1. www.NursesLabs.com
Altered Repolarization of
the Myocardium
Release of Lysosomal
Enzymes
Anaerobic Lactic Acid
Glycolysis Production
Myocardial Irritability
Decreased Contractility ANGIN
DYSRHYTHMI A
A
↓ Ventricular
Function
↑ Preload ↓ CO
↓ Blood Flow to
Brain
LOSS OF
CONS-
CIOUSNESS
3

2. www.NursesLabs.com
Enlargement of Thrombus
Occlusive Thrombus
WEAKNESS/FATIGUE (JULY 17-
Ischemia of Tissue in Region
PALPITATION
Supplied by Artery
S
↓ O2
Coronary Blood Supply
Less Than Demand
↑ CO2
levels MYOCARDIAL CELL DEATH
(NECROSIS)
↓ Bld
pH
DEEP & Stimulation of
LABORED Sympathetic NS
BREATHIN
G
↑ O2 need ↑ Afterload
↑ HR
Vasoconstriction
↑ Epinephrine &
Norepinephrine
Production
HTN
↑ BMR
↓ Blood Supply to
ARRHYTHMI
GI Tract
A
DIAPHORESI N/V
S
2

3. PATHOPHYSIOLOGY OF ACUTE MI (BOOK-
www.NursesLabs.com
BASED)
. ACUTE MYOCARDIAL INFARCTION
MODIFIABLE FACTORS: NONMODIFIABLE
FACTORS:
Hypertension
Smoking Aging
↑ levels of triglyceride, total cholesterol & LDL Gender(Male)
Obesity
Excessive intake of saturated fats, carbohydrates
or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Change in the Condition of
Plaque in the Coronary Artery
Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of
Claudi-
Platelet Mass
cation
ATHERO- THROMBOSIS
SCLEROSI
N/V S
Release of Thromboplastin
Fainting
Platelet release Thromboxane
A2, Serotonin, Platelet Factors 3
Sweating &4
Coagulation and Vasospasm
Cool
extremities Enlargement of Thrombus
1

4. PATHOPHYSIOLOGY OF ACUTE MI (BOOK-
www.NursesLabs.com
BASED)
. ACUTE MYOCARDIAL INFARCTION
MODIFIABLE FACTORS: NONMODIFIABLE
FACTORS:
Hypertension
Smoking Aging
↑ levels of triglyceride, total cholesterol & LDL Gender(Male)
Obesity
Excessive intake of saturated fats, carbohydrates
or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Change in the Condition of
Plaque in the Coronary Artery
Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of
Claudi-
Platelet Mass
cation
ATHERO- THROMBOSIS
SCLEROSI
N/V S
Release of Thromboplastin
Fainting
Platelet release Thromboxane
A2, Serotonin, Platelet Factors 3
Sweating &4
Coagulation and Vasospasm
Cool
extremities Enlargement of Thrombus
1

5. PATHOPHYSIOLOGY OF ACUTE MI (BOOK-
www.NursesLabs.com
BASED)
. ACUTE MYOCARDIAL INFARCTION
MODIFIABLE FACTORS: NONMODIFIABLE
FACTORS:
Hypertension
Smoking Aging
↑ levels of triglyceride, total cholesterol & LDL Gender(Male)
Obesity
Excessive intake of saturated fats, carbohydrates
or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Change in the Condition of
Plaque in the Coronary Artery
Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of
Claudi-
Platelet Mass
cation
ATHERO- THROMBOSIS
SCLEROSI
N/V S
Release of Thromboplastin
Fainting
Platelet release Thromboxane
A2, Serotonin, Platelet Factors 3
Sweating &4
Coagulation and Vasospasm
Cool
extremities Enlargement of Thrombus
1

6. PATHOPHYSIOLOGY OF ACUTE MI (BOOK-
www.NursesLabs.com
BASED)
. ACUTE MYOCARDIAL INFARCTION
MODIFIABLE FACTORS: NONMODIFIABLE
FACTORS:
Hypertension
Smoking Aging
↑ levels of triglyceride, total cholesterol & LDL Gender(Male)
Obesity
Excessive intake of saturated fats, carbohydrates
or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Change in the Condition of
Plaque in the Coronary Artery
Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of
Claudi-
Platelet Mass
cation
ATHERO- THROMBOSIS
SCLEROSI
N/V S
Release of Thromboplastin
Fainting
Platelet release Thromboxane
A2, Serotonin, Platelet Factors 3
Sweating &4
Coagulation and Vasospasm
Cool
extremities Enlargement of Thrombus
1