FLUID THERAPY
NIKHIL NANJAPPA B A
FLUID AND ELECTROLYTE
BALANCE IS AN EXTREMELY
COMPLICATED THING.
IMPORTANCE
• Need to make a decision regarding fluids in pretty
much every hospitalized patient.
• Can be life-saving in c...
KINDS OF IV FLUID SOLUTIONS
• HYPOTONIC - 1/2NS
• ISOTONIC - NS, LR, ALBUMEN
• HYPERTONIC – HYPERTONIC SALINE.
• CRYSTALLO...
CRYSTALLOID VS COLLOID
TYPE OF PARTICLES (LARGE OR
SMALL)
• Fluids with small “crystalizable” particles like NaCl are
call...
THERE ARE TWO COMPONENTS TO FLUID THERAPY:
• MAINTENANCE THERAPY REPLACES NORMAL
ONGOING LOSSES, AND
• REPLACEMENT THERAPY...
MAINTENANCE THERAPY
• Maintenance therapy is usually undertaken when the
individual is not expected to eat or drink normal...
MAINTENANCE REQUIREMENTS CAN BE
BROKEN
INTO WATER AND ELECTROLYTE
REQUIREMENTS:
WATER
• Two liters of water per day are generally sufficient for
adults;
• Most of this minimum intake is usually derived ...
• Water requirements increase with:
fever, sweating, burns, tachypnea, surgical drains,
polyuria, or ongoing significant g...
SEVERAL FORMULAS CAN BE USED TO CALCULATE
MAINTENANCE FLUID RATES.
• A comparison of formulas produces a wide
variety of fluid recommendations:
• 2000 cc to 3378 cc for an obese woman who i...
4/2/1 RULE A.K.A WEIGHT+40
• I PREFER THE 4/2/1 RULE (WITH A 120 ML/H LIMIT)
BECAUSE IT IS THE SAME AS FOR PEDIATRICS.
• 4/2/1 rule
4 ml/kg/hr for first 10 kg (=40ml/hr)
then 2 ml/kg/hr for next 10 kg (=20ml/hr)
then 1 ml/kg/hr for any kgs o...
MAINTENANCE IV RATE:
4/2/1 RULE -> WEIGHT IN KG +
40
WHAT TO PUT IN THE FLUIDS
•
START: D5 1/2NS+20 MEQ K @
WT+40/HR
• A reasonable approach is to start 1/2 normal saline to which 20 meq of
potassium chl...
START D5 1/2NS+20 MEQ K, THEN
ADJUST:
• IF SODIUM FALLS, INCREASE THE CONCENTRATION (EG, TO
NS)
• IF SODIUM RISES, DECREAS...
USUALLY KIDNEYS REGULATE
WELL, BUT:
ALTERED HOMEOSTASIS IN THE
HOSPITAL
• IN THE HOSPITAL, STRESS, PAIN, SURGERY CAN ALTER...
HYPOVOLEMIA
• Hypovolemia or FVD is result of water & electrolyte loss
• Compensatory mechanisms include: increased sympat...
CAUSES OF FVD=HYPOVOLEMIA:
• GASTROINTESTINAL LOSSES: N/V/D
• RENAL LOSSES: DIURETICS
• SKIN OR RESPIRATORY LOSSES: BURNS
...
REPLACEMENT THERAPY.
• A variety of disorders lead to fluid losses that deplete the
extracellular fluid .
• This can lead to a potentially fata...
• There is no easy formula for assessing the degree of
hypovolemia.
• Hypovolemic shock, the most severe form of hypolemia...
HISTORY FOR ASSESSING
HYPOVOLEMIA
• The history can help to determine the presence and etiology of volume
depletion.
• Wei...
BASIC SIGNS OF HYPOVOLEMIA
• URINE OUTPUT, LESS THAN 30ML/HR
• DECREASED BP, INCREASE PULSE
PHYSICAL EXAM
• Physical exam in general is not sensitive or specific
• Acute weight loss; however, obtaining an accurate ...
SIGNS & SYMPTOMS OF FLUID
VOLUME EXCESS
• ORTHOPNEA
• EDEMA & WEIGHT GAIN
• DISTENDED NECK VEINS & TACHYCARDIA
• INCREASED...
WHICH BRINGS US TO:
LABNORMALITIES SEEN WITH
HYPOVOLEMIA
• A variety of changes in urine and blood often accompany
extrace...
BUN/CR
• BUN/cr ratio normally around 10
• Increase above 20 suggestive of “prerenal state”
• (rise in BUN without rise in...
HGB/HCT
• Acute loss of EC fluid volume causes hemoconcentration (if
not due to blood loss)
• Acute gain of fluid will cau...
PLASMA NA
• Decrease in intravascular volume leads to greater avidity for
na (through aldosterone) AND water (through ADH)...
URINE NA
• Urine na – goes down in prerenal states as body tries to hold
onto water.
• Getting a fena helps correct for ur...
IV MODES OF ADMINISTRATION
• PERIPHERAL IV
• PICC
• CENTRAL LINE
• INTRAOSSEOUS
IV PROBLEM:
EXTRAVASATION /
“INFILTRATED”
• THE MOST SENSITIVE INDICATOR OF EXTRAVASATED
FLUID OR "INFILTRATION" IS TO TRA...
intravenous fluid therapy
intravenous fluid therapy
intravenous fluid therapy
intravenous fluid therapy
intravenous fluid therapy
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intravenous fluid therapy

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a brief insight into iv fluids and replacement. a surgical perspective.

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intravenous fluid therapy

  1. 1. FLUID THERAPY NIKHIL NANJAPPA B A
  2. 2. FLUID AND ELECTROLYTE BALANCE IS AN EXTREMELY COMPLICATED THING.
  3. 3. IMPORTANCE • Need to make a decision regarding fluids in pretty much every hospitalized patient. • Can be life-saving in certain conditions • Loss of body water, whether acute or chronic, can cause a range of problems from mild lightheadedness to convulsions, coma, and in some cases, death. • Though fluid therapy can be a lifesaver, it's never innocuous, and can be very harmful.
  4. 4. KINDS OF IV FLUID SOLUTIONS • HYPOTONIC - 1/2NS • ISOTONIC - NS, LR, ALBUMEN • HYPERTONIC – HYPERTONIC SALINE. • CRYSTALLOID • COLLOID
  5. 5. CRYSTALLOID VS COLLOID TYPE OF PARTICLES (LARGE OR SMALL) • Fluids with small “crystalizable” particles like NaCl are called crystalloids • Fluids with large particles like albumin are called colloids, these don’t (quickly) fit through vascular pores, so they stay in the circulation and much smaller amounts can be used for same volume expansion. (250ml albumin = 4 L NS) • Edema resulting from these also tends to stick around longer for same reason. • Albumin can also trigger anaphylaxis.
  6. 6. THERE ARE TWO COMPONENTS TO FLUID THERAPY: • MAINTENANCE THERAPY REPLACES NORMAL ONGOING LOSSES, AND • REPLACEMENT THERAPY CORRECTS ANY EXISTING WATER AND ELECTROLYTE DEFICITS.
  7. 7. MAINTENANCE THERAPY • Maintenance therapy is usually undertaken when the individual is not expected to eat or drink normally for a longer time (eg, perioperatively or on a ventilator). • Big picture: most people are “npo” for 12 hours each day. • Patients who won’t eat for one to two weeks should be considered for parenteral or enteral nutrition.
  8. 8. MAINTENANCE REQUIREMENTS CAN BE BROKEN INTO WATER AND ELECTROLYTE REQUIREMENTS:
  9. 9. WATER • Two liters of water per day are generally sufficient for adults; • Most of this minimum intake is usually derived from the water content of food and the water of oxidation, therefore • It has been estimated that only 500ml of water needs be imbibed given normal diet and no increased losses. • These sources of water are markedly reduced in patients who are not eating and so must be replaced by maintenance fluids.
  10. 10. • Water requirements increase with: fever, sweating, burns, tachypnea, surgical drains, polyuria, or ongoing significant gastrointestinal losses. • For example, water requirements increase by 100 to 150 ml/day for each c degree of body temperature elevation.
  11. 11. SEVERAL FORMULAS CAN BE USED TO CALCULATE MAINTENANCE FLUID RATES.
  12. 12. • A comparison of formulas produces a wide variety of fluid recommendations: • 2000 cc to 3378 cc for an obese woman who is 65 inches tall and weighs 248 pounds (112.6 kg) • This is a reminder that fluid needs, no matter what formula is used, are at best an estimation.
  13. 13. 4/2/1 RULE A.K.A WEIGHT+40 • I PREFER THE 4/2/1 RULE (WITH A 120 ML/H LIMIT) BECAUSE IT IS THE SAME AS FOR PEDIATRICS.
  14. 14. • 4/2/1 rule 4 ml/kg/hr for first 10 kg (=40ml/hr) then 2 ml/kg/hr for next 10 kg (=20ml/hr) then 1 ml/kg/hr for any kgs over that this always gives 60ml/hr for first 20 kg then you add 1 ml/kg/hr for each kg over 20 kg this boils down to: weight in kg + 40 = maintenance IV rate/hour. For any person weighing more than 20kg
  15. 15. MAINTENANCE IV RATE: 4/2/1 RULE -> WEIGHT IN KG + 40
  16. 16. WHAT TO PUT IN THE FLUIDS •
  17. 17. START: D5 1/2NS+20 MEQ K @ WT+40/HR • A reasonable approach is to start 1/2 normal saline to which 20 meq of potassium chloride is added per liter. (1/2NS+20 K @ wt+40/hr) • Glucose in the form of dextrose (D5) can be added to provide some calories while the patient is NPO. • The normal kidney can maintain sodium and potassium balance over a wide range of intakes. • So,start: d5 1/2ns+20 meq k at a rate equal to their weight + 40ml/hr, but no greater than 120ml/hr. • Then adjust as needed, see next page.
  18. 18. START D5 1/2NS+20 MEQ K, THEN ADJUST: • IF SODIUM FALLS, INCREASE THE CONCENTRATION (EG, TO NS) • IF SODIUM RISES, DECREASE THE CONCENTRATION (EG, 1/4NS) • IF THE PLASMA POTASSIUM STARTS TO FALL, ADD MORE POTASSIUM. • IF THINGS ARE GOOD, LEAVE THINGS ALONE.
  19. 19. USUALLY KIDNEYS REGULATE WELL, BUT: ALTERED HOMEOSTASIS IN THE HOSPITAL • IN THE HOSPITAL, STRESS, PAIN, SURGERY CAN ALTER THE NORMAL MECHANISMS. • INCREASED ALDOSTERONE, INCREASED ADH • THEY GENERALLY MAKE PATIENTS RETAIN MORE WATER AND SALT, INCREASE TENDENCY FOR EDEMA, AND BECOME HYPOKALEMIC.
  20. 20. HYPOVOLEMIA • Hypovolemia or FVD is result of water & electrolyte loss • Compensatory mechanisms include: increased sympathetic nervous system stimulation with an increase in heart rate & cardiac contraction; thirst; plus release of ADH & aldosterone • Severe case may result in hypovolemic shock or prolonged case may cause renal failure
  21. 21. CAUSES OF FVD=HYPOVOLEMIA: • GASTROINTESTINAL LOSSES: N/V/D • RENAL LOSSES: DIURETICS • SKIN OR RESPIRATORY LOSSES: BURNS • THIRD-SPACING: INTESTINAL OBSTRUCTION, PANCREATITIS
  22. 22. REPLACEMENT THERAPY.
  23. 23. • A variety of disorders lead to fluid losses that deplete the extracellular fluid . • This can lead to a potentially fatal decrease in tissue perfusion. • Fortunately, early diagnosis and treatment can restore normovolemia in almost all cases.
  24. 24. • There is no easy formula for assessing the degree of hypovolemia. • Hypovolemic shock, the most severe form of hypolemia, is characterized by tachycardia, cold, clammy extremities, cyanosis, a low urine output (usually less than 15 ml/h), and agitation and confusion due to reduced cerebral blood flow. • This needs rapid treatment with isotonic fluid boluses (1-2l ns), and assessment and treatment of the underlying cause. • But hypovolemia that is less severe and therefore well compensated is more difficult to accurately assess.
  25. 25. HISTORY FOR ASSESSING HYPOVOLEMIA • The history can help to determine the presence and etiology of volume depletion. • Weight loss! • Early complaints include lassitude, easy fatiguability, thirst, muscle cramps, and postural dizziness. • More severe fluid loss can lead to abdominal pain, chest pain, or lethargy and confusion due to ischemia of the mesenteric, coronary, or cerebral vascular beds, respectively. • Nausea and malaise are the earliest findings of hyponatremia, and may be seen when the plasma sodium concentration falls below 125 to 130 meq/l. This may be followed by headache, lethargy, and obtundation • Muscle weakness due to hypokalemia or hyperkalemia • Polyuria and polydipsia due to hyperglycemia or severe hypokalemia • Lethargy, confusion, seizures, and coma due to hyponatremia, hypernatremia, or hyperglycemia
  26. 26. BASIC SIGNS OF HYPOVOLEMIA • URINE OUTPUT, LESS THAN 30ML/HR • DECREASED BP, INCREASE PULSE
  27. 27. PHYSICAL EXAM • Physical exam in general is not sensitive or specific • Acute weight loss; however, obtaining an accurate weight over time may be difficult • Decreased skin turgor - if you pinch it it stays put • Dry skin, particularly axilla • Dry mucus membranes • Low arterial blood pressure (or relative to patient's usual BP) • Orthostatic hypotension can occur with significant hypovolemia; but it is also common in euvolemic elderly subjects. • Decreased intensity of both the korotkoff sounds (when the blood pressure is being measured with a sphygmomanometer) and the radial pulse ("thready") due to peripheral vasoconstriction. • Decreased jugular venous pressure • The normal venous pressure is 1 to 8 cmh2o, thus, a low value alone may be normal and does not establish the diagnosis of hypovolemia.
  28. 28. SIGNS & SYMPTOMS OF FLUID VOLUME EXCESS • ORTHOPNEA • EDEMA & WEIGHT GAIN • DISTENDED NECK VEINS & TACHYCARDIA • INCREASED BLOOD PRESSURE • CRACKLES & WHEEZES • PLEURAL EFFUSION
  29. 29. WHICH BRINGS US TO: LABNORMALITIES SEEN WITH HYPOVOLEMIA • A variety of changes in urine and blood often accompany extracellular volume depletion. • In addition to confirming the presence of volume depletion, these changes may provide important clues to the etiology.
  30. 30. BUN/CR • BUN/cr ratio normally around 10 • Increase above 20 suggestive of “prerenal state” • (rise in BUN without rise in cr called “prerenal azotemia.”) • This happens because with a low pressure head proximal to kidney, because urea (bun) is resorbed somewhat, and creatinine is secreted somewhat as well
  31. 31. HGB/HCT • Acute loss of EC fluid volume causes hemoconcentration (if not due to blood loss) • Acute gain of fluid will cause hemodilution of about 1g of hemoglobin (this happens very often.)
  32. 32. PLASMA NA • Decrease in intravascular volume leads to greater avidity for na (through aldosterone) AND water (through ADH), • So overall, plasma na concentration tends to decrease from 140 when hypovolemia present.
  33. 33. URINE NA • Urine na – goes down in prerenal states as body tries to hold onto water. • Getting a fena helps correct for urine concentration. • Screwed up by lasix. • Calculator on pda or medcalc.Com
  34. 34. IV MODES OF ADMINISTRATION • PERIPHERAL IV • PICC • CENTRAL LINE • INTRAOSSEOUS
  35. 35. IV PROBLEM: EXTRAVASATION / “INFILTRATED” • THE MOST SENSITIVE INDICATOR OF EXTRAVASATED FLUID OR "INFILTRATION" IS TO TRANSILLUMINATE THE SKIN WITH A SMALL PENLIGHT AND LOOK FOR THE ENHANCED HALO OF LIGHT DIFFUSION IN THE FLUID FILLED AREA. • CHECKING FLOW OF INFUSION DOES NOT TELL YOU WHERE THE FLUID IS GOING

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