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Introduction to
micro Electro-osmotic (EO) pumps
  & micro-fluidic technologies

           April 2009


     Nano Fusion ...
Nano Fusion Technologies, Inc.
Founders and Managements
   Tihiro Ohkawa (Founder)

   Masana Nishikawa (Founder)

   I...
Objective
NFT Objective:
  Offer micro fluid delivery solutions with unique micro pumps and
  micro-fluidic control device...
Principle of micro EO pump
  Liquid                  - Electro-osmotic Pump - Inside ceramic disc
                        ...
Features of Micro EO pump




         Nano Fusion Technologies, Inc.   5
Features of Micro EO pump




         Nano Fusion Technologies, Inc.   6
Typical pump performances

                                  Flow Rate (mL/min)             Pressure (kPa)
               ...
RP5A-RL (evaluation sample)
                                 RP5A-RL-N311       RP5A-RL-N610
              Model
         ...
LFHP (evaluation sample)
- For high pressure or extremely low flow rate -
                                                ...
PWM Power Source and Controller
for Micro EO Pump (PS-PWM-24)
 Enable stable micro-flow
 by micro Electro-osmotic pump

 1...
Evaluation Kits for micro EO pump
       Evaluation Kits for full EO pump testing
   

       Include all necessary compo...
EO Pumps on a Micro-Channel Chip
      Basic Concept
            Direct mount on micro-channel chips (Pump-on-chip)
     ...
EO pump applications
              for Microfluidics I




          Nano Fusion Technologies, Inc.   13
EO pump applications
              for Microfluidics II




          Nano Fusion Technologies, Inc.   14
Thank You

Nano Fusion Technologies, Inc.
Headquarters: (Mailing address)
Nano Fusion Technologies, Inc.
2-21-7 Naka-cho, ...
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Nano Fusion Technologies Overview)

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Overview of electro-osmotic pump technology and company info.

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Transcript of "Nano Fusion Technologies Overview)"

  1. 1. Introduction to micro Electro-osmotic (EO) pumps & micro-fluidic technologies April 2009 Nano Fusion Technologies, Inc. 1
  2. 2. Nano Fusion Technologies, Inc. Founders and Managements  Tihiro Ohkawa (Founder)  Masana Nishikawa (Founder)  Ichiro Yanagisawa (CEO/CTO)  Masataka Ogawa (VP, Business Development) Major Shareholders (Founders & VCs)  Yasuda Enterprise Development Co., Ltd (Japan)  Conduit Ventures Limited (UK)  4 Japanese VCs Founded: March 15, 2004 Capital: 229,750,000 yen Headquarters: 2-21-7, Naka-cho, Meguro-ku, Tokyo, Japan Laboratory: B-M202 Collaborative Research Bldg. (CCR) Institute of Industrial Science, the University of Tokyo Nano Fusion Technologies, Inc. 2
  3. 3. Objective NFT Objective: Offer micro fluid delivery solutions with unique micro pumps and micro-fluidic control devices to advance bio-science and micro- electronics functions. Major Technologies: Micro electro-osmotic pump (Micro EO pumps)  Micro-fluidic control devices and systems  Application Area: Bio-Science, Environmental and Chemical Applications  mTAS / Analytical device Pipetting / Dispensing Drug delivery (infusion) Micro Electronics  Micro Fuel Cell & others Industrial (lubrication, etc.) Nano Fusion Technologies, Inc. 3
  4. 4. Principle of micro EO pump Liquid - Electro-osmotic Pump - Inside ceramic disc Ceramic particle Liquid Liquid Porous Electric field ceramic EOF disc Voltage (dielectric Porous material) material Electrodes Nozzle Pumping Electro-osmotic Flow (EOF)-generating mechanism Interface Liquid I. Negative charges on the dielectric material surface. II. Excessive positive charges generated in the liquid Flow Electric field near the liquid-ceramics interface. III. The applied electric field would force the positively charged liquid layer to flow, that drags the whole liquid. Electro-osmotic flow (EOF) Dielectric material (Ceramics) Nano Fusion Technologies, Inc. 4
  5. 5. Features of Micro EO pump Nano Fusion Technologies, Inc. 5
  6. 6. Features of Micro EO pump Nano Fusion Technologies, Inc. 6
  7. 7. Typical pump performances Flow Rate (mL/min) Pressure (kPa) 10-1 102 103 102 103 1 10 1 10 Overall Coverage RP3-N1/N2 RP5A-RL-N311/N610 RP5A-SP-N311/N610 7B-SP-N311/N610 LFHP Nano Fusion Technologies, Inc. 7
  8. 8. RP5A-RL (evaluation sample) RP5A-RL-N311 RP5A-RL-N610 Model 1) Pumping principle Electro-osmosis Max.Flow rate2) 110μ L/min 190μ L/min 3) @DC 24V 5) 140 kPa 110 kPa Max.Pressure 13 mW 100mW Power 4) consumption Working liquid Methanol De-ionized water Polypropylene(Body・Nozzle・Reservior) Material Diameter 8mm,length 3.5mm(Body) Size Reservior capacity 1.2mL 0.5g Weight Performance of RP5A-RL-N311 Performance of RP5A-RL-N610 160 300 140 250 120 200 Flow rate (μL/min) Flow rate (μL/min) 100 30V 80 150 30V 24V 24V 60 18V 100 18V 40 12V 12V 50 20 0 0 0 50 100 150 200 0 50 100 150 Back pressure (kPa) Back pressure (kPa) Nano Fusion Technologies, Inc. 8
  9. 9. LFHP (evaluation sample) - For high pressure or extremely low flow rate - Performance of LFHP 9 1) High pressure performance up to 2,000kPa (at 60 Volts) 8 2) Extremely low flow rate (around 100 nL/min) 7 Working liquid: Flow rate (μL/min) 3) Standard fitting design compatible with Upchurch fitting 6 De-ionized water 4) Extendable reservoir design 5 60V 4 3 LFHP Model 2 24V Pumping principle1) Electro-osmosis 1 8μL/min Max.Flow rate2) 0 0 1000 2000 3000 Max.Pressure3) @DC 60V5) 2000kPa Back pressure (kPa) Power consumption4) 15mW De-ionized water Working liquid Material PPS Body size Diameter 10.3mm,length 27.3mm Nozzle port Upchurch NanoPort Assemblies F-333Nx Nozzle fitting Upchurch NanoPort Assemblies N-333-01 Weight 1.8g Nano Fusion Technologies, Inc. 9
  10. 10. PWM Power Source and Controller for Micro EO Pump (PS-PWM-24) Enable stable micro-flow by micro Electro-osmotic pump 1) PWM power source 2) Easy operation from Personal Computer 3) Built-in Feedback Control Function PS-PWM-24 PS-PWM4C-24 Model Output voltage1) 24V max Duty ratio 0~100% Pulse-frequency Variable (10~2000Hz) Resolution of voltage 6mV Power supply USB bus power AC adaptor Input 100-240V 50/60Hz 0.3A Output DC5V 2A Output current 50mA max 50mAmax/1 channel Number of I/O channel 1 4 Size(W×D×H) 85×55×21mm 85×55×48mm Nano Fusion Technologies, Inc. 10
  11. 11. Evaluation Kits for micro EO pump Evaluation Kits for full EO pump testing  Include all necessary components (pumps, power supply, flow sensor,  reservoirs and so on) Evaluation Kits for different flow rate ranges  Low flow/High pressure kits (EVK-001) 0.1-1.5μL/min (-2000kPa)  Middle flow kits (EVK-002) 5-50μL/min  High flow kits (EVK-003) 100-1000μL/min  Low flow/High pressure kits EVK-001 formation High flow kits EVK-003 formation Power supply PS-PWM4C-24 Reservoir for RP20-SP Connecter Power supply PS-PWM-24 Reservoir Filter LFHP Tube (Teflon) RP20-SP Connecter Flow sensor LG16-0025A Reservoir Flow sensor LG16-1000A Tube (Teflon) Nano Fusion Technologies, Inc. 11
  12. 12. EO Pumps on a Micro-Channel Chip Basic Concept  Direct mount on micro-channel chips (Pump-on-chip)  Integrated pump (Reservoir-on-pump) Less redundant space Reservoir Less sample fluid  Precise flow rate &  flow amount control EO Pump Micro-channel chip Nano Fusion Technologies, Inc. 12
  13. 13. EO pump applications for Microfluidics I Nano Fusion Technologies, Inc. 13
  14. 14. EO pump applications for Microfluidics II Nano Fusion Technologies, Inc. 14
  15. 15. Thank You Nano Fusion Technologies, Inc. Headquarters: (Mailing address) Nano Fusion Technologies, Inc. 2-21-7 Naka-cho, Meguro-ku, Tokyo 153-0065 JAPAN e-mail: nft-info@nft-eop.co.jp Website: http://www.nft-eop.co.jp/ Laboratory: B-M202 Collaborative Research Bldg. (CCR) Institute of Industrial Science, the University of Tokyo 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505 JAPAN TEL: +81-3-5452-6619 FAX: +81-3-5452-6620 Nano Fusion Technologies, Inc. 15
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