Stem Cells, Complexity, and the Science of Being                             Neil Theise MD                  Departments o...
1o Female RecipientMale Donor BM                                                     48 Hours                             ...
Bone Marrow              One            Adult CellEpithelia of             Skin, Hair follicles• Liver• Lung• Gut, (Pancre...
MESODERM                      One                    Adult Cell       ENDODERM                  ECTODERMTrue clonality = T...
The Standard Paradigm:  Restricted Plasticity
Embryology &Adult Tissue Reconstitution      Self renewal      Irreversible gene restrictions
BEWARE  OFDOGMA
What if gene restrictionsare REVERSIBLE?
3 Principles of Plasticity           Theise & Krause           BCMD, May 2001    Leukemia, April Fool’s Day 2002Comptes Re...
1. Genomic Completeness2. Cellular Uncertainty3. Stochasticity of   Cell Origins and Fates
1. Genomic Completeness2. Cellular Uncertainty3. Stochasticity of   Cell Origins and Fates
“…the internal and the external co-determine the cell.”                                        Richard Lewontin, 2000
2nd Principle:            Cellular UncertaintyAny attempt to observe a cell alters the state of that cell at the time of c...
2nd Principle:            Cellular UncertaintyAny attempt to observe a cell alters the state of that cell at the time of c...
Meanwhile,back at the plasticity debates…
Controversy!!!
trivial...    vs.ROBUST!!!
Conversations with Jane Prophet        New Media Artist and Professor, Interdisciplinary StudiesUniversity of Westminster,...
Date: 9th May 2002          Location: Neils office, New YorkJane says: “Ideas about pathways are interesting. A lot of peo...
Complex Adaptive Systems:1,21  Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed.     Chicago IL: University of Chica...
Complex Adaptive Systems:       Interacting individuals that,           if they fulfill 4 criteria,organize themselves fro...
Complex Adaptive Systems:          Interacting individuals that,             if they fulfill 4 criteria,   organize themse...
Complex Adaptive Systems:         Interacting individuals that,            if they fulfill 4 criteria,  organize themselve...
Complex Adaptive Systems:         Interacting individuals that,            if they fulfill 4 criteria,  organize themselve...
Complex Adaptive Systems:Rise and fall of economic markets       Urban development        Immune systems          Beatlema...
Complex Adaptive Systems:Rise and fall of economic markets       Urban development        Immune systems          Beatlema...
Complex Adaptive Systems:     • Numbers matter
Complex Adaptive Systems:     • Numbers matter • Negative feedback loops
Complex Adaptive Systems:              • Numbers matter         • Negative feedback loops• Interactions are local without ...
Complex Adaptive Systems:              • Numbers matter         • Negative feedback loops• Interactions are local without ...
Complex Adaptive Systems:              • Numbers matter         • Negative feedback loops• Interactions are local without ...
Low level engraftment    is not only NOT trivial,    but it is VITAL    – literally so.1-31  Theise ND. Exp Hematology 200...
Implications of Cell Lineagesas Complex Adaptive Systems       Mass extinctions.
“chaos”disorder           order
“chaos”disorder                   complex                     adaptive                        systems           order
Implications of Cell Lineagesas Complex Adaptive Systems     Mass extinctions, eg:       ? Aplastic anemia    ? Fulminant ...
Implications of Cell Lineagesas Complex Adaptive Systems    The price of adaptation,          i.e. of LIFE,           is D...
Implications of Cell Lineagesas Complex Adaptive SystemsHierarchies of complex systems…
Implications of Cell Lineagesas Complex Adaptive SystemsHierarchies of complex systems…     thing vs. phenomenadepends on ...
Communities  Bodies   Cells
e.g. cities, cultures, ecosystems, Gaia                  Bodies                   Cells
Communities  Bodies   Cells              ?
Communities   Bodies    CellsBiomolecules   ?
Communities   Bodies    CellsBiomolecules
Communities          Bodies           Cells       BiomoleculesMore implications, of course.
1. Genomic Completeness?   Cellular Uncertainty3. Stochasticity of   Cell Origins and Fates
Communities   Bodies    CellsBiomoleculesTheise ND.Now you see it, now you don’t.Nature, May 2005“Cell doctrine: modern bi...
Communities   Bodies    CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed…
Communities   Bodies    CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed....
Communities   Bodies    CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed....
Communities   Bodies    CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed....
What kind of models?
for example,          2 models from Ancient Greece:              Is the body made of…indivisible subunits or an endlessly ...
Models of the body are perspective/technique dependent         Look at it this way (cell membranes):               the bod...
Models are perspective/technique dependent      Look at it this way (cell membranes):            the body is made of cells...
Still more implications of   complexity in life…
Communities   Bodies    CellsBiomolecules   Atoms
Communities   Bodies    CellsBiomolecules   Atoms
Communities   Bodies    CellsBiomolecules   Atoms
Communities                  Bodies                   Cells               Biomolecules                  AtomsWe are walkin...
Communities     Bodies      Cells  Biomolecules      AtomsSubatomic Particles
Communities       Bodies        Cells    Biomolecules       AtomsSubatomic ParticlesStrings (or whatever)
Communities       Bodies        Cells    Biomolecules       AtomsSubatomic ParticlesStrings (or whatever)The Quantum Foam
We don’t live in the universe . . .
. . . we are the universe
Implications of Everything as Complex Adaptive System Science-Metaphysics Interface       Complementarity   Consciousne...
Implications of Everything as Complex Adaptive System Science-Metaphysics Interface       Complementarity   Consciousne...
The Relative
The Absolute
Implications of Everything    as Complex Adaptive System3. “thingness” is dependent on scale
Implications of Everything   as Complex Adaptive System3. Emptiness of inherent existence
Implications of Everything   as Complex Adaptive System3. Emptiness of inherent existence   2. Inevitable mass extinction
Implications of Everything   as Complex Adaptive System3. Emptiness of inherent existence         2. Impermanence
Implications of Everything      as Complex Adaptive System   3. Emptiness of inherent existence            2. Impermanence...
Implications of Everything   as Complex Adaptive System3. Emptiness of inherent existence         2. Impermanence        3...
Implications of Everything      as Complex Adaptive System   3. Emptiness of inherent existence            2. Impermanence...
Implications of Everything   as Complex Adaptive System3. Emptiness of inherent existence         2. Impermanence        3...
Implications of Everythingas Complex Adaptive System   Buddhist Metaphysics
Implications of Everythingas Hierarchical Complex Systems       Jewish Mysticism
Implications of Everythingas Complex Adaptive Systems      Hindu Mysticism
Implications of Everything as Complex Adaptive System Science-Metaphysics Interface  Biological Complementarity   Consc...
Bohr, Delbruck, Menas Kafatos
Implications of Everything as Complex Adaptive System Science-Metaphysics Interface       Complementarity   Consciousne...
HUMBERT R. MATURANA and FRANCISCO J. VARELA    All living systems are autopoietic systems.          AUTOPOIESIS           ...
HUMBERT R. MATURANA and FRANCISCO J. VARELA    All living systems are autopoietic systems.          AUTOPOIESIS           ...
HUMBERT R. MATURANA and FRANCISCO J. VARELA    All living systems are autopoietic systems.          AUTOPOIESIS           ...
HUMBERT R. MATURANA and FRANCISCO J. VARELA    All living systems are autopoietic systems.          AUTOPOIESIS           ...
HUMBERT R. MATURANA and FRANCISCO J. VARELA   All living systems are cognitive systems.          AUTOPOIESIS             A...
HUMBERT R. MATURANA and FRANCISCO J. VARELA   All living systems are cognitive systems.          AUTOPOIESIS             A...
All living systems are cognitive systems.Conciousness <> Sense Making <> Sentience
They’ve found that some of the key molecularbuilding blocks of neurons predate even the firstmulticellular organisms. By l...
s          g         s nes        akin       ce     ciou        se M       tienCo n        Sen         Sen                ...
s          g         s nes        akin       ce     ciou        se M       tienCo n        Sen         Sen                ...
s          g         s nes        akin       ce     ciou        se M       tienCo n        Sen         Sen                ...
Biomolecules!!!
Only biomolecules???
Atoms!!!
Only atoms???
Subatomic particles!!!                         10-18m                                  Strings                         10-...
Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in s...
Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in s...
Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in s...
Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in s...
s          g         s nes        akin       ce     ciou        se M       tienCo n        Sen         Sen                ...
Single cell multiorgan plasticity        Diane Krause MD PhDSaul Sharkis MD PhD, Michael Collector       Octavian Henegari...
Cell Team              Jane Prophet             Mark D’Inverno             Rob Saunders               Peter Ride          ...
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Science of Being - UBC 2012
Upcoming SlideShare
Loading in...5
×

Science of Being - UBC 2012

379

Published on

Talk for UBC students 3/2012

Published in: Health & Medicine, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
379
On Slideshare
0
From Embeds
0
Number of Embeds
0
Actions
Shares
0
Downloads
11
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide
  • 1
  • 1
  • Science of Being - UBC 2012

    1. 1. Stem Cells, Complexity, and the Science of Being Neil Theise MD Departments of Pathology & Medicine Beth Israel Medical Center – Albert Einstein College of Medicine New York City www.neiltheise.com
    2. 2. 1o Female RecipientMale Donor BM 48 Hours PKH26 Lin Deplete Label Elutriate Sort PKH-bright Transplant single cell into 2o Female Recipient
    3. 3. Bone Marrow One Adult CellEpithelia of Skin, Hair follicles• Liver• Lung• Gut, (Pancreas)
    4. 4. MESODERM One Adult Cell ENDODERM ECTODERMTrue clonality = True adult stem cell plasticity!
    5. 5. The Standard Paradigm: Restricted Plasticity
    6. 6. Embryology &Adult Tissue Reconstitution Self renewal Irreversible gene restrictions
    7. 7. BEWARE OFDOGMA
    8. 8. What if gene restrictionsare REVERSIBLE?
    9. 9. 3 Principles of Plasticity Theise & Krause BCMD, May 2001 Leukemia, April Fool’s Day 2002Comptes Rendus Biologies, December 2002
    10. 10. 1. Genomic Completeness2. Cellular Uncertainty3. Stochasticity of Cell Origins and Fates
    11. 11. 1. Genomic Completeness2. Cellular Uncertainty3. Stochasticity of Cell Origins and Fates
    12. 12. “…the internal and the external co-determine the cell.” Richard Lewontin, 2000
    13. 13. 2nd Principle: Cellular UncertaintyAny attempt to observe a cell alters the state of that cell at the time of characterization and potentially alters the likelihood of subsequent differentiation events.
    14. 14. 2nd Principle: Cellular UncertaintyAny attempt to observe a cell alters the state of that cell at the time of characterization and potentially alters the likelihood of subsequent differentiation events. ?
    15. 15. Meanwhile,back at the plasticity debates…
    16. 16. Controversy!!!
    17. 17. trivial... vs.ROBUST!!!
    18. 18. Conversations with Jane Prophet New Media Artist and Professor, Interdisciplinary StudiesUniversity of Westminster, London UKSciArt Award, Wellcome Trust 2002
    19. 19. Date: 9th May 2002 Location: Neils office, New YorkJane says: “Ideas about pathways are interesting. A lot of people who are involved in digital biology are interested in things like swarming people and so called ’soup organism’ behaviour. And one of the useful models to take forward is about ant colonies…”
    20. 20. Complex Adaptive Systems:1,21 Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002.2 Johnson S, Emergence. New York NY: Scribner; 2001.
    21. 21. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria,organize themselves from the bottom up, into larger structures…
    22. 22. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures,which appear planned from the top, downward…
    23. 23. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures,which appear planned from the top, downward, BUT ARE NOT!
    24. 24. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structureswhich appear planned from the top, downward, BUT ARE NOT! These structures are referred to as “emergent self-organization” and are ADAPTIVE.
    25. 25. Complex Adaptive Systems:Rise and fall of economic markets Urban development Immune systems Beatlemania Rise and fall of civilizations Evolution and speciation
    26. 26. Complex Adaptive Systems:Rise and fall of economic markets Urban development Immune systems Beatlemania Rise and fall of civilizations Evolution and speciation Conciousness
    27. 27. Complex Adaptive Systems: • Numbers matter
    28. 28. Complex Adaptive Systems: • Numbers matter • Negative feedback loops
    29. 29. Complex Adaptive Systems: • Numbers matter • Negative feedback loops• Interactions are local without global sensing
    30. 30. Complex Adaptive Systems: • Numbers matter • Negative feedback loops• Interactions are local without global sensing • Low level randomness
    31. 31. Complex Adaptive Systems: • Numbers matter • Negative feedback loops• Interactions are local without global sensing • “Quenched disorder”
    32. 32. Low level engraftment is not only NOT trivial, but it is VITAL – literally so.1-31 Theise ND. Exp Hematology 20032 D’Inverno M, Theise ND. BCMD 20043 D’Inverno M, Theise ND, Prophet J. In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications
    33. 33. Implications of Cell Lineagesas Complex Adaptive Systems Mass extinctions.
    34. 34. “chaos”disorder order
    35. 35. “chaos”disorder complex adaptive systems order
    36. 36. Implications of Cell Lineagesas Complex Adaptive Systems Mass extinctions, eg: ? Aplastic anemia ? Fulminant liver failure
    37. 37. Implications of Cell Lineagesas Complex Adaptive Systems The price of adaptation, i.e. of LIFE, is DEATH
    38. 38. Implications of Cell Lineagesas Complex Adaptive SystemsHierarchies of complex systems…
    39. 39. Implications of Cell Lineagesas Complex Adaptive SystemsHierarchies of complex systems… thing vs. phenomenadepends on scale of observation
    40. 40. Communities Bodies Cells
    41. 41. e.g. cities, cultures, ecosystems, Gaia Bodies Cells
    42. 42. Communities Bodies Cells ?
    43. 43. Communities Bodies CellsBiomolecules ?
    44. 44. Communities Bodies CellsBiomolecules
    45. 45. Communities Bodies Cells BiomoleculesMore implications, of course.
    46. 46. 1. Genomic Completeness? Cellular Uncertainty3. Stochasticity of Cell Origins and Fates
    47. 47. Communities Bodies CellsBiomoleculesTheise ND.Now you see it, now you don’t.Nature, May 2005“Cell doctrine: modern biology and medicine see thecell as the fundamental building block of livingorganisms, but this concept breaks down at differentperspectives and scales.”
    48. 48. Communities Bodies CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed…
    49. 49. Communities Bodies CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed. To limit ourselves to theperspective of this model may mean that explications ofsome bodily phenomena remain outside the capacity ofmodern biology…
    50. 50. Communities Bodies CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed. To limit ourselves to theperspective of this model may mean that explications ofsome bodily phenomena remain outside the capacity ofmodern biology… e.g. Acupuncture
    51. 51. Communities Bodies CellsBiomolecules“The validity of cell doctrine depends on the scale atwhich the body is observed. To limit ourselves to theperspective of this model may mean that explications ofsome bodily phenomena remain outside the capacity ofmodern biology. It is perhaps time to dethrone thedoctrine of the cell, to allow alternative models of thebody for study and exploitation in this new, postmodernera of biological investigation.”
    52. 52. What kind of models?
    53. 53. for example, 2 models from Ancient Greece: Is the body made of…indivisible subunits or an endlessly divisible fluid
    54. 54. Models of the body are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid
    55. 55. Models are perspective/technique dependent Look at it this way (cell membranes): the body is made of cells Look at it that way (organelles): the body is an endlessly divisible fluid Yet another way (the genome):… overlapping spatial/temporal fields of molecular organization
    56. 56. Still more implications of complexity in life…
    57. 57. Communities Bodies CellsBiomolecules Atoms
    58. 58. Communities Bodies CellsBiomolecules Atoms
    59. 59. Communities Bodies CellsBiomolecules Atoms
    60. 60. Communities Bodies Cells Biomolecules AtomsWe are walking, talking Earth…
    61. 61. Communities Bodies Cells Biomolecules AtomsSubatomic Particles
    62. 62. Communities Bodies Cells Biomolecules AtomsSubatomic ParticlesStrings (or whatever)
    63. 63. Communities Bodies Cells Biomolecules AtomsSubatomic ParticlesStrings (or whatever)The Quantum Foam
    64. 64. We don’t live in the universe . . .
    65. 65. . . . we are the universe
    66. 66. Implications of Everything as Complex Adaptive System Science-Metaphysics Interface  Complementarity  Consciousness Studies
    67. 67. Implications of Everything as Complex Adaptive System Science-Metaphysics Interface  Complementarity  Consciousness Studies
    68. 68. The Relative
    69. 69. The Absolute
    70. 70. Implications of Everything as Complex Adaptive System3. “thingness” is dependent on scale
    71. 71. Implications of Everything as Complex Adaptive System3. Emptiness of inherent existence
    72. 72. Implications of Everything as Complex Adaptive System3. Emptiness of inherent existence 2. Inevitable mass extinction
    73. 73. Implications of Everything as Complex Adaptive System3. Emptiness of inherent existence 2. Impermanence
    74. 74. Implications of Everything as Complex Adaptive System 3. Emptiness of inherent existence 2. Impermanence3. Systems depend on EVERY member
    75. 75. Implications of Everything as Complex Adaptive System3. Emptiness of inherent existence 2. Impermanence 3. Interdependence
    76. 76. Implications of Everything as Complex Adaptive System 3. Emptiness of inherent existence 2. Impermanence 3. Interdependence4. The fact of emergence is predictable, the nature of it is not.
    77. 77. Implications of Everything as Complex Adaptive System3. Emptiness of inherent existence 2. Impermanence 3. Interdependence 4. Karmic law (cause and effect)
    78. 78. Implications of Everythingas Complex Adaptive System Buddhist Metaphysics
    79. 79. Implications of Everythingas Hierarchical Complex Systems Jewish Mysticism
    80. 80. Implications of Everythingas Complex Adaptive Systems Hindu Mysticism
    81. 81. Implications of Everything as Complex Adaptive System Science-Metaphysics Interface  Biological Complementarity  Consciousness Studies
    82. 82. Bohr, Delbruck, Menas Kafatos
    83. 83. Implications of Everything as Complex Adaptive System Science-Metaphysics Interface  Complementarity  Consciousness Studies
    84. 84. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are autopoietic systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS 1. Boundary: open to energy but closed to foreign materials – i.e. is semi-porous.
    85. 85. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are autopoietic systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS 1. Boundary: open to energy but closed to foreign materials – i.e. is semi-porous. 2. Processes: the boundary is the ’being’ and the processes are the ‘doing’ of a living system.
    86. 86. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are autopoietic systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS 1. Boundary: open to energy but closed to foreign materials – i.e. is semi-porous. 2. Processes: the boundary is the ’being’ and the processes are the ‘doing’ of a living system. 3. Nervous System: the connection between external events and the internal processes of the living system.
    87. 87. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are autopoietic systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS 1. Boundary: open to energy but closed to foreign materials – i.e. is semi-porous. 2. Processes: the boundary is the ’being’ and the processes are the ‘doing’ of a living system. 3. Nervous System: the connection between external events and the internal processes of the living system. 4. Communication Channels: between the living system and its external environment.
    88. 88. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are cognitive systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS
    89. 89. HUMBERT R. MATURANA and FRANCISCO J. VARELA All living systems are cognitive systems. AUTOPOIESIS AND COGNITION The Realization of the Living With a preface on “Autopoiesis” by SIR STAFFORD BEERS
    90. 90. All living systems are cognitive systems.Conciousness <> Sense Making <> Sentience
    91. 91. They’ve found that some of the key molecularbuilding blocks of neurons predate even the firstmulticellular organisms. By looking down the treeof life, they are concluding that assembling thesecomponents into a cell a modern neuroscientistwould recognize as a neuron probably happenedvery early in animal evolution, more than 600million years ago. Most scientists agree thatcircuits of interconnected neurons probably arosesoon thereafter, first as diffuse webs and later as acentralized brain and nerves. G. Miller, Science, 2009
    92. 92. s g s nes akin ce ciou se M tienCo n Sen Sen Communities Bodies Cells Biomolecules Atoms Subatomic Particles Strings (or whatever)
    93. 93. s g s nes akin ce ciou se M tienCo n Sen Sen Communities Bodies Cells Biomolecules Only living (biological) Atoms systems ??? Subatomic Particles Strings (or whatever)
    94. 94. s g s nes akin ce ciou se M tienCo n Sen Sen Communities Bodies Cells Biomolecules ? Atoms Subatomic Particles Strings (or whatever)
    95. 95. Biomolecules!!!
    96. 96. Only biomolecules???
    97. 97. Atoms!!!
    98. 98. Only atoms???
    99. 99. Subatomic particles!!! 10-18m Strings 10-35m (or whatever)
    100. 100. Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in scale onlyto the smallest, autopoietic elements of life– namely the cell – a complexity analysis ofthe universe (as a unified, self-organizingand emergent system) reveals that theuniverse is sentient throughout; thatsentience is inherent and universal in thestructures of existence.
    101. 101. Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in scale onlyto the smallest, autopoietic elements of life– namely the cell – a complexity analysis ofthe universe (as a unified, self-organizingand emergent system) reveals that theuniverse is sentient throughout; thatsentience is inherent and universal in thestructures of existence.
    102. 102. Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in scale onlyto the smallest, autopoietic elements of life– namely the cell – a complexity analysis ofthe universe (as a unified, self-organizingand emergent system) reveals that theuniverse is sentient throughout; thatsentience is inherent and universal in thestructures of existence.
    103. 103. Conclusion:While one may argue that sense makingand therefore some form of conciousness islimited, extending downward in scale onlyto the smallest, autopoietic elements of life– namely the cell – a complexity analysis ofthe universe (as a unified, self-organizingand emergent system) reveals that theuniverse is sentient throughout; thatsentience is inherent and universal in thestructures of existence.
    104. 104. s g s nes akin ce ciou se M tienCo n Sen Sen Communities Bodies Cells Biomolecules? ? Atoms Subatomic Particles Strings (or whatever)
    105. 105. Single cell multiorgan plasticity Diane Krause MD PhDSaul Sharkis MD PhD, Michael Collector Octavian Henegariu MD Sonya Hwang MD, Rebekah Gardner Sarah Neutzel
    106. 106. Cell Team Jane Prophet Mark D’Inverno Rob Saunders Peter Ride Neil TheiseDiscussions were part of the production of "Cell", a collaboration across art and science funded by a Wellcome Trust SciArt Award and an award from Future Physical. "Cell" is coordinated by Peter Ride and is a DA2 Digital Arts Agency production.
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.

    ×