Dr Wei, Tsai and Chou published a highly-citated paper showing that HLA-B60 and B61 are strongly associated with B27-negative AS in Taiwan.
Dr Wei and colleagues in Chung Shan medical university had set up an AS databank to investigate the association of AS genotype and clinical phenotype. They had found that MMP-3/ TIMP alleles correlate to disease activity and functional index of AS.
They also collaborated with Prof Brown in Australia and found that IL1 gene complex was associated with AS in Taiwanese Chinese.
Moreover, investigators from Taiwan, China and Prof David Yu in UCLA had close collaboration to discover candidate biomarker for spondyloarthritis by microarray and rt-PCR.
They had found RGS1 as candidate biomarker for USpA, as well as NR4A2, IL-8…etc.
台灣僵直性脊椎炎資料庫 Ankylosing Spondylitis Databank Project in Taiwan 魏 正 宗 James Cheng-Chung Wei, M.D., Ph.D. 中山醫學大學附設醫院過敏免疫風濕科主任 Director, Division of Allergy, Immunology & Rheumatology Chung Shan Medical University Hospital, Taichung, Taiwan Chairman, Taiwan AS caring society
Psochometric validation of the Chinese version of Bath indices : Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), and Bath Ankylosing Spondylitis Global Index (BAS-G
Chinese version of Bath indices Reliability of BASDAI 、 BASFI 、 BAS-G James Cheng-Chung Wei , Ruey-Hong Wong,Jun-Huang Huang, Chen-Tung Yu, Chung-Tei Chou, Ming-Shiou Jan, Gregory J. Tsay, Ming-Chih Chou, Hong-Shen Lee. Clin Rheumatol 2007;26:1685-1691 BASDAI BASFI BAS-G Number of items in Scale 6 10 2 Cronbach’s coefficient Alpha 0.85 0.94 0.91 ICC Test/Retest 0.93 0.92 0.94
BASDAI 活性量表 Bath Ankylosing Spondylitis Activity Index James Cheng-Chung Wei, Ruey-Hong, Ming-Chih Chou, Hong-Shen Lee. Clin Rheumatol (2007) 26:1685–1691
Clinical manifestations Variables Patient number (%) History of the buttock pains and back, no. (%) 755 (93.44) History of peripheral arthritis, no. (%) 518 (64.43) History of uveitis, no. (%) 195 (24.19) History of psoriasis, no. (%) 112 (13.90) History of hematuria no. (%) 55 (6.86) History of oral ulcer, no. (%) (n=805) 94 (11.68) Onset symptom, no. ( peripheral arthristis / enteritis / back pain / uveitis) (%) ( 21.55 /2.96/50.56/2.54) HLA-B27 positive 91.2 % Family history of spondyloarthritis 349 (43.35)
HS-CRP Variable HS-CRP- p value HSCRP- r BASDAI 0.0005 0.15117 BASFI 0.0002 * 0.16228 BAS-G 0.0001 * 0.22709