Retrogardmenstruation: menstrual bloodflow back troughthefallopiantubesinsted of flowingouttrhoughthevagaina.Colelomicmetaplasia: undifferentiedcellsdevelopto endometrial cells
Immunolabeling:prosess in whichparticular antigens within tissue are localize. Can be used to identify the effects of a drug on a particular organ1) antibodiesare used to identify antigens within an organism2) secondary antibody arebinded to the primary antibody3) microscopy can be combined with immunolabeling
Lacroscopy is not the most efficiesce
presence of endometrial tissue outside the uterine cavity endometrial tissue is misplaced and grows in other places outside the uterus 10% of the female population of reproductive age The exact cause of endometriosis is still unknown.
Even though the exact cause of endometriosis is still unknown there are some theories that could explain the reason of it1) Retrograde Menstruation2) Coelomic Metaplasia3) hereditary disease
1)Sever pain in the abdominal and pelvic areas2) Infertility About 30% of woman who suffer from endometriosis will have infertility
1) Oestrogen● group of hormones that promotes the reproductive system and the secondary characteristic in females●simulate the production of Follicle Stimulating Hormone.●endometriosis is an oestrogen- dependant disease.
2) Growth hormone and Growth- Hormone releasing hormone●Growth hormone is a protein hormone●Regulates growth and development● involved in the process of sexual differentiation, pubertal maturation● Growth- Hormone Releasing Hormone is produced by the hypothalamus and stimulates the release of Growth Hormone.
Slater’s study (2003) indicate that Growth hormone releasing hormone (GHRH) and GH hormone promote endometrial proliferation and endometrial carciroma. During this study1) banked tissue : normal uterine sample and endometriosis samples2) Immunochemistry of each tissue was analyzed using different antibodies3) Immunolabeling of both samples were performed
Results show that endometriotic tissue showed increase in immunolabeling of GH compared with normal tissue. Slater (2003) concluded that GH may play a role in the progression of both endoetriosis and endometrial canciroma
● stimulate the production and development of the human reproductive system● kinds of gonadotropic hormones: Luteinizing Hormone (LH) and Follicle stimulating hormone (FSH)● LH stimulates sex steroid secretion● FSH stimulates the growth and maturation of the ovarian follicles.
Gonadotropin releasing hormone is used in form of an agonist, called Gonadotropin releasing hormone agonist, to treat endometriosis pain most used and effective clinical treatment for endometriosis pain.
Apart from surgery, the treatments administered for endometriosis are mostly to reduce pain. Hormones had been used to control the thickening and bleeding of the tissue and are proved to be the most effective in pain reduction.
1. Growth hormone releasing hormone agonist● GnRH agonist inhibits the secretion of GnRH to the gonadotrophs● These hormones work by turning off the ovaries causing a pseudo-menopause.●They inhibit the effect of hormones that cause ovulation, especially estrogen, and leads to inflammation and pain● GnRH agonist therapy consists of several injections or nasal spray during approximately three months
Meresman’s (2003) study indicate that GnRH play an important role in the reduction of cell proliferation in endometriosis. During this study:1) Tissue were selected: 16 with untreated endometriosis and 14 control2) Tissue was planted and incubated3) Cells were washed and different agents (including LA, as a GnRH) were added4) Tissue was inclubated for 48 additional hours
Meresman (2003) concluded that GnRH-a appear to have a direct effect in decreasing the cell proliferation in endoetrial cells.
GH and GhRH may play a role in endometrial proliferation. It may also play a role in the progression of both endoetriosis and endometrial canciroma. As more proliferation occurs, more misplaced tissue is found, increasing the pain prdoduce by this condition. While GnRH was been proven to decrease cell proliferation in endometrial tissues. As proliferation is reduced, the patient experiences less pain due to a decrease of the amount of the misplaced tissue.
Studies about how Growth hormone and Growth hormone releasing hormone work in the progression of cell proliferation during endometriosis, could be related to the cause of this condtition. Studing this hormone can give a cause of why is this condition produced.
Meresman G, Bilotas M,Buquet R,Baraño R,Sueldo C,Tesone M.2003.“Gonadotropin- releasing hormone agonist induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis”. Fertility and sterility. [Internet];[revised 2002 May 17] Vol 80: Available in: http://www.s ciencedirect.com/science/article/pii/S00150 28203007696
National Institute of Health [Internet].[unknown].USA: National Institute of Health;[unknown]. Available in:http://www.nichd.nih.gov/health/topics/ Endometriosis.cfm Slater M,Copper M,Murphy CR. 2006. Human Growth Hormone and Interleukin-6 are Unregulated in Endometriosis and Endometriod Adenocarcinoma.Acta Histochemica [internet];[revised 2005 Oct 5];[cited 2008 Jan 18].108,13-18:Available in: http://www.sciencedirect.com/ science /article/pii/S0065128106000158
The hormone foundation [Internet]..Connecticut: The hormone foundation;[cited unknown]. http://www.hormone.org/Endo101/page2.cf m Rose G.2005.What is endometriosis.Women’s Health Medicine [Internet];[unknown].Available in:Science Direct Mona.Endometriosis-what is it [video].USA:icyou, A Benefitfocus Company. Available in: http://www.youtube.com/user/icyouhealth# p/search/0/pVrKiBUPoL4