Drugs that reduce GABAergic transmission enhance cognition
Inadequate maintenance of circuits
One gene has been identified
The mechanism is being explored
Neuronal Circuits Are Disrupted In Down Syndrome
Neurotrophic Factor Signals Are Critical for Survival and Maintenance of Neurons And The Circuits In Which They Work Signaling Endosomes Carry Trophic Signals
PP Sch MF CA1 A lv CA3 Entorhinal Cortex 1 2 3 Cortex DG BFCN DGC Perforant Path Raphe Locus Defining A Role For Neurotrophic Factors in Hippocampal Circuits Dysfunction in Down Syndrome APP Gene Dose Plays A Role
We do not know that what is true in models is true in man.
We need to build a research program that links observations in models to man.
We need to understand better the natural history and the needs of people with Down syndrome.
It will be essential to build a stronger more diverse community to achieve success.
Acknowledgements Supported by: -Down Syndrome Research and Treatment Foundation -National Institutes of Health -Larry L Hillblom Foundation -Thrasher Foundation -Alzheimer’s Association -Cure Alzheimer’s Fund