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Ig a nephropathy

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  • 1. IgA NEPHROPATHY
  • 2. IgA NEPHROPATHY •It is also known as Berger’s disease,Berger’s syndrome and IgA nephritis. •IgA nephropathy is a form of glomerulonephritis characterized by the deposition of IgA in the mesengial cells. •It is the most common glomerulonephritis throughout the world. •It is a nephritic type of glomerular disease in which the glomerular damage is due to the cell proliferation mainly nuetrophills unlike the nephrotic type in which the glomerular basement membrane is damaged.
  • 3. SIGNS AND SYMPTOMS •Hematuria which usually starts within a day or two of a non-specific upper respiratory tract infection,gastrointestinal infection or urinary infection. •These symptoms are also seen in another type of glomerulonephritic disease called poststreptococcal glomerulonephritis. •The differentiating point between these two is the duration between the infection and the occurrence of hematuria. •In post-streptococcal glomerulonephritis hematuria occurs some time (weeks) after initial infection whereas in IgA nephropathy it occurs after 1-2 days of infection. •HSP  Henoch-Schönlein purpura disease is also accociated with IgA nephropathy characterized by purpuric skin lesions,abdominal pain,vomiting and intestinal bleeding.
  • 4. PATHOGENESIS • Infection(gastrointestinal,pulmonary,urinary) can be the inciting agent. All of these infections have in common the activation of mucosal defenses and hence IgA antibody production. •IgA goes into the blood circulation and when it reaches the kidney,it selectively deposits in the messengial cells. •This deposition of IgA in the messengial cells leads to the proliferation. •Sometime it is benign and sometime it is recurring over and over and that may slowly and progressively lead to renal failure
  • 5. TREATMENT • Angiotensin converting enzyme inhibitors-due to their anti-proteinuric effect. • Tonsillectomy –cases where tonsillitis is the precipitating factor for episodic hematuria,  has  been claimed to reduce the frequency of those episodes • Immunosuppressive drugs and Corticosteroid- combination of steroids  and cyclophosphamide for the initial 3 months followed by azathioprine for a minimum of 2  years