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Managing CSS vendor prefixes can require a lot of maintenance. There are many good tools that help automate this process, but they require either static prefixes in your source files or mixins.
Autoprefixer takes this concept one step further by allowing you to keep prefixes out of your source CSS (or LESS/SASS/Stylus) entirely. It references your supplied configuration, compares that against the Can I Use API, and outputs only the prefixes you need. The result: clean style files that are always current and trivially easy to maintain.
From a talk given at the December 2013 Seattle JS meetup.