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Computational Protein Design. Overview

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  • 1. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University d’Évry-Val d’Essonne, France mSSB: December 2010Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 1/3
  • 2. Overview 1 Challenges in Protein Engineering The protein design cycle Types of protein interacions Locating and introducing the substitutions Engineering protein activity Screening and library creation 2 Computational Protein Design Protein descriptors Sequence-based methods Structure-based methods Search algorithms De novo design 3 Applications in Systems and Synthetic Biology Protein affinity enhancement Protein modular design Protein promiscuity reengineering 4 Practical exercise Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 2/3
  • 3. Computational Protein Design Overview Pablo Carbonell pablo.carbonell@issb.genopole.fr iSSB, Institute of Systems and Synthetic Biology Genopole, University d’Évry-Val d’Essonne, France mSSB: December 2010Pablo Carbonell (iSSB) Computational Protein Design mSSB: December 2010 3/3