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16. nicole final

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  • Retrogardmenstruation: menstrual bloodflow back troughthefallopiantubesinsted of flowingouttrhoughthevagaina.Colelomicmetaplasia: undifferentiedcellsdevelopto endometrial cells
  • Immunolabeling:prosess in whichparticular antigens within tissue are localize. Can be used to identify the effects of a drug on a particular organ1) antibodiesare used to identify antigens within an organism2) secondary antibody arebinded to the primary antibody3)  microscopy can be combined with immunolabeling
  • Lacroscopy is not the most efficiesce
  • Transcript

    • 1.  presence of endometrial tissue outside the uterine cavity endometrial tissue is misplaced and grows in other places outside the uterus 10% of the female population of reproductive age The exact cause of endometriosis is still unknown.
    • 2.  Even though the exact cause of endometriosis is still unknown there are some theories that could explain the reason of it1) Retrograde Menstruation2) Coelomic Metaplasia3) hereditary disease
    • 3. 1)Sever pain in the abdominal and pelvic areas2) Infertility About 30% of woman who suffer from endometriosis will have infertility
    • 4. 1) Oestrogen● group of hormones that promotes the reproductive system and the secondary characteristic in females●simulate the production of Follicle Stimulating Hormone.●endometriosis is an oestrogen- dependant disease.
    • 5. 2) Growth hormone and Growth- Hormone releasing hormone●Growth hormone is a protein hormone●Regulates growth and development● involved in the process of sexual differentiation, pubertal maturation● Growth- Hormone Releasing Hormone is produced by the hypothalamus and stimulates the release of Growth Hormone.
    • 6.  Slater’s study (2003) indicate that Growth hormone releasing hormone (GHRH) and GH hormone promote endometrial proliferation and endometrial carciroma. During this study1) banked tissue : normal uterine sample and endometriosis samples2) Immunochemistry of each tissue was analyzed using different antibodies3) Immunolabeling of both samples were performed
    • 7.  Results show that endometriotic tissue showed increase in immunolabeling of GH compared with normal tissue. Slater (2003) concluded that GH may play a role in the progression of both endoetriosis and endometrial canciroma
    • 8. ● stimulate the production and development of the human reproductive system● kinds of gonadotropic hormones: Luteinizing Hormone (LH) and Follicle stimulating hormone (FSH)● LH stimulates sex steroid secretion● FSH stimulates the growth and maturation of the ovarian follicles.
    • 9.  Gonadotropin releasing hormone is used in form of an agonist, called Gonadotropin releasing hormone agonist, to treat endometriosis pain most used and effective clinical treatment for endometriosis pain.
    • 10.  Apart from surgery, the treatments administered for endometriosis are mostly to reduce pain. Hormones had been used to control the thickening and bleeding of the tissue and are proved to be the most effective in pain reduction.
    • 11. 1. Growth hormone releasing hormone agonist● GnRH agonist inhibits the secretion of GnRH to the gonadotrophs● These hormones work by turning off the ovaries causing a pseudo-menopause.●They inhibit the effect of hormones that cause ovulation, especially estrogen, and leads to inflammation and pain● GnRH agonist therapy consists of several injections or nasal spray during approximately three months
    • 12.  Meresman’s (2003) study indicate that GnRH play an important role in the reduction of cell proliferation in endometriosis. During this study:1) Tissue were selected: 16 with untreated endometriosis and 14 control2) Tissue was planted and incubated3) Cells were washed and different agents (including LA, as a GnRH) were added4) Tissue was inclubated for 48 additional hours
    • 13.  Meresman (2003) concluded that GnRH-a appear to have a direct effect in decreasing the cell proliferation in endoetrial cells.
    • 14.  GH and GhRH may play a role in endometrial proliferation. It may also play a role in the progression of both endoetriosis and endometrial canciroma. As more proliferation occurs, more misplaced tissue is found, increasing the pain prdoduce by this condition. While GnRH was been proven to decrease cell proliferation in endometrial tissues. As proliferation is reduced, the patient experiences less pain due to a decrease of the amount of the misplaced tissue.
    • 15.  Studies about how Growth hormone and Growth hormone releasing hormone work in the progression of cell proliferation during endometriosis, could be related to the cause of this condtition. Studing this hormone can give a cause of why is this condition produced.
    • 16.  Meresman G, Bilotas M,Buquet R,Baraño R,Sueldo C,Tesone M.2003.“Gonadotropin- releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis”. Fertility and sterility. [Internet];[revised 2002 May 17] Vol 80: Available in: http://www.s ciencedirect.com/science/article/pii/S00150 28203007696
    • 17.  National Institute of Health [Internet].[unknown].USA: National Institute of Health;[unknown]. Available in:http://www.nichd.nih.gov/health/topics/ Endometriosis.cfm Slater M,Copper M,Murphy CR. 2006. Human Growth Hormone and Interleukin-6 are Unregulated in Endometriosis and Endometriod Adenocarcinoma.Acta Histochemica [internet];[revised 2005 Oct 5];[cited 2008 Jan 18].108,13-18:Available in: http://www.sciencedirect.com/ science /article/pii/S0065128106000158
    • 18.  The hormone foundation [Internet].[2011].Connecticut: The hormone foundation;[cited unknown]. http://www.hormone.org/Endo101/page2.cf m Rose G.2005.What is endometriosis.Women’s Health Medicine [Internet];[unknown].Available in:Science Direct Mona.Endometriosis-what is it [video].USA:icyou, A Benefitfocus Company. Available in: http://www.youtube.com/user/icyouhealth# p/search/0/pVrKiBUPoL4

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