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SKP Pharma Nigeria Limited TO BE DELIVERED BY OKE, MUSHAFAU ADEBAYO WELCOMES YOU TO THIS CLINICAL PRESENTATION
SCIENCE OF CHELATION ADVANCE IN DRUG DELIVERY
DRUG DELIVERY <ul><li>Drug delivery  is the method or process of administering a  pharmaceutical  compound to achieve a  t...
DRUG DELIVERY <ul><li>Drug delivery technologies are patent protected formulation technologies that modify </li></ul><ul><...
ESSENCE OF DRUG DELIVERY <ul><li>How much vitamin/mineral did you take?  </li></ul><ul><li>How much did your body absorb? ...
PROBLEMS ASSOCIATED WITH INORGANIC MINERALS INTAKE <ul><li>Low bioavailability:-  </li></ul><ul><li>The effective absorpti...
PROBLEMS ASSOCIATED WITH INORGANIC MINERALS INTAKE <ul><li>Gastrointestinal disturbances such as constipation and diarrhea...
WAY FORWARD <ul><li>One way to circumvent or prevent the problems associated with the oral administration of inorganic min...
WAY FORWARD <ul><li>Organic minerals:- e.g. metal proteinates, sequestered minerals, EDTA chelates and methionine complexe...
CHELATION AND CHELATES <ul><li>Chelation in simple terms is the process of attaching a central metal atom to a large molec...
Amino Acid Chelated Mineral
DEFICIENCIES OF POPULAR METAL CHELATES <ul><li>Several metal chelates are presently in the market; however many of the so-...
ADVANTAGES OF AMINO ACID CHELATES <ul><li>Increased mineral bioavailability: - they are able to resist the attack of anion...
ADVANTAGES OF AMINO ACID CHELATES <ul><li>All trace minerals in the body are transported by either protein polypeptides or...
ADVANTAGES OF AMINO ACID CHELATES <ul><li>In a study conducted by Fang  et. al .(1982) and Scholmerich  et. al .(1987) on ...
ADVANTAGES OF AMINO ACID CHELATES <ul><li>This indicates that a large portion of most inorganic metal salts will precipita...
 
AMINO ACID CHELATES
AMINO ACID CHELATES
AMINO ACID CHELATES
AMINO ACID CHELATES Source: AMT Labs, 2008
SKP PRODUCTS ARE PREPARED WITH THE POWER OF CHELATION <ul><li>Our metal proteinates are advanced forms of chelates with bo...
SKP PRODUCTS ARE PREPARED WITH THE POWER OF CHELATION <ul><li>Efficient mineral delivery is not about how much of a minera...
Calcifer Comprehensive Iron and Calcium formula for Anemia and Bone health
CALCIFER <ul><li>HVP Chelated Calcium 20%  300 mg  </li></ul><ul><li>Calcium Carbonate  270 mg  </li></ul><ul><li>Magnesiu...
CALCIFER <ul><li>Comprehensive formula for both A nemia  and  Bone Health.  </li></ul><ul><li>Support iron and calcium in ...
CALCIFER <ul><li>Suggested users </li></ul><ul><li>Teenage girls </li></ul><ul><li>Adult women at childbearing age </li></...
CALCIFER <ul><li>Economic/Market Advantage </li></ul><ul><ul><li>Combines all the minerals needed by pregnant women and an...
Osteoforte Support healthy bones  from 9 to 90
OSTEOFORTE <ul><li>Vitamin D3  40 IU  </li></ul><ul><li>Calcium (amino acid chelate)  154.6 mg  </li></ul><ul><li>Phosphor...
OSTEOFORTE <ul><li>Comprehensive formula for supporting bone health  </li></ul><ul><li>Amino Acid Chelated calcium, magnes...
OSTEOFORTE <ul><li>Suggested users </li></ul><ul><li>Children (above 5) </li></ul><ul><li>Teenage boys and girls  </li></u...
OSTEOFORTE <ul><li>Economic/Market Advantage </li></ul><ul><ul><li>Takes care of bone faster than inorganic preparations. ...
Glucotin DS The leading choice of nutritional support for joint structure and function
 
GLUCOTIN DS <ul><li>Glucosamine sulphate  375mg </li></ul><ul><li>Chondroitin sulphate  100mg </li></ul><ul><li>Vit D3  4m...
GLUCOTIN DS <ul><li>Glucosamine  </li></ul><ul><li>Helps maintain healthy joints and reduce cartilage wear. </li></ul><ul>...
GLUCOTIN DS <ul><li>Glucosamine and Chondroitin are two molecules that make up the type of cartilage found within joint. I...
How Glucosamine and Chondroitin Work <ul><li>For over two decades Glucosamine and Chondroitin have been widely used in the...
REFERENCES  <ul><li>A.A.F.C.O. 1987. “Official Publication of American Association of Feed Control Officials” Section 57.2...
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Skp Pharma product presentation

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  1. 1. SKP Pharma Nigeria Limited TO BE DELIVERED BY OKE, MUSHAFAU ADEBAYO WELCOMES YOU TO THIS CLINICAL PRESENTATION
  2. 2. SCIENCE OF CHELATION ADVANCE IN DRUG DELIVERY
  3. 3. DRUG DELIVERY <ul><li>Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals . </li></ul>
  4. 4. DRUG DELIVERY <ul><li>Drug delivery technologies are patent protected formulation technologies that modify </li></ul><ul><ul><li>drug release profile </li></ul></ul><ul><ul><li>absorption, distribution and elimination </li></ul></ul><ul><li>for the benefit of improving </li></ul><ul><ul><li>product efficacy and safety, </li></ul></ul><ul><ul><li>as well as patient convenience and compliance. </li></ul></ul>
  5. 5. ESSENCE OF DRUG DELIVERY <ul><li>How much vitamin/mineral did you take? </li></ul><ul><li>How much did your body absorb? </li></ul><ul><li>Efficient mineral/drug delivery is not about how much of a mineral/drug you take, it’s a question of how much your body absorbs. </li></ul>
  6. 6. PROBLEMS ASSOCIATED WITH INORGANIC MINERALS INTAKE <ul><li>Low bioavailability:- </li></ul><ul><li>The effective absorption of inorganic minerals is generally less than 10% (Fouad, 1976). </li></ul><ul><li>For a mineral to be absorbed in the small intestine, it has to be soluble in the luminal fluid of the small intestine and present itself as a singular molecule or an ionic entity. </li></ul><ul><li>Most inorganic metals ions are soluble in an acidic medium but not in a medium with a pH value greater than 7.0. </li></ul><ul><li>Therefore, at the pH of the small intestinal fluid below the duodenum which is in the range of 7.0-7.2, the minerals tend to form insoluble hydroxides, a gelatinous magma type of precipitation, thereby rendering the metals non-absorbable (Fang et. al., 1982 ) . </li></ul>
  7. 7. PROBLEMS ASSOCIATED WITH INORGANIC MINERALS INTAKE <ul><li>Gastrointestinal disturbances such as constipation and diarrhea. </li></ul><ul><li>Malabsorption of other nutrients due to the coating of magma on the mucous membrane of the small intestine. </li></ul><ul><li>Formation of insoluble complexes with various substances present in foodstuffs such as carbonates, phytates, phosphates, and oxalates. </li></ul><ul><li>Decrease vitamin bioavailabilty and stability. </li></ul>
  8. 8. WAY FORWARD <ul><li>One way to circumvent or prevent the problems associated with the oral administration of inorganic minerals is to use metal chelates or organic minerals. </li></ul><ul><li>A well-prepared metal chelate would resist the attack of anions such as hydroxides, phosphates, carbonates, oxalates or phytates, thus keeping the minerals in a soluble and readily absorbable form in the small intestine. </li></ul>
  9. 9. WAY FORWARD <ul><li>Organic minerals:- e.g. metal proteinates, sequestered minerals, EDTA chelates and methionine complexes. These forms of organic minerals contain less mineral potency than inorganics, and are more expensive per unit of elemental mineral. Some organic minerals are complexed by such strong bonds that they cannot be broken by the animal’s enzymes. Other bonds are so weak that they dissociate prior to absorption. </li></ul>
  10. 10. CHELATION AND CHELATES <ul><li>Chelation in simple terms is the process of attaching a central metal atom to a large molecule, called a ligand in a cyclic or ring structure through covalent bonds. According to the American Association of Feed Control Officials (AAFCO), </li></ul><ul><li>“ Metal proteinate is defined as the product resulting from the chelation of a soluble salt with amino acid and/or partially hydrolysed protein.” </li></ul><ul><li>“ Metal Amino Acid Chelate is defined as the product resulting from the reaction of a metal ion from a soluble metal salt with amino acids with a mole ratio of one metal to one to three moles of amino acids to form coordinate covalent bonds.” (AAFCO, 1987) </li></ul>
  11. 11. Amino Acid Chelated Mineral
  12. 12. DEFICIENCIES OF POPULAR METAL CHELATES <ul><li>Several metal chelates are presently in the market; however many of the so-called “metal chelates” are found to be simple physical mixtures of inorganic metal salts with ligands such as amino acids, hydrolysed proteins, monosaccharides, polysaccharides or other organic compounds. Most of these metal preparations are physical mixtures or weak chelates at best and have dubious advantages over the inorganic metal salts. </li></ul>
  13. 13. ADVANTAGES OF AMINO ACID CHELATES <ul><li>Increased mineral bioavailability: - they are able to resist the attack of anions thus keeping the mineral in a soluble and readily absorbable form in the small intestine. </li></ul><ul><li>Decreased gastrointestinal tract side effects. </li></ul><ul><li>Increased bioavailablility of vitamins due to decreased mineral adsorption with vitamins. </li></ul><ul><li>Increase vitamin’s antioxidant effect:- by decreasing vitamin’s oxidation by minerals. </li></ul>
  14. 14. ADVANTAGES OF AMINO ACID CHELATES <ul><li>All trace minerals in the body are transported by either protein polypeptides or amino acid carrier systems. </li></ul><ul><li>Chelates have ability to cross placental barriers to feed the foetus (Jensen, N., 1979). </li></ul><ul><li>At pH 7.5-10.0, amino acid chelates have higher stability constant and biological life: - the charts below show the comparison of our amino acid chelates for Cu and Fe with the inorganic sulphates. </li></ul>
  15. 15. ADVANTAGES OF AMINO ACID CHELATES <ul><li>In a study conducted by Fang et. al .(1982) and Scholmerich et. al .(1987) on man and rats, the amino acid chelate, zinc-histidine was absorbed three times greater than zinc sulphate. </li></ul><ul><li>In another study, the inorganic CuSO4 and FeSO4 both precipitate out at about pH 6, which is below the normal physiological pH of the small intestine of pH 7.2. </li></ul>
  16. 16. ADVANTAGES OF AMINO ACID CHELATES <ul><li>This indicates that a large portion of most inorganic metal salts will precipitate out in the small intestine and become non-absorbable. </li></ul><ul><li>This explains why the bioavailabilities of some of these inorganic minerals are less than 10% after the oral administration. </li></ul><ul><li>Some people advocate compensation by using an excess amount of the inorganic salts because of their inexpensive costs. This however, greatly enhances the potential side effects. </li></ul>
  17. 18. AMINO ACID CHELATES
  18. 19. AMINO ACID CHELATES
  19. 20. AMINO ACID CHELATES
  20. 21. AMINO ACID CHELATES Source: AMT Labs, 2008
  21. 22. SKP PRODUCTS ARE PREPARED WITH THE POWER OF CHELATION <ul><li>Our metal proteinates are advanced forms of chelates with bonds between the metals and the ligands of proper strength. </li></ul><ul><li>The resulting product is resistant to hydroxide ion attack- the metal will not precipitate until the pH is higher than 10.5. </li></ul><ul><li>Therefore, it is assured that the metals in our metal proteinates will remain soluble in the small intestine for subsequent absorption into the body to serve their intended physiological action. </li></ul>
  22. 23. SKP PRODUCTS ARE PREPARED WITH THE POWER OF CHELATION <ul><li>Efficient mineral delivery is not about how much of a mineral you take, it is a question of how much your body absorbs. </li></ul><ul><li>Amino acid chelated minerals by SKP have the highest bioavailalbility. </li></ul><ul><li>Prof. Fang of SK Pharmaceuticals, Texas, USA owns the patent of amino acid chelated minerals. </li></ul>
  23. 24. Calcifer Comprehensive Iron and Calcium formula for Anemia and Bone health
  24. 25. CALCIFER <ul><li>HVP Chelated Calcium 20% 300 mg </li></ul><ul><li>Calcium Carbonate 270 mg </li></ul><ul><li>Magnesium Oxide 100 mg </li></ul><ul><li>Calcium Ascorbate 50 mg </li></ul><ul><li>HVP Chelated Iron 10% 30 mg </li></ul><ul><li>Vitamin E 15 UI </li></ul><ul><li>Magnesium Stearate 9 mg </li></ul><ul><li>Manganese Sulfate 5 mg </li></ul><ul><li>Copper Sulfate 2.5 mg </li></ul><ul><li>Vitamin B 12 1% 1 mg </li></ul><ul><li>Folic Acid 10% 0.8 mg </li></ul><ul><li>Vitamin D 3 10 mcg </li></ul><ul><li>Silicon Dioxide 10 mg </li></ul>Active Ingredients
  25. 26. CALCIFER <ul><li>Comprehensive formula for both A nemia and Bone Health. </li></ul><ul><li>Support iron and calcium in one capsule. </li></ul><ul><li>Provides 100% of amino acid chelated iron, calcium and other minerals with h igher bioavailability than inorganic minerals. </li></ul><ul><li>100% soluble iron and calcium in the small intestine, ready to be absorbed. </li></ul><ul><li>No Side Effects Commonly Seen in Other Products. </li></ul><ul><li>Protect Vitamins from Being Destroyed. </li></ul>Key Features
  26. 27. CALCIFER <ul><li>Suggested users </li></ul><ul><li>Teenage girls </li></ul><ul><li>Adult women at childbearing age </li></ul><ul><li>Pregnant women </li></ul><ul><li>Women and men with anaemia </li></ul><ul><li>Directions </li></ul><ul><li>Take 1 to 2 capsules once a day. </li></ul>
  27. 28. CALCIFER <ul><li>Economic/Market Advantage </li></ul><ul><ul><li>Combines all the minerals needed by pregnant women and anaemics into a single dose. </li></ul></ul><ul><ul><li>Takes care of blood and bone at the same time. </li></ul></ul><ul><ul><li>Most affordable in that category. </li></ul></ul><ul><ul><li>Easy compliance due to convenient dosage. </li></ul></ul><ul><ul><li>American product at an affordable price. </li></ul></ul>
  28. 29. Osteoforte Support healthy bones from 9 to 90
  29. 30. OSTEOFORTE <ul><li>Vitamin D3 40 IU </li></ul><ul><li>Calcium (amino acid chelate) 154.6 mg </li></ul><ul><li>Phosphorus 18.9 mg </li></ul><ul><li>Magnesium (amino acid chelate) 6.8 mg </li></ul><ul><li>Manganese (amino acid chelate) 2.0 mg </li></ul><ul><li>Copper (amino acid chlate) 0.2 mg 22% </li></ul><ul><li>Zinc (oxide) 8.0 mg 84% </li></ul>Active Ingredients
  30. 31. OSTEOFORTE <ul><li>Comprehensive formula for supporting bone health </li></ul><ul><li>Amino Acid Chelated calcium, magnesium, manganese, and copper with h igher bioavailability than inorganic minerals </li></ul><ul><li>Vitamin D3 – maintain serum calcium and phosphorus concentration, reduce bone fracture </li></ul><ul><li>No Side Effects Commonly Seen in Other Products </li></ul><ul><li>Protect Vitamins from Being Destroyed </li></ul>Key Features
  31. 32. OSTEOFORTE <ul><li>Suggested users </li></ul><ul><li>Children (above 5) </li></ul><ul><li>Teenage boys and girls </li></ul><ul><li>Adult, men and women </li></ul><ul><li>Seniors </li></ul><ul><li>Lactose intolerance </li></ul><ul><li>Vegetarians </li></ul><ul><li>Osteoporosis </li></ul><ul><li>Directions </li></ul><ul><li>Take 1 to 2 capsules once a day. </li></ul>
  32. 33. OSTEOFORTE <ul><li>Economic/Market Advantage </li></ul><ul><ul><li>Takes care of bone faster than inorganic preparations. </li></ul></ul><ul><ul><li>Most affordable in that category. </li></ul></ul><ul><ul><li>Easy compliance due to convenient dosage. </li></ul></ul><ul><ul><li>American product at an affordable price. </li></ul></ul>
  33. 34. Glucotin DS The leading choice of nutritional support for joint structure and function
  34. 36. GLUCOTIN DS <ul><li>Glucosamine sulphate 375mg </li></ul><ul><li>Chondroitin sulphate 100mg </li></ul><ul><li>Vit D3 4mg (40 I.U.) </li></ul><ul><li>Amino acid chelated calcium 300mg </li></ul>Active Ingredients Directions Take one capsule by mouth 1-2 times a day with a meal
  35. 37. GLUCOTIN DS <ul><li>Glucosamine </li></ul><ul><li>Helps maintain healthy joints and reduce cartilage wear. </li></ul><ul><li>Chondroitin </li></ul><ul><li>Play an important role in the lubrication and nutrition of the joint. Vital for structure and function of cartilage </li></ul>
  36. 38. GLUCOTIN DS <ul><li>Glucosamine and Chondroitin are two molecules that make up the type of cartilage found within joint. Inside the joint, cartilage undergoes a constant process of breakdown and repair. However to be properly repaired, the building blocks of cartilage must be present and available. The theory behind using the Glucosamine and Chondroitin joint supplements is that more of the cartilage building blocks will be available for cartilage repair. </li></ul>
  37. 39. How Glucosamine and Chondroitin Work <ul><li>For over two decades Glucosamine and Chondroitin have been widely used in the treatment of Osteoarthritis, which is a condition that causes problems of wearing out of the normal smooth cartilage surface of the joints. Often called wear-and-tear arthritis, including joint pain, swelling and deformity. </li></ul><ul><li>Clinical studies indicated that Glucosamine and Chondroitin substantially reduce joint pain inflamation without NSAIDS which might cause serious side effects such as G.I. complaints and bleeding. </li></ul>
  38. 40. REFERENCES <ul><li>A.A.F.C.O. 1987. “Official Publication of American Association of Feed Control Officials” Section 57.23. </li></ul><ul><li>AMT Labs Inc., U.S.A. 2008. </li></ul><ul><li>Fang, S.M., Burton, S.A. and Peterson, R.V. 1982. “Bioavailability of zinc: Effect of amino acid chelation”. Chelated Mineral Nutrition in Plants, Animals and Man. Charles C. Thomas. Publisher, Springfield, IL pp. 134-151. </li></ul><ul><li>Fouad, M.T. 1976. “Chelation and chelated minerals” J. Appl. Nutr. 28:6. </li></ul><ul><li>Jensen, N. 1979. “Amino acid chelates: their mechanisms of action and key aspects of preparations” J. Appl. Nutr. 31: 25-6. </li></ul>
  39. 41. Thank You for listening
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