This presentation was part of the 2010 faces (Finding A Cure for Epilepsy and Seizures) sponsored Event Lecture Series.  F...
Pervasive Developmental Disorder, Autistic Spectrum Disorder and Epilepsy: What is the link? Judith Bluvstein, MD Assistan...
What is PDD/ASD? <ul><li>Wide spectrum of lifelong neurological conditions that affect socialization and communication:  <...
<ul><li>So… how does it impact? </li></ul><ul><li>Social reciprocity (social interaction) </li></ul><ul><li>Communication ...
Specific   disorders <ul><li>Autism </li></ul><ul><li>Asperger’s disorder </li></ul><ul><li>Childhood disintegrative disor...
How to recognize it? <ul><li>Mode A: </li></ul><ul><li>Child with developmental delay with more obvious social deficits as...
On a day to day?
How frequent is it? <ul><li>3-6:1000 ASD </li></ul><ul><li>10-15:10000 Autistic disorder </li></ul><ul><li>Latest increase...
Many, many theories… <ul><li>Hormonal theory  (Dr Baron Cohen’s fetal testosterone theory)  </li></ul><ul><li>Toxic theory...
Diagnosis <ul><li>See a pediatric neurologist </li></ul><ul><li>Think about genetics  </li></ul><ul><li>Think about metabo...
Some genetic causes <ul><li>Tuberous Sclerosis </li></ul><ul><li>Fragile X syndrome </li></ul><ul><li>Rett’s syndrome </li...
Some metabolic causes <ul><li>What makes proteins </li></ul><ul><li>What makes fat </li></ul><ul><li>Sugars </li></ul><ul>...
What is Epilepsy? <ul><li>Many seizures </li></ul><ul><li>Abnormal brain waves </li></ul>
What is a seizure? <ul><li>Abnormal electrochemical “communication” between neurons </li></ul><ul><li>They look different ...
Is there more than one type? <ul><li>Focal </li></ul><ul><li>Generalized </li></ul><ul><li>Focal with secondary generaliza...
Causes of Epilepsy <ul><li>Familial </li></ul><ul><li>Infections </li></ul><ul><li>Structure </li></ul><ul><li>Injuries </...
PDD and Epilepsy <ul><li>Increased risk of epilepsy  </li></ul><ul><li>7 to 46 % higher risk  </li></ul><ul><li>The more n...
Remain alert! <ul><li>Kids with autism may not be able to tell a seizure  </li></ul><ul><li>Medications should be managed ...
Excerpt from &quot;Born on a Blue Day” by Daniel Tammet <ul><li>“ I was born on January 31, 1979 -- a Wednesday. I know it...
<ul><li>Thank you! </li></ul>
Upcoming SlideShare
Loading in...5
×

Pdd epilepsy judith bluvstien

527

Published on

Published in: Health & Medicine
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total Views
527
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
9
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide
  • Abstract thinking “u can take the horse to the water but u can not make it drink” Restricted interests: car brands, numbers, dates, dinosaurs, trading cards, etc
  • Language not neccesarily delayed, can be peculiar in content or quality, for example prosody.
  • Mode B much less common 1/4 Think about epileptic encephalopathies, degenerative disorders, etc
  • Fetal testosterone dysregulation May play a role in autism. Autism research centre Cambridge UK. Refrig mothers: cold distant rejecting
  • Absence of proof is not proof of absence…
  • Writer Learned icelandic in a couple of weeks Had seizures as a child…
  • Pdd epilepsy judith bluvstien

    1. 1. This presentation was part of the 2010 faces (Finding A Cure for Epilepsy and Seizures) sponsored Event Lecture Series. For more information about faces please visit us at www.nyufaces.org
    2. 2. Pervasive Developmental Disorder, Autistic Spectrum Disorder and Epilepsy: What is the link? Judith Bluvstein, MD Assistant Professor of Neurology
    3. 3. What is PDD/ASD? <ul><li>Wide spectrum of lifelong neurological conditions that affect socialization and communication: </li></ul><ul><li>Impaired social interaction </li></ul><ul><li>Verbal and non verbal language disorder </li></ul><ul><li>Deficit in abstract thinking </li></ul><ul><li>Restricted interests and behaviors </li></ul>
    4. 4. <ul><li>So… how does it impact? </li></ul><ul><li>Social reciprocity (social interaction) </li></ul><ul><li>Communication realm (language) </li></ul><ul><li>Abstract thinking (imaginative play, later on academics) </li></ul>
    5. 5. Specific disorders <ul><li>Autism </li></ul><ul><li>Asperger’s disorder </li></ul><ul><li>Childhood disintegrative disorder </li></ul><ul><li>Pervasive developmental disorder NOS </li></ul>
    6. 6. How to recognize it? <ul><li>Mode A: </li></ul><ul><li>Child with developmental delay with more obvious social deficits as time goes by </li></ul><ul><li>Mode B: </li></ul><ul><li>Child with language/social/cognitive regression </li></ul>
    7. 7. On a day to day?
    8. 8. How frequent is it? <ul><li>3-6:1000 ASD </li></ul><ul><li>10-15:10000 Autistic disorder </li></ul><ul><li>Latest increase may be due to improved and earlier recognition, possible overdiagnosis, etc </li></ul><ul><li>Boys:girls 3-4:1 </li></ul>
    9. 9. Many, many theories… <ul><li>Hormonal theory (Dr Baron Cohen’s fetal testosterone theory) </li></ul><ul><li>Toxic theory (heavy metals, thimerosal) </li></ul><ul><li>Diet/nutritional theory (gluten/casein/lactose) </li></ul><ul><li>Immune system theory (vaccines, fevers) </li></ul><ul><li>“ Refrigerator mother” theory (Leo Kanner late 40’s) </li></ul>
    10. 10. Diagnosis <ul><li>See a pediatric neurologist </li></ul><ul><li>Think about genetics </li></ul><ul><li>Think about metabolism </li></ul><ul><li>Visualize the brain </li></ul><ul><li>Rule out what can’t be seen in daytime </li></ul>
    11. 11. Some genetic causes <ul><li>Tuberous Sclerosis </li></ul><ul><li>Fragile X syndrome </li></ul><ul><li>Rett’s syndrome </li></ul><ul><li>Angelman </li></ul>
    12. 12. Some metabolic causes <ul><li>What makes proteins </li></ul><ul><li>What makes fat </li></ul><ul><li>Sugars </li></ul><ul><li>Our cell’s lungs </li></ul>
    13. 13. What is Epilepsy? <ul><li>Many seizures </li></ul><ul><li>Abnormal brain waves </li></ul>
    14. 14. What is a seizure? <ul><li>Abnormal electrochemical “communication” between neurons </li></ul><ul><li>They look different based on location </li></ul>
    15. 15. Is there more than one type? <ul><li>Focal </li></ul><ul><li>Generalized </li></ul><ul><li>Focal with secondary generalization </li></ul>
    16. 16. Causes of Epilepsy <ul><li>Familial </li></ul><ul><li>Infections </li></ul><ul><li>Structure </li></ul><ul><li>Injuries </li></ul><ul><li>Metabolic </li></ul><ul><li>Others still unknown in 2010 </li></ul>
    17. 17. PDD and Epilepsy <ul><li>Increased risk of epilepsy </li></ul><ul><li>7 to 46 % higher risk </li></ul><ul><li>The more neurological compromise, the more of a chance of epilepsy </li></ul><ul><li>More common when an organic cause is found </li></ul>
    18. 18. Remain alert! <ul><li>Kids with autism may not be able to tell a seizure </li></ul><ul><li>Medications should be managed very very carefully </li></ul><ul><li>Sleep should be screened </li></ul><ul><li>Some medications for seizures can help behavior </li></ul>
    19. 19. Excerpt from &quot;Born on a Blue Day” by Daniel Tammet <ul><li>“ I was born on January 31, 1979 -- a Wednesday. I know it was a Wednesday, because the date is blue in my mind and Wednesdays are always blue, like the number 9 or the sound of loud voices arguing. I like my birth date, because of the way I'm able to visualize most of the numbers in it as smooth and round shapes, similar to pebbles on a beach. That's because they are prime numbers: 31, 19, 197, 97, 79 and 1979 are all divisible only by themselves and 1. I can recognize every prime up to 9,973 by their &quot;pebble-like&quot; quality. It's just the way my brain works.” </li></ul>
    20. 20. <ul><li>Thank you! </li></ul>
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×