APLA SYNDROME

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APLA SYNDROME

  1. 1. APLA SYNDROME - Anti Phospholipid Antibody Syndrome Myriad Presentation Dr.AnitaDr.K.S.V.Chalam,Dr.A.Lalitha,Dr.A.P.Naveen Kumar,Dr.D.V.N.Sharma, Dr. M.K.Tripathy
  2. 2. • Polyarthritis and rash• Gangrene of tips of fingers• Treated with LMWH and then acitrom• Recovered completely• ANA , DsDNA , Anti Cardiolipin positive• On follow up
  3. 3. • 28 yr. female• Recurrent abortions• Anti cardiolipin antibodies positive• Started on anticoagulants• Delivered a female baby with LMWH
  4. 4. ACA SYNDROME
  5. 5. • 34 yr. female• Polyarthritis and skin rash• Developed swelling of leg• Doppler showed DVT• ANA,DsDNA,Smith and Anti cardiolipin Ab. positive
  6. 6. • Presented with septicemia and MODS• Recovered completely except for thrombocytopenia• ANA positive – treated with steroids• After 1 yr. developed swelling of abdomen• U/S s/o Budd Chiari• Investigations confirmed APLA
  7. 7. • 12 yr. girl• Recurrent abdominal pain• Confirmed as pancreatitis• Later symptoms of rash and arthritis• Investigations for SLE and APLA positive• On immunomodulants and acitrom• Developed CNS lupus and recovered
  8. 8. • Presented with convulsions• MRI brain – large bleed• Thrombocytopenia• MR Venogram – Sup. Saggital sinus thrombosis• APLA workup positive

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