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Stem Cell Therapies and Regeneration: Your Body as a Self-Healing Ecosystem Neil Theise, MD Departments of Pathology and M...
December ‘99
January ’00 December ‘99
Lethal Irradiation Male Bone Marrow Transplant FISH for Y-Chromosome
 
July ’00 January ’00 December ‘99
Controversy!!!
Sort PKH-bright Male Donor BM <ul><li>Lin Deplete </li></ul><ul><li>Elutriate </li></ul>PKH26 Label 48 Hours Transplant  s...
 
 
 
 
 
 
 
Bone Marrow One  Adult Cell <ul><li>Epithelia of  </li></ul><ul><li>Liver </li></ul><ul><li>Lung </li></ul><ul><li>Gut, (P...
MESODERM ENDODERM ECTODERM One  Adult Cell
Adult cells can do whatever embryonic cells can do! MESODERM ENDODERM ECTODERM One  Adult Cell
The Standard Paradigm of Embryology & Adult Tissue Repair
The Revised Paradigm
Proof of Principle
Controversy!!!
trivial... vs. ROBUST!!!
 
 
 
 
 
Meanwhile,  back at the stem cell debates… trivial vs. robust...?
Conversations with Jane Prophet New Media Artist and Professor, Interdisciplinary Studies University of Westminster, Londo...
Date: 9th May 2002  Location: Neil's office, New York     Jane says: “Ideas about pathways are interesting. A lot of peopl...
Complex Adaptive Systems: Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed.  Chicago IL: University of Chicago Press...
… Complex Adaptive Systems: Interacting individuals that,  if they fulfill 4 criteria, organize themselves from the bottom...
Complex Adaptive Systems: Interacting individuals that,  if they fulfill 4 criteria, organize themselves from the bottom u...
Complex Adaptive Systems: Interacting individuals that,  if they fulfill 4 criteria, organize themselves from the bottom u...
Complex Adaptive Systems: Interacting individuals that,  if they fulfill 4 criteria, organize themselves from the bottom u...
Complex Adaptive Systems: Rise and Fall of Economic Markets Urban Development Immune Systems Beatlemania Rise and Fall of ...
<ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul>
<ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops   </li></ul>
<ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops  </li></ul><u...
<ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops  </li></ul><u...
 
 
 
Low level engraftment  is not only NOT trivial,  but it is VITAL  –  literally so. 1-3 1 Theise ND. Exp Hematology 2003 2 ...
 
 
 
Hierarchies of complex systems… thing  vs. phenomenon depends on scale of observation
 
 
How does this relate to disease and injury?
 
 
HEART ATTACK!!!
STEM CELLS
STEM CELLS
STEM CELLS
 
Stem Cells!
Stem Cells!
Here at Beth Israel (in collaboration with NeoStem, Inc) The Team: Drs. Theise, Karpeh, and Bodenheimer
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>E...
More…
2006 Conference: Longevity & Optimal Health Integrating Eastern & Western Perspectives
 
 
GLOBAL  mind/body interventions e.g. YOGA, MEDITATION, etc….
GLOBAL  mind/body interventions Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking e.g. YOGA, MEDITATION...
GLOBAL  mind/body interventions LOCAL  effects Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site S...
Still more…
Communities Bodies Cells
e.g. cities, cultures, ecosystems,  Gaia Bodies Cells
 
If our parks are the lungs of the city…?
Are our hospitals its organs of healing and regeneration?
 
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Beth Israel President's Reception

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December 1, 2009: Your body as a self healing ecosystem...

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  • Transcript of "Beth Israel President's Reception"

    1. 1. Stem Cell Therapies and Regeneration: Your Body as a Self-Healing Ecosystem Neil Theise, MD Departments of Pathology and Medicine Beth Israel Medical Center - Albert Einstein College of Medicine New York City www.neiltheise.com this talk: Posted on slideshare.net (search “theise”)
    2. 2. December ‘99
    3. 3. January ’00 December ‘99
    4. 4. Lethal Irradiation Male Bone Marrow Transplant FISH for Y-Chromosome
    5. 6. July ’00 January ’00 December ‘99
    6. 7. Controversy!!!
    7. 8. Sort PKH-bright Male Donor BM <ul><li>Lin Deplete </li></ul><ul><li>Elutriate </li></ul>PKH26 Label 48 Hours Transplant single cell into 2 o Female Recipient 1 o Female Recipient
    8. 16. Bone Marrow One Adult Cell <ul><li>Epithelia of </li></ul><ul><li>Liver </li></ul><ul><li>Lung </li></ul><ul><li>Gut, (Pancreas) </li></ul>Skin, Hair follicles
    9. 17. MESODERM ENDODERM ECTODERM One Adult Cell
    10. 18. Adult cells can do whatever embryonic cells can do! MESODERM ENDODERM ECTODERM One Adult Cell
    11. 19. The Standard Paradigm of Embryology & Adult Tissue Repair
    12. 20. The Revised Paradigm
    13. 21. Proof of Principle
    14. 22. Controversy!!!
    15. 23. trivial... vs. ROBUST!!!
    16. 29. Meanwhile, back at the stem cell debates… trivial vs. robust...?
    17. 30. Conversations with Jane Prophet New Media Artist and Professor, Interdisciplinary Studies University of Westminster, London UK SciArt Award, Wellcome Trust 2002
    18. 31. Date: 9th May 2002 Location: Neil's office, New York    Jane says: “Ideas about pathways are interesting. A lot of people who are involved in digital biology are interested in things like swarming people and so called ’soup organism’ behaviour. And one of the useful models to take forward is about ant colonies…”
    19. 32. Complex Adaptive Systems: Lewin R, Complexity: Life at the Edge of Chaos. 2nd ed. Chicago IL: University of Chicago Press; 2002. Johnson S, Emergence. New York NY: Scribner; 2001.
    20. 33. … Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures
    21. 34. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward ,
    22. 35. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward, BUT ARE NOT!
    23. 36. Complex Adaptive Systems: Interacting individuals that, if they fulfill 4 criteria, organize themselves from the bottom up, into larger structures that appear planned from the top, downward, BUT ARE NOT! These self organizing structures are ADAPTIVE.
    24. 37. Complex Adaptive Systems: Rise and Fall of Economic Markets Urban Development Immune Systems Beatlemania Rise and Fall of Civilizations Coral Reefs Evolution and Speciation
    25. 38. <ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul>
    26. 39. <ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops </li></ul>
    27. 40. <ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops </li></ul><ul><li>Interactions are local without global sensing </li></ul>
    28. 41. <ul><li>Complex Adaptive Systems: </li></ul><ul><li>Numbers matter </li></ul><ul><li>Negative feedback loops </li></ul><ul><li>Interactions are local without global sensing </li></ul><ul><li>Low level randomness </li></ul>
    29. 45. Low level engraftment is not only NOT trivial, but it is VITAL – literally so. 1-3 1 Theise ND. Exp Hematology 2003 2 D’Inverno M, Theise ND. BCMD 2004 3 D’Inverno M, Theise ND, Prophet J. In: Potten C, Wilson J, Clarke R, Renahan A: Tissue stem cells: Biology and applications
    30. 49. Hierarchies of complex systems… thing vs. phenomenon depends on scale of observation
    31. 52. How does this relate to disease and injury?
    32. 55. HEART ATTACK!!!
    33. 56. STEM CELLS
    34. 57. STEM CELLS
    35. 58. STEM CELLS
    36. 60. Stem Cells!
    37. 61. Stem Cells!
    38. 62. Here at Beth Israel (in collaboration with NeoStem, Inc) The Team: Drs. Theise, Karpeh, and Bodenheimer
    39. 63. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>with Dr. Jonathan Raskin, Pulmonary Medicine </li></ul>
    40. 64. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul><ul><ul><li>with Dr. Martin Karpeh, Chair of Surgery </li></ul></ul>
    41. 65. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul>
    42. 66. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul>
    43. 67. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul>
    44. 68. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul>
    45. 69. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul>
    46. 70. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul><ul><li>Projects in exploration/planning stages: </li></ul><ul><li>End stage liver disease (cirrhosis) </li></ul><ul><li>Type I diabetes </li></ul>
    47. 71. Here at Beth Israel (in collaboration with NeoStem, Inc) <ul><li>Grant applications now submitted for: </li></ul><ul><li>Emphysema/COPD </li></ul><ul><li>Chronic non-healing cutaneous wounds </li></ul><ul><li>Projects in exploration/planning stages: </li></ul><ul><li>End stage liver disease (cirrhosis) </li></ul><ul><li>Type I diabetes </li></ul><ul><li>In the future…? What interests you…? Talk to me! </li></ul>
    48. 72. More…
    49. 73. 2006 Conference: Longevity & Optimal Health Integrating Eastern & Western Perspectives
    50. 76. GLOBAL mind/body interventions e.g. YOGA, MEDITATION, etc….
    51. 77. GLOBAL mind/body interventions Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking e.g. YOGA, MEDITATION, etc….
    52. 78. GLOBAL mind/body interventions LOCAL effects Humoral factors Nerve signaling Bioelectromagnetism Cell trafficking Site Specific, Tissue Regeneration e.g. YOGA, MEDITATION, etc….
    53. 79. Still more…
    54. 80. Communities Bodies Cells
    55. 81. e.g. cities, cultures, ecosystems, Gaia Bodies Cells
    56. 83. If our parks are the lungs of the city…?
    57. 84. Are our hospitals its organs of healing and regeneration?
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