Disorders of consciousness and experience of self dr ali


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Disorders of consciousness and experience of self dr ali

  1. 1. Disorders of consciousness and experience of self Presenter: Dr Mohd Osman Ali MBBS, DPM dr_osmanali@yahoo.com
  2. 2. Scheme of presentation  Introduction to consciousness--consciousness, unconscious, preconscious, three dimensions , attention, concentration, orientation  Disorders of consciousness-psychopathological aspects --Quantitative lowering--clouding, drowsiness, coma --Qualitative change—delirium, fluctuations, confusion --other changes(restriction)– twilight state, dissociative fugue, mania a potu(pathological intoxication), automatism, dreamlike(oneroid) state, stupor, locked-in syndrome,  Introduction to attention  Disturbance of active attention
  3. 3. Scheme of presentation 2  Introduction to self and experience of self --ego and self, self concept and body image, the body schema and cathexis, experience of self-four aspects  Disorders of experience of self —of awareness of self activity – depersonalisation, derealisation, desomatisation, deaffectualisation, jamais vu, déjà vu --of the immediate awareness of self unity --of the continuity of the self --of boundaries of the self --of awareness of the body  Psychiatric aspects-- Theoey of mind (mentalisation)
  5. 5. Study of consciousness Through combining and sharing the perspective of different disciplines: philosophy, psychology, medicine and neuroscience (Bock and Marsh, 1993)
  6. 6. Definition of consciousness For the purpose of descriptive clinical psychopathology, consciousness can be simply defined as -- a state of awareness of the self and the environment (Fish, 1967)
  7. 7. Consciousness is to be consciousness to know about oneself and the world. It is better used as an adjective than noun– a man does not posses consciousness--- -the object of consciousness is its essential social dimension ( Sharfetter,1980)
  8. 8. preconscious Among unconscious, for which there is a good evidence of their existence, frequency, and complexity, there are some which have been, or may yet become, conscious. This is what Freud called Preconscious (Frith, 1979)
  9. 9. conscious Vs preconscious  Strict limit to the no of items available  Very much more information is stored  If stimulus is, only one interpretation is possible at one time  Multiple meanings are available  Very difficult to carry out more than one task  Undertaking parallel task is usual  Flexible, strategic  automatic  Conscious is executive in nature and is dominant to and has the capacity to override the perceptions and functions of preconscious process
  10. 10. unconscious Jasper(1957)- meaning of unconsciousness --it is not an inner existence, does not occur as experience --not thought as an object and has gone unregarded --something which has not reached any knowledge of self
  11. 11. Clinicians use of consciousness and unconsciousness inner awareness of experience subject reacting to objects intentionally There is no subjective experience the denotes a knowledge of conscious self Seen as conscious– unconscious continuum
  12. 12. Three dimensions of consciousness and unconsciousness  Vigilance(wakefulness)----drowsiness(sleep) axis  Lucidity ----clouding axis  Consciousness of self   Normal state of consciousness----- death(in a person suffering from serious brain disease) Full wakefulness-----to deep sleep( in a person who is sleep)  Full vigilance ------total unawareness(in an alert and healthy person  The organic state of brain, as for instance, demonstrated by EEG, is utterly different in these three situations
  13. 13. Vigilence(wakefulness)--drowsiness(sleep) axis The faculty of deliberately remaining alert when otherwise one might be drowsy or sleep.It fluctuates Factors influencing vigilance – interest, anxiety, extreme fear or enjoyment (promotes vigilance) -- boredom( promotes drowsiness) --the situation in the environment and the way the individual perceives the situation
  14. 14. Qualitative difference in the nature of wakefulness --- the significant state of mind of a person scanning radar screen for possible enemy interceptor is very different from the rapt attention of music lover listening to a symphony
  15. 15. Lucidity--- clouding axis Consciousness is inseparable from the object of conscious attention: lucidity can only be demonstrated in clarity of thought on a particular topic Lucidity Vs vigilance– unless the person is fully awake he cannot be clear in consciousness
  16. 16. Clouding denotes the lesser stages of a impairment on a continuum from full alertness and awareness to coma(Lishman,1997) The pt may be drowsy or agitated, and is likely to show memory disturbance and disorientation Most intellectual functions are impaired including attention, and concentration, comprehension and recognition, understanding, forming associations, logical judgment, communication by speech and purposeful action
  17. 17. Consciousness of self Ability to experience self and awareness of self that is both immediate and complex
  19. 19. Classification of disorders of consciousness (Fish) Consciousness can be changed in three basic ways it may be dream like, depressed, or restricted
  20. 20. Quantitative lowering of consciousness Qualitative change of consciousness Normal(alert, vigilant, Delirium lucid) Clouding  Drowsiness Sopor Coma Death Fluctuations Confusion Classification of Disorders of consciousness(Sims)
  21. 21. Disorders of consciousnes Vs dementia Disorders of consciousness are associated with disorders of perception, attention, attitudes, thinking, registration and orientation The pt with disturbance of consciousness usually shows, therefore, a discrepancy between their grasp of the environment and their social situation, personal appearance and occupation. This lack of comprehension in the absence of other florid symptoms of disordered consciousness may lead to a mistaken diagnosis of dementia
  22. 22. Disorders of consciousness Vs orientation When consciousness disturbed it tends to affect three aspects– time, place, and person in that order If patient is disoriented for time and place, it is customary to say that they are confused Most patients with confusion are perplexed, but this sign is also seen in sever anxiety and acute schizophrenia in the absence of disorientation
  23. 23. QUANTITATIVE heightening of consciousness There is a subjective sense of richer perception: colours seem brighter, and so on. There are changes in mood, usually exhilaration perhaps amounting to ecstasy There is subjective experience of increased alertness and a greater capacity for intellectual activity, memory and understanding
  24. 24. May be associated with synaesthesia- a sensory stimulus in one modality resulting in sensory experience in another --eg; hearing a finger nail drawn down a blackboard results in a cold feeling down the spine
  25. 25. Conditions seen are -- normal healthy people– esp in adolescence or at times of emotional, social or religious crisis, when falling in love, on winning a large sum of money, at sudden religious conversion and so on --drugs– notably with hallucinogens(LSD), CNS stimulant(amphetamine) --occasionally in early psychotic illness, esp mania, or less often in schizophrenia
  26. 26. QUANTITATIVE lowering of consciousness Impairment of consciousness is the primary change in acute organic reactions and holds a fundamentally important place in the detection of acute disturbance of brain function and in assessment of severity(Lishman,1997) Some conditions may produce a variable level of diminution of consciousness: that occurring with migraine: for example, may range from blunted awareness through lethargy and drowsiness to loss of consciousness(Lishman,1997)
  27. 27. clouding Lesser stage of consciousness associated with deterioration in thinking, attention, perception, and memory and usually drowsiness and reduced awareness of environment  although pts awareness is clouded, he may be agitated and excitable rather drowsy  The term clouding should be used for the psychopathological state a)impairment of consciousness b)slight drowsiness with or without c)and difficulty with attention and concentration
  28. 28. This will usually occur with organic impairment of function Clouding Vs sleeping--There are important differences between the reduced wakefulness before falling sleep and clouding in an organic state (Liowski, 1967)
  29. 29. drowsiness Next level to clouding of consciousness As a descriptive term simply means diminished alertness and attention which is not clear under the patients control Pt is awake but will drift into sleep if left without sensory stimulation Associated with --slow in action --slurred speech --sluggish in intention --and sleepy on subjective description
  30. 30.  There is an attempt at avoidance at avoidance of painful stimuli; reflexes, including coughing and swallowing are present but reduced muscle tone is also diminished  These level of diminished consciousness are quite non-specific and occur whatever the nature of the cause Conditions seen-- in the psychiatric practice this is commonly seen following over dosage with drugs that have a central nervous depressant effect. In such case interviewing the pt is impossible
  31. 31. coma Pt is unconscious. In slight state, with strong stimuli he may be momentarily arousable. In later stages pt is no longer arousable, he is deeply unconscious There are no verbal responses or responses to painful stimuli The righting response of posture has been lost. Reflexes and muscle tone are present but greatly reduced Breathing is slow, deep and rhythmic. The face and skin may be flushed
  32. 32. Distinct stages of coma have identifiable physical signs ultimately culminating in brain death, (conference of medical royal college,1976) Practical assessment of the depth and duration of impaired consciousness and coma has been quantified in the scale devised by Teasdale and Jennett(1974)
  33. 33. QUALITATIVE changes of consciousness Definition of delirium  Lishman– a syndrome of impairment of consciousness along with intrusive abnormalities of perception and affect  DSM-IV– in a global sense to describe a disturbance of consciousness that is accompanied by a change in cognition that cannot be better accounted for by a preexisting or evolving dementia. There is a reduction in the clarity of awareness of environment(DSM III term– acute brain syndrome, dementia is its chronic form)  ICD-10 (P. 54) an etiologically nonspecific syndrome characterised by concurrent disturbance of consciousness and attention, perception, thinking, memory, psychomotor behaviour, emotion and the sleep-wake cycle
  34. 34. Symptoms of delirium  There is some lowering of consciousness, which is subjective experience of a rise in the threshold for all incoming stimuli  The pt is disoriented for time and place but not for person.  Thinking is disordered as it is in dreams and shows excessive displacement, condensation and misuse of symbols.  The pt is unable to distinguish between their mental images and perceptions, so that their mental images acquire the value of perceptions
  35. 35. Hallucinations in delirium  Visual hallucinations– --often the outstanding feature --usually of small animals and associated with fear or even terror  Elementary auditory hallucinations are common.  Rarely hallucinatory voices occur if they do– the change of consciouness and visual hallucinations often disappear in a few days, leaving behind an organic hallucinosis with little or no change in consciousness  Other hallucinations of touch, pain, electric feelings, muscle sense and vestibular sensations often occur
  36. 36.  They may be associated with Lilliputian hallucinations (seeing little men), so that the pt describes little creatures walking over him--He feels their footsteps and hears them shouting obscene jokes(associated with feeling of pleasure) and abusive remarks in his ear
  37. 37. The patient is fearful and often misinterpretes the behaviour of others as threats. ----Thus a patient with delirium tremens said ‘Don’t hit me; please don’t hit me’ whenever anyone approached, although he had never been subjected to assault Pt is highly suggestible to spoken comments and perceptual clues, but there is loss of grasp: misidentification and misinterpretation occur
  38. 38. Conditions of delirium  One tests the patients orientation and if they are disoriented there is prima facie case they have and organic disorder. (Exception to this may include the patient with chronic schizophrenia)  If this is of recent origin, then it is an acute organic state with disturbance of consciousness.  Although disorientation in an acute illness is strongly suggestive of disordered consciousness, the absence of this sign does not rule out an acute organic state with mild disorder of consciousness  Poor performance on intellectual and memory tasks, inability to estimate the passage of time, and changes in EEG may all suggest an acute organic state
  39. 39. Delirium Vs schiziophrenia It is important to note that the patients with schizophrenia, regardless of their history of institutionalisation, may also demonstrate significant disturbance of memory(McKenna et al,1990), including impairment of working and semantic memory(Kuperberg& Heckers,2000) These impairments may also have a significant impact on social functioning
  40. 40. Mild degree of delirium/? Toxic confusional state  General lowering of consciousness during the day and be incoherent and confused  At night delirium occurs with visual hallucinations and restlessness, but it improves in the morning(diurnal varation}  Pt may have inconsistent orientation, orientation may vary during 24 hours of the day  There may also be some restriction so that the mind is dominated by a few ideas, attitudes and hallucinations
  41. 41. The pt is usually restless and may carry out the customary actions of this trade; this is known as occupational delirium eg: an accountant may make out a long series of accounts or a bus conductor may ask other patients for their bus fares This milder varieties of delirium may pass over into an amnestic state, torpor, severe delirium or a twilight state
  42. 42. fluctuations Occurs in health, sleep and in fatigue. in In is epileptics there fluctuation in relation to fits In delirious states there may be considerable diurnal fluctuation of consciousness Also seen with drugs-- mescaline
  43. 43. confusion Refer to subjective symptoms and signs indicating loss of capacity for coherent thought objective clear and It is purely descriptive(of pt’s experience or doctors observation) term does not apply to clouding of consciousness The term acute confusional state is often used as a synonym for acute organic psyho syndrome( or delirium in DSM IV and ICD 10) in medical literature. Here it refers to a more comprehensive syndrome with chaotic thinking and cognitive failure that includes delirium as sub category (Berrios, 1981)
  44. 44. It is seen in both organic(acute and chronic), and non-organic disturbance(associated with powerful emotions in neurotic disorders) Confusion may be a prominent symptom in the acute toxic psychosis resulting from the use of high-potency cannabis(Ghodse,1986). It is then, of sudden onset and usually associated with delusions, hallucinations and emotional lability
  45. 45. Other states- RESTRICTION of consciousnessAwareness is narrowed down to a few ideas attitudes that dominate the patient’s mind and There is some lowering of level of consciousness Disorientation in time and place occur
  46. 46. Twilight state  A well defined interruption of the continuity of consciousness (Sims et al,2000) Restriction of the morbidly changed behaviourAnd relatively well oriented behaviour It is characterised by a) abrupt onset and end; b)variable duration from a few hours to several weeks; and c)the occurrence of unexpected violent acts or emotional outbursts during otherwise normal, quiet behaviour (Lishman,1997)
  47. 47.  ICD_10 includes twilight states under the heading of dissociative(conversion) disorder and when, criteria for organic etiology are met organic mental disorders  Consciousness may be markedly impaired or relatively normal between episodes  There may be associated dreamlike states, delusions, or hallucinations.  Ganser state is, in practice, a sort of twilight state, in which the organic element is often doubious  Different types described are—simple, hallucinatory, perplexed, excited, expansive, psychomotor and oriented twilight states
  48. 48. It is usually an organic condition and occurs in the context of -- epilepsy, --alcoholism(mania a potu), -- brain trauma -- and general paresis;  it may also occur with dissociative states. The commonest twilight state is the result of epilepsy 
  49. 49. Hysterical twilight state  Restriction motives of consciousness resulting from unconscious  In some cases the subject sees to be deliberately running away from his troubles. It may be difficult to how much motivation of hysterical twilight is unconsciuos  In severe anxiety the patient may be so preoccupied by their conflicts that they are not fully aware of their environment and find that they have only a hazy idea of what has happened in the past hour or so  This may suggest to the patient that amnesia is a solution for their problems, so that they forget their personal identity and whole of their past a temporary solution for their difficulties
  50. 50. Dissociative fugue  Fugue– wandering state with some loss of memory. May be of variable duration  Conscious simulation of fugue may be difficult to differentiate from dissociative fugue  Hysterical fugue may be more common in subjects who have previously had a head injury with concussion, possibly because they are familiar with the pattern of amnesia from their past experience of concussion and can therefore present it as a hysterical symptom  Depression Vs fugue--Not all fugues are hysterical-Depression pts may start to kill themselves and wander about indecisively for some days before finding their home or being stopped by police
  51. 51. Mania a potu(pathological intoxication) This is one type of twilight, specially associated with alcoholism It is important to distinguish this syndrome of acute pathological intoxication with alcohol from delirium tremens, which is a symptom of withdrawl.
  52. 52.  Four components of pathological intoxication(Coid,1979) a)the condition follows the consumption of a variable quantity of alcohol b)senseless, violent behaviour then ensues c)there is then prolonged sleep d)total or partial amnesia for disturbed behaviour occurs  Pathological reaction to alcohol is preferred term. The reaction is thought to be associated with exhaustion, great strain or hypoglycemia, and to occur esp in poorly defended against their own violent impulses (Keller,1997)
  53. 53. automatism  Phenomenologically, it is action without any knowledge acting.  It is a defense because mind does not go with what is being done(Kilmur,1963). Behaviour during automatism is usually purposeful and often appropriate  Violence is rare during automatism. When occur it fulfils the criteria for the definition of twilight state  Awareness of environment is impaired. Pt has no memory later what is done  Epileptic automatism---occur during,or immediately after, a seizure and during which individual retains control of posture and muscle tone and perform simple or complex movements
  54. 54. Dream-like(oneroid) state An unsatisfactory term not clearly differentiated delirium The pt may appear to be dream world and so called occupational delirium could be mentioned It from living a is important to look for other symptoms or organic states to make the important distinction between physical illness and a dissociative organic condition
  55. 55. stupor  names a symptom complex whose central feature is a reduction in, or absence of, relational functions: that is, action and speech(Berrios, 1996)  The inability to initiate speech or action(mutism and akinesis) in a patient who appear awake and even alert  Usually occur with some degree of clouding of consciousness. The pt may look ahead or his eyes may wander, but he appear to take nothing in  Characteristic of lesions in the area of diencephalon and upper brain stem, and also frontal lobe and basal ganglia, It is important to realise , however, that the syndrome of akinesis and mutism in a conscious patient also occur with schizophrenia, affective psychosis( bothe depressive and manic) and in dissociative states 
  56. 56. Organic Vs functional stupor  The difference between psychogenic(so called functional) and neurological(organic) --presence of clear consciousness in former  It is not possible at the time of observation to know whether consciousness clear or not; and even for functional stupor subsequent amnesia is common  After excluding consciousnes, diagnosis of stupor must then be followed by investigation of the differential diagnosis which include both organic and non-organic conditions
  57. 57. Locked-in syndrome A rare but specific condition Involving pons There the motor pathways in the ventral is full alertness and feeling but aphonia and total muscle paralysis apart from blinking, and jaw and eye movements(Plum and Posner,1972)
  58. 58. torpor  The pt is psychologically benumbed  Without hallucinations, illusions, delusions, and restlessness  Pt is apathetic, generally slowed down, unable to express themselves clearly, and may perseverate.( may be mistakenly diagnosed as severe dementia)  Seen in severe infection such a typhoid and typhus, arteriosclerotic cerebral disease following a cerebrovascular accident  After some weeks there is a remarkably partial recovery and the patient is left with a mild organic deficit
  60. 60. attention  The ability to focus on a particular sensory stimulus to the exclusion of others  It can be--active----when the subject focuses their attention on some internal or external event --passive--- when the same events attract the subject’s attention without any conscious effort on their part  Active and passive attention are reciprocally related to each other, since the more the subject focuses their attention the greater must be the stimulus that will distract them( i.e. bring passive attention into action)   Attention is affected by an individuals mind set Generally non rigid, and is altered in response to incoming information
  61. 61. Disturbance of active attention--distractability  can occurs in --fatigue, -- anxiety,(by anxious pre occupation) -- severe depression, -- mania, -- schizophrenia and organic states(may be result of a paranoid frame of mind)
  62. 62. schizophrenia and disturbance of active attention-In acute schizophrenia– as the result of formal thought disorder because the pt is unable to keep the marginal thoughts(which are connected with external objects by displacement, condensation and symbolism) out of their thinking, so that irrelevant external objects are incorporated into their thinking  Amnestic syndrome and attention--Pt’s thinking and observation are dominated by rigid sets, so that perception and comprehension are affected by selective attention
  64. 64. Ego and self Freud (1933) described ego as standing for reason and good sense while id stands for the untamed passions The ego has been modified by the proximity of the external world with its threat of danger. The poor ego has the masters and does what it can to bring their claims and demands into harmony with with one another------. Its three tyrannical masters are the external world, the super ego and the id(Freud,1933)
  65. 65. Self concept and body image  The body is unique in that it is experienced both inside and outside; in both self and object. It is through our body that we have contact with the world outside our self: movement of the body relate us to external space  Self concept refers to the fully consciousness and abstract awareness of self.  Body image is more concerned with unconsciousness and physical matters: it includes experiential aspects of body awareness of self  Sometimes self concept is the same as body concept and at other times, conscious self is conceptualised as being independent of its cage: the body
  66. 66. The body schema and cathexis The body schema implies a spatial element and is more than and usually bigger than the body itself. Eg; the body along with clothes, spectacles, instruments, car(while driving) Cathexis implies the notion of power, force, libido– perhaps analogous to electrical change, the self that makes things happen
  67. 67.  According to shield(1935) body images are never isolated, they are always encircled by the body images of others  At any one time the individual only perceives a small sample from a gallery of possible self images  It is the nature of the self and ego to be experienced as either subject of object  The central core of self image consists for a person his name, his body feelings, body images , sex and age
  68. 68. Experience of self Although there is substantial German literature on Ichbewusstsein or ego consciousness, both of these terms have now been replaced by the term ‘selfexperience’ Disturbance is self experience has two aspects --awareness of existence and activity of the self --awareness of being separate from the environment
  69. 69. Four aspects of selfawareness(Jasper,1997)  the existence and ACTIVITY of the self  being a unity(SINGLENESS) at any given point of time  Continuity of IDENTITY over a period of time  being separate from the environment ( awareness of ego BOUNDARIES/DEFINITION)  Fifth dimension of ego vitality(Scharfetter,1981,1995) Previously this characteristic was incorporated within the awareness of activity, Which subsumed ‘being’ and existing with other principles
  70. 70. Awareness of BEING OR EXISTING, EGO VITALITY “ I know that I exist” and this is fundamental to awareness of self
  71. 71. Awareness of ACTIVITY I do something and that I know that I am doing it Everything I do, in everything I experience, though every event that impinges upon me, I am aware that the experience has the unique quality of being mine. “I pinched myself to make sure it was really happening to me” express the relationship we experience between 
  72. 72. Awareness of UNITY/SINGLENESS At any given moment I know that I am one person In health, a person is integrated in his thinking and behaviour, so that he does not have to be aware of feeling of unity
  73. 73. Awareness of IDENTITY/CONTINUITY I am who I was last week, or 30 years ago: I am who I will be next week, or in 10 years time A feeling of continuity for oneself and one’s role is a fundamental assumptions of life without which competent behaviour cannot take place
  74. 74. Awareness of BOUNDARIES OF SELF I can distinguish what is myself from the outside world, and all that is not the self
  75. 75. Awareness of THE BODY The ego is firstly the body ego (Freud, 1933) The body schema the picture of our body which we form in our mind, that is to say, the way in which the body appears to ourselves  not have abnormal body sensations In transsexual there is conflict between ego and body image
  77. 77. Clinical range of disordered self  In certain normal life experiences in association with exhaustion, hunger, thirst, ecstasy, acute but appropriate anxiety, sexual arousal, hypnogogic states  In normal people in abnormal effects of pressure or gravity, in sensory deprivation and during hypnosis  Normal people taking drugs a) mild depersonalisation is very common with drugs Eg; tricyclic antidepressents b) more marked change occur with cannabis, mescalin, LSD (Lysergic acid diethylamide)
  78. 78.  In almost all neurotic conditions and related disorders complaints about self-awareness occur  In acute anxiety state, hypochondriacal disorder, dissociation with conversion symptoms, and anorexia nervosa, disturbance of self image is prominent  In psychosis, the self is self disturbed as a part of loss of reality judgment  The neurotic person, irrespective of type of neurosis, is very concerned with himself and how others see him
  79. 79. Disturbance of awareness of BEING OR EXISTING All event that can be brought into consciousness are associated with a sense of personal possession, although this is not usually in the forefront of consciousness. This ‘I’ quality has been called personalisation (Jasper,1997) and may be disturbed in psychological disorders There are two aspects to the sense of self activity -- the sense of existence --the awareness of the performance of one’s action
  80. 80. Definition of depersonalisation A change in the awareness of one’s own activity occur when the pt feels that they are no longer their natured self and this is known as depersonalisation Associated with a feeling of unnreality so that environment is experienced as flat, dull and unreal (derealisation)
  81. 81. Depersonalisation is the term used to designate a peculiar change in awareness of self, in which individual feels as if he is unreal (Sedman, 1972) A subjective state of unreality in which there is a feeling of estrangement, either from a sense of self or from the external environment( Fewtrell, 1986)
  82. 82. Positive features of Depersonalisation (Acner, 1954)  Is always subjective, it is a disorder of experience  The experience is that of an internal or external change, characterised by a feeling of strangeness, or unreality  The experience is unpleasant  Any mental functions may be the subject of change, but affect is invariably involved  Insight is preserved
  83. 83. Excluded from depersonalisation (Acner, 1954) The experience of unreality of self, when there is delusional elaboration The ego boundary disorder of schizophrenia The loss of attenuation of personal identity
  84. 84. Depersonalisation Vs delusion Depersonalisation (as if feeling) is not a delusion(experience of unreality that occur in psychosis) It should be distinguished from nihilistic delusions – mood congruent delusions occurring in the setting of severe depression -- in which pt denies that they exist or they are alive or that the world or other people exist
  85. 85. Components of depersonalisation(Sierre and Berris, 2001) Emotional blunting Changes in body experience Changes in visual experience Changes in auditory experience Changes in tactile experience Changes in gustatory experience Changes in olfactory experience Loss of feeling of agency Distortions in the experience of time Changes in the subjective experience of memory Feeling of thought emptiness Subjective feeling of an inability to evoke images Heightened self-observation
  86. 86. Features most prevalent for diagnosis Seirra and Berrios(2001) ◦ FOllowing four features are most prevalent for diagnosis --emotional numbing --changes in visual perception --changes in the experience of the body --loss of feeling of the agency ◦ These are features of the disorder that are additional to the the symptom itself
  87. 87. Depersonalisation Vs dizziness The dizziness and depersonalisation are same experience described differently Bipolar hypothesis– that two experiences form opposite ends of a dimension describing disturbed self/outside world relationships
  88. 88. Clinical features of depersonalisation It has been considered that after depression, anxiety depersonalisation is the most frequent symptom to occur in psychiatry(Stewart, 1964) When the pt first experiences the symptoms they are likely to find it very frightening and often think it is a sign that they are going mad. In the course of time they may become more or less accustomed to it. Many pt who complain of depersonalisation also state that their capacity to feeling diminished
  89. 89. It frequently occurs in attacks which may be of any duration from seconds to months Typically, in depersonalisation disorder , the altered state lasts for a few hours, in temporal lobe epilepsy for a few minutes and in anxiety disorder for a few seconds Onset may be insidious and and with no known cause, or it may be in response to provocation
  90. 90. Conditions of depersonalisation  Organic brain disease– esp temporal lobe disorders (Matthew et al, 1993)  Substance misuse- cannabis, LSD, mescalin, marijuana  Depressive illness--Very occasionally, depersonalisation may be the outstanding feature in a patient with depressive state(DD-schizphrenia- examinar may be mislead by the bizarre description of the symptom)  Anxiety with agoraphobic symptoms, panic disorder, PTSD  Hysterical dissociation– depersonalisation as a symptom , is more frequently associated with depression and anxiety than dissociation
  91. 91.  May also occur from time to time in individuals without mental illness, esp when severely tired and with sensory deprivation  Milder degree of dissociative depersonalisation occur in moderately stressful situation, so that depersonalisation is quite common experience and is reported to occur in at least once in 30– 70 % of young individuals(Freeman, 1996)  True depersonalisation symptoms do occur in schizophrenic patients, especially in the early stages of illness alongside definite schizophrenic psychopathology  It is also described as a side-effect with prescribed psychotropic drugs, such as tryiyclic anti depressants but because of the common association between depersonalisation and depression, it is difficult always to attribute cause
  92. 92. Depersonalisation symptom Vs disorder It is important to emphasize the distinction between depersonalization as a symptom occuring associated with many psychiatric conditions or no disorder at al, and depersonalization as syndrome While the epidemiology of depersonalisation disorder remains poorly understood, it is thought to be twice as common in women as in men (Kaplan& Sadock, 1996)
  93. 93. Depersonalisation disorder ICD-10 Vs DSM-IV  Classinfied as depersonalisation and derealisation syndrome  Occuring in a setting of clear consciousness with retention of insight  A disorder in which sufferer complain that his or her mental activity, body and  Depersonalisation disorder  Emphasis recurrent feeling of detachment, retention of reality testing, and resultant personal distress, all occuring in the absence of another mental disorder
  94. 94. Social and situational aspects Frequently, the person feels that he is less able to himself, his personality, his behaviour than other people accept their own There is barrier to his giving an account of his symptoms and this in turn is a barrier to communication in all areas of life.
  95. 95. Organic and psychological theories of depersonalisation  The relationship between brain pathology and remains unclear. Depersonalisation is certainly not pathognomic of organic diseases, in fact there is no organic or psychotic abnormality in the vast majority of sufferers  The state of increased alertness observed in depersonalisation is considered by Sierra and Berrios (1998) to result from activation of prefrontal attention systems and reciprocal inhibition of anterior cingulate, leading to experience of ‘mind emptiness’ and indifference to pain  the lack of emotional colouring, reported as feelings of unreality, would be accounted for by a left-sided prefrontal mechanism with inhibition of the amygdala
  96. 96. derealisation Frequently depersonalisation is accompanied by the symptoms of derealisation because– the ego and its environment are experienced as one continuous whole The less a patient takes himself for granted the more unfamiliar and alien does the world around him become(Schrfer,1980)
  97. 97. desomatisation Localisation Kuru, to individualised organ described by Yap(1965)- culture specific example, in which sufferer experiences acute anxiety, believes his penis is shrinking and fears that it will ultimately disappear
  98. 98. Distortion of time Change of feeling concerning the body may be associated with distortion of time sense, the passage of time appears altered in some way: time both past and present, seems unreal to me, as if it had never happened and was never going to happen
  99. 99. Deaffectualisation--Loss of emotional resonance Normal emotional resonance experiences a series of positive and negative feeling as they encounter both animate and inanimate objects in the environment An emotional crisis or a threat to life may lead to complete dissociation of affect, which can be regarded as an adaptive mechanism that allows the subject to function reasonably without being overwhelmed by emotion Loss of emotional resonance is seen in— depression-depersonalisation
  100. 100. Depression and loss of emotional resonance Pt has feeling that they cannot feel Most marked when the pt with depression encounters their loved ones If the pt has ideas of guilty, this apparent loss of feeling will make the pt feel even more guilty and morally reprehensible
  101. 101. Jamais vu and deja vu Jamais vu – there is no sense of previously having seen a well-known object Déjà vu – where an unfamiliar object or experience seem to be familiar These abnormalities are similar to depersonalisation and have common origin
  102. 102. Disturbance of awareness of SELF ACTIVITY Perception– a pt of endogenous depression “I do not feel alive, my eyes stare like out of a corpse; I as if nowhere Moving– a household wife suffering from a phobic neurosis said “ if I am in the street on my own, I panic, I feel as if I am falling over” schizophrenia-- delusion of control Memorizing and imaging-- depression feels that he is unable to initiate act of memory or fantasy. Schiz this activiy when it occurs in not initiated by him but from outside himself
  103. 103. Loss of feeling– occurs as a common symptom in depression. “ I cannot love my husband. Nothing has happened to us. I have just lost my feeling for him” Willing– schiz– no longer experiences his will as being his own. Commonly neurotic describe an inability to initiate activity, a feeling of powerlessness, of being ground down, in the face of life’s vicissitudes
  104. 104. Abnormalities of experience of one’s own activities are closely associated with mood: depressed patient believes that he is incapable of doing anything at all Sometimes belief about initiation of activity changed(passivity experiences)
  105. 105. Disturbance in the immediate awareness of SELFUNITY/SINGLENESS In dreams one sometimes sees oneself, even perhaps with some surprise, in the drama In some forms of transcendental meditation, by carrying out repetitive monotonous acts, the subject enters a self-induced trance in which he can observe himself carrying out the behavioiur
  106. 106.  They feel as if they are two persons Seen in  in psychogenic and depressive depersonlisation(the pt may feel that they are talking and acting in an automatic way).this may lead to say as if they are two persons  individuals with appreciation needing personalities or with learning disability. May leave out the as if and say they are two persons  delusion of demonic possession( themselves and devil)  schizophrenia (may feel they are two or more people)
  107. 107. Autoscopy (heautoscopy/phantom mirror image)  Autoscopy is complex psychosensorial hallucinatory perception of one’s own body image projected into the external visual space (Lukianowicz, 1958)  “in this strange experience the pt sees himself and knows that it is he. It is not just a visual hallucination because kinesthetic and somatic sensation must also be present to give the subject that impression that the hallucination is he” (Fish, 1967 ).  The disturbance in visual perception is an essential feature. The loss of familiarity for oneself is prominent  Especially associated with disorders of parietal lobe
  108. 108. The double phenomenon: doppleganger It is an awareness of oneself as being both outside alongside, and inside oneself: the subjective phenomenon of doubling The experience occur with different conditions, or with no mental disorder et al Six possible psychopathological explanations for phenomenon of non-organic, non-psychotic– fantasy, depersonalization, conflict, compulsive ideas, double personality(alternating states of consciousness), being doubled
  109. 109. dual, double or multiple personality Very rarely pt may complain of experiencing multiple personalities ---In multiple personality disorder(dissociative idetity disorders)  differential diagnosis– other dissociative disorders, schizophrenia, rapid cycling bipolar disorder, borderline personality disorder, malingering and complex epilepsy
  110. 110. Related terms Delusional misidentification or Capgras syndrome Double orientation; is the situation where an individual appears to live in two worlds simultaneously– a psychotic world and the real world; for a confused patient on a psychogeriatric ward he believes both this man visiting him is the doctor and also the person come to marry him to his young wife
  111. 111. Disturbance of the CONTINUITY/IDENTITY of the self  This disorder is characterised by changes in the identity of self over time  The complete alteration in the sense of identity is exclusively psychotic  A feeling of loss of continuity which is, of lesser intensity than the psychotic change without element of passivity, may be experienced in health, and in neuroses and personality disorders  The person knows both people, before and after, are truly himself, but he feels very altered from what he was. This may occur following an overwhelmingly important life situation, or during emotional
  112. 112. A part of continuity of self is accepting that the changes in one’s total state at present are due to illness. This is characteristic usually described in the mental status examination under the term insight (David, 1990) The feeling of loss of continuity contribute to the inertia of the person with schizophrenia, and apathy of the depressive Lack of clear sense of identity from the past continuity into the future is a strong disincentive to concerted activity
  113. 113. In schizophrenia They are not the same person that they were before the illness (sense of change) may be described as--religious conversion or being born again Following an acute shift of the illness, may describe how they seemed to pass from being one or personality to another They may seem to be personifying natural events, seminars and historical event, animals and historical figures during the acute illness
  114. 114. The depressive secondary to disorder of mood, often sees no continuation into the future “everything is bleak, there is nothing to look forward to”
  115. 115. Possession state Altered state of conscious awareness is prerequisite It can occur in normal, healthy people in unusual situations either as a group phenomenon(mass hypnosis) or individually The difference between those conditions that constitute and those that may be considered as being within a cultural or religious context alone is that the former are unwanted, cause distress to the individual and those around, and may be prolonged the immediate event or ceremony at which it was induced
  116. 116. Near death experience The most prominent clusters of symptoms seem to be depersonalisation, increased alertness and various descriptions of ‘mystic consciousness’. Out-of-body experience with autoscopy was frequent, as was passage of consciousness into a foreign region or transcendental experience
  117. 117. Disturbances of BOUNDARIES of the self  Disturbance in knowing where I ends and not I begins  One of the most fundamental of the experience is the difference between one’s body and the rest of the world  Knowledge of what is body and what is not -- is based on the link between information from the extroceptors and the proprioceptors -- a link that is probably learned--has to be maintained constantly  The physiologic schema of the body and the continuity and integrity of memory and psychological function is the basis of awareness of the self
  118. 118. Seen in schizophrenia LSD intoxication– feeling of impending ego dissolution associated with the feeling of self ‘slipping away with considerable anxiety ( Anderson and Rawnsley, 1954)  Conditions disturbance of body image seen-hypnogogic state -depression(eg; face has become ugly)-schizophreniaorganic disorders
  119. 119. In schizophrenia  In schizophrenia, the sense of invasion of self appears to be fundamental to the nature of the condition as it experience  First rank symptoms have in common permeability of the barrier between the individual and his environment, loss of ego boundaries (Sims, 1993)  “Other people are doing things to me, events are taking place outside myself” the external observer finds a blurring or loss of the boundaries of self, which is not apparent to the patient himself
  120. 120. Passivity experience Falsely attribute functions to not self influence from outside, which are actively coming from the inside self  Alienation of motor actions and feelings( passivity phenomenon/ made or fabricated experiences) -- their actions are not their own -- attribute it to the hypnosis, radiowaves, the internet, and so on -experiences these as being made by outside influence --pt knows that all the event around them as being made for their benefit (apophaneous experience)
  121. 121.  In early stages of acute schizophrenia– changes in their awareness of their own activity that is becoming alienated from them(differential diagnoses: depersonalisation– they feel like machines as if their actions are carried out automatically, loss of control in obsessions and compulsions but belonging to pt)  Pt know that their actions and thoughts have excessive effects on the world around them and he experiences activity that is not directly related to them as having an effect on them -- eg: a patient may believe that when they pass urine, they cause bad things to happen to other people
  122. 122. Auditory hallucinations and third person auditory hallucination AH confidently ascribed by the patient to sensory stimuli outside the self, where as in fact they arise inside the self 3rd person AH– usually I think of myself n the first person singular. Occasionally I address myself in my thoughts in the second person, but I do not think about myself nor comment on my action in the third person
  123. 123. Hearing one’s own thoughts spoken aloud Implies locating one’s innermost core experience as in distant past
  124. 124. Delusional percept Object of perception which is actually neutral and irrelevant to self, is delusionally interpreted as highly relevant, having intense personal meaning. The implication is that meaning of the perception, although in reality outside self, has become incorporated within self
  125. 125. Thought broadcasting -- because the pt ‘knows’ that as he thinks the whole world is thinking in unison
  126. 126. Other alterations to boundaries of self– in states of ecstasy Person might describe feeling at one with universe merging with Nirvana experiencing unity with saints or in oneness with God Occur in normal people in those with personality disorder as well as in sufferers from psychoses  This alteration in awareness in boundaries of self is different from that of schizophrenia. In ecstasy it is an as if experience and is mediated affectively( there is no loss of judgment, ability to discriminate)
  128. 128. Theory of mind (mentalisation) refers to the ability of an individual to infer or understand the mental states of others in given situation (Bentall, 2003)  Many of the disturbances in the experience of self may co-exist with deficits in theory of mind esp in the context of psychosis
  129. 129.  Deficits in theory of mind have been particularly associated with-- autism(Baron, Cohen et al, 1993) --paranoid symptoms in psychotic illness(Frith,1992; Frith&Corcoran,1996)  Theory of mind prove valuable in informing other approaches to understanding the psychopathology of schizophrenia (Bentall,2003) or elucidating etiology  Schiffman et al (2004) - suggesting that some aspects of theory of mind may be impaired in these individuals prior to development of schizophrenia spectrum disorders
  130. 130. Sass & Parnas(2003) have proposed -- a unified account of symptoms in schizophrenia, in which they have emphasized the importance of abnormalities of consciousness -- argued that schizophrenia is fundamentally a self disorder characterised by particular distortions of awareness of aspects of the self. Eg: increased self-consciousness, diminished self affection The study of consciousness, and the study of theory of mind are clearly related fields in schizophrenia research------may well play imp role in understanding clinical features of the illness
  131. 131. Disorders of the awareness of the body(body image) Undue concern with illness– Hypochondriasis Dislike of body– Dysmorphophobia, transsexualism Undue concern with appearance– Narcissism Distortion obesity of body image– anorexia nervosa,
  132. 132. references Andrew Sims. (2003)Symptoms in Mind ( 3rdedition). Saunders/Elsevier Patricia Casey, Brenden Kelly.(2007) Fish’s Clinical psychopathology (3rd edition). Gaskell
  133. 133. THANK YOU
  134. 134. Floor discussion