Cushings final project
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    Cushings final project Cushings final project Presentation Transcript

    • Cushing’s Syndrome By: Laura Brown, Sarah Afiz and Nick Olson
    • What is Cushing’sSyndrome?  Cushing’s syndrome is caused by prolonged exposure of the bodies’ tissue to high levels of the hormone cortisol
    • What is Cortisol?  Cortisol is a hormone secreted by the adrenal glands  Helps maintain proper glucose metabolism, regulation of blood pressure, insulin released for blood sugar control, immune function and inflammatory response  Most importantly cortisol helps the body respond to stress (called the “stress hormone”)
    • Causes of Cushing’s  Majority of the people who suffer from Cushing’s syndrome have had prior use of glucocorticoid hormones -Glucocorticoid hormones are used to prevent transplant rejection as well as treat inflammatory diseases such as asthma, rheumatoid arthritis and lupus
    • Causes of Cushing’s(cont.) Other causes:  Pituitary Adenomas: tumors of pituitary gland  Adrenal gland overgrowth or adrenal tumors
    • Who’s affected?  Can affect anyone but the disease is extremely rare  Affects 20,000 people in the U.S, and 10-15 million people worldwide  Most commonly occurs in females ages 25-50
    • Symptoms Upper body obesity (rounded face, increased neck fat) Thinning around the arms and legs Delayed growth Easy bruising of skin Purplish-pink stretch marks on the abdomen, thigh, buttocks, arms, and breasts
    • Symptoms (cont.)  High blood sugar, high blood pressure  Depression and anxiety  Increased hair growth in women  Irregular menstrual cycles  Bones are fragile, susceptible to fractures easily
    • Treatments  Depending on the reason for cortisol excess, treatments include: 1. Surgery (pituitary/ adrenal gland surgery on tumors – first line approach) 2. Radiation (can take many years to be effective) 3. Chemotherapy 4. Cortisol inhibiting drugs: An example is -Steroidogenesis inhibitor medications such as Mitotane (83% of Cushing patients treated with Mitotane went into remission).
    • New Treatment  Corcept Therapeutics Inc won U.S. approval for a drug known as Korlym that uses the active ingredient of the abortion pill RU-486
    • Korlym  Korlym blocks the binding of cortisol to its receptor  Korlym inhibits or reduces the effects of excess cortisol  Orphan drug status: Given to drugs discovered for rare diseases. Allows Corcept to have exclusive rights.
    • Other Facts  This disease is not inherited  People who are more prone to developing tumors are at greater risk  If the disease is not treated, it can be lethal  Cushing’s can also lead to heart attacks and strokes  70% of patients with Cushing’s suffer from diabetes.
    • Children with Cushing’sSyndrome
    • Works Cited