08.25.08: Neoplasia I
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08.25.08: Neoplasia I

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Slideshow is from the University of Michigan Medical School's M1 Patients and Populations: Medical Genetics Sequence. ...

Slideshow is from the University of Michigan Medical School's M1 Patients and Populations: Medical Genetics Sequence.

View additional course materials on Open.Michigan:
openmi.ch/med-M1PatientsPopulations

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08.25.08: Neoplasia I 08.25.08: Neoplasia I Presentation Transcript

  • Author(s): Gerald Abrams, M.D., 2009License: Unless otherwise noted, this material is made available under the termsof the Creative Commons Attribution–Non-commercial–Share Alike 3.0License: http://creativecommons.org/licenses/by-nc-sa/3.0/We have reviewed this material in accordance with U.S. Copyright Law and have tried to maximize yourability to use, share, and adapt it. The citation key on the following slide provides information about how youmay share and adapt this material.Copyright holders of content included in this material should contact open.michigan@umich.edu with anyquestions, corrections, or clarification regarding the use of content.For more information about how to cite these materials visit http://open.umich.edu/education/about/terms-of-use.Any medical information in this material is intended to inform and educate and is not a tool for self-diagnosisor a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional. Pleasespeak to your physician if you have questions about your medical condition.Viewer discretion is advised: Some medical content is graphic and may not be suitable for all viewers.
  • Citation Key for more information see: http://open.umich.edu/wiki/CitationPolicyUse + Share + Adapt { Content the copyright holder, author, or law permits you to use, share and adapt. } Public Domain – Government: Works that are produced by the U.S. Government. (USC 17 §105) Public Domain – Expired: Works that are no longer protected due to an expired copyright term. Public Domain – Self Dedicated: Works that a copyright holder has dedicated to the public domain. Creative Commons – Zero Waiver Creative Commons – Attribution License Creative Commons – Attribution Share Alike License Creative Commons – Attribution Noncommercial License Creative Commons – Attribution Noncommercial Share Alike License GNU – Free Documentation LicenseMake Your Own Assessment { Content Open.Michigan believes can be used, shared, and adapted because it is ineligible for copyright. } Public Domain – Ineligible: Works that are ineligible for copyright protection in the U.S. (USC 17 § 102(b)) *laws in your jurisdiction may differ { Content Open.Michigan has used under a Fair Use determination. } Fair Use: Use of works that is determined to be Fair consistent with the U.S. Copyright Act. (USC 17 § 107) *laws in your jurisdiction may differ Our determination DOES NOT mean that all uses of this 3rd-party content are Fair Uses and we DO NOT guarantee that your use of the content is Fair. To use this content you should do your own independent analysis to determine whether or not your use will be Fair.
  • M1 Patients and Populations: DISTURBANCES OF GROWTH NEOPLASIA I Gerald D. Abrams MDFall 2008 View slide
  • ORGANS/TISSUES SMALLER THAN NORMAL•  DEVELOPMENTAL AGENESIS APLASIA HYPOPLASIA ATRESIA•  ACQUIRED ATROPHY View slide
  • UNILATERAL RENAL AGENESIS Department of Pathology, University of Michigan
  • UNILATERAL RENAL HYPOPLASIA Department of Pathology, University of Michigan
  • LIVER, BROWN ATROPHY G.D. Abrams, University of Michigan Medical School
  • ORGANS / TISSUES LARGER THAN NORMAL•  HYPERTROPHY INCREASE IN CELL SIZE•  HYPERPLASIA INCREASE IN CELL NUMBER
  • HEART, NORMALDepartment of Pathology, University of Michigan
  • HEART, HYPERTROPHYDepartment of Pathology, University of Michigan
  • MYOCARDIUM, NORMALG.D. Abrams, University of Michigan Medical School
  • MYOCARDIUM, HYPERTROPHY G.D. Abrams, University of Michigan Medical School
  • SKIN, NORMALG.D. Abrams, University of Michigan Medical School
  • SKIN, HYPERPLASIAG.D. Abrams, University of Michigan Medical School
  • SKIN, HYPERKERATOSISG.D. Abrams, University of Michigan Medical School
  • MAMMARY GLANDG.D. Abrams, University of Michigan Medical School
  • MAMMARY GLAND, LACTATING G.D. Abrams, University of Michigan Medical School
  • PROSTATE, HYPERPLASIA Source Undetermined
  • BREAST- FIBROCYSTIC CHANGE Source Undetermined
  • NORMAL BREASTG.D. Abrams, University of Michigan Medical School
  • BREAST FIBROCYSTIC CHANGEG.D. Abrams, University of Michigan Medical School
  • ABNORMAL PATTERNS OF CELL GROWTH / DIFFERENTIATION•  METAPLASIA•  DYSPLASIA
  • ENDOCERVIX, SQUAMOUS METAPLASIA G.D. Abrams, University of Michigan Medical School
  • ENDOCERVIX, SQUAMOUS METAPLASIAG.D. Abrams, University of Michigan Medical School
  • SQUAMOUS EPITHELIUM, NORMALG.D. Abrams, University of Michigan Medical School
  • SQUAMOUS EPITHELIUM, MODERATE DYSPLASIAG.D. Abrams, University of Michigan Medical School
  • SQUAMOUS EPITHELIUM, SEVERE DYSPLASIAG.D. Abrams, University of Michigan Medical School
  • NEOPLASM / TUMOR•  MASS ( NEW GROWTH ) – PROLIFERATING CELLS•  AUTONOMOUS•  NON-EQUILIBRIUM, UNCOORDINATED GROWTH•  PERSISTENT / IRREVERSIBLE
  • NEOPLASTIC TRANSFORMATION•  SERIES OF GENETIC EVENTS•  CLONAL CHARACTERISTICS
  • Benign Tumor: growth by expansion Malignant Tumor: growth by invasionRegents of The University of Michigan
  • BENIGN AND MALIGNANT GROWTH•  BENIGN COHESIVE /EXPANSILE CIRCUMSCRIBED / LOCALIZED•  MALIGNANT POORLY CIRCUMSCRIBED / INVASIVE….METASTASIZING
  • UTERUS, LEIOMYOMA Department of Pathology, University of Michigan
  • UTERUS, LEIOMYOMAG.D. Abrams, University of Michigan Medical School
  • BREAST CANCER Department of Pathology, University of Michigan
  • COLON CANCERDepartment of Pathology, University of Michigan
  • COLON CANCERDepartment of Pathology, University of Michigan
  • CANCER INVADING COLONIC WALL G.D. Abrams, University of Michigan Medical School
  • METASTASIS•  A COMPLEX CASCADE OF EVENTS•  VIA BLOOD•  VIA LYMPH•  DIRECT
  • CANCER CELLS WITHIN BLOOD VESSEL G.D. Abrams, University of Michigan Medical School
  • CANCER CELLS WITHIN LYMPHATIC G.D. Abrams, University of Michigan Medical School
  • PERITONEUM, CARCINOMATOSISDepartment of Pathology, University of Michigan
  • PERITONEAL METASTASES Department of Pathology, University of Michigan
  • LIVER, METASTASESDepartment of Pathology, University of Michigan
  • EYE, PRIMARY MALIGNANT MELANOMA Department of Pathology, University of Michigan
  • LUNG, METASTASES Department of Pathology, University of Michigan
  • VERTEBRAE, METASTASES Department of Pathology, University of Michigan
  • VERTEBRA, METASTASIS Department of Pathology, University of Michigan
  • BRAIN, METASTASISDepartment of Pathology, University of Michigan
  • LIVER, METASTASESDepartment of Pathology, University of Michigan
  • Additional Source Information for more information see: http://open.umich.edu/wiki/CitationPolicySlide 5: Department of Pathology, University of MichiganSlide 6: Department of Pathology, University of MichiganSlide 7: G.D. Abrams, University of Michigan Medical SchoolSlide 9: Department of Pathology, University of MichiganSlide 10: Department of Pathology, University of MichiganSlide 11: G.D. Abrams, University of Michigan Medical SchoolSlide 12: G.D. Abrams, University of Michigan Medical SchoolSlide 13: G.D. Abrams, University of Michigan Medical SchoolSlide 14: G.D. Abrams, University of Michigan Medical SchoolSlide 15: G.D. Abrams, University of Michigan Medical SchoolSlide 16: G.D. Abrams, University of Michigan Medical SchoolSlide 17: G.D. Abrams, University of Michigan Medical SchoolSlide 18: Source UndeterminedSlide 19: Source UndeterminedSlide 20: G.D. Abrams, University of Michigan Medical SchoolSlide 21: G.D. Abrams, University of Michigan Medical SchoolSlide 23: G.D. Abrams, University of Michigan Medical SchoolSlide 24: G.D. Abrams, University of Michigan Medical SchoolSlide 25: G.D. Abrams, University of Michigan Medical SchoolSlide 26: G.D. Abrams, University of Michigan Medical SchoolSlide 27: G.D. Abrams, University of Michigan Medical SchoolSlide 30: Regents of the University of MichiganSlide 32: Department of Pathology, University of MichiganSlide 33: G.D. Abrams, University of Michigan Medical SchoolSlide 34: Department of Pathology, University of MichiganSlide 35: Department of Pathology, University of MichiganSlide 36: Department of Pathology, University of MichiganSlide 37: G.D. Abrams, University of Michigan Medical SchoolSlide 39: G.D. Abrams, University of Michigan Medical SchoolSlide 40: G.D. Abrams, University of Michigan Medical SchoolSlide 41: Department of Pathology, University of MichiganSlide 42: Department of Pathology, University of MichiganSlide 43: Department of Pathology, University of MichiganSlide 44: Department of Pathology, University of MichiganSlide 45: Department of Pathology, University of MichiganSlide 46: Department of Pathology, University of MichiganSlide 47: Department of Pathology, University of MichiganSlide 48: Department of Pathology, University of MichiganSlide 49: Department of Pathology, University of Michigan