Fig. 7.29. The same flow chart as Fig. 7.28 with emphasis on the concepts developed largely in animal models that the lesions associated with steatohepatitis are explained by pathogenetic models.
Fig. 7.28. A simplified flow chart of the cyclic pathogenic events that both lead to and result in steatosis and steatohepatitis.
Fig. 7.9. Most of the ballooned hepatocytes in this field contain intracytoplasmic ropy material consistent with Mallory’s hyaline. Satellitosis can be seen. H&amp;E.
Fig. 7.11. The frequency of megamitochondria in NAFLD and NASH has not been rigorously evaluated. This example shows round intracytoplasmic inclusions that are characteristic of megamitochondria. Needle-shaped inclusions may also be seen. H&amp;E (reproduced with permission from Kliener DE et al. Hepatology 2005; 41: 1313–1321 with permission).
Fig. 7.5. Portal inflammation in NASH is common, but usually mild. H&amp;E.
Fig. 7.7. On this higher power view, the distinct pericellular, perisinusoidal location of collagen deposition can be seen. Masson trichrome.
Fig. 7.6. Collagen deposition can be appreciated in zone 3 in this low power photomicrograph. Masson trichrome.
Fig. 7.18. Paediatric NAFLD. A low power photomicrograph of a paediatric liver biopsy shows diffuse steatosis with prominent portal tracts. The latter is due to inflammation and slightly increased fibrosis. There was no ballooning or zone 3 perisinusoidal fibrosis. H&amp;E. (Courtesy Dr Cynthia Behling)
Fatty Liver Disease Neil Theise, MD Depts of Pathology and Medicine (Digestive Diseases) Beth Israel Medical Center – Albert Einstein College of Medicine New York City
Alcoholic And Non-alcoholic Fatty Liver Disease (NAFLD)
Alcoholic And Non-alcoholic Fatty Liver Disease (NAFLD) NOT NASH!