Hypersensitive type ii

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  • 激活补体经典途径
  • Hypersensitive type ii

    1. 1. Hypersensitivity Type II Yingping Xu yingpxu@126.com
    2. 2. Type II Hypersensitivity (cytotoxic hypersensitivity) 1. Characteristic features 2. Mechanism of Type II Hypersensitivity 3. Common diseases of Type II Hypersensitivity
    3. 3. 1. Characteristic features Primed IgG or IgM + Antigen or hapten on membrane Injury and dysfunction of target cells Type II hypersensitivity involve antibody-mediated destruction cells. Antibody can activate the complement system-MAC to punch pores in the membrane of a target cell, or it can mediate cell destruction by ADCC(antibody-dependent cell-mediated cytotoxicity).
    4. 4. 2. Mechanism of Type II hypersentivity (1) Surface antigen on target cells Target cells: Normal tissue cell, changed or modified self tissue cells Antigen : Blood group antigen, Common antigen, Drug antigen, Self-antigen modified by physical factors or infection Antigen-antibody complex
    5. 5. (2) Antibody, complement and modified self-cell IgG or IgM mediated Activate complement Lyse target cells Opsonic phogacytosis Ig M Destroy target cells Mf 、 NK 、 T ADCC IgG
    6. 6. Allergen Stimulate Antibody Target cell A. Opsonic phagocytosis Combined opsonic activitie D. ADCC of NK C. Effect of complement Cell injury ways of type II hypersensitivity
    7. 7. Activate complexment to lyse target cells
    8. 8. Opsonization to lyse target cells of phagocytes
    9. 9. ADCC effect to lyse target cells
    10. 10. Antigen or hapten on cell Antibody (IgG, IgM) Activate complement Opsonic phagocytosis NK , phagocyte Lyse target cell phagocytoseDestroy target cell Target cell injury Stimulate / block ADCC Change the function ofTarget cell Mechanism of Type II hypersensitivity
    11. 11. 3. Common disease of type II hypersensitivity (1)Transfusion reaction hemolysis : mismatch of ABO blood group, severely destroy RBC
    12. 12. (2) Hemolytic disease of newborn (erythroblastosis fetalis) Mother Rh- : first baby Rh+(Ab), second baby Rh+, fetal RBC destroyed First pregnency Anti-Rh+ secondary pregnency hemolysis
    13. 13. Prevention with Rhogram
    14. 14. 3) Autoimmune hemolytic anemia Foreign antigen or hapten Penicillin + RBC = hemolytic anemia bind to the protein of RBC, and form hapten + carrier ,Induce antibodies production, which can bind to the adsorbed drug on the red cells , inducing complementmediated lysis and processive anemia.
    15. 15. 4. Goodpasture syndrome or Goodpasture disease It is an autoimmune disease in which antibodies attack the lungs and kidneys, leading to bleeding from the lungs or kidneys. Goodpasture antigen lie in the lung and kidneys.
    16. 16. 5.Anti -glomerular basement membrane nephritis β-Hemolytic streptococcus and human glomerular basement membrane ---- cross reaction
    17. 17. 6. Hyperthyroidism or hypothyroidism —receptor diseases TSH Thyroid stimulating hormone T3 Thyroxine 3

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