Chapter 8 lipids


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Chapter 8 lipids

  1. 1. CHAPTER 8 LIPIDS Definition of Lipids Functions of Lipids
  2. 2. Classification of lipids:2. Fatty acids - Fatty acyls - made up of hydrocarbon chain terminates with a carboxylic group. - the carbon chain, typically between four to 24 carbons long, maybe saturated or unsaturated.
  3. 3. Biologically important fatty acids:a. Eicosanoids -are signaling molecules made by oxygenation of twenty-carbon essential fatty acids (EFAs). -derive from either omega-3 (ω-3) or omega-6 (ω-6) EFA. - prostaglandins, prostacyclins, the thromboxanes and the leukotrienes.
  4. 4.  Prostaglandins: different types  Some stimulate contraction of smooth muscle during menstruation and labor  Others produce fever and inflammation and pain Thromboxanes: act in the formation of blood clot Leukotrienes: induces contraction of the muscle lining the lungs  overproduction leads to asthma
  5. 5. 2. Glycerolipids -are composed mainly of mono-, di- and tri- substituted glycerols, the most well- known being the fatty acid esters of glycerol (triglycerides).- - energy storage.
  6. 6. Triacylglycerides Glycerol in blue Fatty acids in red Condensation produces 3 water molecules
  7. 7. 3. Glycerophospholipids-phospholipids - are ubiquitous in nature and are key components of the lipid bilayer of cells -involved in metabolism and cell signaling.
  8. 8. Phosphoacylglycerols/ Phosphoglycerols O H2C O R1 O O HC O R2X O P O CH2 O
  9. 9. Phosphatidyl choline with fatty acids as oleate and palmitate O H2C O O (CH2)7 C C (CH2)7 CH3 H H O HC O (CH2)14 CH3 CH3 + O P O CH2 NH3C O CH3
  10. 10. 4. Sphingolipids - are a complex family of compounds that share a common structural feature - a sphingoid base backbone.
  11. 11. Sphingolipids Different types are found in plasma membrane and myelin sheaths Gangliosides  cell to cell interactions  antigenic
  12. 12. Sphingolipids X name H HO C C C (CH2)12-CH3 H H H ceramide O monosaccharide cerebroside HC N R H carbohydrate gangliosideX O CH2 sphingomyelin
  13. 13. Sphingophospholipid with choline and the fatty acid as linolenic H HO C C C (CH2)12-CH3 H H O O HC N (CH2)7 CH CH CH2 CH CH CH2 CH CHCH2CH3 H CH3 + O P O CH2 NH3C O CH3
  14. 14. 5. Sterol lipids -such as cholesterol and its derivatives, are an important component of membrane lipids, along with the glycerophospholipids and sphingomyelins.
  15. 15. Role of Cholesterol Keeps the lipids in membrane from aggregrating: Keeps the membrane intact as a bilayer Precursor to Bile Acids  Act as detergents to dissolve dietary fats  Fats can be broken better by enzymes Precursor to steroid hormones that regulate gene expression Precursor to Vitamin D
  16. 16. Good vs. Bad Cholesterol Related to lipoproteins (protein + lipid complexes) Dietary excess fat is packaged into VLDL Fat cells (adipose cells) take these up convert to fatty acids Some VLDL is converted to LDL LDL is very rich in Cholesterol
  17. 17. LDL VS. HDLLDL Too much LDL can circulate in the blood Build up in arteries; lead to heart attack HDL Another lipoprotein that converts cholesterol into a lipoprotein that returns to the liver ; Removes cholesterol out of the bloodstream; believed to prevent heart attacks
  18. 18. Ratio of LDL to HDL LDL cholesterol of less than 100 mg/dL is the optimal level. Less than 130 mg/dL is near optimal for most people. A high LDL level (more than 160 mg/dL or 130 mg/dL or above if you have two or more risk factors for cardiovascular disease) reflects an increased risk of heart disease Low HDL cholesterol levels [less than 40 mg/dL] is thought to increase the risk for heart disease.
  19. 19. 6. Prenol lipids Biologically important prenol lipids: a. Carotenoids are important simple isoprenoids that function as antioxidants and as precursors of vitamin A. b. Vitamin E and vitamin K.7. Saccharolipids -fatty acids are linked directly to a sugar backbone, forming structures that are compatible with membrane bilayers.
  20. 20. Lipid Soluble VitaminsVitamin A   800 μg ( upper limit ca. 3000 μg)Vitamin D   5 to 10 μg ( upper limit ca. 2000 μg)Vitamin E   15 mg ( upper limit ca. 1 g)Vitamin K   110 μg ( upper limit not specified)
  21. 21. Characteristics of Lipids: 1. Amphiphatic 2. Naturally occcuring 3. Soluble in organic solvents but insoluble in water. 4. Undergo saponification 5. Undergo emulsification
  22. 22. Clinical Significance:1. Tay-Sachs Disease-infantile form: rapidly progressing mental retardation, blindness, early mortality .2. Gaucher Disease- hepatosplenomegaly, mental retardation in infantile form, long bone degeneration.3. Fabry Disease-kidney failure, skin rashes4. Fucosidosis-cerebral degeneration, thickened skin, muscle spasticity
  23. 23. 5. Cholera- protein portion of ganglioside.6. Hypercholesterolemia - Artherosclerosis -Coronary Heart Disease - Diabetes - Anorexia nervosa
  24. 24. 1. Imbalance in the rate oftriacylglycerol formation andexport causes fatty liver. -Accumulation of lipid astriacylglycerol in the liver causescirrhosis and impaired liver function.
  25. 25. Fatty liver falls into two categories:a. Raised levels of plasma free fatty acids resulting from mobilization of fat from adipose tissue or from the hydrolysis of lipoprotein triacylglycerol by lipoprotein lipase in extrahepatic tissues.  Increasing amounts of free fatty acids are taken up by the liver and esterified. The production of VLDL does not keep pace with the influx of free fatty acids, allowing triacylglycerol to accumulate, causing fatty liver.  During starvation, quantity of triacylglycerol in the liver is increased, and ability to secret VLDL is impaired. This may be due to low levels of insulin.
  26. 26. a. Due to a metabolic block in the production of plasma lipoproteins, thus allowing triacylglycerol to accumulate.  Lesion could be due to:  1. A block in apolipoprotein synthesis 2. A block in the synthesis of lipoprotein from lipid and apolipoprotein 3. A failure in the secretory mechanism itself.  In experimental animals, deficiency of choline, treatment with puromycin, ethionine, carbon tetrachloride, chloroform, phosphorous, lead, and arsenic causes fatty liver.
  27. 27. Ethanol also causes fatty liver: Alcoholism leads to fat accumulation in the liver, hyperlipidemia, and ultimately cirrhosis
  28. 28. A. Increased NADH/NAD+ ratio causes Shift in the malate oxaloacetate, which may reduce activity of the citric acid cycle.  Net effect of inhibiting fatty acid oxidation is to cause increased esterification of fatty acids in triacylglycerol, which may be the cause of fatty liver. B. also causes increase in lactate/pyruvate ratio that results in hyperlacticacidemia, which in turn decreases the capacity of kidney to excrete uric acid. C. Increase in acetyl-CoA causes increased lipogenesis and cholesterol