Genscript overview 030110[1]


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Genscript overview 030110[1]

  1. 1. March 2010 Introducing GenScript
  2. 2. Presentation Overview 1 2 3 4 The Biology CRO About GenScript Service Overview Your Reliable Partner
  3. 3. About GenScript <ul><li>Founded in 2002 </li></ul><ul><li>>800 employees </li></ul><ul><li>Headquarters in Piscataway, NJ, USA </li></ul><ul><li>Facilities and branches: </li></ul>New Jersey, USA Nanjing, China Paris, France Osaka, Japan
  4. 4. Fast Growing Company <ul><li>Organic Growth Since Inception </li></ul>2002 2003 2004 2005 2006 2007 2008
  5. 5. <ul><li>The largest provider of custom gene synthesis services in the U.S. </li></ul><ul><li>We offer the best antibody service guarantee in the industry </li></ul><ul><li>We provide small- and large-molecule one-stop biology CRO services for early drug discovery and development </li></ul><ul><li>Local access and 24-hour customer support </li></ul><ul><li>ISO 9001:2000-certified and full client IP protection </li></ul><ul><li>We offer advanced bioinformatics tools and IT infrastructure for value-added services </li></ul><ul><li>Customers include top pharmaceutical companies, major biotech firms, and research institutions in over 70 countries </li></ul><ul><li>Seasoned science and business management teams </li></ul>Key Facts About GenScript
  6. 6. INVESTORS <ul><li>Most respected VC in the world </li></ul><ul><li>Funded Genentech, Google, Amazon, Pacific Biosciences, etc </li></ul><ul><li>Invested in > 300 IT , life science, and biotech companies </li></ul><ul><li>Leading independent advisory company </li></ul><ul><li>Top boutique investment banking firm in China </li></ul><ul><li>Clients include Sinopec, Jiangsu Lihua, Masterrind, Medical Systems </li></ul>In Search of the Next Big Idea
  7. 7. Comprehensive Biology Services
  8. 8. Transforming Molecular Biology Gene Synthesis — Any gene you desire! Synthesize genes OptimumGene TM Codon Optimization Large-Scale Gene Synthesis Cloning — Any construct you want to build! PCR Cloning/Subcloning GenPool TM ORF Cloning KI & KO Vector Construction Custom vector construction Mutagenesis — Any variant from your design! Mutagenesis Service Site-Directed Mutagenesis Libraries Sequential Permutation Scanning Libraries Randomized and Degenerated Libraries Plasmid Preparation — Any amount to fit your plan! Flexible Scale: 100 μg to 1,000 mg Low Endotoxin Levels: <5 EU/mg Largest Gene Synthesis Supplier in USA
  9. 9. GenScript One Stop Protein Services <ul><li>Gene Services </li></ul><ul><li>Largest gene synthesis supplier in US </li></ul><ul><li>Comprehensive portfolio of molecular biology services: </li></ul><ul><li> Codon Optimization </li></ul><ul><li>Cloning </li></ul><ul><li>Vector Construction </li></ul><ul><li>Mutagenesis </li></ul><ul><li>Plasmid Preparation </li></ul><ul><li>etc. </li></ul><ul><li>Protein Services </li></ul><ul><li>Expression (E.coli, yeast, insect, mammalian) </li></ul><ul><li>Purification </li></ul><ul><li>Production of biologically functional protein </li></ul><ul><li>Large capacity for scale-up (fermentation, protein production from stable cell lines) </li></ul><ul><li>Antibody Services </li></ul><ul><li>pAb production </li></ul><ul><li>mAb production </li></ul><ul><li>Hybridoma development </li></ul><ul><li>Assay Services </li></ul><ul><li>Assay development & validation (GPCR, ion channel, enzyme) </li></ul><ul><li>Compound screening & profiling </li></ul>
  10. 10. <ul><li>Custom Peptide Synthesis Services </li></ul>Custom Peptide Synthesis Services Non-GMP Peptides GMP Peptides Standard Peptide Synthesis High complexity and purity Long peptides up to 200 aa High success rate ≥ 95% Peptide Libraries Rapid parallel platform Competitive prices Guaranteed delivery Flexible screening tools Cosmetic Peptides FlexPeptide TM technology Comprehensive documents Batch size from mg to 2 kg Peptides up to 50 aa Recombinant Peptides Flexible technology Variety of modifications Any length, any sequence, any scale
  11. 11. Guaranteed Antibody Services Custom pAb and mAb Services Catalog antibodies Express services Best guaranty in the industry pAb Services Affinity-Purified pAb Phospho-Specific pAb Express Antibody TM Services Species: rabbit, goat/sheep, chicken, mouse, rat, etc mAb services MonoExpress TM Antibody Services mAb Production Services Most Popular: Phospho-Specific pAb Package Large Scale Antibody Production Services Additional Services Ab Modification Ab Purification Ab Characterization Cell Line Storage Peptide Synthesis Services Immunoassay Development Services for Drug Discovery & Clinical Studies Leading the industry standard on antibody guarantee …
  12. 12. In house Project Design Antibody Affinity Maturation Stable Cell Line Generation Antibody Production Bioprocess Development Target Validation Industry-scale Antibody Drug Development Immunon-ization Hybridoma Selection Maturation Production Target Validation Antibody Drug Development Center
  13. 13. <ul><li>Antibody Drug Development Center </li></ul><ul><ul><ul><li>Protein </li></ul></ul></ul><ul><ul><ul><ul><li>Antigen production </li></ul></ul></ul></ul><ul><ul><ul><li>Molecular Biology </li></ul></ul></ul><ul><ul><ul><ul><li>Library construction </li></ul></ul></ul></ul><ul><ul><ul><ul><li>mAb sequencing </li></ul></ul></ul></ul><ul><ul><ul><li>Antibody Engineering </li></ul></ul></ul><ul><ul><ul><ul><li>Affinity maturation </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Antibody humanization </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Anti-idiotype antibody generation </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Epitopic mapping </li></ul></ul></ul></ul><ul><ul><ul><li>Antibody Production </li></ul></ul></ul><ul><ul><ul><ul><li>Hybridoma </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Protein purification </li></ul></ul></ul></ul><ul><ul><ul><li>Bioprocess Development </li></ul></ul></ul><ul><ul><ul><ul><li>Transient and stable expression in flexible scales </li></ul></ul></ul></ul>Comprehensive Antibody Drug Development
  14. 14. Transient Gene Expression and Protein Production Proprietary technology Serum free 293 and CHO suspension systems Rapid protein and mAb production up to grams Stable Cell Line Development and Protein Production Proprietary expression system High flexibility with parental cell types State-of-the-Art facilities Record proven on-time delivery Process Development and Transfer — We pay attention to every single detail BioProcess Services Stable cell development Bioreactors and WAVE-bag technology Industry Scale Protein Production Custom Solution Bioprocess Services
  15. 15. Our Innovation <ul><li>Innovative technologies for enhanced services </li></ul><ul><li>Gene-on-Demand TM gene synthesis technology </li></ul><ul><li>- best and most economic gene synthesis </li></ul><ul><li>FlexChem TM ligation technology </li></ul><ul><li>- peptide synthesis up to 200 amino acids </li></ul><ul><li>CloneEZ TM seamless cloning technology </li></ul><ul><li>- state-of-art cloning into any vector at any site </li></ul><ul><li>Nanotechnology for adjuvant mixing </li></ul><ul><li>- induction of enhanced immune response </li></ul><ul><li>Diversified expression systems </li></ul><ul><li>- bacteria, yeast, insect cells, and mammalian cells </li></ul><ul><li>T-Max TM adjuvant </li></ul><ul><li>- increased titer of at least ten times, and reduced cost </li></ul><ul><li>FoldingArt TM technology </li></ul><ul><li>- refold rate of 95% for inclusion bodies and proteins (virus expression) </li></ul><ul><li>OptimumAntigen TM antigen design </li></ul><ul><li>- optimized antigen design </li></ul><ul><li>293TGE TM system </li></ul><ul><li>- most efficient transient expression system </li></ul><ul><li>OptimumGene TM codon optimization technology </li></ul><ul><li>- optimized gene expression </li></ul>
  17. 17. <ul><li>Business Model </li></ul>Your Reliable Partner
  18. 18. <ul><li>Confidentiality agreement for each contract project </li></ul><ul><li>Secure online information transfer </li></ul><ul><li>Account specific document management </li></ul><ul><li>Strict access control for dedicated research areas </li></ul>Client Client Your Reliable Partner <ul><li>IP protection is crucial to a sustainable partnership between pharmaceutical clients and GenScript </li></ul>
  19. 19. Thank you! Your Innovation Partner in Drug Discovery! Nicole Niu, Ph.D. Regional Sales Manager GenScript USA Inc. 120 Centennial Ave, Piscataway, NJ 08854, USA Tel: 732-885-9188 x 155 Fax: 732-210-0262 Email: [email_address]