The Pistoia
                             Alliance
                                                pistoiaalliance.org




...
Agenda

• Origins of Pistoia
  – History
  – Industry Drivers
  – Technology Trends
• Scope and Operations of Pistoia
  – ...
Industry Driver: Externalization
Cost pressures, disruptive technologies, and other forces
often drive business processes ...
Emerging Net-centric Pharma
Processes

   PHARMA              CRO
      1                 1

   PHARMA              CRO
  ...
Inconsistent Semantics degrade
Effective Communication
                 C

                 B

                 A


      ...
Greater Challenge: Unknown Semantic
 Collisions




Image/quote from Abdul-Malik Shakir

                                 ...
Opportunity: Changing Tech
Landscape

More Robust Technologies
• Web 2.0 / 3.0
• Services-Oriented Architecture
• Software...
The Path Forward:
Standardize, Simplify, Centralize

• Standardize our interfaces and
  messages
• Simplify our cross-indu...
Background—How it all started

• In Pistoia, Italy

• Meeting of GSK, AZ,
  Pfizer and Novartis—
  identified similar
  ch...
Pistoia Mission
• The Mission
  – Pistoia will standardize and streamline data
    interchange in life science R&D.
• The ...
Benefits of Pistoia

• R&D Organizations
  – Optimized investments
     • e.g. reduction of redundant investments across i...
Pistoia Membership




                     updated: April 2010
Pre-competitive Space in the
Technology Lifecycle

  Experiment
  Innovation
 Mainstream           Precompetitive Space
  ...
Crossing the Chasm

• Pistoia is the BRIDGE to cross the chasm
  to a more agile pre-competitive
  environment




     ST...
Learn from Other Industries

Transportation

                         Geospatial
Banking

Retail                    Clinic...
Scope of Pistoia Efforts

   Target ID        Hit ID          Lead ID             Lead Opt     Phase I      Phase II    Ph...
Pistoia Standards Process

Governance &     Pistoia Working               Life Science
Operations           Groups        ...
Current, Active Pistoia Projects
• Semantic Enrichment of Scientific Literature
   – An open knowledge brokering framework...
SESL: Biomedical Knowledge Service
  Framework
                                                                     Multip...
A Production SESL Service
Consumer                                                                                        ...
SESL Mock Up Slide 1




          Gene: abc
    Relationship: Any
       Disease: Diabetes
     Constraint: Species: Any
...
SESL Mock Up Slide 2


                                  Export to Network View
                                  Pivot on...
SESL Mock Up Slide 3


                                  Export to Network View
                                  Return
 ...
Current SESL Participants

AstraZeneca                         Funding
GSK                                 Funding
Roche  ...
www.pistoiaalliance.org




If you want to go fast, go alone.
If you want to go far, go together.
Backup Slides
Where We Are
Who we Are: Board of Directors

GSK             Accelrys
AZ              ChemAxon
Novartis        Symyx
Pfizer          Ca...
Pistoia Membership Levels
• Core Member ($15,000)
   – Those organisations wishing to strongly influence the strategy &
  ...
Upcoming SlideShare
Loading in …5
×

Pistoia presentation bio it-worldexpo 21april2010

1,388 views
1,330 views

Published on

Published in: Business
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
1,388
On SlideShare
0
From Embeds
0
Number of Embeds
238
Actions
Shares
0
Downloads
45
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Pistoia presentation bio it-worldexpo 21april2010

  1. 1. The Pistoia Alliance pistoiaalliance.org A Construct for Pre-competitive Collaboration and Open Innovation Ramesh Durvasula, Ph.D. Communications Officer, Pistoia Alliance Director, Chemistry Informatics, BMS BioIT World 2010
  2. 2. Agenda • Origins of Pistoia – History – Industry Drivers – Technology Trends • Scope and Operations of Pistoia – Mission, Membership, Governance – Projects and Deliverables • Discussion
  3. 3. Industry Driver: Externalization Cost pressures, disruptive technologies, and other forces often drive business processes to be externalized. Fully Internal Model Selectively PHARMA Integrated CHEM CRO Model BIO CRO DATA CRO
  4. 4. Emerging Net-centric Pharma Processes PHARMA CRO 1 1 PHARMA CRO 2 2 PHARMA CRO 3 3 CRO 4
  5. 5. Inconsistent Semantics degrade Effective Communication C B A The result from our proprietary assay is “B” CRO But we only record numbers in our assays!! PHARMA
  6. 6. Greater Challenge: Unknown Semantic Collisions Image/quote from Abdul-Malik Shakir Revealing assumptions is an essential component of effective communication.
  7. 7. Opportunity: Changing Tech Landscape More Robust Technologies • Web 2.0 / 3.0 • Services-Oriented Architecture • Software-as-a-Service • Open Source Initiatives More Robust External Content • Publicly available chem and bio sources • Richer literature content • Academic Sources of Tools and Data
  8. 8. The Path Forward: Standardize, Simplify, Centralize • Standardize our interfaces and messages • Simplify our cross-industry architectures and support models • Centralize services to reap economies of scale and scope
  9. 9. Background—How it all started • In Pistoia, Italy • Meeting of GSK, AZ, Pfizer and Novartis— identified similar challenges and frustrations in discovery informatics 9
  10. 10. Pistoia Mission • The Mission – Pistoia will standardize and streamline data interchange in life science R&D. • The Method – Precompetitive collaboration between life science, academia, and commercial partners. • The Result – Standardization will drive down the cost of data exchange, cloud computing, and process outsourcing. • The Benefit – Informatics organizations can streamline commodity services, and focus investment on innovation in R&D.
  11. 11. Benefits of Pistoia • R&D Organizations – Optimized investments • e.g. reduction of redundant investments across industry – Increased agility to leverage global R&D • Rapid integration, streamlined data interchange and analysis • Informatics Solution Providers – New markets and business models – Reduced cost-of-entry to markets – Reduction of customized solutions, leading to higher margins
  12. 12. Pistoia Membership updated: April 2010
  13. 13. Pre-competitive Space in the Technology Lifecycle Experiment Innovation Mainstream Precompetitive Space Opportunities for Standards Commodity Legacy
  14. 14. Crossing the Chasm • Pistoia is the BRIDGE to cross the chasm to a more agile pre-competitive environment STANDARDIZE SIMPLIFY CENTRALIZE PISTOIA MEMBERS SUPPLIERS
  15. 15. Learn from Other Industries Transportation Geospatial Banking Retail Clinical Automotive Healthcare
  16. 16. Scope of Pistoia Efforts Target ID Hit ID Lead ID Lead Opt Phase I Phase II Phase III Which Disease? Which Target? Which Compound? What Biomarkers? Disease Association DMPK Properties? CD positioning? Bioprocess Assoc BioAssay Development Safety Biomarkers? Druggability Activity-Dose studies? Efficacy Biomarkers? ‘On Target’ Safety Risk ‘Off Target’ Safety Risk? … Validation Tools Synthesis routes? Competitive Position Competitive Position? Variant Selection … … Genome/Genetic Data Genome/Genetic Data Sequence Data Expression Data Structural Data Pathway Data Patent Data Pharmacology Data Literature Data 16
  17. 17. Pistoia Standards Process Governance & Pistoia Working Life Science Operations Groups Community Governance Software and & Strategy Service Board Providers propose, Technical & comment Standards Pharma/ Operational Teams BioTech/Agro Team publish Not for coordinate Profit (e.g. IMI, EBI) 17
  18. 18. Current, Active Pistoia Projects • Semantic Enrichment of Scientific Literature – An open knowledge brokering framework standard which will reduce the costs of integration from disparate sources. • Sequence Services – A standard service to provide access to public, private & commercial data & tools, that will enable scientists to search, store & analyse all their sequence based data in a single web interface. • ELN Query Service – A query service standard applicable for use with data types commonly found in electronic lab notebooks
  19. 19. SESL: Biomedical Knowledge Service Framework Multiple Consumers Target Compound Disease Network Knowledge Dossier Dossier Dossier Viz Applications Service Layer Std Public Common Proprietary Open Assertion & Meta Data Mgmt Vocabularies Service Service Stds Transform / Translate Business Broker Broker Consumer Integrator Rules Firewall Supplier Content Firewall Suppliers Db 2 Effort required Db 4 to fit DBs to Corpus 1 service layer Db 3 Corpus 5
  20. 20. A Production SESL Service Consumer Exemplar Disease Dossier Side Application License Service Layer Std Public Service Layer Std Public Service Layer Std Public Service Layer Std Public Vocabularies Vocabularies Vocabularies Vocabularies Assertion & Meta Data Mgmt Assertion & Meta Data Mgmt Assertion & Meta Data Mgmt Assertion & Meta Data Mgmt Transform / Translate Business Transform / Translate Business Transform / Translate Business Transform / Translate Business Rules Rules Rules Rules Integrator Integrator Integrator Integrator Broker Org #1 Broker Org #2 Broker Org #3 Broker Org #4 Corpus 1 Db 3 Corpus 5 Db 7 Corpus 9 Db 11 Corpus 13 Db 15 Corpus 4 Corpus 8 Corpus 12 Corpus 16 Db 2 Db 6 Db 10 Db 14 Supplier Side
  21. 21. SESL Mock Up Slide 1 Gene: abc Relationship: Any Disease: Diabetes Constraint: Species: Any Tissue: Any
  22. 22. SESL Mock Up Slide 2 Export to Network View Pivot on Assertion Gene R’ship Disease Species Evidence 1 abc1 Co-occurs Diabetes Mus Paper UID:1234 2 abc1 Up-Reg Diabetes Homo ArrayExpress: XXX 3 abc2 Co-occurs Diabetes Homo Paper UID:1344 4 abc13 Co-occurs Diabetes Mus Paper UID:1314 5 abc7 Mutation Diabetes Rattus OMIMI: XXX 6 abc1 Co-occurs Diabetes Mus Paper UID:45643 7 abc1 Co-occurs Diabetes Homo Paper UID:2143 8 abc1 Co-occurs Diabetes Mus Paper UID:1204
  23. 23. SESL Mock Up Slide 3 Export to Network View Return Gene R’ship Disease Species Supporting Evidence 1 abc1 Co-occurs Diabetes Mus 3 2 abc1 Co-occurs Diabetes Homo 1 3 abc1 Up-Reg Diabetes Homo 1 4 abc7 Mutation Diabetes Rattus 1 5 abc13 Co-occurs Diabetes Mus 1 6 abc2 Co-occurs Diabetes Rattus 1
  24. 24. Current SESL Participants AstraZeneca Funding GSK Funding Roche Funding Pfizer Funding Unilever FTEs European Bioinformatics Institute FTEs & Hosting Oxford University Press Content Nature Publishing Group Content Elsevier Content Royal Society of Chemistry Content
  25. 25. www.pistoiaalliance.org If you want to go fast, go alone. If you want to go far, go together.
  26. 26. Backup Slides
  27. 27. Where We Are
  28. 28. Who we Are: Board of Directors GSK Accelrys AZ ChemAxon Novartis Symyx Pfizer CambridgeSoft Lundbeck Infosys BMS Thomson Reuters Roche
  29. 29. Pistoia Membership Levels • Core Member ($15,000) – Those organisations wishing to strongly influence the strategy & direction of the Alliance – Have a majority on the Governance & Strategy Board – Pharma, Life Science, Chemicals/Biologics primary business focus • Participating Member ($10,000) – Those wishing to influence the technical outcomes – Access to Governance & Strategy Board member openings – Technical & Standards Team voting • Contributing Member (free) – Technical & Standards Team voting member – Working Group participation – Offer opinions on technical issues Based around the experiences of: http://www.consortiuminfo.org/

×