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Lactobacillus Pro-t-action is a revolutionary innovation of the German BASF Future Business GmbH company, developed from probiotic cultures of the L. paracasei bacteria. The special characteristic of Pro-t-action is that it reacts only with the cavity-causing bacteria, and it does not affect the number of other bacteria in the mouth. According to the recent studies presented at international conferences, Lactobacillus pro-t-action reduces the number of S. mutans bacteria, the most responsible pathogens in forming cavities, to even up to 50% if used daily. The new toothpaste Plidenta Pro-t-action was developed by the experts in Croatian based cosmetic company Neva, an Atlantic Group member, as the first toothpaste in the world to contain this probiotic culture. The clinical testing conducted by doc.dr.sc. Dubravka Negovetić Vranić and prof.dr.sc. Martina Majstorović was the first such testing of a toothpaste with the probiotic Lactobacillus paracasei bacteria in the world. The Ministry of Health and Social Welfare of the Republic of Croatia listed Plidenta Pro-t-action toothpaste as a special use cosmetics.