gastroenterology.” pp 510-515108. Liu C; Crawford JM. (2003) Liver biopsy. In: Madara ed. “Encyclopedia of Gastroenterology.” pp. 516-522.109. Liu C; Crawford JM. (2004) Graft-versus-Host Disease of the Liver. In: Ferrara ed. “Graft- vs- Host Disease. ” 3 rd edn. Marcel Dekker, New Yrok. pp: 257-278 17
  18. 18. Liu, C110. Liu C; Crawford JM (2005) Chapter 17 and 18, in “Robbins and Cotran Pathologic Basis of Disease.” Pocket book. pp. 516-522111. Liu C (2006) Hepatitis C Virology and Experimental Models. “Clinics in Liver Disease”. 10:773-791.112. Liu C (2008) Primary Hepatocyte Culture in HCV Research. "Hepatitis C Protocols". In Press113. Liu C, Crawford JM (2009) Chapter 18, Liver Pathology, in Robbins and Cotran Pathologic Basis of Disease, 8 th ed. In press.114. Liu C Crawford JM. (2009) Pathological staging of biliary tract cancers. In Biliary Tract and Gallbladder Cancers. Pp. 77-84 Ed. Thomas and Fuller, Demos Medical, New York.115. Kim Y, Liu C, Tan WH, (2009) Aptamers generated by cell-based SELEX for biomarker discovery. Future Medicine Biomarkers in Medicine. In press.MEETING PRESENTATIONS ( selected) :1. Novel cell culture model for hepatitis C virus. Oral presentation, 14th International meeting on hepatitis C virus and related viruses. September 20072. Anti-HCV small molecules that blocks CD81 binding. Oral presentation. 14th International meeting on hepatitis C virus and related viruses. September 20073. Neutralizing HCV antibodies. Oral presentation. Keystone Symposium, Jan 20074. Hepatitis C affects dendritic cell function. Oral presentation. Keystone Symposium, Jan 20075. Quantitative assay for HCV RNA in liver biopsies, Oral presentation, 94 th Annual meeting, International Pathology Academy. Feb, 20056. Novel type I interferon IL-28A inhibits HCV replication. Poster, AASLD, 2004.7. Defective STAT3 activation in host cells confers hepatitis C viral interferon resistance. Oral presentation at 10th International meeting on hepatitis C virus and related viruses. 20038. Mutant beta catenin promotes hepatocyte proliferation and inhibits apoptosis. Poster, AASLD, 2003. Hepatology, 411A9. Culture and immortalization of hepatitis C viral positive human hepatocytes. Poster, AASLD, 2003. Hepatology, 34: 462A 18
  19. 19. Liu, C10. Activated STAT3 initiates antiviral activity against hepatitis C viral RNA replication. Poster, AASLD, 2003. Hepatology, 34: 455A11. CD8 T cells suppress HCV through direct cytolytic activity and cytokine-mediated pathway. Oral presentation, 9th International meeting on hepatitis C virus and related viruses, 200212. Gene expression profiles related interferon anti-HCV activity. Oral presentation, AASLD, 2002.INVITED SEMINARS2001 University of Michigan, Liver pathology in graft-versus-host disease.2003 University of Florida Cancer Center, Grand Round. Pathogenesis of Liver Cancer.2003 Institute for Medicinal Biotechnology, Chinese Academy of Medical Sciences. Interferon signaling in hepatitis C viral infection.2003 Institute for Infectious Diseases, Beijing, China. Functional genomics in hepatitis C viral infection.2004 University of Florida, Division of Critical Care & Pulmonary Medicine. Hepatic injury in alpha-1 antitrypsin deficiency.2004 Keynote speaker, Shandong University, China, Hepatitis C diagnosis and therapy.2005 Harvard Medical School, Innate and adaptive immunity in HCV infection.2005 Invited speaker, Alpha-1 Foundation International Scientific Conference, Small molecules for AAT deficient therapy.2005 Grand rounds, University of Florida Cancer Center. Liver Cancer Diagnosis and Therapy.2006 Keynote speaker, Shandong University, China, Hepatitis C diagnosis and therapy.2007 Invited speaker, US-Canadian Academy of Pathology, Hepatocellular Lesions: Diagnosis and differential diagnosis.2007 Invited speaker, Chinese Academy of Medical Sciences, Innate immunity in HCV.2008 Invited speaker, China Medical University, Novel therapy for liver cancer.2008 Falk Symposium, Mainz, Germany, Trail agonists for liver cancer therapy2008 Invited speaker, Inner Mongolia Medical College. Liver disease updated therapies.2008 University of Louisville, Hepatitis C virus and Liver cancer.2008 College of Veterinary Medicine, University of Florida. Innate Immunity2008 Harvard Medical School and Brigham and Womens Hospital, TRAIL pathway in hepatitis C viral infection and liver cancer. 19
  20. 20. Liu, C2008 Invited speaker, Moffitt Cancer Center. Immunotherapy for HCV and liver cancer.2008 Keynote speaker, Florida State University, Innate immunity in hepatitis C infection2008 Duke University Medical Center, "Apoptosis in HCV and Liver cancer".2009 Invitrogen Inc. " Liver cell line and mouse model in liver disease research.2009 Keynote speaker and scientific session chair, 2nd World cancer congress2009. Invited speaker, Beijing University, "Hepatitis C animal models".2009 Invited speaker, Hunan University "Liver cancer therapy, current progress".2009 Invited speaker, Chinese Academy of Sciences, "Aptamer in translational medicine".2010 Invited speaker, PennState School of Medicine, "TRAIL-agonists in liver cancer therapy".2010 Invited speaker, Chinese pathology association annual conference, Chongqing, China2010 Invited speaker, Drexel University, Institute of Biotechnology. Apoptosis and liver cancer therapy.TRAINEES AND STUDENTS IN LIU LABORATORYCurrent Members:Frank Zhao, Ph.D., Postdoctoral fellow, 2009-presentHongyan Liu, Ph.D., Postdoctoral fellow, 2007-presentOlorunseun Ogunwobi, M.D., Ph.D. Postdoctoral fellow, 2009-presentLiping Sun, Ph.D., Postdoctoral fellow, 2009-present.Houda Darwiche, Ph.D., Postdoctoral fellow, 2009-presentTrinh Thu Le, B.S., Graduate student, 2010-presentLucy Zhang, B.S., Technician, 2007-presentPrevious Members:Erika Eksioglu, M.S. Graduate student, 2005-2010Jennifer Bess, Ph.D. Graduate student, 2004-2009Rafal Witak, Ph.D., Postdoctoral fellow, 2005-2007John Elyar, Ph.D., Postdoc Fellow, 2003-2006Jane Dong, Ph.D., Postdoc Fellow, 2005-2007 20
  21. 21. Liu, CQi Su, M.D., Ph.D., Postdoct Fellow, 2005-2006Megan Larsen, Undergraduate student, 2004-2006Michael Butera, B.S, Technician, 2002-2006Victor Young, Undergraduate student, 2001-2004Xiang-Zhang Shang, Graduate Student, 2002-2003Rebekah Robinette, Graduate Student, 2003-2004Vicent Young, Undergraduate student, 2003-2004Klanit, K., Visiting Scientist (Thailand), 2002-2003Karrie Lin, Undergraduate student, 2002-2003Nga Phuong Nguyen (Ohio State), 2004-2004TEACHING ACTIVITIESGraduate mentor for PhD students (Jennifer Bess, Erika Eksioglu)Course Director, Gastrointestinal and liver pathology for medical studentsMolecular pathology rotation director for pathology residents (2001-2006) 21