Physiology ofEmotion                ©Dr. Anwar Siddiqui
• Aristotle: People are THINKING            ANIMAL.What makes peoplr specialHistory            is they can overcome their ...
Introduction   • The word emotion is derived from                 the latin word emovere which means                 to st...
• Emotion has two components:  – Mental  – Physical• Mental component:  – Cognition- Awareness of sensation and it’s    ca...
Oh it’s a roar. The                  roar seems to be                  that of lion                  (Cognition)          ...
• Physical components:  – Changes in viscera and skeletal muscle  – Coordinated activity of autonomic and    somatic nervo...
Theories of emotion                      •   James-Lang theory                      •   Cannon-Bard theory                ...
James lange theory                     • Developed independently by Williams                       James and Carl Lange in...
James-Lange theory
Cannon-Bard Theory   • Walter Cannon and Phillip Bard – 1927                     • The physiological reaction and the emot...
Cannon-Bard Theory   • The influence of the cerebral cortex in                       controlling emotion is show in the   ...
Cannon-Bard Theory
theorySchachter-Singer                   • Also called cognitive arousal theory.                   • A two-stage theory st...
Schachter-Singertheory
Current Theory   • No single neural system produces emotions                 • Different emotions may depend on           ...
Limbic system   • Limbus means a ring                • Limbic system          part of cortical and                  subcor...
Limbic system   • Consist of limbic lobe and related                  subcortical nuclei.                • Limbic lobe inc...
Limbic system                From Arthur C Gyuton Physiology
Limbic system
Connections of limbic system
• Described by James Papez in 1937.Papez circuit                • Papez Proposed that there is an                  emotion...
Papez circuit                •   The original circuit proposed by Papez is shown by thick lines and more                  ...
• Buried within the anterior-inferior             temporal lobe.Amygdala           • Essential in the control of love,    ...
Amygdala Connections
Amygdala connections
Amygdala nuclei
Amygdala nuclei   • Medial nucleus: Sensory input,                    especially odour, relayed to                    fore...
Central nucleus   • Plays the major role in emotional                    response patterns                  • Affects hypo...
Effect of amygdala
Amygdala lesion   • Reduced ability to identify motivational and                    emotional significance of events      ...
Effect of emotion   Autonomic nervous system                    • In threatening situation sympathetic                    ...
Effects of emotion   Endocrine disturbances                     • HPA activity: elevated in stress                        ...
Physiology of special emotion   Fear                                • Site: The hypothalamus and amygdaloid               ...
The classical and curious case ofPhineus Gage.• Phineas P. Gage (July 9, 1823 – May 21,  1860) was an American railroad co...
Physiology of special emotion   Anxiety: It is normal emotion in                                appropriate situation but ...
Physiology of special emotion   Rage and placidity:                                  – Rage- extreme form of anger        ...
Motivation             • Motivation literally means that               which moves the will.             • It is a factor ...
Reward and punishment   Rewards:                        • Things that an individual work for                        • They...
Reward and punishment   Neural mechanism involved:                        • The neural mechanism of motivation has        ...
Reward and punishment   • The brain area where stimulation leads                          to repeated bar pressing are loc...
Reward and punishment                        • The brain area where stimulation is                          avoided are:  ...
in reward systemNeurotransmitter involved                            • The catecholamines (dopamine and                   ...
in reward systemNeurotransmitter involved   • Drugs that block postsynaptic D3                              dopaminergic r...
dopamineSelf stimulation rewardpathway
Physiology of addiction   • A kind of dependence which manifests as:                             – compulsive non-medical ...
Physiology of addiction
Physiology of addiction
• A presentation by Dr Anwar H  Siddiqui
Physiology of emotion
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Physiology of emotion

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Physiology of emotion

  1. 1. Physiology ofEmotion ©Dr. Anwar Siddiqui
  2. 2. • Aristotle: People are THINKING ANIMAL.What makes peoplr specialHistory is they can overcome their brutish emotions. • Rousseau: Emotiuons are what makes people special and gives us reason for living. • Hippocrates: Brain is the site of emotion
  3. 3. Introduction • The word emotion is derived from the latin word emovere which means to stir up to get agitated • Complex feeling state with psychic, somatic, autonomic and behavioral components.
  4. 4. • Emotion has two components: – Mental – Physical• Mental component: – Cognition- Awareness of sensation and it’s cause. – Affect- The feeling itself. – Conation- urge to take action.
  5. 5. Oh it’s a roar. The roar seems to be that of lion (Cognition) I feel frightenedRoaring of lion(stimulus) (Affect) Must run to safety (conation)
  6. 6. • Physical components: – Changes in viscera and skeletal muscle – Coordinated activity of autonomic and somatic nervous system – Example: tachycardia, tachypnoea, cutaneous vasoconstriction etc in fear
  7. 7. Theories of emotion • James-Lang theory • Cannon-Bard theory • Schachter-Singer theory. • Current Theory
  8. 8. James lange theory • Developed independently by Williams James and Carl Lange in 1884 • According to the theory an emotional event causes response in ANS. This response is detected by CNS to produce an emotional experience. • Different emotional stimuli produces different bodily response and lead to different emotions
  9. 9. James-Lange theory
  10. 10. Cannon-Bard Theory • Walter Cannon and Phillip Bard – 1927 • The physiological reaction and the emotion are assumed to occur at the same time. • Emotional stimuli simultaneously produce a response in the ANS and in the cerebral cortex. • The emotional experience is the combination of these two system.
  11. 11. Cannon-Bard Theory • The influence of the cerebral cortex in controlling emotion is show in the phenomenon of Sham rage. • When animals have their cortex removed they go in extreme rages at the slightest provocation. • The response is often unrelated to provocation and is short lived
  12. 12. Cannon-Bard Theory
  13. 13. theorySchachter-Singer • Also called cognitive arousal theory. • A two-stage theory stating that for an emotion to occur, there must be (1) physiological arousal and (2) an explanation for the arousal. • Emotions are produced when autonomic arousal is noticed by the person. He/She tries to come up with an explanation for the arousal and depending on the explanation, label their emotion.
  14. 14. Schachter-Singertheory
  15. 15. Current Theory • No single neural system produces emotions • Different emotions may depend on different neural circuits, but many of these circuits converge in the same parts of the brain • The limbic system may be involved in some emotional experiences, but it is not the sole neural system underlying emotion • Feelings (emotion) result from the interplay between: – The amygdala, hypothalamus, brain stem & autonomic nervous system.
  16. 16. Limbic system • Limbus means a ring • Limbic system part of cortical and subcortical structure forming a ring around brainstem. • The French physician Paul Broca first called this part of the brain "le grand lobe limbique" in 1878. • Formerly called rhinencephalon. • The components of the limbic system located in the cerebral cortex have fewer layers than the classical 6-layered neocortex, and are classified as allocortex or archicortex.
  17. 17. Limbic system • Consist of limbic lobe and related subcortical nuclei. • Limbic lobe includes – Cingulate gyrus – Isthmus – Hippocampal gyrus – Uncus • Subcortical nuclei include – Amygdala – Septal nuclei – Hypothalamus – Anterior thalamic nuclei
  18. 18. Limbic system From Arthur C Gyuton Physiology
  19. 19. Limbic system
  20. 20. Connections of limbic system
  21. 21. • Described by James Papez in 1937.Papez circuit • Papez Proposed that there is an emotion system that links the cortex to the hypothalamus. • Discovered the circuit after injecting rabies virus into a cats hippocampus and monitoring its progression through the brain. • One of the major pathways of the limbic system and is chiefly involved in the cortical control of emotion.
  22. 22. Papez circuit • The original circuit proposed by Papez is shown by thick lines and more recent connections as proposed by Paul D. MacLean are shown by thin line
  23. 23. • Buried within the anterior-inferior temporal lobe.Amygdala • Essential in the control of love, friendliness, affection, fear, rage, aggression
  24. 24. Amygdala Connections
  25. 25. Amygdala connections
  26. 26. Amygdala nuclei
  27. 27. Amygdala nuclei • Medial nucleus: Sensory input, especially odour, relayed to forebrain and hypothalamus • Central nucleus: Sensory input via cortex and thalamus, relayed to hypothalamus and brainstem nuclei • Basal nucleus: Sensory input relayed to rest of amygdala and to PAG
  28. 28. Central nucleus • Plays the major role in emotional response patterns • Affects hypothalamus and both branches of ANS: Increased HR and BP; ulcers, urination, and defecation • Affects brainstem nuclei to increase arousal (VTA), vigilance (LC), cortex activation (DLTN and nucleus basalis) and startle (pons) • Destruction of central nucleus limits emotional response patterns. • Electrical stimulation of central nucleus triggers fear, agitation, stress illness
  29. 29. Effect of amygdala
  30. 30. Amygdala lesion • Reduced ability to identify motivational and emotional significance of events • Electrical stimulation of amygdala can lead to emotional attacks (rage) Kluver-Bucy Syndrome: • Results from bilateral removal of the amygdala and inferior temporal cortex. Includes: – loss of fear – Indiscriminate dietary behaviour – Greatly increased autoerotic sexual activity – Tendency to attend to every visual stimulus – Tendency to examine all objects by mouth – Visual agnosia (cannot recognize objects visually) – Inability to recognize facial expression
  31. 31. Effect of emotion Autonomic nervous system • In threatening situation sympathetic nervous system releases norepinephrine that causes – Palm sweating – Increased heart rate – Focused attention – Greater skin conductance Immune system • Depressive disorders are associated with decreased lymphocyte production
  32. 32. Effects of emotion Endocrine disturbances • HPA activity: elevated in stress increased in depression • Thyroid axis activity: In depression both hypothyroidism (5-10%) & hyperthyroidism (20-30%) found. Growth hormone: • NE and dopamine stimulates growth hormone secretion whereas somatostatin inhibits it. • Decreased csf somatostatins are found in depression, increased level is seen in mania
  33. 33. Physiology of special emotion Fear • Site: The hypothalamus and amygdaloid nuclei • Effects of lesion: After destruction of amygdala the fear reaction and its autonomic and endocrine manifestation are absent.eg monkeys are normally terrified of snakes but after bilateral lobectomy they approach snake pick them n eat them • In humans amygdala damage causes deficient fear response to visual and auditory stimulus
  34. 34. The classical and curious case ofPhineus Gage.• Phineas P. Gage (July 9, 1823 – May 21, 1860) was an American railroad construction foreman now remembered for his improbable survival of an accident in which a large iron rod was driven completely through his head, destroying much of his brains left frontal lobe.• The damage to Gage’s frontal cortex had resulted in a complete loss of social inhibitions, which often led to inappropriate behaviour. In effect, the tamping iron had performed a frontal lobotomy on Gage, but the exact nature of the damage incurred to his brain has been a subject of debate ever since the accident occurred.
  35. 35. Physiology of special emotion Anxiety: It is normal emotion in appropriate situation but excessive anxiety & anxiety in inappropriate situation is disabling. • Site: associated with bilateral increase in blood flow in discreet portion of anterior end of each temporal lobe. • Facts: Anxiety is relieved by benzodiazepine which binds to GABA receptors and increase conductance of these ion channels.
  36. 36. Physiology of special emotion Rage and placidity: – Rage- extreme form of anger – Placidity- Calm and peaceful • Site: Neocortex, ventromedial hypothalamic nuclei • Facts: Human maintains a balance between rage and placidity. Major irritation make normal individual loose temper but minor stimuli are ignored.
  37. 37. Motivation • Motivation literally means that which moves the will. • It is a factor in most of the behaviour. • Factors that are responsible for goal direction of a behaviour are the motivation for that behaviour.
  38. 38. Reward and punishment Rewards: • Things that an individual work for • They make the behaviours leading to them more often to occur. Punishments: • Opposite of rewards • Associated with avoidance leading to behaviour where an individual tries to escape a painful situation.
  39. 39. Reward and punishment Neural mechanism involved: • The neural mechanism of motivation has ben obtained by studying the effect of brain self stimulation. • An unanaesthetised animal (rat) regulates the rate at which electrical stimuli are delivered through electrode implanted in defined area of limbic system.
  40. 40. Reward and punishment • The brain area where stimulation leads to repeated bar pressing are located in: – The medial fore brain bundle – Midbrain tegmentum – Nucleus accumbens – Dorsal brain stem – Ventral tegmental area • Stimulation of these sites produce pleasurable sensation like relief of tension, relaxed feelings
  41. 41. Reward and punishment • The brain area where stimulation is avoided are: – Lateral portion of posterior hypothalamus – Dorsal midbrain – Entrorhinal cortex • Stimulation of these sites produces sensation ranging from vague fear to terror
  42. 42. in reward systemNeurotransmitter involved • The catecholamines (dopamine and norepinephrine), morphine, enkephalin are involved in the pathways mediating reward system. • Drugs that increase the self stimulation are: – Amphetamine- cause increase release of dopamine – Cocaine- binds and inhibit dopamine transporter-dopamine uptake is reduced- extracellular dopamine level is increased.
  43. 43. in reward systemNeurotransmitter involved • Drugs that block postsynaptic D3 dopaminergic receptors such as chlorpromazine hydrochloride lower activity in catecholamine pathways and decrease self stimulation.
  44. 44. dopamineSelf stimulation rewardpathway
  45. 45. Physiology of addiction • A kind of dependence which manifests as: – compulsive non-medical use of a substance – loss of control over its use despite negative consequences • Despite many differences, virtually all substances with the potential for addiction affect dopamine levels in the pleasure / reward pathway of the brain.
  46. 46. Physiology of addiction
  47. 47. Physiology of addiction
  48. 48. • A presentation by Dr Anwar H Siddiqui
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