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A New Understanding of What Causes Uncontrolled Cravings, Low Energy,Stress, Fat Storage, and Un-Happiness Empowering a Balanced Mind and Body
Conventional Wisdum: You are Fat Because You Eat Too Much and You Don’t Exercise Enough If that was true then Everyone who ate less and exercised more would be thinner than Everyone who didn’t And we KNOW that is not the case
The Key issue is NOT that people eat more and exercise less But, WHY do people Eat More and Exercise Less? The conventional perspective is forced to conclude that they are Lazy Gluttons BUT, the real answer resides in how your genes respond to your lifestyle activities…. Your Body Has…
1. To SURVIVE,… AND2. To Achieve PLEASURABLE and REWARDING experiences, and avoid painful & stressful ones These are the GENETIC PRIME DIRECTIVES that drive ALL behaviors Any strategy to achieve optimal health MUST satisfy BOTH mandates Deprivation- or abstinence-dependent tactics alone cause survival/reward panic & Resistance “White Knuckle Abstinence”
Deprivation Reducing calorie (and nutrient) intake/absorption using sugar & fat blockers, calorie restricted diets, appetite suppressants, fiber/water fill-you-up pre- meal bulking agents, etc. ~ad nauseum Stimulation Fat burners & Central nervous system stimulants – caffeine, synephrine, salicylic acid, gotu kola, etc… Elimination Herbal diuretics, colon cleansers, laxatives, etc… Excessive Exercise All Cause a Defensive Survival Reaction
Lower the BMR – Energy Retardation and Conservation Lower the muscle cells ability to produce energy Increased fatigue Increase Energy Storage Fat is Survival Insurance Increase Cravings & Energy Consumption This is Metabolic Retardation – The Real Energy Crisis
So, are the Conventional strategies that focus Entirely on ‘Reducing Heaviness’ by variations of the genetically defiant tactics of deprivation, stimulation, and elimination wrong? YES!!!...SO… What is a lead cause of the desire to overeat? What is a lead cause of low energy & fatigue And the low motivation to be more active It’s not an excess Fat Crisis; It’s an Energy Crisis What has to happen BEFORE the body will let go of fat, i.e. stored energy ala ‘Survival Insurance’
Lifestyle Choices Taking in not enough of the good and too much of the bad i.e. Nutritional Deficiencies + Toxic and Overburdening Excesses ill health ‘Dis’Stress Which adds to ‘too much of the bad’ factor Genetic Predispositions We can’t change our genes BUT, we CAN improve (Optimize) gene expression Epigenetics and Nutrigenomics
FACT: Any strategies to improve vitality, energy, stress relief, body composition, and overall health must FIRST promote a Metabolic Correction in a genetically allowable ‘Body Friendly’ manner. Reducing heaviness is not the priority MUST Fix the ‘Deficient Energy’ Crisis
How Gene Variants (Polymorphisms) Retard Energy Production, Increase Cravings & the Risk of Excessive Reward Seeking Behaviors
Nutrientsat Specific Dosages That Improve GeneExpression& Optimize“Reward”
Pleasure PathwayImmune Stress Pathway Pathway CRAVING RISK Energy Neuro- and endocrine Pathway Metabolic Pathway
The brain is hard wired to feel good. Dopamine is the „feel good, stress relief and happy‟ neurotransmitter! Dopamine is the „Payoff‟ of the “Brain Reward Cascade” but exerts an interactive direct and indirect influence on other important neurotransmitters, hormones, and metabolic molecules like: Serotonin Enkephalin/Endorphin Norepinephrine GABA Cholecystokinin Insulin Leptin Ghrelin Substance P ATP…etc. Problems that can occur with dopamine include: Dopamine deficiency Reduced dopamine sensitivity Reduced amount of dopamine receptors Dopamine Resistance “Reward Deficiency Syndrome” (RDS), etc.
Two Factors are key to Dopamine Sensitivity and Function Synthesis Receptivity Dopamine has 5 types of Receptors D1-D5 Dopamine D2 Receptors are Most Important for Cravings, Reward, Stress Relief, Energy, and Feelings of Happiness There are at least Two Forms of D2 Receptors A1 A2 But…they come in pairs, so there are three variations – A1/A1; A1/A2; A2/A2
50% of African Americans carry the DRD2 A1 gene 58% of Hispanics carry the DRD2 A1 gene 72% of Asians carry the DRD2 A1 gene 85% of Native Americans carry the DRD2 A1 gene Barr & Kidd, Bio Psych 1993
Adequate dopamine (DA) function improves energy and creates feelings of pleasure, satisfaction, satiety, motivation, happi ness, and more. Dopamine Resistance causes an increased need for a pleasure-satisfying “dopamine fix” The “Dopamine Fix” is pursued by eating sugary & fatty foods; over- eating, drinking, drugs, gambling, sex, internet gaming, thrill seeking behaviors, etc. (ALL excessive ‘Reward Seeking Behaviors”) This is called “Reward Deficiency Syndrome” (RDS) Blum et al. JRSM, 1996
Dopamine Resistance = Hypodopaminergic Function Low number of dopamine receptors Reduced dopamine release Low dopamine responsivity Impaired dopamine function Increased (excessive) dopamine stimulating behaviors Substitution/Transfer Addiction Chemical Substances, Sugar/Food, Risk/Excess, Consumpti on/Compensation Behaviors, etc.
Inability to cope with Blunted reward stress response to pleasurable Reduction of energy experiences expenditure Intensified bingeing Lower BMR (Energy behavior Conservation) and Fatigue Addictive behaviors Increased carbohydrate Thrill-seeking behaviors & fat cravings Impulsive behaviors Increased food intake Compulsive behaviors Energy consumption Personality disorders Increased blood Poor executive function pressure Reduced global Increased % body fat cognition Higher Body Mass Index
Addictive Impulsive Compulsive PersonalityBehaviors Behaviors Behaviors Disorderssevere attention-deficit aberrant sexual conductalcoholism disorder behavior disorder hyperactivitypolysubstance tics & Tourette Internet antisocialabuse Syndrome gaming personalitysmoking autism pathological aggressive gambling behaviorOver Obsessive/ CompulsiveEating - Disorderobesity Blum et al. Am Sci, 1996
Research On Social Genetic Research Networks Blum’s group found Research at UC San that in a family with Diego found that the very serious RDS A1 allele is common behavior, the A1 allele among friends up to was present in 100% of 3 degrees of married males and separation females down five generationsFowler et al. PNAS,2011 Blum et al Int J Env Res Pub Health,2011.
Stress lowers brain endorphins and increases craving behavior Blum et al, JPD, 2000
Obesity is an Epigenetic induced RDS condition that positively responds tonutritional support of the brainreward cascade and dopamine agonist actions of the KB220Z neuroadaptogen complex.
PERCENT PREVALENCE DRD2 A1 POSITIVE CORRELATION OF ALLELE & BODY FAT AS MEASURED BY DEXA LEPTIN LEVELS AND FAT MASS Leptin in ng/mL Fat Mass in Kg Chen et al. Food & Function, 2011 Thomas et al. Metabolism, 2000
Weight loss, uncontrollable carbohydrate bingeing and relapse rates were evaluated in 27 outpatients for 90 days, all of whom were attending a supervised reduced calorie diet- controlled treatment program. The patients were assigned to two matched treatment groups: Those receiving KB220 (N= 16) and, Those not receiving KB220 (N=11). After 90 days, the KB220 group lost an average of 27 pounds. The Non-KB220 control group lost only 10.2 pounds. Only 3 subjects (out of 16) in the KB220 group relapsed in contrast to 9 subjects (out of 11) in the Non-KB220 control group. Over the 90 day period, the KB220 group was easily able to comply with the mandated prohibition from carbohydrate bingeing compared to the subjects in the Control (no KB220). Blum et al., Current Therapeutic Research 1990.
Reduces Weight (90 Day Study) Blum et al., Current Therapeutic Research 1990.
Prevents Relapse (90 Day Study) Blum et al., Current Therapeutic Research.
The effects of LG839 intake in 21 individuals were evaluated in an open label study. Pre- and post study analysis revealed a significant difference between starting BMI and the BMI after an average of only 41 days of LG839 intake. The pre-BMI was 31.2 (weight/Ht2) compared to the post BMI of 30.4 (weight/Ht2) with a significance value of P <0.034. Similarly the average pre–weight in pounds was 183.52 compared to the post weight of 179 pounds with a significance value of P < 0.047 (average weight loss of 4.52 lbs or 2.5% of starting weight). This research found, and confirmed, trends of reduced late night snacking and carbohydrate craving, reduction of stress, and reduction of waist circumference. Blum et al. 2008 Gene Therapy & Mol. Biol. 12: 371-382
A 2-year study was conducted to evaluate the efficacy of Optifast® (a meal replacement drink) in a ‘fasting’ program. Following its termination, 247 of the subjects of that original study who had difficulty attaining and/or maintaining their desired weight constituted the experimental group in a second two-year study (84.2% were female; 73% of which were morbidly obese). The experimental group participated in a very low calorie fasting program and was divided into 2 sub- groups. one taking Centrum (N=117) and, the other group, expressing the highest complaint of difficulty in weight loss (the hardest cases in the 4 year study!), took KB220 plus Centrum (N=130).
After the second 2-year term, compared to the Centrum control group, the Centrum + KB220 (patented formula) group achieved the following results a twofold decrease in percent overweight for both males and females; a 70% decrease in food cravings for females and a 63% decrease in males; a 60% decrease in binge eating for females and a 41% decrease for males. Most importantly, similar to the KB220 - 1 study, at the end of the 2 year study, the KB220 - 2 study group only gained back 14.7% of the weight lost during the fasting program. The Centrum control group regained 41.7% of the lost weight(1). Statistical analysis also revealed that morbid obesity and binge eating scores were significant predictors of how beneficial the KB220 treatment would be at preventing weight gain after 2 years. The more you need it, the better it works! Blum et al. Current Therapeutic Res. 1997
# of Total Lbs RegainedStudy Duratio Subject Weight lost/wk Weight n s LostKB220-1 12.86 16 27 lbs 2.1 lbs 3 people wk (90 days) Non 12.86 11 10.2 lbs 1.26 lbs 9 peopleKB220 wk (90 days)LG839 5.86 wk 21 4.52 lbs 0.77 lbs OL (41 days)KB220+ 2 years 130 2Xs Post FastCentrum 14.7% betterCentrum 2 years 117 X Post Fast Only 41.7%
Research tested whether abnormalities in food reward predict weight gain over a 1- year follow-up (Study 1) Carriers of the A1 allele experienced a ‘blunted response’ to palatable food and increased consumption A1 allele interacted with responsivity to predict increases in BMI from baseline to 1- year follow-up Stice et al. Neuroscience, 2011
KB220Z Neuroadaptogen Benefits Other Reward Deficiency Syndrome Behaviors
Brain Map of RDS VictimsImpairment of Reward Sensitivity Braverman & Blum, Clin EEG, 1996
IV KB220 qEEG Study After Before Subject 1.1: Post Amino Acid qEEG (Fig. 2) Post qEEG analyses shows decreased frontal theta (4-8hz) and decreased frontal beta (12-15hz) indicating improved functioning immediately post amino acid intravenous treatment. Miller et al., Post Graduate Medicine 2010
In a triple blind placebo controlled qEEG study, KB220Z significantly increasedalpha with concomitant increases in low beta bands compared to placebo resulting in a normalization of brainfunction in protracted abstinent psycho stimulant addicts Blum et al., Post Graduate Medicine 2010
KB220Z vs Placebo in Psychostimulant Addicts 70FFT Absolute Power (microvolts) 60 50 40 30 Placebo 20 KB220Z 10 0 Alpha(12-15Hz) Beta1(15-18Hz) qEEG Bands Blum et al Post Grad Med, 2010
One year outpatient Recovery Programfor Both Federal and Municipal Court Systems in the Bio-Clarity Rehabilitation Clinic in Las Vegas using the KB220 ComplexAlcoholism Relapse Rate was Only 7% Chen TJH, et al. Adv Therapy 2007
A preliminary study of 106 eating disordered females was conducted at a medically supervised outpatient addiction treatment program (Recovery Systems, Inc.), utilizing the patented Symbiotic MB (SMB) formula for this application. In follow-up interviews, six randomly selected former eating disordered female clients (three of which were also chemically dependent) were contacted nine months to three years post-treatment to evaluate efficacy of the BRS formula. Follow-up confirmed significant initial benefits in elevated mood and freedom from compulsive eating behavior and ideation to eat in 100% of the subjects. In the other 100 patients, 98% experienced significant improvement in both mood and reduced sugar craving behavior. The preliminary work has been completed and published. However, the research is still in progress with the commencement of a ten–year extensive follow–up study. [Ross J. Molecular Psychiatry, 2000 S8]
Taking the patented Endorphamine® formula in Symbiotic MBTM, >80% of recovering alcoholics were able to abstain from taking a drink for an average of 11 months; the duration of the study period. (also reducing ‘white knuckle sobriety’ and promoting a greater sense of happiness) Nutritionally supports over an 80% recovery rate and greater ‘happiness’. Brown et al. J Psychoactive Drugs. 1990 57
The patented Endorphamine® formula in the Symbiotic MBTM significantly reduced relapse rates and enhanced recovery in DUI outpatient offendersover a 10-week period. Follow-up after 10 months revealed an average 83% continued overall recovery rate. Brown et al. Psychoactive Drugs. 1990.
A significant increase in Cognitiveand Attention Processing Speed (P300 component) of the ‘Event Related Potentials’ and ‘Contingent Continuous Performance Task’ wasseen after taking the patented KB220Z complex in the Symbiotic MBTM De France et al. Clin Electro Encephalograph. 1997.
KB220Z Increases Attention & Concentration De France et al Clin EEG, 1997
The Symbiotic MB ™ positively influences gene expressions that drive the brain’s control of every bodily function (especially in the dopamine receptor genes) and its reaction to environmental/lifestyle forces. Symbiotic MB™ results in: Reduced Cravings Greater Self-Control No More Feelings of Helplessness Increased Energy, Vitality, and Sense of Wellness Reduced Stress and Anxiety Greater Focus, Concentration, Cognition Improved Executive Function Elevated Mood and Greater Sense of Happiness