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  • 1. Diagnosis of Occupational DiseaseThe key criteria for diagnosing an occupational disease in any individual are:a) The clinical features must fit in with what is known about the health effects followingexposure to the specified agent. The symptoms and signs should fit, and this may besupported in some cases by suitable diagnostic tests.b) There must be indication of sufficient occupational exposure. Evidence on exposuremay be obtained through taking the occupational history, results of occupational hygienemeasurements taken at the workplace, biological monitoring results, and/or records ofincidents of over-exposure.c) The time interval between exposure and effect must be consistent with what is knownabout the natural history and progress of the disease. Exposure must precede healtheffects. However, in some conditions such as occupational asthma, a past history ofchildhood asthma and/or asthmatic attacks occurring before occupational exposure, doesnotautomatically rule out the possibility of a workplace agent causing subsequent asthmaticattacks.d) The differential diagnosis must be considered. There are non-occupational conditionsthat have similar clinical features as occupational diseases, and a physician will have totakethis into account before diagnosing or excluding an occupational disease. Information notices on occupational diseases: a guide to diagnosis EC, 2009
  • 2. As an additional aid to diagnosing occupational diseases, retain the following concepts forexposure:i. Minimum intensity of exposure – This is the minimum level of exposure that is required tocause disease. Lower exposures are unlikely to lead to occupational disease. This concept isapplicable especially for toxic agents. For agents that are carcinogenic or allergenic, it is notusually possible to define a minimum threshold dose. Direct acting carcinogens in molecularamounts are in theory capable of affecting cellular DNA and initiating carcinogenesis.However, for some carcinogens, it may be possible to identify a threshold of initiation ofadverse health effects. Allergens may require substantial exposure to cause sensitization.But once an individual is sensitized, minute amounts can be capable of eliciting an allergicresponse.ii. Minimum duration of exposureThis is the shortest exposure period for which disease can occur. Periods of exposure lessthan this are unlikely to cause disease.iii. Maximum latent periodThis refers to the length of time from cessation of exposure, beyond which it is unlikely thatany disease can be attributed to the exposure. E.G., , acute myocardial ischemia occurring ayear after an acute exposure to carbon monoxide is not attributable to that exposure.iv. Minimum induction periodThis is the shortest period from beginning of exposure to beginning of disease below whichthe exposure would have been unlikely to have caused the disease. For example, lung cancerdeveloping within a year after first exposure to asbestos is unlikely to be attributed to thatexposure Information notices on occupational diseases: a guide to diagnosis EC, 2009