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Lancet onc vol100_tables

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  • 1. Hormonal treatments assessed by the IARCMonograph Working Group, Vol. 100, 2009 The Lancet Oncology, volume 10, 13-14, January 2009A review of human carcinogens—volume 100 Part A: Pharmaceuticals
  • 2. Antineoplastic drugs, and other drugs evaluated by the IARC Monograph Working Group Vol. 100, 2009 A review of human carcinogens— Vol. 100 - Part A: PharmaceuticalsThe Lancet Oncology, volume 10, 13-14, January 2009
  • 3. Biological agents assessed by the IARCMonograph Working Group - Vol. 100, 2009 The Lancet Oncology, volume10, 321-322, April2009A review of human carcinogens—volume 100 Part B: Biological Agents
  • 4. Biological agents assessed by the IARCMonograph Working Group - Vol. 100, 2009 The Lancet Oncology, volume10, 321-322, April2009A review of human carcinogens—volume 100 Part B: Biological Agents
  • 5. Metals, arsenic, dusts, and fibres assessed by the IARC Monograph Working Group Vol. 100, 2009 The Lancet Oncology, volume10, 453-454, May 2009 A review of human carcinogens—volume 100 Part C: Metals, arsenic, dusts, and fibres
  • 6. ASBESTO: Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite EVALUATION• There is sufficient evidence in humans for the carcinogenicity of all forms of asbestos. – Asbestos causes mesothelioma and cancer of the lung, larynx, and ovary [sufficiente]. – Also positive associations have been observed between exposure to all forms of asbestos and cancer of the pharynx, stomach, and colo-rectum [limitato].• There is sufficient evidence in experimental animals for the carcinogenicity of all forms of asbestos. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.PA Bertazzi, UNIMI
  • 7. Esposizione occupazionale ad amianto e tumore ovarico Camargo C.M. et al. Env Hlth Perspect. 2011PA Bertazzi, UNIMI
  • 8. Esposizione occupazionale ad amianto e tumore ovarico Analisi dei sei studi su alta esposizione Camargo C.M. et al. Env Health Perspect. 2011PA Bertazzi, UNIMI
  • 9. Laringe• The IOM conducted a meta-analysis of cohort studies examining the association between asbestos exposure and cancer of the larynx. For studies examining “any” versus no exposure, the summary relative risk was 1.4 (95%CI: 1.19–1.64).For studies comparing “high” versus no exposure, the lower bound summary relative risk was 2.02 (95%CI: 1.64–2.47), and the upper bound summary relative risk was 2.57 (95%CI:1.47–4.49).• The IOM also conducted a meta-analysis of the published case– control studies examining the association between asbestos exposure and cancer of the larynx (IOM, 2006). This meta-analysis calculated a summary relative risk of 1.43 (95%CI: 1.15–1.78), before adjusting for consumption of tobacco and alcohol. After adjusting for tobacco and alcohol consumption, the association of cancer of the larynx with asbestos exposure persisted, with an adjusted summary relative risk of 1.18 (95%CI: 1.01–1.37).PA Bertazzi, UNIMI
  • 10. ASBESTO: Crisotilo, Amosite, Crocidolite, Tremolite, Actinolite, Antofillite EVALUATION• There is sufficient evidence in humans for the carcinogenicity of all forms of asbestos. – Asbestos causes mesothelioma and cancer of the lung, larynx, and ovary [sufficiente]. – Also positive associations have been observed between exposure to all forms of asbestos and cancer of the pharynx, stomach, and colo-rectum [limitato].• There is sufficient evidence in experimental animals for the carcinogenicity of all forms of asbestos. All forms of asbestos are carcinogenic to humans (Group 1).Talc containing asbestiform fibres is carcinogenic to humans (Group 1) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. A Review of Human Carcinogens: Arsenic, Metals, Fibres, and Dusts. Vol.100 C , 2011.PA Bertazzi, UNIMI
  • 11. Esposizione occupazionale ad amianto e cancro colo-rettale RR per le categorie di esposizione più alta a confronto con i non espostiPA Bertazzi, UNIMI IARC Monographs Vol. 100 C, 2012
  • 12. Malattie per le quali Denuncia è Obbligatoria Lista 1- Elevata probabilità di origine lavorativa-Gruppo 6: – MM in sede pleurica, pericardica, peritoneale e della tunica vaginale del testicolo per esposizione ad ‘asbesto’ – MM pleurico per esposizione ad ‘erionite’. Inoltre – MM pleurico per esposizione a ‘talco contenente fibre asbestiformi.’ Lista 2 - Limitata probabilità di origine lavorativa - Gruppo 6 – Tumore laringeo per esposizione ad ‘asbesto’ Lista 3 - Possibile origine lavorativa - Gruppo 6 – Tumori gastroenterici per esposizione ad ‘asbesto’ Inoltre – Mesotelioma pleurico per esposizione a ‘fibre ceramiche’ MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 gennaio 2008 Elenco delle malattie per le quali è obbligatoria la denuncia ai sensi e per gli effetti dellarticolo 139 del testo unico approvato con decreto del Presidente della Repubblica 30 giugno 1965, n. 1124, e successive modificazioni e integrazioni SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 70 22.3.2008PA Bertazzi, UNIMI
  • 13. Nuova Tabella Malattie Professionali Figurano nella Nuova Tabella delle Malattie Professionali nell’Industria: – MM insorto in sede pleurica, pericardica, peritoneale e della tunica vaginale del testicolo a causa di ‘Lavorazioni che espongano all’azione di fibre di asbesto’ – MM pleurico e peritoneale insorto a causa di ‘Estrazione e utilizzazione di erionite’. MINISTERO DEL LAVORO E DELLA PREVIDENZA SOCIALE - DECRETO 14 Gennaio 2008 Nuove Tabelle delle Malattie professionali nell’Idustria e nell’Agricoltura SUPPLEMENTO ORDINARIO ALLA GAZZETTA UFFICIALE SERIE GENERALE N. 169 21.7.2008PA Bertazzi, UNIMI
  • 14. Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009 The Lancet Oncology,vol.10, 751-752, August 2009 A review of human carcinogens—volume 100 Part D: Radiation
  • 15. Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009 The Lancet Oncology,vol.10, 1033-1034, November 2009 A review of human carcinogens—volume 100 Part E: Lifestyle factors
  • 16. • Aflatoxins, • Soot, as found in occupational exposure of chimney-sweeps,• 4-Aminobiphenyl, • Coal gasification,• Benzene, • Occupational exposures during coal-tar• Benzidine, distillation,• Dyes metabolized to benzidine, • Coke production,• Bis(chloromethyl)ether & chloromethyl • Coal-tar pitch, methyl ether (technical grade), • Untreated or mildly treated mineral oils,• 1,3-Butadiene, • Shale oils• Ethylene oxide, • Occupational exposures during aluminum production,• Formaldehyde, • Auramine production,• 4,4′-methylenebis(2-chloroaniline), • Occupational exposures during iron and steel• Mustard gas, founding,• 2-Naphthylamine, • Isopropyl alcohol manufacture by the strong- acid process,• 2,3,7,8-TCDD, • Magenta production, Occupational exposure• 2,3,4,7,8-PeCDF, as a painter,• PCB 126, • Occupational exposures in the rubber• o-Toluidine, manufacturing industry,• Vinyl chloride, • Mists from strong inorganic acids were found to be carcinogenic to humans (Group1).• Benzo[a]pyrene, Auramine and magenta were found to be possibly carcinogenic to humans (Group 2B).
  • 17. Chemical agents andrelated occupationsassessed by the IARCMonograph WorkingGroup Vol. 100, 2009 A review of human carcinogens—volume 100 Part F: Chemical agents and related occupations
  • 18. Chemical agents and related occupations assessed by the IARC Monograph Working Group Vol. 100, 2009 A review of human carcinogens—volume 100 Part F: Chemical agents and related occupations
  • 19. A review of human carcinogens - Part F: Chemical agents and related occupations• Formaldehyde was confirmed as • Occupational exposure as a painter carcinogenic to humans. There is causes cancers of the lung, urinary sufficient evidence in humans of an bladder and pleural mesothelioma increased incidence of nasopharyngeal in humans. Due to the diversity and carcinomas. In addition, the complexity of the exposures, it is epidemiological evidence on leukemia difficult to identify causal agents or has become stronger, and new a causal mechanism, although there mechanistic studies support a is strong evidence that the conclusion of sufficient evidence in exposures are genotoxic. The humans. This highlights the value of Working Group found limited mechanistic studies, which in only 5 evidence of an association between years have replaced previous maternal exposure to painting assertions of biological implausibility before and during pregnancy and an with new evidence that formaldehyde increased risk of childhood leukemia can cause blood-cell abnormalities in the offspring. These findings that are characteristic of leukemia confirm those of a previous Working development. Group (2007).
  • 20. IARC Monograph Working Group Vol. 101, 2011 The Lancet Oncology, Volume 12, 328-329, April 2011