08.25.08 - 08.27.08: Neoplasia II & III
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08.25.08 - 08.27.08: Neoplasia II & III

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08.25.08 - 08.27.08: Neoplasia II & III 08.25.08 - 08.27.08: Neoplasia II & III Presentation Transcript

  • Author(s): Gerald Abrams, M.D., 2009License: Unless otherwise noted, this material is made available under the termsof the Creative Commons Attribution–Non-commercial–Share Alike 3.0License: http://creativecommons.org/licenses/by-nc-sa/3.0/We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize yourability to use, share, and adapt it. The citation key on the following slide provides information about how youmay share and adapt this material.Copyright holders of content included in this material should contact open.michigan@umich.edu with anyquestions, corrections, or clarification regarding the use of content.For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use.Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosisor a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Pleasespeak to your physician if you have questions about your medical condition.Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
  • Citation Key for more information see: http://open.umich.edu/wiki/CitationPolicyUse + Share + Adapt { Content the copyright holder, author, or law permits you to use, share and adapt. } Public Domain – Government: Works that are produced by the U.S. Government. (USC 17 §105) Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Creative Commons – Zero Waiver Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation LicenseMake Your Own Assessment { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in your jurisdiction may differ { Content Open.Michigan has used under a Fair Use determination. } Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair.
  • M1 Patients and Populations: NEOPLASIA II Gerald D. Abrams MDFall 2008
  • MICROSCOPIC FEATURES OF NEOPLASMS•  CONCEPT OF STROMA / ANGIOGENESIS•  CONCEPT OF DIFFERENTIATION•  GRADING / STAGING
  • CANCER CELLS AND STROMA G.D. Abrams, University of Michigan Medical School
  • CANCER CELLS AND STROMA SCIRRHOUS G.D. Abrams, University of Michigan Medical School
  • NORMAL COLONIC MUCOSA G.D. Abrams, University of Michigan Medical School
  • COLON CANCER, MODERATELY DIFFERENTIATED G.D. Abrams, University of Michigan Medical School
  • NORMAL BRONCHIAL MUCOSA G.D. Abrams, University of Michigan Medical School
  • CANCER OF THE BRONCHUS ANAPLASTIC G.D. Abrams, University of Michigan Medical School
  • GRADING OF NEOPLASMS•  ASSESSMENT OF THE DEGREE OF DIFFERENTIATION OF A NEOPLASM•  BASED ON THE RESEMBLANCE OF THE NEOPLASM TO THE NORMAL TISSUE OF ORIGIN
  • WELL DIFFERENTIATEDSQUAMOUS CELL CARCINOMA G.D. Abrams, University of Michigan Medical School
  • MODERATELY DIFFERENTIATEDSQUAMOUS CELL CARCINOMA G.D. Abrams, University of Michigan Medical School
  • POORLY DIFFERENTIATEDSQUAMOUS CELL CARCINOMA G.D. Abrams, University of Michigan Medical School
  • STAGING OF NEOPLASMS•  ASSESSMENT OF THE EXTENT OF PROGRESSION OF A NEOPLASM IN THE BODY•  BASED ON THE SIZE AND EXTENT OF THE PRIMARY, AND ON THE PRESENCE OR ABSENCE OF REGIONAL AND DISTANT METASTASES
  • HISTOPATHOLOGIC DIAGNOSIS OF NEOPLASMS•  DIAGNOSIS AS A PREDICTION•  EVALUATION OF: -ARCHITECTURAL ARRANGEMENT -RELATION OF NEOPLASTIC CELLS TO NORMAL SURROUNDINGS -CYTOLOGIC FEATURES OF NEOPLASTIC CELLS
  • INVASIONG.D. Abrams, University of Michigan Medical School
  • NORMAL COLONIC EPITHELIAL CELLSG.D. Abrams, University of Michigan Medical School
  • NEOPLASTIC COLONIC EPITHELIAL CELLSG.D. Abrams, University of Michigan Medical School
  • NORMAL SQUAMOUS EPITHELIUMG.D. Abrams, University of Michigan Medical School
  • DYSPLASTIC SQUAMOUS EPITHELIUMG.D. Abrams, University of Michigan Medical School
  • CARCINOMA IN SITUG.D. Abrams, University of Michigan Medical School
  • CELLULAR FEATURES OF ANAPLASIAG.D. Abrams, University of Michigan Medical School
  • PAP SMEAR NORMAL CELLSG.D. Abrams, University of Michigan Medical School
  • PAP SMEAR MALIGNANT CELLSG.D. Abrams, University of Michigan Medical School
  • NEOPLASIA IIIGerald D. Abrams
  • CLINICAL CONSEQUENCES OF NEOPLASMSBENIGN LOCAL MECHANICAL EFFECTS LOCAL COMPLICATIONS SYSTEMIC ENDOCRINE EFFECTSMALIGNANT ALL OF THE ABOVE CANCER CACHEXIA PARANEOPLASTIC SYNDROMES
  • NOMENCLATURE OF NEOPLASMS•  BASED ON TISSUE OF ORIGIN BENIGN OR MALIGNANT
  • EPITHELIAL NEOPLASMS•  ADENOMA!!!ADENOCARCINOMA•  PAPILLOMA...PAPILLARY CARCINOMA•  CYSTADENOMA..... CYSTADENOCARCINOMA
  • ADRENAL CORTICAL ADENOMA Source Undetermined
  • PANCREAS, ISLET CELL ADENOMADepartment of Pathology, University of Michigan
  • COLON, ADENOMADepartment of Pathology, University of Michigan
  • COLON, ADENOMADepartment of Pathology, University of Michigan
  • Image of sketch of papilloma removed
  • OROPHARYNX, PAPILLOMA G.D. Abrams, University of Michigan Medical School
  • OVARY CYSTADENOMASource Undetermined
  • OVARY CYSTADENOMASource Undetermined
  • PENIS, SQUAMOUS CELL CARCINOMASource Undetermined
  • VULVA, SQUAMOUS CELL CARCINOMA Source Undetermined
  • CERVIX, SQUAMOUS CELL CARCINOMA Source Undetermined
  • TONGUE, SQUAMOUS CELL CARCINOMA Department of Pathology, University of Michigan
  • LARYNX, SQUAMOUS CELL CARCINOMA Source Undetermined
  • ESOPHAGUS, SQUAMOUS CELL CARCINOMA Department of Pathology, University of Michigan
  • STOMACH, ADENOCARCINOMA Source Undetermined
  • COLON, ADENOCARCINOMA Department of Pathology, University of Michigan
  • COLON, ADENOCARCINOMA Source Undetermined
  • LUNG, SQUAMOUS CELL CARCINOMA Source Undetermined
  • LUNG, SQUAMOUS CELL CARCINOMA Department of Pathology, University of Michigan
  • BRONCHUS, SQUAMOUS CELL CARCINOMA Department of Pathology, University of Michigan
  • BRONCHUS, SQUAMOUS CELL CARCINOMA Department of Pathology, University of Michigan
  • OVARY CYSTADENOCARCINOMASource Undetermined
  • OVARY CYSTADENOCARCINOMASource Undetermined
  • SUPPORTING TISSUE NEOPLASMS•  LIPOMA!!!!LIPOSARCOMA•  CHONDROMA!CHONDROSARCOMA•  FIBROMA!!! FIBROSARCOMA•  OSTEOMA!! OSTEOSARCOMA ETC
  • COLON, LIPOMADepartment of Pathology, University of Michigan
  • UTERUS, LEIOMYOMAS Department of Pathology, University of Michigan
  • BONE, OSTEOSARCOMADepartment of Pathology, University of Michigan
  • MUSCLE,RHABDOMYOSARCOMADepartment of Pathology, University of Michigan
  • LYMPHOID / HEMATOPOIETIC NEOPLASMS•  LYMPHOMA(S)•  LEUKEMIA(S)
  • LYMPHOMASource Undetermined
  • RETROPERITONEUM, LYMPHOMADepartment of Pathology, University of Michigan
  • SPLEEN, LYMPHOMADepartment of Pathology, University of Michigan
  • KIDNEY, LYMPHOMA Department of Pathology, University of Michigan
  • CNS NEOPLASMS•  MENINGIOMA•  GLIOMA
  • BRAIN, GLIOMADepartment of Pathology, University of Michigan
  • NEOPLASMS WITH MIXED DIFFERENTIATION•  CARCINOSARCOMA•  TERATOMA BENIGN MALIGNANT
  • OVARY, TERATOMADepartment of Pathology, University of Michigan
  • OVARY, TERATOMADepartment of Pathology, University of Michigan
  • OVARY, TERATOMADepartment of Pathology, University of Michigan
  • Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicySlide 5: G.D. Abrams, University of Michigan Medical SchoolSlide 6: G.D. Abrams, University of Michigan Medical SchoolSlide 7: G.D. Abrams, University of Michigan Medical SchoolSlide 8: G.D. Abrams, University of Michigan Medical SchoolSlide 9: G.D. Abrams, University of Michigan Medical SchoolSlide 10: G.D. Abrams, University of Michigan Medical SchoolSlide 12: G.D. Abrams, University of Michigan Medical SchoolSlide 13: G.D. Abrams, University of Michigan Medical SchoolSlide 14: G.D. Abrams, University of Michigan Medical SchoolSlide 17: G.D. Abrams, University of Michigan Medical SchoolSlide 18: G.D. Abrams, University of Michigan Medical SchoolSlide 19: G.D. Abrams, University of Michigan Medical SchoolSlide 20: G.D. Abrams, University of Michigan Medical SchoolSlide 21: G.D. Abrams, University of Michigan Medical SchoolSlide 22: G.D. Abrams, University of Michigan Medical SchoolSlide 23: G.D. Abrams, University of Michigan Medical SchoolSlide 24: G.D. Abrams, University of Michigan Medical SchoolSlide 25: G.D. Abrams, University of Michigan Medical SchoolSlide 30: Source UndeterminedSlide 31: Department of Pathology, University of MichiganSlide 32: Department of Pathology, University of MichiganSlide 33: Department of Pathology, University of MichiganSlide 35: G.D. Abrams, University of Michigan Medical SchoolSlide 36: Source UndeterminedSlide 37: Source UndeterminedSlide 38: Source UndeterminedSlide 39: Source UndeterminedSlide 40: Source UndeterminedSlide 41: Department of Pathology, University of MichiganSlide 42: Source UndeterminedSlide 43: Department of Pathology, University of MichiganSlide 44: Source UndeterminedSlide 45: Department of Pathology, University of MichiganSlide 46: Source UndeterminedSlide 47: Source UndeterminedSlide 48: Department of Pathology, University of Michigan
  • Slide 49: Department of Pathology, University of MichiganSlide 50: Department of Pathology, University of MichiganSlide 51: Source UndeterminedSlide 52: Source UndeterminedSlide 54: Department of Pathology, University of MichiganSlide 55: Department of Pathology, University of MichiganSlide 56: Department of Pathology, University of MichiganSlide 57: Department of Pathology, University of MichiganSlide 59: Source UndeterminedSlide 60: Department of Pathology, University of MichiganSlide 61: Department of Pathology, University of MichiganSlide 62: Department of Pathology, University of MichiganSlide 64: Department of Pathology, University of MichiganSlide 66: Department of Pathology, University of MichiganSlide 67: Department of Pathology, University of MichiganSlide 68: Department of Pathology, University of Michigan