1752 0509 3 46 S1


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1752 0509 3 46 S1

  1. 1. ADDITIONAL FILE 1: Annotation of Genetic Association Database (GAD) to collapse similar phenoty Final phenotype label: aggression alcohol abuse
  2. 2. allergy
  3. 3. alopecia areata Alzheimer`s disease
  4. 4. amyloidosis amyotrophic lateral sclerosis anemia
  5. 5. aneurysm ankylosing spondylitis anxiety disorder
  6. 6. arthritis arrhythmia arthritis, juvenile
  7. 7. asthma
  8. 8. ataxia
  9. 9. atherosclerosis
  10. 10. attention deficit hyperactivity disorder autism autoimmune diseases
  11. 11. Behcet's Disease benzene toxicity berylliosis Bipolar Affective Disorder
  12. 12. bladder cancer blood pressure
  13. 13. Body Mass
  14. 14. bone disorders
  15. 15. brain cancer breast cancer
  16. 16. bronchopulmonary disease
  17. 17. cancer
  18. 18. Carbamazepine hypersensitivity cardiomyopathy cardiovascular disease
  19. 19. carotid atherosclerosis
  20. 20. celiac disease cerebrovascular disease
  21. 21. cervical cancer Charcot-Marie-Tooth disease cholangitis, sclerosing cholelithiasis cholestasis cholesterol
  22. 22. chronic fatigue syndrome chronic obstructive pulmonary disease
  23. 23. cirrhosis cleft lip and palate coagulation disorders
  24. 24. cognitive function colorectal cancer
  25. 25. congenital heart anomalies congenital disorders
  26. 26. coronary artery disease
  27. 27. C-reactive protein
  28. 28. Crohn's disease cystic fibrosis dementia depression
  29. 29. dermatitis, atopic diabetes, gestational
  30. 30. diabetes, type I diabetes, type II
  31. 31. diabetic nephropathy diabetic neuropathy diabetic retinopathy disc disease
  32. 32. DNA damage eating disorders EKG, abnormal emphysema end stage renal disease endocrine disorders
  33. 33. endometrial cancer endometriosis epilepsy
  34. 34. esophageal cancer Familial Mediterranean Fever gastric cancer gastrointestinal disorders
  35. 35. giant cell arteritis glaucoma glucose tolerance
  36. 36. graft versus host disease Grave`s disease H. pylori infection
  37. 37. head and neck cancer hearing loss
  38. 38. heart failure hemochromatosis red blood cell disorders
  39. 39. hepatitis B hepatitis C
  40. 40. HIV homocysteine
  41. 41. HTLV-1 infection Huntington's disease hypertension
  42. 42. immune markers
  43. 43. infection
  44. 44. infertility
  45. 45. Inflammatory Bowel Disease insulin sensitivity
  46. 46. intrauterine growth
  47. 47. kawasaki disease keloid disease kidney disease
  48. 48. lead toxicity left ventricular hypertrophy leukemia
  49. 49. leukemia, childhood acute lymphoblastic lipoproteins
  50. 50. liver cancer
  51. 51. liver disease long QT syndrome longevity lung cancer
  52. 52. lung function/disorders
  53. 53. lupus erythematosus lymphoma
  54. 54. lymphoma, Hodgkin's disease macular degeneration malaria mammographic density
  55. 55. melanoma memory impairment menopause metabolic disorders
  56. 56. metabolic syndrome migraine mood disorders multiple sclerosis myasthenia gravis
  57. 57. myeloma, multiple myocardial infarction
  58. 58. myopathy nephropathy, IgA neural tube defects neurological disorders
  59. 59. Obesity obsessive compulsive disorder oral submucous fibrosis osteoarthritis
  60. 60. osteoporosis ovarian cancer pancreatic cancer pancreatitis
  61. 61. Parkinson's Disease pemphigus periodontitis personality traits
  62. 62. polycystic kidney disease polycystic ovarian syndrome posttraumatic stress disorder preeclampsia pregnancy complications
  63. 63. pregnancy loss preterm delivery prostate cancer prostatic hyperplasia
  64. 64. psoriasis psychosis pulmonary fibrosis renal cancer
  65. 65. reproductive dysfunction respiratory distress syndrome restenosis retinopathy rheumatic heart disease rheumatoid arthritis
  66. 66. sarcoidosis schizophrenia
  67. 67. sclerosis, systemic sepsis SIDS/sudden infant death syndrome
  68. 68. silicosis Sjogren's syndrome skin cancer, nonmelanoma sleep disorders smoking
  69. 69. spinal ossification spondyloarthropathies stroke substance abuse
  70. 70. suicide
  71. 71. testicular cancer thromboembolism, venous thrombosis thyroid cancer
  72. 72. Tourette syndrome transplant rejection
  73. 73. triglycerides tuberculosis
  74. 74. ulcerative colitis Vascular Disease vasculitis vision problems
  75. 75. Wegener's granulomatosis
  76. 76. ILE 1: Annotation of Genetic Association Database (GAD) to collapse similar phenotypes. Phenotype label found in GAD: conduct disorder; hyperkinetic disorder criminal behavior impulse control disorder impulsive behavior impulsive inpatients Aggression and anger-related traits impulsive trait impulsivity; response inhibition aggression, impulsivity, and central nervous system serotonergic responsivity irritability hostility impulsivity and memory aggression; impusivity; sensation seeking aggressive behavior aggressive behavior of chondrosarcoma anger-related traits aggressive personality traits conduct disorder; oppositional defiant disorder; antisocial personality disorder alcohol abuse delirium tremens, alcohol withdrawal-induced; seizures, alcohol withdrawal-induced delirium tremens, alcohol-induced; alcohol withdrawal alcohol abuse; personality disorders alcohol induced liver damage alcoholism and alcoholic liver disease alcoholism; personality traits alcohol abuse; blood pressure, arterial alcohol abuse; cocaine abuse Alcohol Withdrawal alcohol abuse; drug dependence; affective psychoses alcohol abuse; alcohol withdrawal alcohol abuse; impulse control disorder heart muscle disease, alcoholic Alcohol Dependence alcohol abuse; liver disease, alcoholic alcohol abuse; neuroticism alcohol alcohol-use disorders alcohol abuse; nicotine dependence alcohol abuse; smoking behavior alcohol associated symptoms; alcoholism alcohol dependence severity of alcohol dependence alcohol dependence, panic disorder without agoraphobia, generalized anxiety disorder, narcolepsy alcohol dependence; alcoholic psychosis alcohol dependence; cocaine dependence alcohol dependence; drug dependence alcohol dependency alcohol effects alcohol elimination alcohol liver disease alcohol use
  77. 77. alcohol withdrawal alcohol withdrawl seizure and delirium tremens alcohol-dependence naltrexone response in alcohol-dependent patients alcohol-elimination rates alcoholic liver disease alcoholism early onset alcoholism/substance abuse. alcoholism. alcoholism; alcohol withdrawal alcoholism; alcoholic psychosis alcoholism; attention deficit hyperactivity disorder alcoholism; cirrhosis alcoholism; cirrhosis; esophageal cancer; pancreatitis, acute alcoholism; cytogenetic studies alcoholism; delirium tremens, alcohol-induced alcoholism; liver disease, alcoholic alcoholism; pancreatitis; pancreatitis, alcoholic alcoholism; renal disease, end stage alcoholism; suicide alcoholism-related traits alcohol-withdrawal delirium early-onset alcoholism alcohol abuse; behavior problems delirium tremens, alcohol withdrawal-induced allergic bronchopulmonary aspergillosis ABPA Atopy atopy Atopy (IgE) atopic disease purpura, allergic Atopy (total & specific IgE) atopy and influence the signal transduction Hyperresponsiveness pollinosis, cedar atopy. asthma. Netherton Atopy. BHR atopy; dermatitis and eczema atopy; IgE levels atopy-susceptibility atopic eczema hyper-IgE syndrome and severe eczema. atopy Hyper-IgE syndrome. severe eczema. atopy allergic disease allergic diseases Allergic diseases Allergic diseases (bronchial asthma. atopic dermatitis and/or food-related anaphylaxis) allergic rhinitis Allergic Rhinitis pollen-induced allergic rhinitis allergies allergies; common cold allergy
  78. 78. Contact Allergy pollen allergy rhinitis bee venom allergy contact hypersensitivity Contact Sensitisation Latex allergy latex allergy allergy, latex; latex allergy allergy, latex; latex allergy; pemphigoid, bullous latex-fruit syndrome nut allergy penicillins allergy alveolitis, extrinsic allergic fibrosing alveolitis irritant contact dermatitis alopecia and lumbar herniated disk alopecia areata Alopecia areata alzheimer`s Disease Alzheimer`s disease Alzheimer's disease; Wernicke-Korsakoff syndrome alzheimer`s disease Alzheimer's disease; Abeta load; Abeta42 concentration Alzheimer's disease; Huntington's disease; progressive supranuclear palsy; dementia, frontotemporal Alzheimer`s Disease Alzheimer's Disease Alzheimer's disease; NEUROLOGICALenerative disease Alzheimer's disease; brain lesions or calcifications Alzheimer's Disease and Vascular Dementia familial Alzheimer's disease associated early-onset familial Alzheimer's disease late-onset Alzheimer's disease. late-onset AD late-onset Alzheimer's disease Alzheimer's Disease/Coronary artery disease Alzheimer's disease; Abeta load Alzheimer's disease; Abeta load in brain Alzheimer's disease; aggressive behavior Lewy Body Formation Alzheimer's disease; aggressive behavior; psychotic symptoms Alzheimer's disease; ALS/amyotrophic lateral sclerosis Alzheimer's disease; anxiety disorder; depression; psychoses; aggressive behavior Alzheimer's disease; arthritis; lupus erythematosus; inflammatory bowel disease; insulin; malaria Alzheimer's disease; asthma Alzheimer's disease; atherosclerosis, coronary Alzheimer's disease; attention deficit disorder; conduct disorder; oppositional defiant disorder; dementia, front Alzheimer's disease; chronic obstructive pulmonary disease/COPD Alzheimer's disease; cognitive function Alzheimer's disease; coronary artery disease; diabetes, type 2; dementia, vascular Alzheimer's disease; delusional disorder; aggressive behavior Alzheimer's disease; dementia Alzheimer's disease; dementia, vascular
  79. 79. Alzheimer's disease; depressive disorder, major Alzheimer's disease; Down syndrome Alzheimers disease; juvenile arthritis Alzheimer's disease; Lewy body disease Alzheimer's disease; multiple sclerosis; HIV Alzheimer's disease; Parkinson's disease Alzheimer's disease; Parkinson's disease; insulin; lung function; depression; longevity Alzheimer's disease; Parkinson's disease; multiple system atrophy Alzheimer's disease; Parkinson's disease; progressive supranuclear palsy; dementia, frontotemporal; multiple s Alzheimer's disease; psychoses Alzheimer's disease; psychosis Alzheimer's disease; schizophrenia Alzheimer's disease; triglycerides; atherosclerosis, coronary Alzheimer's disease; vascular dementia Alzheimer's disease; vascular disease Alzheimer's disease; vascular endothelial growth factor levels cerebral amyloid angiopathy cutaneous lichen amyloidosis. Vitreous amyloidosis secondary and FMF amyloidosis. amyloid cardiomyopathy early-onset aggressive diffuse amyloidosis cerebral amyloid angiopathy; senile plaques Massive leptomeningeal amyloidosis cerebral amyloid angiopathy-related hemorrhage. amyloidosis amyloidosis; Familial Mediterranean Fever familial amyloid polyneuropathy. familial amyloidotic polyneuropathy. amyloid polyneuropathy familial amyloid polyneuropathy familial amyloid polyneuropathy in a Hungarian family. Familial amyloidotic polyneuropathy type 1 renal amyloidosis cerebral amyloid angiopathy. ALS/amyotrophic lateral sclerosis sporadic amyotrophic lateral sclerosis ALS/amyotrophic lateral sclerosis; progressive muscular atrophy earlier age at onset in amyotrophic lateral sclerosis. amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis familial amyotrophic lateral sclerosis familial amyotrophic lateral sclerosis. rapidly progressive familial amyotrophic lateral sclerosis slowly progressive ALS amyotrophic lateral sclerosis cause novel protein interactions syndrome mimicking amyotrophic lateral sclerosis. anemia anemia in pregnancy anemia, aplastic fanconi anemia poikilocytic anemia
  80. 80. hemolytic anemia cyclosporine-dependent aplastic anemia aplastic anaemia aplastic anemia, acquired chronic hemolytic anemia chronic nonspherocytic anemia. chronic non-spherocytic haemolytic anaemia. McLeod syndrome erythrocytosis, idiopathic blood and blood forming organ disorders microcytosis Fanconi Anemia anemia, iron deficiency anemia, iron deficiency; anemia of chronic disease anemia, malaria related; malaria, cerebral anemia; thrombocytopenic purpura, idiopathic sickle cell and thalassaemia genes sickle cell anemia sickle cell anemia; G6PD deficiency sickle cell anemia; thalassemia; Gilbert syndrome G6PD deficiency sickle cell disease chronic haemolytic anaemia. haemolytic anaemia hereditary haemolytic anaemia. hereditary nonspherocytic hemolytic anemia (HNSHA). Bloom syndrome; Fanconi's anemia Bloom's syndrome hereditary hemolytic anemia hereditary hemolytic anemia. sickle cell aneurysm, abdominal aortic abdominal aortic aneurysm Abdominal aortic aneurysm brain aneurysm brain hemorrhage; brain aneurysm aneurysm, intracranial intracranial aneurysm intracranial aneurysms aneurysmal subarachnoid hemorrhage aneurysmal subarachnoid hemorrhage. differential expansion rates of small abdominal aortic aneurysms ruptured intracranial aneurysms ankylosing spondylitis Ankylosing spondylitis juvenile ankylosing spondylitis ankylosing spondylitis independent of HLA-B27 Chinese ankylosing spondylitis patients delusional disorder antisocial substance dependence. antisocial personality disorder anxiety disorder; alcoholism; panic disorder; narcolepsy antisocial behavior
  81. 81. anxiety Panic Disorder panic disorder; psychoses; substance abuse panic disorder Panic disorder stress disorder panic disorder; migraine somatic anxiety aura anxiety and depression Anxiety and hostility and depression anxiety disorder anxiety disorder; alcohol abuse anxiety disorder; alcoholism anxiety disorder; alcoholism; depression; narcolepsy anxiety disorder; blood pressure, arterial; memory impairment anxiety disorder; depression anxiety disorder; depressive disorder, major; panic disorder anxiety disorders anxiety symptoms Anxiety traits caffeine-induced anxiety. neuroticism neuroticism; agreeableness anxiety-related temperament and behavior problems anxiety-related traits arthritis early polyarthritis reactive arthritis Still's disease inflammatory polyarthritis. arthritis, psoriatic Reiter's syndrome arthritis, rheumatoid systemic juvenile idiopathic arthritis arthritis; asthma; diabetes, type 1; pemphigus; IL-1RI polyarthritis Blau Syndrome arthritis; Familial Mediterranean Fever arthritis; felty's syndrome; large granular lymphocyte syndrome arthritis; lupus erythematosus; Still's disease arthritis; diabetes, type 2; osteoarthritis; liver disease; acenocoumarol response arthritis; cholesterol, HDL; diabetes, type 2; osteoarthritis; blood pressure, arterial; liver disease; acetaldehyd arthritis; diabetes, type 1; pregnancy loss, recurrent; juvenile arthritis; pemphigus; IL-1RI Brugada syndrome cardiac arrhythmias and sudden death heart rate; arrhythmia, cardiac arrhythmia, cardiac normal and arrhythmia ventricular arrhythmia, malignant arthritis, juvenile juvenile arthritis juvenile arthritis; measles juvenile oligoarthritis
  82. 82. Juvenile Idiopathic Arthritis juvenile idiopathic arthritis Juvenile Idiopathic arthritis Allergic asthma Asthma and Allergic Rhinitis Atopic asthma. BHR. total IgE. SPT Childhood atopic asthma Atopy. asthma Atopy. spIgE. total IgE. asthma. atopic asthma Atopy/ Asthma asthma phenotypes asthma, aspirin-induced Asthma. allergic rhinitis Asthma. atopy (IgE) Asthma. BHR. eosinophilia. total IgE Asthma. BHR. total IgE. airway obstruction. FEV1 & FVC increased Asthma. DRS Asthma. DRS. BHR. eosinophilia. total IgE Asthma. DRS. eosinophilia Asthma. DRS. total IgE Asthma. DRS. Total IgE Asthma. DRS. total IgE. eosinophilia Asthma. Total IgE. Eosinophilia. DRS Asthma. total IgE. SPT asthma; bronchial hyperresponsiveness asthma; diabetes, type 1 asthma Asthma Physician diagnosed asthma asthma (childhood) asthma and atopy nonatopic asthma and food allergy Asthma. Atopy. specific IgE. total serum IgE asthma and IgE in childhood Asthma drug response Asthma in men Steroid-requiring asthma in sedentary women Asthma or Atopy Asthma severity Asthma smokers Aspirin-induced asthma asthma, aspirin-induced; urticaria, aspirin-intolerant Atopic asthma atopic asthma childhood asthma Childhood Asthma childhood asthma. childhood atopic asthma Mite-sensitive asthma Nocturnal asthma Severe asthma asthma. Asthma. asthma severity
  83. 83. Asthma. atopy Asthma. atopy. atopic dermatitis Asthma. atopy. spIgE. Asthma. BHR. Total IgE. SPT asthma. FEV(1) Asthma. FEV1 Asthma. rhinitis Asthma. total IgE Asthma. total serum IgE asthma; allergen sensitization asthma; allergic disease asthma; allergic disease, IgE mediated asthma; allergic rhinitis asthma; allergic rhinitis; atopic dermatitis asthma; allergies asthma; allergy asthma; aspirin intolerance asthma; atopic dermatitis Atopy. airway obstruction. BHR. asthma asthma; atopy asthma; atopy; dermatitis and eczema asthma; atopy; juvenile arthritis asthma; candidiasis; high-altitude illness asthma; chronic obstructive pulmonary disease asthma; chronic obstructive pulmonary disease/COPD asthma; dermatitis and eczema asthma; dermatitis and eczema; anaphylaxis, food-related asthma; dermatitis and eczema; rhinitis asthma; dermatitis, atopic; chronic obstructive pulmonary disease asthma; dermatitis, atopic; rhinitis, allergic asthma; eczema; allergic disease asthma; endothelium dependent dilatation asthma; folate; hyperhomocystinemia asthma; HIV disease progression asthma; IgE asthma; juvenile arthritis asthma; lipids; C-reactive protein; obesity; glucose; leptin; atopy asthma; lipids; memory impairment asthma; respiratory syncytial virus; juvenile arthritis asthma; rhinitis asthma; urticaria bronchial asthma Bronchial asthma Bronchial asthma (childhood & adult) Bronchial asthma (childhood only) Bronchial hyperreactivity BHR bronchial hyperresponsiveness persistent bronchial hyperresponsiveness airway hyperresponsiveness Decreased airway responsiveness ataxia ataxia (SCA)
  84. 84. ataxia telangiectasia episodic ataxia type 2 Friedreichs ataxia ataxia-telangiectasia fragile X associated tremor/ataxia syndrome fragile X-associated tremor/ataxia syndrome spinocerebellar ataxia spinocerebellar ataxia type 1 spinocerebellar ataxia type 6 spinocerebellar ataxia; muscular dystrophy; neuropathy aortic valve sclerosis arterial disease atherosclerosis and lipid transport atherosclerosis, coronary; diabetes, type 2; hypertension; diabetic nephropathy; retinopathy, diabetic; diabete atherosclerosis, coronary; lipids; longevity; apoB levels atherosclerotic diseases arterial disease, renal atherosclerosis Atherosclerosis progression of carotid atherosclerosis blood pressure and serum lipids atherosclerosis, carotid atherosclerosis, coronary Coronary Atherosclerosis atherosclerosis, coronary; acute coronary syndrome atherosclerosis, coronary; atherosclerosis, carotid atherosclerosis, coronary; cholesterol, LDL atherosclerosis, coronary; cirrhosis, alcoholic atherosclerosis, coronary; diabetes, type 1; nephropathy in other diseases atherosclerosis, coronary; diabetes, type 2 atherosclerosis, coronary; diabetes, type 2; C-reactive protein atherosclerosis, coronary; diabetes, type 2; lipids; stroke, ischemic atherosclerosis, coronary; diabetes, type 2; lipoprotein atherosclerosis, coronary; fibrinogen atherosclerosis, coronary; FVII levels atherosclerosis, coronary; hematology indices atherosclerosis, coronary; homocysteine atherosclerosis, coronary; hypercholesterolemia atherosclerosis, coronary; hypertension atherosclerosis, coronary; hypertension; Fabry's disease atherosclerosis, coronary; hypertriglyceridemia atherosclerosis, coronary; lipid metabolism disorders atherosclerosis, coronary; lipids atherosclerosis, coronary; lipoprotein atherosclerosis, coronary; lipoprotein; lipids atherosclerosis, coronary; lipoproteins atherosclerosis, coronary; longevity atherosclerosis, coronary; metabolic syndrome atherosclerosis, coronary; metabolism disorders atherosclerosis, coronary; myocardial dysfunction, non-ischaemic atherosclerosis, coronary; stroke, ischemic atherosclerosis, coronary; stroke; adiponectin atherosclerosis, coronary; tuberculosis atherosclerosis, generalized
  85. 85. atherosclerosis, generalized; vascular disease atherosclerosis; angina atherosclerosis; coronary vascular endothelial dysfunction atherosclerotic disease atherosclerotic lesions atherothrombosis Atherothrombosis atherothrombotic cerebral infarction. coronary atherosclerosis coronary atherosclerosis. coronary atherosclerotic heart disease in Chinese Atherosclerotic Vascular Disease Aortic atherosclerosis in diabetes mellitus aortic stenosis calcific aortic valve stenosis supravalvular aortic stenosis renal artery stenosis vessel stenosis attention deficit hyperactivity disorder hyperkinetic conduct disorder attention-deficit disorder ADHD subtypes externalizing behavior problems; hyperactivity severe hyperkinetic disorders hyperkinetic disorder Child hyperactivity-impulsivity and oppositional behaviors Attention Defict/ Hyperactivity Disorder ADHD ADHD and conduct disorder attention deficit disorder attention deficit disorder; conduct disorder; aggressive behavior attention deficit disorder; conduct disorder; oppositional defiant disorder attention deficit disorder; seasonal affective disorder attention deficit hyperactivity disorder; reading disability attention deficit hyperactivity disorder-like phenotype attention problems attention-deficit hyperactivity disorder Attention-deficit/hyperactivity disorder autism Autism autism spectrum disorder autism; Asperger syndrome alexithymia susceptibility to autoimmune disease ANCA positive patients type 1 autoimmune hepatitis Semple rabies vaccine-induced autoimmune encephalomyelitis antineutrophil cytoplasmic antibody; (ANCA)-associated vasculitis cryoglobulinemia anti-Ro 52-kd autoantibodies polymyositis and dermatomyositis. polymyositis; dermatomyosis anaphylactoid purpura
  86. 86. PR3-ANCA and MPO-ANCA associated vasculitis autoimmune disease Autoimmune hepatitis type 1 autoimmune pancreatitis Autoimmune thyroid disease autoimmune thyroiditis autoimmune; polyendocrinopathy-candidiasis-ectodermal dystrophy; polyendocrinopathy-candidiasis-ectoderm autoimmune hepatitis Autoimmune Hepatitis autoimmune hypothyroidism inflammatory disease autoimmune inflammatory disease systemic inflammatory response syndrome autoimmune myasthenia gravis autoimmune nephritis autoimmune polyglandular syndrome autoimmune thyroid disease autoimmune thyroid disease; thyroid disease, autoimmune autoimmune thyroid diseases hypothyroidism, autoimmune autoimmune-associated congenital heart block. autoimmunity beta cell autoimmunity thyroid autoimmunity autoimmunity/lymphoproliferation three autoimmune disease anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides hepatitis type 1, autoimmune (AIH-1) hepatitis, autoimmune autoimmune hepatitis types 1 and 2 hepatitis, autoimmune; hepatitis, chronic thryoiditis, chronic lymphocytic thyroiditis, chronic lymphocytic Hashimoto's thyroiditis in an Italian population. thyroiditis, Hashimoto's vitiligo vitiligo; autoimmune disease Vogt-Koyanagi-Harada syndrome Vogt-Koyanagi-Harada's disease vitiligo susceptibility thryoiditis, subacute granulomatous Behcet's Disease Behcet's disease; retinal vasculitis; uveitis Recurrent aphthous stomatitis Behcet's disease; vasculitis benzene toxicity berylliosis beryllium disease Bipolar Affective Disorder bipolar disorder; major depressive disorder BP-Major Depressive bipolar affective disorder bipolar affective disorder.
  87. 87. bipolar affective disorder; unipolar affective disorder bipolar disorder; major depressive disorder; rapid cycling mood disorder bipolar and unipolar disorder major and bipolar depressives bipolar disorder Bipolar disorder bipolar disorder; affective disorder bipolar disorder; affective psychoses bipolar disorder; depression bipolar disorder; mania, antidepressant-induced bipolar disorder; unipolar disorder bipolar I disorder bladder cancer Bladder Cancer Cigarette Smoking- Related Bladder Cancer Urinary Bladder Cancer urinary bladder cancer bladder cancer, urinary bladder cancer. bladder cancer; cytogenetic studies bladder cancer; prostate cancer transitional cell carcinoma of the bladder. superficial bladder tumors blood pressure ACE concentration and blood pressure blood pressure; left ventricular mass; atherosclerosis, carotid systolic blood pressure variation hypotension hypotension, orthostatic Blood Pressure blood flow blood flow; blood pressure, arterial; heart rate blood flow; vascular response; oxidative stress; nitirc oxide production; nitric oxide-mediated effect on resistan systolic blood pressure higher blood pressure after hospitalization in normotensi elevated blood pressure and personality disorders decreased blood pressure and plasma triglycerides blood pressure phenotypes. blood pressure, arterial blood pressure, arterial; adiponectin blood pressure, arterial; arterial wall changes blood pressure, arterial; atherosclerosis blood pressure, arterial; carotid atherosclerosis blood pressure, arterial; cystic fibrosis blood pressure, arterial; heart rate blood pressure, arterial; nephropathy in other diseases blood pressure, arterial; heart rate; adrenaline; coronary flow velocity; ECG; noradrenaline blood pressure, arterial; heart rate; orthostatic intolerance blood pressure, arterial; left ventricular mass blood pressure, arterial; nitric oxide production; salt sensitivity blood pressure, arterial; renin activity; aldosterone blood pressure, arterial; sodium hemostatis diastolic blood pressure
  88. 88. blood pressure; aldosterone blood pressure; aldosterone; glomerular filtration rate; renal plasma flow blood pressure; heart rate blood pressure; hyperlipidemia, familial combined Excessive fat accumulation regional fat distribution fat level and partitioning body mass; atherosclerosis, coronary; eating behavior body mass; cholesterol; cholesterol, HDL; triglycerides; diabetes, type 2; insulin sensitivity; insulin secretion; body mass; cholesterol; insulin; glucose; blood pressure, arterial; sleep apnea; triglyceral body mass; diabetes, type 2; insulin; lipids; adiponectin body mass; obesity, localized body mass; polycystic ovary syndrome; testosterone Body Weight. Bone Mineral Density. and Osteoporotic body composition Body Composition and Muscle Strength body composition changes dietary intake and body composition Adiposity subcutaneous fat accumulation body mass; lipoproteins; blood pressure; CrossLaps, urinary; osteocalcin waist circumference weight gain weight gain (antipsychotic-drug induced) weight gain, antipsychotic drug-induced weight loss weight maintenance body fat body fat distribution body fat; insulin resistance body height body mass larger body mass BMI BMI. Fat Mass. and Leptin Levels body mass index Body Mass Index higher body mass index lower body mass index body mass index and waist circumference body mass index in women. body mass index, blood pressure and cholesterol minimum lifetime body mass index body mass; adiposity body mass; birth weight; height body mass; body fat body mass; bone density body mass; cholesterol, HDL; blood pressure body mass; cholesterol, HDL; insulin; folate; homocysteine body mass; cholesterol, HDL; triglycerides; diabetes, type 2; cholesterol, LDL; hypertension; atherosclerosis body mass; cholesterol, LDL; cholesterol, total; insulin; apoB body mass; cholesterol; cholesterol, HDL; lipoprotein, LDL; triglycerides body mass; cholesterol; cholesterol, HDL; triglycerides; blood pressure; insulin resistance
  89. 89. body mass; cholesterol; diabetes, type 2; blood pressure body mass; cholesterol; hypertension; glucose tolerance; insulin; blood pressure, arterial body mass; cholesterol; triglycerides; blood pressure body mass; cholesterol; triglycerides; insulin; glucose; blood pressure, arterial body mass; diabetes, type 2 body mass; diabetes, type 2; energy expenditure body mass; diabetes, type 2; glucose tolerance; insulin body mass; diabetes, type 2; glucose; birth weight body mass; diabetes, type 2; hypertension; albuminuria; glycohemoglobin A1 body mass; diabetes, type 2; insulin; glucose; body fat body mass; diabetes, type 2; insulin; glucose; HbA(1c) body mass; diabetes, type 2; leukemia; breast cancer; glucose; cytogenetic studies; birth weight; body mass; glucocorticoids body mass; glucose body mass; glucose tolerance; insulin; blood pressure; C-peptide; HbA1c body mass; glucose tolerance; insulin; lipids; blood pressure, arterial; heart rate; autonomic nervous system body mass; glucose tolerance; insulin; obesity body mass; glucose; insulin secretion body mass; height; weight body mass; hemoglobin A(1c) body mass; hypertension; insulin sensitivity body mass; hypertension; insulin; lipids body mass; insulin body mass; insulin sensitivity body mass; insulin; glucose body mass; insulin; glucose; nervous system activity body mass; insulin; lipids; left ventricular hypertrophy; glucose; blood pressure, arterial; metabolic syndrome body mass; insulin; lipids; obesity body mass; insulin; lipids; obesity; glucose; blood pressure; cortisol, salivary; leptin; leptin; testosterone body mass; insulin; obesity; glucose body mass; insulin; polycystic ovary syndrome; hormone disturbance; sex hormones body mass; left ventricular function; blood pressure; left ventricular structure body mass; leptin body mass; leptin; fat mass body mass; lipids body mass; muscle testing body mass; muscle testing; IGF-I body mass; obesity body mass; triglycerides; blood pressure, arterial body mass; triglycerides; diabetes, type 2; glucose body mass; triglycerides; cholesterol, total; blood pressure; leptin; apoA1; apoA2; fasting blood sugar; fasting Body Weight body weight increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins Body Weight Regulation body weight; seasonal affective disorder bone characteristics bone density vertebral fracture scoliosis pseudoachondroplasia and multiple epiphyseal dysplasia prevalent vertebral fractures Frailty in older women
  90. 90. chondrocalcinosis idiopathic scoliosis osteonecrosis osteonecrosis; thrombophilia; hypofibrinolysis human vitiligo or osteopetrosis Ehlers-Danlos syndrome Camurati-Engelmann disease Early postmenopausal bone loss pseudoachondroplasia Strudwick variant of spondyloepimetaphyseal dysplasia Perthes' disease avascular osteonecrosis decreased fracture risk skeletal hyperostosis osteogenesis imperfecta mild osteogenesis imperfecta mild chondrodysplasia osteochondrodysplasias prevalent fractures bone density and spondylosis Bone mineral density bone density; Graves' disease; thyroiditis, Hashimoto's bone density but not spondylosis bone density; bone responsiveness bone density; calcium; fractures, nonvertebral; milk intolerance bone density; coronary calcification bone density; fracture risk bone density; fractures bone density; fractures, vertebral bone density; fractures; osteocalcin bone density; height bone density; height; PTH; pyridinoline, urinary bone density; muscle strength bone density; osteopenia bone density; osteoporosis bone density; spondylosis, lumbar bone density; tricho-dento-osseous syndrome bone fractures skeletal responsiveness to estrogen femoral neck geometry calcium excretion quantitative calcaneal ultrasounds bone loss bone mass combined bone mass very low bone mass osteochondromas hereditary multiple exostoses Hereditary multiple exostoses decreased bone mass in patients bone mass; osteoporotic fractures bone metastases bone mineral density
  91. 91. Bone Mineral Density bone mineral density (BMD) bone mineral density (BMD) / quantitative ultra sound (QUS) Bone mineral mass Bone Mineralization bone remodeling bone resorption bone size Bone Size age-related skeletal disorders Paget disease of bone Legg-Perthes disease Paget's disease Paget's disease of bone low bone-mineral density and rapid postmenopausal bone loss fractures early postmenopausal bone loss at the spine. early marginal bone loss around endosseous dental implants. early marginal bone loss around endosseous implants. brain cancer cerebellar medulloblastomas and cutaneous basal cell carcinomas. brain tumor childhood brain tumor brain tumors adult brain tumors neuroblastoma rapid progression of neuroblastomas Neurofibroma neurofibromas neurofibromatosis 1 Neurofibromatosis type 2 neurofibromatosis1 neurofibromatosis1; Noonan syndrome neurofibromatosis2 isolated unilateral retinoblastoma retinoblastoma retinoblastoma is associated glioblastoma glioblastoma multiforme anaplastic astrocytoma; glioblastoma multiforme Glioma glioma pilocytic astrocytomas gliomas gangliogliomas meningioma oligodendrogliomas astrocytic tumors breast and carcinoma breast cancer; prostate cancer; gastric cancer breast cancer and body mass breast cancer; Hodgkin's disease breast cancer; hormone levels
  92. 92. breast cancer; melanoma breast cancer; prostate cancer; testicular cancer; ovarian cancer breast or ovarian cancer breast/ovarian cancer breast and lung cancer cancer; breast cancer breast and colorectal cancers. breast cancer breast cancer; breast cancer, male breast/ovarian cancer phenotype Breast Cancer increased incidence of invasive breast cancer metastatic breast cancer decreased risk for breast cancer by age 50 breast cancer by the age of 50 years breast cancer cell proliferation using antisense phosphorothioate oligonucleotides breast cancer development breast cancer recurrence breast cancer risk breast cancer risk and prenatal viability breast cancer survival breast cancer susceptibility breast cancer, familial Breast Cancer, male breast cancer, male male breast cancer breast cancer; colorectal cancer breast cancer; colorectal cancer; esophageal cancer; stomach cancer breast cancer; colorectal cancer; liver cancer breast cancer; cytogenetic studies; prostate cancer; longevity breast cancer; endometrial cancer breast cancer; insulin-like growth factor breast cancer; ovarian cancer breast cancer; prostate cancer breast cancer; tamoxifen, prophylactic effect of breast cancer; testosterone; estradiol breast cancer; testosterone; estradiol; morphine glucuronidation breast cancer; thiopurine methyltransferase activity early-stage breast cancers breast carcinoma breast carcinomas non-inflammatory breast carcinomas bronchiectasis familial bronchiectasis. bronchiectasis; common variable immunodeficiency bleomycin-induced pneumonitis chronic lung disease syncytial virus bronchiolitis bronchiolitis obliterans syndrome atypical sinopulmonary disease severe RSV bronchiolitis chronic bronchitis bronchitis; pneumonia
  93. 93. Bronchodilator bronchopulmonary aspergillosis bronchopulmonary dysplasia bronchopulmonary dysplasia. increased aggressiveness cancer Cancer Cell Cancer Cowden syndrome predisposition to cancer cancer predisposition and susceptibility pinealoma Cancer progression and tumor cell motility cancer susceptibility cancer tissues gallbladder cancer Li-Fraumeni and related syndrome non-asbestos-associated mesotheliomas. Li-Fraumeni Syndrome Li-Fraumeni syndrome lymph node involvement and other histopathological indicators of high metastatic potential uterine cancers pituitary cancer malignancy metachronous triple carcinoma metastases metastatic progression and poor survival Multiple familial trichoepithelioma and familial cylindromatosis nevoid basal cell carcinoma syndrome associated tumour characteristics and survival tumor progression tumor progression and patient survival tumor progression of BCR/ABL negative chronic myeloproliferative disorders tumor proliferation and other prognostic indicators tumour grade tumour kinetics and chromosomal instability tumour progression tumour progression and prognosis cancer. cancer; Gilbert syndrome cancer; HIV infection cancer; HIV infection; gastrointestinal bleeding; thiopurine methyltransferase activity cancer; thromboembolism, venous Wilms tumor Wilm's tumor wilms' tumor and congenital male genitourinary malformation adenocarcinoma adenocarcinomas of the parotid gland adenomatous polyposis rhabdomyosarcoma malignant cystosarcoma phyllodes and soft tissue sarcoma malignant mesothelioma; plaques, asbestosis and/or pleural osteosarcoma
  94. 94. adenomatous polyposis coli familial adenomatous polyposis familial adenomatous polyposis. soft tissue sarcoma adult squamous cell carcinoma squamous cell carcinoma vulvar cancer soft tissue sarcomas vulvar carcinogenesis Wilms tumors Ewing's sarcoma megakaryocytic malignancies bone cancer Kaposi's sarcoma bone cancer; soft tissue sarcoma high-grade soft tissue sarcoma Kaposi sarcoma carbamazepine Carbamazepine hypersensitivity cardiomyopathy idiopathic dilated cardiomyopathy Cardiomyopathy maternally inherited cardiomyopathy Maternally inherited cardiomyopathy Nonfamilial Hypertrophic or Dialated Cardiomyopathy cardiomyopathy; MELAS syndrome tachycardia cardiomyopathy desmin-associated restrictive cardiomyopathy. Idiopathic Dilated Cardiomyopathy dilated cardiomyopathy familial hypertrophic cardiomyopathy. hypertrophic cardiomyopathy hypertrophic cardiomyopathy and cytochrome c oxidase deficiency cardiomyopathy, idiopathic dilated cardiomyopathy, nonfamilial hypertrophic nonfamilial idiopathic dilated cardiomyopathy X-linked dilated cardiomyopathy cardiomyopathy; heart anomalies, congenital cardiomyopathy; heart failure cardiomyopathy; heart failure; sudden death angina Vasospastic Angina vasospastic angina associated angina, vasospastic angioedema Type II hereditary angio-oedema recurrent cardiovascular event Cardiovascular disease cardiovascular disease; atherosclerosis cardiovascular disease; lipoprotein cardiovascular disease; mennose-binding lectin deficiency Cardiovascular Pathology macroangiopathy
  95. 95. macroangiopathy and blood pressure Microangiopathy- Related Cerebral Damage (MARCD) microangiopathy, diabetic cardiac disease, chagasic Cardiac hypertrophy aortic stiffness aortic stiffness and disease severity arterial stiffness arterial wall changes arterial wall thickness cardiac and cutaneous amyloidosis cardiac autonomic responsiveness cardiac conduction disturbances and degenerative changes cardiac death cardiac death; cardiac morbidity Cardiac Disease cardiac disease cardiac function cardiac growth cardiac repolarization. cardiac sarcoidosis cardiological syndrome X cardiopulmonary disease increased cardiopulmonary morbidity cardiovascular Cardiovascular cardiovascular abnormalities cardiovascular death cardiovascular disease Cardiovascular Disease cardiovascular disease risk cardiovascular disease risk factors cardiovascular disease; bilirubin cardiovascular disease; carotid artery damage cardiovascular disease; cerebrovascular disease cardiovascular disease; C-reactive protein cardiovascular disease; diabetes, type 1; proteinuria cardiovascular disease; fibrinogen cardiovascular disease; hemodialysis cardiovascular disease; kidney failure, chronic cardiovascular disease; leptin cardiovascular disease; lipid metabolism disorders cardiovascular disease; lipoproteins; triacylglycerol cardiovascular disease; periodontal disease cardiovascular disease; stroke; stroke, ischemic cardiovascular events in non-smokers cardiovascular mortality cardiovascular response to metoprolol cardiovascular risk cardiovascular risk factors carotid atherosclerosis subclinical carotid atherosclerosis carotid and femoral artery stiffness
  96. 96. Wall Thickness of the Radial and carotid Arteries carotid arterial wall thickness carotid artery atherosclerosis increased wall thickness of carotid and femoral arteries carotid artery damage increased carotid plaque area carotid artery distensibility intimal medial thickness intima-media thickness intima-media thickness, carotid intima-media thickness; atherosclerosis, generalized intima-media thickness; flow-mediated dilation of the brachial artery intima-media thickness; carotid plaque carotid artery intima-media thickness carotid artery intima-media thickness; spinocerebellar ataxia; Huntington's disease; myotonic dystrophy carotid artery stenosis carotid intimal-medial thickening carotid intima-media thickness carotid plaque carotid wall thickening celiac disease; Wegener's granulomatosis; cervical cancer celiac celiac disease Coeliac coeliac disease coeliac disease. celiac disease; colitis cerebral arteriopathy cerebral arteriopathy; leukoencephalopathy cerebrovascular disease. intracerebral hemorrhage cerebrovascular disease; coronary artery disease, occlusive cerebral atherosclerosis primary intracerebral hemorrhage and healthy controls Cerebral Amyloid Angiopathy (CAA) cerebral cavernous malformations cerebral circulation Cerebral Circulation in Smokers cerebral hemorrhage cerebral infarct cerebral infarct, atherothrombotic cerebral infarct; cerebral arteriopathy cerebral infarct; stroke, lacunar cerebral infarction cerebral infarction, atherosclerotic cerebral infarction. cerebral ischemia cerebral small-vessel disease cerebral venous thrombosis cerebrovascular disease cerebrovascular disease, ischemic cerebrovascular disease, ischemic; fibrinogen cerebrovascular disease; sickle cell anemia
  97. 97. decreased risk of cerebrovascular mortality spontaneous cervical artery dissection. cervical artery dissection, spontaneous cervical cancer invasive cervical cancer. cervical carcinoma cervical squamous cell carcinoma. cervical carcinoma. risk of cervical dysplasia X-linked Charcot-Marie tooth disease autosomal recessive Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease recessive Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth neuropathy Charcot-Marie-Tooth neuropathy type 1B clinically distinct Charcot-Marie-Tooth phenotype Charcot-Marie-Tooth type 1 disease Charcot-Marie-Tooth type 1B Primary Sclerosing Cholangitis primary sclerosing cholangitis cholangitis, sclerosing cholelithiasis cholelithiasis; urinary calculus biliary duct stones; biliary tract cancer; gallbladder cancer; gallstones cholelithiasis; biliary duct stone cholelithiasis; bilirubin cholelithiasis; sickle cell anemia cholestasis biliary atresia cholestasis; biliary atresia greenland familial cholestasis obstetric cholestasis cholesterol, HDL; blood pressure, arterial; stroke; longevity cholesterol, HDL; cholesterol, LDL; breast cancer serum cholesterol high density lipoprotein cholesterol level cholesterol, HDL; cholesterol, LDL; cholesterol, total; apoA1; apoB; apoE; apoC-III cholesterol, HDL; triglycerides; lipoproteins plasma cholesterol cholesterol; cholesterol, HDL; triglycerides; atherosclerosis, coronary; cholesterol, LDL hypercholesterolaemia hypercholesterolemia; atherosclerosis, generalized cholesterol; cholesterol, HDL; triglycerides; cholesterol, LDL; lipids cholesterol; triacylglycerol cholesterol, HDL cholesterol; cholesterol, HDL; triglycerides; cholesterol, LDL; insulin; obesity; leptin HDL cholesterol levels cholesterol, HDL; triglycerides; coronary artery disease; cerebral infarction hypercholesterolemia coronary artery disease cholesterol, LDL; cholesterol, total; C-reactive protein; apoA2; apoB cholesterol
  98. 98. high and low levels of cholesterol Increased plasma concentrations of total cholesterol LDL-cholesterol choesterol absorption cholesterol absorption plasma high density lipoprotein cholesterol and apolipoprotein AI increased concentration of HDL-C and decreased promoter activity total cholesterol and LDL-cholesterol fasting total cholesterol and LDL-cholesterol concentrations only serum cholesterol and LDL-cholesterol levels reduced HDL cholesterol and LpA-I acid lipase deficiency and cholesterol ester storage disease high-density lipoprotein cholesterol level. normal serum cholesterol levels plasma cholesterol levels and body mass index elevated HDL cholesterol levels increased circulating high density lipoprotein cholesterol levels plasma high-density lipoprotein cholesterol levels cholesterol status HDL Cholesterol HDL cholesterol HDL cholesterol/ BMI HDL-cholesterol HDL-cholesterol level cholesterol, HDL; apoAI cholesterol, HDL; arterial-wall changes; cholesterol efflux cholesterol, HDL; atherosclerosis, coronary cholesterol, HDL; blood pressure, arterial; acetaldehyde; lipid peroxide cholesterol, HDL; cardiovascular disease; obesity; hyperuricemia cholesterol, HDL; cholesterol, LDL cholesterol, HDL; cholesterol, LDL; apoA1; apoB cholesterol, HDL; cholesterol, LDL; cholesterol, total; apoA1; apoE; apoB-100 cholesterol, HDL; cholesterol, LDL; cholesterol, VLDL cholesterol, HDL; cholesterol, LDL; lathosterol cholesterol, HDL; cholesterol, LDL; leukemia; 9-hydroxyrisperidone; risperidone cholesterol, HDL; cholesterol, LDL; lipids cholesterol, HDL; cholesterol, total; insulin; cortisol cholesterol, HDL; cholesterol, VLDL cholesterol, HDL; cholesteryl ester transfer protein cholesterol, HDL; C-reactive protein; carotid intima-media thickness cholesterol, HDL; diabetes, type 2; blood pressure, arterial; liver disease; periodontitis; acenocoumarol respon cholesterol, HDL; heart disease, ischemic; diabetes, type 2; insulin cholesterol, HDL; hypertension cholesterol, HDL; hypoalphalipoproteinemia; triglyceride cholesterol, HDL; lipids cholesterol, HDL; lipids; blood pressure, arterial cholesterol, HDL; lipoprotein cholesterol, HDL; lipoprotein, LDL cholesterol, HDL; lipoproteins cholesterol, HDL; obesity cholesterol, HDL; paraoxonase activity cholesterol, HDL; triglyceride cholesterol, HDL; triglycerides
  99. 99. cholesterol, HDL; triglycerides; adiposity cholesterol, HDL; triglycerides; atherosclerosis, coronary cholesterol, HDL; triglycerides; blood pressure, arterial cholesterol, HDL; triglycerides; cholesterol, LDL cholesterol, HDL; triglycerides; cholesterol, LDL; cholesterol, total; glucose cholesterol, HDL; triglycerides; cholesterol, LDL; cholesterol, total; glucose; stroke; carotid artery intima-medi cholesterol, HDL; triglycerides; cholesterol, LDL; lipoprotein; fatty acid; uric acid cholesterol, HDL; triglycerides; cholesterol, total cholesterol, HDL; triglycerides; coronary heart disease; cholesterol, LDL; cholesterol, total cholesterol, HDL; triglycerides; diabetes, type 2; cholesterol, LDL cholesterol, HDL; triglycerides; lipids cholesterol, HDL; triglycerides; lipids; lipoproteins cholesterol, HDL; triglycerides; lipoprotein cholesterol, HDL; triglycerides; personality trait cholesterol, LDL cholesterol, LDL; bile acid synthesis cholesterol, LDL; blood pressure, arterial; nitric oxide production; salt sensitivity cholesterol, LDL; cholesterol, total cholesterol, LDL; cholesterol, total; apoB; apoAI cholesterol, LDL; cholesterol, total; apolipoproteins cholesterol, LDL; cholesterol, total; insulin sensitivity; hyperinsulinemia cholesterol, LDL; cholesterol, total; lipoprotein cholesterol, LDL; C-reactive protein; triacylglycerol cholesterol, LDL; hypertension; C-reactive protein; fibrinogen; homocysteine; white blood cell count cholesterol, LDL; insulin resistance cholesterol, LDL; insulin sensitivity; fatty acid cholesterol, LDL; insulin; metabolism disorders cholesterol, LDL; lipoprotein cholesterol, LDL; lipoproteins plasma HDL-cholesterol cholesterol, response to; dietary fat, response to cholesterol, total cholesterol; apoA-IV; apoE; triacylglycerols cholesterol; cholesterol, HDL; atherosclerosis, coronary; cholesterol, LDL cholesterol; cholesterol, HDL; cholesterol, LDL cholesterol; cholesterol, HDL; cholesterol, LDL; hypertension; lipoproteins; obesity cholesterol; cholesterol, HDL; cholesterol, LDL; triacylglycerol cholesterol; cholesterol, HDL; lipoprotein, LDL; triglycerides; hypertension cholesterol; cholesterol, HDL; lipoprotein; lipids cholesterol; cholesterol, HDL; triglycerides cholesterol; cholesterol, HDL; triglycerides; cholesterol, LDL cholesterol; cholesterol, HDL; triglycerides; cholesterol, LDL; hypertension; glucose cholesterol; cholesterol, HDL; triglycerides; cholesterol, LDL; lipoprotein cholesterol; cholesterol, HDL; triglycerides; diabetes, type 2; ulcerative colitis; cholesterol, LDL; liver disease; cholesterol; cholesterol, LDL cholesterol; cholesterol, LDL; campesterol; sitosterol cholesterol; cholesterol, LDL; carotid atherosclerosis cholesterol; cholesterol, LDL; insulin; apoB cholesterol; cholesterol, LDL; lipoproteins; fatty acid cholesterol; coronary heart disease; lipoproteins cholesterol; diabetes, type 2 cholesterol; diabetes, type 2; hypertension; nephropathy, diabetic; albuminuria cholesterol; diabetes, type 2; insulin; glucose; insulin resistance; PC-1 protein content; systolic blood pressure
  100. 100. cholesterol; hypercholesterolemia; cholesterol, LDL; hypertriglyceridemia cholesterol; insulin; obesity; blood pressure lower levels of hepatic lipase activity buoyant LDL and higher HDL2 cholesterol cholesterol; lathosterol cholesterol; lipids cholesterol; lipoprotein, LDL; atherosclerosis, coronary cholesterol; triglycerides cholesterol; triglycerides; atherosclerosis, coronary cholesterol; triglycerides; cholesterol, LDL cholesterol; triglycerides; cirrhosis, alcoholic; lipids cholesterol; triglycerides; diabetes, type 2; cholesterol, LDL; lipoproteins; indulinh cholesterol; triglycerides; diabetes, type 2; obesity cholesterol; triglycerides; glucose tolerance; beta-cell function; insulin; lipids cholesterol; triglycerides; hypertension; blood pressure, arterial; potassium; urea cholesterol; triglycerides; hypertension; glucose tolerance cholesterol; triglycerides; lipoprotein cholesterol; triglycerides; lipoproteins cholesterol; triglycerides; obesity mild familial hypercholesterolaemia endogenous hypertriglyceridemia and familial hypercholesterolemia cholesteryl ester storage disease cholesteryl ester transfer protein familial hypercholesterolaemia Familial Hypercholesterolemia familial hypercholesterolemia hypercholesterolemia hypercholesterolemia of hypothyroidism hypercholesterolemia; cholesterol, LDL hypercholesterolemia; drug hypersensitivity hypercholesterolemia; H. pylori infection; coagulation disorder hypercholesterolemia; hyperlipidemia; hypertriglyceridemia; dysbetalipoproteinemia low high-density lipoprotein cholesterol concentration elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations cholesterol gallstone disease High-density lipoprotein-cholesterol levels serum potassium and total cholesterol levels but not plasma apoB and low density lipoprotein (LDL) cholesterol levels plasma apolipoprotein AI (apoAI) and high-density lipoprotein cholesterol (HDL) levels dominant effect on HDL-cholesterol mild familial hypercholesterolemia cholesteryl ester transfer protein plasma lipid levels familial hypercholesterolemia. chronic fatigue chronic fatigue syndrome fibromyalgia chronic obstructive pulmonary disease chronic obstructive pulmonary disease/COPD copd COPD and diffuse panbronchiolitis COPD. bronchiectasis chronic obstructive pulmonary disease/COPD; bronchiectatic disease chronic obstructive pulmonary disease/COPD; emphysema chronic obstructive airways disease.
  101. 101. COPD COPD severity cirrhosis, alcoholic; esophageal cancer; head and neck cancer; liver cancer; pancreatitis, alcoholic cirrhosis, alcoholic; liver cancer liver cirrhosis liver disease, chronic and cirrhosis cirrhosis; liver cancer cirrhosis; liver cancer; hepatitis C, chronic primary biliary cirrhosis cirrhosis; pancreatitis; esophageal cancer Primary Biliary Cirrhosis Primary Billiary Cirrosis primary biliary cirrhosis] cirrhosis cirrhosis, alcoholic cirrhosis, alcoholic; alcoholism cirrhosis, biliary primary cirrhosis, biliary primary; cholangitis, sclerosing cirrhosis, biliary primary; liver disease cirrhosis, primary biliary cirrhosis, alcoholic; hepatitis C cirrhosis, alcoholic; liver disease cirrhosis, biliary primary; diabetes, gestational cirrhosis, biliary primary; hepatitis type 1, autoimmune (AIH-1) cirrhosis, biliary primary; hepatitis, autoimmune cirrhosis; hepatocellular carcinoma cirrhosis; hepatocellular carcinoma; hepatitis cirrhosis; pancreatitis cleft lip cleft lip and palate Cleft lip and palate non-syndromic cleft lip and palate cleft lip with cleft palate; cleft lip without cleft palate cleft lip with cleft palate; cleft lip without cleft palate; cleft lip cleft lip with cleft palate; cleft lip without cleft palate; cleft palate cleft lip with or without cleft palate cleft lip with or without cleft palate; cleft palate, isolated cleft lip without cleft palate; cleft palate cleft palate and calvaria defects. hypothyroidism; cleft palate, isolated; thyroid agenesis cleft palate; cleft lip cleft palate; hypothyroidism congenital anomalies; cleft lip with or without cleft palate oral clefting oral clefts Bernard-Soulier Syndrome bleeding tendency type 1 von Willebrand disease thrombocythemia, non-familial essential variation in platelet integrin alpha 2 beta 1 density thrombophilia, venous von Willebrand factor von Willebrand's Disease
  102. 102. coagulation disorder purpura, Henoch-Schonlein purpura, idiopathic thrombocytopenic Hyperprothrombinemia Fibrinogen plasma levels reduced levels of von Willebrand factor messenger RNA Heterozygous factor XI deficiency Glanzmann thrombasthenia antiphospholipid syndrome anticoagulant complications thrombin-activatable fibrinolysis inhibitor levels anticoagulant complications; bleeding complications anticoagulant complications; ibuprofen clearance bleeding complications anticoagulant complications; bleeding events, warfarin therapy-related; overanticoagulation, warfarin therapy- Increased platelet aggregability platelet aggregation platelet aggregation; coagulation platelet aggregation; nitric oxide activity platelet aggregation; thromboxate platelet alpha(2)beta(1), densities of dominant type 1 von Willebrand's disease Aalpha and gamma fibrinogen plasma levels plasma fibrinogen levels albuminuria; fibrinogen plasma fibrinogen levels in smokers and non-smokers fibrinogen fibrinogen; Budd-Chiari syndrome fibrinogen; factor VII; plasminogen activator inhibitor-1 Factor XII deficiency factor XI deficiency. factor VIII and factor IX genes f12 plasma deficiency, moderate Activated factor XII levels factor XII-deficient patients factor XI deficiency plasma factor XIII plasma factor VII activity and antigen levels thrombosis of the central retinal vein trans Mutation 1691 g-->a du gene du facteur V reduced intrapartum blood loss--a possible evolutionary selection mechanism elevated plasma prothrombin levels and an increase high or low factor XIII specific activity. factor V levels factor V Leiden factor 13 activity plasma prothrombin levels deficiency of coagulation factor V factor VII antigen; factor VII coagulant activity factor VII high plasma factor VIII: C levels factor VII levels factor VII deficiency fibrinogen; platelet aggregability
  103. 103. fibrinogen; triglyceride fibrinogen; thrombosis, venous platelet count platelet phamacodynamics platelet thrombogenicity platelet alpha2 beta1 density platelet monoamine oxidase B activity platelet receptor density and the response to SFLLRN thrombocythemia thrombocytopenia abnormal fibrin polymerization and thrombophilia thrombophilia thrombophilia and vascular disease thrombocytopenic purpura, idiopathic neonatal thrombocytopenia childhood idiopathic thrombocytopenic purpura. chronic immune thrombocytopenic purpura. macrothrombocytopenia and anemia X-linked thrombocytopenia myeloproliferative disorders; thrombocytosis neurocognitive decline Brain aging high versus low IQ: the IQ Quantitative Trait Loci (QTL) cognitive decline cognitive ability; hypothyroidism normal cognitive ageing Early cognitive decline human intelligence general cognitive ability cognitive function cognitive function in older men cognitive impairment intelligence personality trait and intelligence prefrontal activity cognition, prefrontal information processing IQ cognitive ability cognitive function; motor function cognitive impairment; Alzheimers disease cognitive performance colon adenomas/carcinomas cancer; colorectal cancer colon cancer late onset familial adenomatous polyposis late onset of familial adenomatous polyposis colorectal cancer; esophageal cancer; stomach cancer diet lifestyle and risk of colon cancer hereditary nonpolyposis colon cancer. hereditary non-polyposis colon cancer. increased colon cancer colon cancer; rectal cancer
  104. 104. colon polyps colorectal adenocarcinomas colorectal adenoma conversion from colorectal adenoma to early carcinoma colorectal adenomas colorectal cancer Colorectal Cancer advanced colorectal cancer metastatic colorectal cancer rectal cancer colorectal cancer patients colorectal cancer, hereditary nonpolyposis colorectal cancer, nonpolyposis colorectal cancer. colorectal cancer: association colorectal cancer; colon polyps colorectal cancer; colorectal polyps colorectal cancer; drug hypersensitivity colorectal cancer; drug hypersensitivity; liver cancer; bladder cancer colorectal cancer; endometrial cancer colorectal cancer; esophageal cancer colorectal cancer; folate, erythrocyte colorectal cancer; stomach cancer colorectal cancer; Tourette syndrome; bone density; pregnancy loss, recurrent; cleft lip without cleft palate; ju colorectal cancers colorectal carcinoma colorectal carcinomas clonal homozygosity of rectal cell carcinoma colorectal neoplasia. Colorectal Hyperplastic Polyps. colorectal polyps colorectal polyps (adenoma or hyperplastic) colorectal tumors Colon Cancer heart anomalies, congenital Heart-Hand Syndrome, Holt-Oram Syndrome infantile hypertrophic pyloric stenosis. heart anomalies, congenital; cleft lip with cleft palate; cleft lip without cleft palate heart anomalies, congenital; pulmonary hypertension fetal akinesia Alagille syndrome Chuvash-type congenital polycythemia CATCH 22 syndrome Rieger syndrome Prader-Willi and Angelman syndromes Angelman syndrome Griscelli syndrome congenital adrenal hyperplasia (CAH) congenital generalized lipodystrophy Caroli's disease congenital adrenal hyperplasia congenital and subclinical hypothyroidism congenital athyreosis
  105. 105. isolated cryptorchidism congenital cardiac malformations Silver syndrome CHARGE syndrome variant late infantile neuronal ceroid lipofuscinosis. congenital absence of the uterus and vagina father-child incompatibility of Gc Rubinstein-Taybi syndrome congenital fibrosis of extraocular muscles type 2 congenital goiter and defective TG synthesis. congenital heart defects Chiari type I malformation and syringomyelia Williams syndrome congenital intrinsic factor deficiency. achondroplasia Ullrich congenital muscular dystrophy Pfeiffer syndrome Aarskog-Scott syndrome achromatopsia adrenal hyperplasia, congenital late-onset congenital adrenal hyperplasia agenesis of the corpus callosum Alport syndrome Axial skeletal defects Beckwith Wiedemann syndrome birth defects Coffin-Lowry syndrome. congenital anomalies congenital anomalies; renal disease congenital bilateral absence of the vas deferens congenital central hypoventilation syndrome congenital contractural arachnodactyly congenital fibrosis of the extraocular muscles congenital heart disease congenital nephrosis congentical adrenal hyperplasia craniosynostosis cryptochidism cryptorchidism cryptorchidism. Down syndrome fetal alcohol syndrome fetal hemoglobin fragile X syndrome Fragile X Syndrome Fragile X Syndrome; periodontitis hypoplastic left heart syndrome hip dislocation, congenital holoprosencephaly Holt-Oram Syndrome Hurler syndrome hypodontia hypospadias
  106. 106. icterophyloric syndrome idiopathic short stature intracranial cavernous malformations isolated congenital pituitary hypoplasia and septo-optic dysplasia isolated penile hypospadias Laron-type dwarfism Leber congenital amaurosis Leber congenital amaurosis and a normal ocular phenotype Leber congenital amaurosis/LCA Left-right axis malformations left-right laterality defects Marfan phenotype Marfan syndrome mental disorder mental retardation Non-syndromic X-linked mental retardation micropenis microphthalmia multiple epiphyseal dysplasia multiple epiphyseal dysplasia; pseudoachondroplasia muscular dystrophy Muscular Dystrophy, oculopharyngeal Becker muscular dystrophy; Duchenne muscular dystrophy non-syndromic oligodontia Noonan syndrome oculocutaneous albinism type 2 oculocutaneous albinism type 4 omphalocele Familial spondyloepiphyseal dysplasia tarda, brachydactyly, and precocious osteoarthritis Peutz-Jeghers syndrome Peutz-Jegher's syndrome pituitary anomalies and holoprosencephaly-like features. postnatal growth precocious puberty puberty onset tuberous sclerosis Tuberous sclerosis 1 short stature small for gestational age Small for gestational age infant Smith-Lemli-Opitz syndrome Sotos syndrome Swyer syndrome thyroid dysgenesis abnormal urogenital development Van der Woude syndrome WAGR syndrome Denys-Drash syndrome congenital polycythemia. congenital primary hypothyroidism Congenital sick sinus syndrome Congenital thrombotic thrombocytopenic purpura congenital uropathies
  107. 107. connatal Pelizaeus-Merzbacher disease salt-wasting congenital adrenal hyperplasia Hirschsprung disease Hirschsprung's disease x-linked mental retardation coronary artery calcification coronary artery calcium coronary artery disease reduced coronary artery calcification acute coronary events coronary artery bypass graft coronary artery bypass graft surgery coronary artery bypass grafting; platelet hyperreactivity coronary artery disease and myocardial infarction. coronary artery disease; myocardial infarction; angina Coronary Heart Disease and Myocardial Infarction coronary heart disease or insulin resistance coronary heart disease. coronary heart disease; diabetes, type 2 Coronary Artery Disease premature coronary artery disease premature coronary artery disease and familial hypoalphalipoproteinemia premature coronary artery disease. Ischemic Heart Disease CHD premature coronary heart disease. coronary artery disease and myocardial infarction coronary artery disease and plasma soluble thrombomodulin coronary artery disease risk factors angiographic coronary artery disease coronary artery disease, occlusive coronary artery disease. Cigarette Smoking. Coronary Artery Disease. and Diabetes Coronary Artery Disease. Plasma Lipoproteins. and Longevity coronary artery disease; aortic stiffness coronary artery disease; coronary atherosclerosis coronary artery disease; diabetes, type 2; lipoproteins; longevity coronary artery disease; lipoproteins; fluvastatin, clinical events with; treatment with fluvastatin, response to coronary artery disease; myocardial infarction coronary artery disease; nitric oxide coronary artery disease; P-selectin coronary artery disease; restenosis coronary artery disease; stroke coronary artery disease; sudden cardiac death coronary artery ectasia coronary artery lesions development of coronary artery lesions coronary artery luminal dimensions coronary artery plaque calcification coronary artery reactivity; lipoprotein oxidation coronary artery spasm coronary artery stenosis coronary artery thrombosis
  108. 108. coronary artery vasoconstriction. coronary artery vasomotility coronary blood flow age at first coronary bypass operation coronary calcification coronary disease early coronary disease. coronary endothelial vasodilator function coronary events coronary fibrinolysis coronary heart disease Coronary Heart Disease coronary heart disease among Japanese. coronary heart disease and plasma lipid levels. coronary heart disease and serum very low density lipopro coronary heart disease in non-insulin-dependent diabetic coronary heart disease in non-Type 1 diabetes coronary heart disease in younger individuals. high coronary heart disease risk particularly affects ser coronary heart disease, transplant associated acute coronary syndrome acute coronary syndrome; aspirin resistance coronary heart disease; hypertension; myocardial infarction coronary heart disease; lipids; lipoproteins coronary heart disease; myocardial infarction coronary heart disease; myocardial infarction; stroke; cerebrovascular disease coronary in-stent restenosis. coronary ischaemic syndrome coronary spasm coronary spasm. coronary heart disease in nondiabetic subjects coronary spastic angina. coronary stent outcome coronary syndromes, acute non-ST-elevation acute coronary syndromes coronary vasculopathy coronary vasomotion coronary vasomotor function coronary artery disease; diabetes, type 2 Early occlusion of coronary by-pass ischemia ischaemic heart disease early onset ischemic heart disease. heart disease, ischemic heart disease, ischemic; atherosclerosis, coronary; hyperlipidemia heart disease, ischemic; cerebrovascular disease, ischemic heart disease, ischemic; insulin heart disease, ischemic; lipoprotein heart disease, ischemic; myocardial infarction; sudden cardiac death heart disease, ischemic; peripheral arterial disease heart disease, ischemic; peripheral vascular disease plasma protein C levels activated protein C resistance
  109. 109. circulating protein C levels and thrombotic risk plasma protein C levels and thrombotic risk Hereditary protein C deficiency C-reactive protein C-reactive protein (CRP) concentration C-reactive protein; ferritin; iron C-reactive protein; fibrinogen; coronary artery bypass graft C-reactive protein; kawasaki disease C-reactive protein; longevity; interleukin 6 levels Crohn's disease Crohn's disease and IBD Crohn's disease and ulcerative colitis Crohn's disease; asthma; malaria Crohn's disease; ulcerative colitis Crohn's disease; ulcerative colitis; inflammatory bowel disease Crohn's disease; ulcerative colitis; pancolitis cystic fibrosis CFTR mutation spectrum Cystic Fibrosis cystic fibrosis lung disease cystic fibrosis. cystic fibrosis; Candida cystic fibrosis; chronic bronchopulmonary diseases; chronic obstructive pulmonary disease/COPD cystic fibrosis; chronic bronchopulmonary diseases; chronic obstructive pulmonary disease/COPD; 21-hydroxyl cystic fibrosis; P. aeruginosa infection dementia vascular dementia dementia with Lewy bodies dementia but not cardiovascular mortality familial and sporadic frontotemporal dementia inherited dementia FTDP-17 dementia in other conditions dementia, frontotemporal frontotemporal dementia frontotemporal dementia and Pick-like 3R and 4R tauopathy Frontotemporal dementia dementia, multi-infarct dementia, vascular hereditary dementia. dementia; ALS/amyotrophic lateral sclerosis argyrophilic grain disease dementia; neuropathy depressive disorder, major depression depression; anxiety-related traits unipolar affective disorder Major Depression depressive disorder, major; bipolar disorder; dysthymic disorder manic depression manic depressive illness aura depression and response to antidepressant treatment affective disorder; suicidal behavior
  110. 110. depression in Parkinson's disease dysthymia major depression major depressive disorder mania, antidepressant-induced manic depressive disorders Manic depressive illness manic-depressive illness Manic-depressive illness depression, psychosis and antipsychotic response seasonal affective disorder; premenstrual dysphoric disorder seasonal affective disorder Unipolar Affective Disorder affective disorder affective disorders/ suicide affective psychoses depression; alcohol withdrawal antidepressant adverse effects antidepressant response antidepressant medication intolerance. depression; neuroticism depression; thrombocyte MAO activity depressive disorder, major; alcoholism depressive disorder, major; bipolar disorder depressive disorder, major; bipolar disorder; affective psychoses depressive disorder, major; bipolar disorder; suicide depressive disorder, major; nausea depressive disorder, major; phobia depressive disorder, major; suicide depressive disorders depressive episode, major dermatitis and eczema atopic dermatitis but two of them Atopic Eczema dermatomyositis/ polymyositis urticaria urticaria/angioedema dermatitis syndrome; eczema eczema atopic eczema/dermatitis syndrome dermatitis and eczema; IgE levels dermatitis herpetiformis. dermatitis, atopic atopic dermatitis Atopic dermatitis atopic dermatitis. Atopic dermatitis. atopy adult atopic dermatitis diabetes, gestational Gestational Diabetes diabetic pregnancy gestational diabetes mellitus mild gestational diabetes mellitus
  111. 111. diabetes, type 1 Type 1 Diabetes and Type 2 Diabetes diabetes mellitus type I diabetes, type 1; Addison's disease; celiac disease diabetes, type 1; Addison's disease; Graves; thyroiditis, Hashimoto diabetes, type 1; carotid artery damage diabetes, type 1; hypothyroidism diabetes, type 1; Addison's disease diabetes, type 1; Addison's disease; Graves' disease; thyroiditis, chronic lymphocytic diabetes, type 1; Addison's disease; Hashimoto's thyroiditis diabetes, type 1; autoimmune diabetes; diabetes, autoimmune beta-cell function; diabetes, type 1 diabetes, type 1; blood group incompatibility diabetes, type 1; blood pressure, arterial; nephropathy in other diseases diabetes, type 1; carotid atherosclerosis diabetes, type 1; celiac disease diabetes, type 1; celiac disease; myasthenia gravis diabetes, type 1; Graves' disease diabetes, type 1; Graves' disease; Hashimoto's thryroiditis diabetes, type 1; IL-1RI diabetes, type 1; measles diabetes, type 1; nephropathy in other diseases diabetes, type 1; renal transplant outcome diabetes, type 1; thyroid disease, autoimmune diabetes, latent autoimmune type I diabetes Childhood Diabetes diabetes, maternally inherited MODY3 (Mature Onset Diabetes of the young MODY maturity-onset diabetes of young people neurohypophyseal diabetes insipidus diabetes, neurological manifestations diabetes, NOS diabetes, pancreatic diabetes, post-renal transplant; post-renal transplant diabetes IDDM latent autoimmune diabetes diabetes, type 2; hypertension Type 2 diabetes Type 1 diabetes Type II diabetes Type II diabetes mellitus or insulin resistance diabetes, type 2; albuminuria diabetes, type 2; cerebrovascular disease Insulin Dependent Diabetes diabetes, type 2; cholesterol, LDL; diabetes, gestational diabetes, type 2; hypertension; glucose tolerance diabetes, type 2; hypertension; obesity diabetes, type 2; insulin; diabetic nephropathy; obesity diabetes, type 2; insulin; hemoglobin A(1c) diabetes, type 2; retinopathy, diabetic; nephropathy in other diseases diabetes, type 2; hypertension; atherosclerosis; cerebrovascular disease; dyslipemia Type II diabetes and hypertension
  112. 112. diabetes, type 2; glucose tolerance; insulin diabetes, type 2 Diabetes mellitus and cardiomyopathy diabetes, type 2; diabetes diabetes, type 2; alveolitis, extrinsic allergic diabetes, type 2; atherosclerosis, generalized diabetes, type 2; beta-cell function diabetes, type 2; beta-cell function; insulin diabetes, type 2; bipolar disorder diabetes, type 2; body fat; lipid metabolism diabetes, type 2; cardiovascular disease diabetes, type 2; cardiovascular disease; birth weight diabetes, type 2; cholesterol, LDL; cholesterol, total; insulin diabetes, type 2; cholesterol, LDL; glucose tolerance; blood pressure, arterial; glycosylated hemoglobin A1 diabetes, type 2; diabetes, gestational diabetes, type 2; diabetes, type 1 diabetes, type 2; glucose tolerance diabetes, type 2; glucose tolerance; metabolic syndrome diabetes, type 2; glucose tolerance; obesity diabetes, type 2; glucose; HbA1c diabetes, type 2; hepatic lipase activity diabetes, type 2; hyperglycemia; uric acid diabetes, type 2; hypertension; insulin diabetes, type 2; hypertension; insulin; obesity diabetes, type 2; hypertension; metabolic syndrome diabetes, type 2; hypertension; obesity, localized diabetes, type 2; hypertriglyceridemic waist diabetes, type 2; insulin diabetes, type 2; insulin sensitivity diabetes, type 2; insulin; glucose diabetes, type 2; insulin; glucose; C-peptide; fatty acid diabetes, type 2; insulin; leptin diabetes, type 2; insulin; lipids; obesity diabetes, type 2; insulin; obesity diabetes, type 2; kidney failure, chronic diabetes, type 2; lipids; glucose diabetes, type 2; lipoprotein diabetes, type 2; liver disease diabetes, type 2; liver disease, chronic; hemochromatosis diabetes, type 2; macroangiopathy; microangiopathy diabetes, type 2; metabolic syndrome diabetes, type 2; MODY diabetes, type 2; myocardial infarction diabetes, type 2; nephropathy diabetes, type 2; nephropathy in other diseases diabetes, type 2; nephropathy, diabetic diabetes, type 2; obesity diabetes, type 2; obesity; birth weight diabetes, type 2; polycystic ovarian syndrome diabetes, type 2; polymetabolic syndrome diabetes, type 2; sex hormones diabetes, type 2; stroke, ischemic diabetes, type 2; weight loss; weight gain
  113. 113. diabetes diabetes and obesity diabetes mellitus Diabetes Mellitus Diabetes Mellitus. Obesity. and Lipaemia diabetes or impaired glucose tolerance Type II diabetic Type 2 Diabetes (Retinopathy) Type 2 Diabetes Mellitus type 2 diabetic Type 2 diabtes diabetes, type 2; hyperlipidemia; obesity diabetes, type 2; pancreatitis, tropical calcific non-Type 1 diabetes mellitus diabetes, type 2; diabetic nephropathy diabetes, type 2; hypertension; diabetes, type 1 diabetes, type 2; hypertension; diabetes, type 1; albuminuria diabetic nephropathy; retinopathy, diabetic nephropathy, diabetic; diabetes, type 1 nephropathy, diabetic nephropathy, diabetic; retinopathy, diabetic; neuropathy, diabetic; microalbuminuria, diabetic nephropathy, diabetic; retinopathy, diabetic nephropathy, diabetic; blood pressure, arterial; proteinuria nephropathy, diabetic; proteinuria nephropathy in other diseases; diabetes nephropathy in diabetes mellitus Diabetic Nephropathy diabetic nephropathy diabetic nephropathy and retinopathy. diabetic nephropathy. diabetic nephropathy; polycystic kidney disease diabetic glomerulopathy; glomerulopathy, diabetic; kidney failure diabetic neuropathy diabetic polyneuropathy diabetic retinopathy retinopathy, diabetic proliferative diabetic retinopathy. retinopathy, diabetic; nephropathy in other diseases; neuropathy retinopathy, diabetic; albumin excretion rate retinopathy, diabetic; diabetes, type 1 retinopathy, diabetic; macular edema retinopathy, diabetic; nephropathy in other diseases Diabetic Retinopathy Diabetic Retinopathy in Type 2 Diabetes diabetic retinopathy. disc degeneration disc degeneration, lumbar spine degeneration of intervertebral discs intervertebral disc disease disc disease, intervertebral lumbar disc disease lumbar disk disease lumbar disc degeneration
  114. 114. DNA replication error and shorter survival mutagen sensitivity microsatellite instability radiation sensitivity radiation, ionizing, sensitivity to radiation, UV, sensitivity to radiation-induced damage to normal tissues radiation-induced ocular telangiectasia radiosensitivity microsatellite polymorphism of the interleukin 8 (IL-8) gene DNA adducts abnormal splicing mammalian microsatellite instability DNA damage DNA damage, biomarkers of spontaneous chromosomal instability sister-chromatid exchanges DNA damage, oxidative global DNA methylation defect DNA repair capacity DNA strand breakage Cockayne syndrome or the DeSanctis-cacchione variant of xeroderma pigmentosum xeroderma pigmentosum Xeroderma pigmentosum Xeroderma pigmentosum and trichothiodystrophy mild phenotype Xeroderma pigmentosum eating behavior Eating disorder anorexia nervosa. personality disorders; eating disorders eating disorder bulimia binge eating eating disorders anorexia nervosa Anorexia Nervosa anorexia nervosa and food intake anorexia nervosa; bulimia anorexia nervosa; bulimia nervosa EKG, abnormal EKG, abnormal; Brugada syndrome electrocardiogram PR interval emphysema Emphysema end-stage renal disease renal disease, end stage end stage renal disease renal disease, end stage; hyperhomocystinemia End- Stage Renal Disease (ESRD) extra-adrenal and/or malignant phaeochromocytomas Addison's disease thyroid orbitopathy sporadic pheochromocytoma
  115. 115. familial diabetes insipidus X-linked adrenoleukodystrophy resistance to thyroid hormone serum testosterone level parathyroid hormone secretion thryotoxic periodic paralysis thyroid and neurological abnormalities thyroid function thyroid-associated ophthalmopathy thyrotoxic hypokalaemic periodic paralysis thyrotoxicosis, juvenile increased thyroxine binding Nelson's syndrome DiGeorge syndrome androgenetic alopecia alopecia, androgenetic adrenal androgen excess Albright hereditary osteodystrophy; pseudohypoparathyroidism thyroid associated orbitopathy postpartum thyroiditis. H-Thyroiditis Addison's disease; Graves' disease hormone concentrations in postmenopausal women Conn's syndrome androgen insensitivity syndrome hormone disturbance hormone levels serum testosterone levels adrenal hyperplasia combined pituitary hormone deficiency growth hormone deficiency growth hormone responsiveness growth hormone secretion and height hyperandrogenism hyperandrogenism; precocious puberty hyperandrogenism; premature pubarche hyperparathyroidism hyperparathyroidism, primary hypogonadism hypoparathyroidism hypothyroidism ovarian hyperandrogenism ovarian hyperstimulation syndrome primary hyperparathyroidism serum androgen concentrations sex hormones sex-dependent growth testosterone; androgen; phytoestrogen testosterone; epitestosterone; follicle stimulating homone; luteinizing homone; sex horomone binding globulin testosterone; estradiol; androstenedione; DHEA; progesterone testosterone; FSH, basal; inhibin B levels; semen parameters testosterone; infertility, male; hypogonadism testosterone; prostate specific antigen
  116. 116. androgen estrogen levels complete androgen insensitivity leiomyoma uterine fibroids uterine fibroids; hyperprolactinemia uterine leiomyomas cutaneous and uterine leiomyomata complete androgen insensitivity syndrome and Sertoli cell adenoma Cushing's disease elevated response to GHRH by pituitary somatotrophinomas serum estrogen and progesterone concentrations evolving hypopitutarism hyperthyroidism Kallmann syndrome testosterone; bone density; stature androgen levels acromegaly adrenomedullary hormone activity; sympathetic nervous function estradiol; sex hormone binding globulin estrogen estrogens sex steroid hormone-binding globulin clinical parameters and endocrine status in elderly men multiple endocrine neoplasia multiple endocrine neoplasia type 1 multiple endocrine neoplasia type 2A Multiple endocrine neoplasia type 1 endometrial adenocarcinoma endometrial cancer; cervical cancer; radiosensitivity, clinical endometrial cancer uterine endometrial carcinoma endometrial cancer risk. endometrial cancer; hyperinsulinemia endometrial carcinoma endometrioid and clear cell ovarian cancer Endometriosis endometriosis endometriosis adenomyosis and leiomyomata. endometriosis. endometriosis; adenomyosis epilepsy early onset temporal lobe epilepsy. idiopathic generalized epilepsies generalized epilepsy childhood absence epilepsy. Juvenile Myoclonic Epilepsy epilepsy, idiopathic generalized epilepsy, juvenile myoclonic juvenile myoclonic epilepsy nocturnal frontal lobe epilepsy epilepsy, temporal lobe Temporal Lobe Epilepsy
  117. 117. temporal lobe epilepsy epilepsy; anticoagulant complications epilepsy; seizures, febrile epilpsy oesophageal adenocarcinoma. esophageal cancer Esophageal Cancer gastroesophageal cancer esophageal cancer and gastric cardiac carcinoma esophageal cancer and lung cancer esophageal cancer; Barrett esophagus; gastroesophageal reflux disease esophageal cancer; Barrett's esophagus esophageal cancer; cardiac cancer esophageal cancer; gastric cardia adenocarcinoma esophageal cancer; gastric cardia cancer esophageal cancer; gastric cardiac cancer esophageal cancer; laryngeal cancer; oropharynx cancer esophageal cancer; oropharyngolaryngeal cancers; stomach cancer esophageal cancer; stomach cancer esophageal cancer; stomach cancer; Barret's esophagus esophageal carcinoma multiple oesophageal dysplasia esophageal squamous cell carcinoma oesophageal squamous cell carcinoma Familial Mediterranean Fever familial mediterranean fever familial Mediterranean fever Familial Mediterranean Fever; hyper-IgD syndrome diffuse gastric cancer gastric adenocarcinoma aerodigestive tract cancers adenocarcinoma of the upper gastrointestinal tract. upper aerodigestive tract cancer stomach cancer stomach cancer; gastric ulcer; duodenal ulcer stomach cancer; gastric ulcer; gastritis; duodenal ulcer stomach cancer; gastritis stomach cancer; ovarian cancer stomach cancer; pancreatic cancer; fallopian cancer stomach cancer; stomach atrophy gastric adenocarcinomas gastric cancer gastrointestinal cancer noncardia gastric cancer chronic atrophic gastritis and gastric carcinoma gastric carcinoma gastric carcinoma risk gastric cardia adenocarcinoma gastrointestinal nerve sheath tumors gastritis, chronic atrophic; stomach cancer gastroesophageal reflux disease varicose ulcers colon polyps; adenomatous polyps
  118. 118. juvenile polyposis peptic ulcer polyposis, juvenile Idiopathic slow-transit constipation intragastric acidity gastritis gastritis, chronic atrophic gastritis, chronic atrophic; metaplasia, intestinal esophagitis irritable bowel syndrome dyspepsia gastrointestinal bleeding peptic ulcer disease gastric ulceration ulcer, duodenal duodenal ulcer gastric ulcer gastric body ulcer gastric disease ulcer, gastric; repaglinide pharmacology; coagulation disorder recurrent oral ulcers gastric ulcer, HIV, malaria gastritis; intestinal metaplasia gastrointestinal toxicity gastrointestinal disorders ulcer, gastric giant cell arteritis polymyalgia rheumatica/giant cell arteritis Giant Cell Arteritis giant cell arteritis; purpura, Henoch-Schonlein; hypersensitivity vasculitis giant cell arteritis. giant cell arteritis; polymyalgia rheumatica glaucoma Glaucoma glaucoma, early-onset glaucoma, normal tension normal tension glaucoma open-angle glaucoma adult-onset primary open-angle glaucoma glaucoma, primary congenital primary congenital glaucoma primary open angle glaucoma primary open-angle glaucoma glaucoma, primary open-angle glaucoma, primary open-angle; glaucoma, normal tension glaucoma, primary open-angle; glaucoma, primary congenital glaucoma; glaucoma, primary open-angle glucose glucose tolerance; insulin; lipids plasma glucose concentration increased serum glucose concentrations elevated glucose and insulin levels postprandial hyperglycaemia
  119. 119. postprandial responses to glucose or fat tolerance tests glucose intolerance hyperglycemia plasma glucose levels elevated fasting blood glucose levels glucose metabolism glucose response glucose tolerance glucose tolerance; adiponectin glucose tolerance; fatty acid glucose tolerance; insulin glucose tolerance; insulin; blood pressure; body weight; C-peptide; HbA1c glucose tolerance; insulin; body fat glucose tolerance; insulin; obesity; energy expenditure glucose tolerance; insulin; polycystic ovary syndrome; androgen levels; anthropometric measuments glucose tolerance; insulin; polycystic ovary syndrome; hormone disturbance glucose tolerance; insulin; vascular disease glucose tolerance; lipid metabolism glucose tolerance; lipids; atherosclerosis, generalized glucose tolerance; lipids; fibrinogen; hematology indices glucose tolerance; metabolic syndrome; adiponectin glucose tolerance; metabolic syndrome; hyperglycemia glucose; adiponectin glucose; birth weight glucose; diabetes, unspecified glucose; insulin resistance glucose; insulin secretion glucose; lactose intolerance glucose; paraoxonase-1 oral glucose tolerance graft versus host disease GVHD graft-versus-host disease graft-versus-host disease; bone marrow transplantation acute graft-versus-host disease acute GVHD graft-versus-host disease; longevity; spondyloarthropathies; aphthous stomatitis graft-versus-host disease; psoriasis; celiac disease graft-vs-host disease chronic graft-versus-host disease Grave`s disease Graves disease Graves' disease; Hashimoto's thryoiditis Graves` Disease Graves' disease Graves' ophthalmopathy Graves' disease; Hashimoto's thyroiditis Graves' disease; Hashimoto's thyroiditis; autoimmune polyglandular syndrome Graves' disease; Hashimoto's thyroiditis; primary idiopathic myxedema Graves' disease; ophthalmopathy, Graves' Graves' disease; thyroiditis, chronic lymphocytic Graves' hyperthyroidism gastric atrophy
  120. 120. Helicobacter pylori cagA subtype infection Helicobacter pylori eradication H. pylori infection Helicobacter pylori infection Helicobacter pylori infection. Helicobacter pylori infection; gastritis, Helicobacter pylori-induced H. pylori infection; Helicobacter pylori infection H. pylori infection; stomach cancer H. pylori infection; stomach cancer; peptic ulcer H. pylori infection; thrombocytopenic purpura, idiopathic head and neck cancer paragangliomas, head and neck squamous cell carcinoma of the tongue paragangliomas, head and neck; pheochromocytomas nasopharyngeal carcinomas head and neck cancer; benzene toxicity head and neck squamous cell carcinoma squamous cell carcinoma of the head and neck laryngeal cancer laryngeal squamous cell carcinoma Nasopharyngeal angiofibroma nasopharyngeal cancer nasopharyngeal carcinoma nasopharyngeal carcinoma. oral cancer Oral cancer oral cancer; leukoplakia oral cancer; oral submucous fibrosis hypopharyngeal cancer; laryngeal cancer; oral cancer; oropharynx cancer oral carcinoma betel-associated oral carcinoma oral cavity cancer oral squamous carcinoma oral squamous cell cancer oral squamous cell carcinoma premalignant oral lesions and oral squamous cell carcinoma areca quid chewing-associated oral squamous cell carcinomas oral squamous cell carcinomas orolaryngeal cancer orolaryngeal carcinoma Head and neck squamous cell cancer Dominant Progressive Deafness deafness Maternally inherited deafness Non-syndromic deafness maternally inherited diabetes and deafness cochlear pathology idiopathic progressive sensorineural hearing loss hearing loss/deafness; hearing loss, sensorineural nonsyndromic autosomal dominant hearing loss deafness, nonsyndromic otosclerosis auditory evoked potential
  121. 121. auditory evoked potentials aminoglycoside ototoxicity non-syndromic deafness nonsyndromic deafness DFNB3 nonsyndromic hearing impairment nonsyndromic hearing loss non-syndromic neurosensory deafness (DFNB1) hearing loss nonsyndromic neurosensory deafness Hearing loss ototoxicity dominant non-syndromic sensorineural hearing loss Jervell and Lange-Nielsen syndrome londness dependence loudness dependence hearing loss, nonsyndromic sensorineural Pendred syndrome Pendred's syndrome hearing loss, sensorineural sensorineural hearing loss hearing loss, sensorineural nonsyndromic hearing loss/deafness hearing loss/deafness; osteogenesis imperfecta hearing loss/deafness; retinal disease chronic heart failure heart failure congestive heart failure end-stage heart failure hemochromatosis increased transferrin saturation idiopathic haemochromatosis haemochromatosis iron overload Hemochromatosis Type 3 hemochromatosis hereditary hemochromatosis in African Americans. hereditary hemochromatosis. hereditary hemochromatosis Juvenile Hemochromatosis hemochromatosis; dermatomyositis; juvenile arthritis; polymyositis ferritin; transferrin saturation increased serum iron transferrin saturation and hemoglobin iron levels iron levels; soluble transferrin receptor; transferrin iron load iron metabolism iron stores porphyria variegate porphyria spherocytosis polycythemia polycythemia vera porphyria cutanea tarda
  122. 122. porphyria, acute intermittent (AIP) hereditary elliptocytosis severe elliptopoikilocytosis hereditary elliptocytosis in spectrin Napoli. sickle cell and beta-thalassaemia gene mild beta-thalassemiphenotype Poikilocytic hereditary elliptocytosis Mild elliptocytosis hereditary spherocytosis thalassaemia hereditary stomatocytosis. hereditary spherocytosis hyperactivity of Na+/Li+ counte Haemophilia with Chronic synovitis Familial erythrocytosis hemoglobin disorders mild HDN hemolytic disease hereditary spherocytosis (protein 4.2Notame). erythropoietin elliptocytosis Haemophilia hemolytic disease of the newborn ovalostomatocytosis erythrocyte band 4.2 deficiency. erythropoietic protoporphyria haemoglobinopathies alpha-thalassaemia alpha-thalassemia-2 and Hb S hemophilia thalasemia, alpha beta-thalassaemia intermedia beta thalassemia beta-thalassemia thalassemia thalassemia, alpha thalassemia, beta thalassemia; thalassemia, beta hepatitis hepatitis A vaccination, humoral immune response hepatitis B hepatitis; liver disease, chronic Hepatitis hepatitis B vaccination, humoral immune response hepatitis B, chronic hepatitis B; cirrhosis; liver cancer hepatitis B; Graves' disease; thyroiditis, Hashimoto's hepatitis B-related hepatocellular carcinoma chronic hepatitis C chronic hepatitis C virus infection. hepatitis C HCV infection Hepatitis C virus infection associated with human hepatocellular carcinoma interferon-resistant hepatitis C virus infection
  123. 123. hepatitis C infection HCV-induced liver fibrosis chronic active hepatitis C infection. hepatitis C viral load hepatitis C virus infection hepatitis C virus infection. hepatitis C, chronic hepatitis C; hepatitis B hepatitis C; hypothyroidism hepatitis C; liver cancer hepatitis C; longevity hepatitis C; Schistosoma mansoni infection hepatitis E hepatitis, fulminant non-A, nonB clinical courses of HIV HIV susceptibility or resistance to immunodeficiency virus type 1 infection increased perinatal immunodeficiency virus type 1 transmission HIV Infected Long- Term Nonprogressors HIV viral load HIV-related disease HIV disease HIV disease progression HIV infection HIV infection; dementia, AIDS HIV infection; hepatitis C infection Progression to AIDS AIDS extranodal disease pediatric AIDS progression. HIV/SIV infection HIV; atherosclerosis, generalized HIV; CYP3A activity HIV; CYP3A activity; prostate cancer HIV; cytomegalovirus retinitis HIV; folate; vitamin B12 HIV; HIV disease progression HIV; hypertension; nephrotic syndrome HIV; myocardial infarction HIV; nasopharyngeal cancer HIV; pneumocystis carinii pneumonia HIV; sclerosis, systemic HIV; Toxoplasmic encephalitis HIV; tuberculosis; cleft lip with cleft palate; cleft lip without cleft palate HIV-1 susceptibility to HIV-1 HIV-1 disease HIV-1 infection HIV-1 propagation in vitro. homocysteine, cholesterol and vascular endothelial function hyperhomocysteinemia and cardiovascular disease mild hyperhomocysteinaemia homocysteine concentrations
  124. 124. folate; homocysteine plasma folate vitamin B12 homocyst(e)ine and colorectal cancer risk plasma homocysteine folate; homocystinuria folate; hyperhomocystinemia homocysteine plasma levels of homocysteine plasma total homocysteine and folate concentrations plasma homocysteine level plasma homocysteine levels reduced CBS activity and elevated post-load homocysteine levels homocysteine; vitamin B12; holotranscobalamin; methylmalonic acid homocysteine; vitamin B12; transcobalamin hyperhomocysteinemia hyperhomocystinemia homocystinuria homocyteine hyperhomocystinemia; cystathionine beta-synthase deficiency mild homocystinuria myelopathy, HTLV-1 associated myelopathy/tropical spastic paraparesis HTLV-1 infection human T lymphotropic virus type I infection HTLV-I-associated myelopathy Huntington disease Huntingtons disease Huntington's disease Huntington's disease; ataxia (SCA) hypertension; lung cancer; abdominal aortic aneurysm hypertension polygenic hypertension Hypertension hypertension and ESRD hypertension, salt sensitive hypertension; homocysteine hypertension and left ventricular mass hypertension and obesity familial hypertension of early onset. Abdominal adiposity and Hypertension hypertension, cirrhotic portal Essential Hypertension essential hypertension hypertension, gestational grade II hypertension hypertension, pregnancy induced pulmonary hypertension; scleroderma hypertension, pulmonary hypertension; autonomic nervous system dysfunction hypertension; beta-glucuronidase; anaphylactoid purpura hypertension; blood pressure hypertension; blood pressure, arterial hypertension; cardiovascular disease hypertension; cerebral infarction
  125. 125. hypertension; cirrhosis hypertension; dyslipidemia hypertension; exercise hypertension; glucose hypertension; glucose tolerance; insulin; hematology indices hypertension; H. pylori infection hypertension; hyperaldosteronism hypertension; insulin; blood pressure, arterial hypertension; insulin; metabolic syndrome; hypertriglyceridemia hypertension; insulin; obesity hypertension; kallikrein activity, urinary hypertension; left ventricular function hypertension; left ventricular hypertrophy hypertension; left ventricular structure hypertension; myocardial infarction hypertension; nephropathy hypertension; nephrotic syndrome hypertension; obesity hypertension; preeclampsia hypertension; renal disease, end stage hypertension; renal dysfunction, posttransplantation hypertension; renal sodium handling hypertension; stroke hypertension; stroke, ischemic hypertension; stroke, lacunar; atherothrombotic brain infarction Erythropoietin Induced Hypertension plasma IL-6 levels IgA, IgD, IgG, IgM Total Serum IgE level IgD EO soluble cytotoxic T lymphocyte-associated antigen-4 soluble e-selectin levels soluble IL-6 receptor Specific IgE. Wheeze specific levels of Lp(a) in plasma islet cell antibodies IgA deficiency IgA deficiency and common variable immunodeficiency high interleukin-1 beta plasma levels hyper-IgM syndrome High serum IgE concentrations hypereosinophilia high TNF levels is not a risk factor for venous thromboem High total IgE High total IgE. asthma. atopy eosinophilia Eosinophilia cytokine production diabetes-associated autoantibodies cytokine release cytokine response cytokine response to measles vaccine
  126. 126. cytokine synthesis cytokines; tumor markers anti-Ro autoantibodies severe chronic neutropenia IgE hyper-IgM syndrome can form oligomers and trigger CD40-mediated signals CD14 levels CD14 expression Increased IgE increased IgE Specific IgE tIgE Total IgE Total IgE. atopic asthma Total IgE. Eosinophilia. DRS Total IgE. SPT. FEV1 Total serum IgE total serum IgE levels Total serum IgE. atopic dermatitis Total serum IgE. specific IgE. AR IgE levels serum IgE levels IgE response IgE. SPT IGF-I IGF-I levels; IGFBP-3 levels interleukin-1 beta (IL-1 beta) synthesis capacity increased interleukin-10 (IL-10) plasma levels IL-1beta soluble CD14 plasma levels IL-4 IL-4 production Plasma IL6 levels neutropenia IL6 transcription total serum calcium interleukin-10 response after cardiopulmonary bypass. IL-12 production from monocyte IL4R allele frequency alveolar echinococcosis Boutonneuse fever pneumococcal infection upper genital tract infections and histopathology susceptibility to meningococcal disease Trypanosoma Trypanosoma cruzi infection viral clearance Postoperative infectious complications Scarring trachoma Staphylococcus aureus infection postoperative systemic inflammatory reaction bacterial vaginosis schistosomal worm antigen
  127. 127. chronic infections and risk of stable coronary artery dis higher prevalence of multiple infections CP infection. childhood infection Childhood Stroke After Varicella Meningococcal Disease herpes zoster infectious risk and outcome in surgical intensive care patients Chlamydia trachomatis aphthous stomatitis human T-cell lymphotropic virus type I associated myelopathy appendicitis bacterial infection Leprosy leprosy phenotypes leprosy susceptibility recurrent bacterial infections interstitial cystitis brucellosis gram-negative infections gram-negative infection Candida candidiasis cervical cancer Chagas Disease Chlamydia Chlamydia pneumoniae infection dengue disease dengue hemorrhagic fever dental implants enteroaggregative Escherichia coli diarrhea echinococcosis necrotizing enterocolitis Epstein-Barr virus Epstein-Barr virus infection filiariasis hepatosplenic schistosomiasis japonica human papillomavirus infection papillomavirus infection HPV-associated cervical dysplasia HPV infection and cervical disease neonatal infection Leishmania chagasi infection leishmaniasis susceptibility to visceral leishmaniasis mucocutaneous leishmaniasis lep. Leprosy leprosy tuberculoid type of leprosy leprosy type leptospirosis liver disease Lyme disease
  128. 128. measles measles antibody level Mediterranean fever mediterranean visceral leishmaniasis meliodosis meningococcal disease meningococcal disease. meningococcal septic shock fulminant meningococcal septic shock in children oral lichen planus otitis media otitis media; pneumococcal infection ascaris infection Parasitic infection poliomyelitis parvovirus parvovirus B19 infection Plasmodium falciparum infection Plasmodium falciparum reinfections pneumoconiosis pneumoconiosis, coal workers' pneumonia community-acquired pneumonia (CAP) cryptosporidiosis; Mycobacterium avium complex; pneumocystis carinii pneumonia; toxoplasmosis Streptococcus pneumoniae Legionnaire's disease pulmonary tuberculosis Q fever respiratory distress syndrome (RDS) recurrent respiratory infections recurrent respiratory papillomatosis respiratory papillomatosis, juvenile-onset; recurrent respiratory syncytial virus Respiratory Syncytial Virus (RSV) respiratory syncytial virus disease respiratory syncytial virus infection rickets SARS SARS (severe acute respiratory syndrome) SARS infection severe acute respiratory syndrome schistosomiasis staphylococcal infection typhoid fever urinary infection urinary tract infection urinary tract infections after renal transplantation West Nile virus anovulation and fecundity impaired sperm production oligospermia idiopathic azoospermia immature sperm cells