Summary on Ms. Olga González's Seminar: "Herpesviral Reactivation: A Key Step for Disease Development"
UPR Cayey Summary 1: Ms. Olga González Herpesviral Reactivation: A Key Step for Disease Development BIOL. 3095-140 Nicolle A. Rosa Mercado September 21, 2012 There are many different types of herpes viruses. During this seminar Ms. Olga Gonzálezdiscussed five of them, which were Herpes Simplex Virus (types 1 and 2), Varicella Zoster Virus,
Human Cytomegalovirus, Epstein Barr virus, and Kaposi’s sarcoma (KSHV), which is anassociated herpesvirus. She explained the importance of the latency and reactivation processes forthese viruses. Ms. Olga’s research is specifically based on KSHV. The understanding of this virus isof extreme importance due to the fact that it is known to cause three different types of cancer:Kaposi’s sarcoma, Primary effusion lymphoma, and Multicentric Castleman disease. She explainedhow Rta, the lytic switch protein, is used for the reactivation process of KSHV and the differentsteps that Rta has to go through in order to do so. Her research may lead to innovating discoverieson “molecular piracy” processes and may give our society a better understanding of molecularmechanisms and cancer development.