Fetal Neurosonogram

15,161 views

Published on

Fetal CNS Examination,Fetal Neurosongram

4 Comments
47 Likes
Statistics
Notes
  • My dear, How are you today? i will like to be your friend My name is Sheikha Ghunaim , am a 43 years old divorcee. Please write to me in my email ( sheikhaghunaim2@hotmail.com ). im honest and open mind single woman. im going to tell more when i see your response. Regards Sheikha.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • It's fantastic to see such a useful post. I also can be helpful here :) I've found PDFfiller - online service for forms filling. It's pretty easy to use and pretty cheap. You can find fillable FL DoR UCT-6 here https://goo.gl/07D6Va.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • thanks a lot
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
  • Its a beutifull slide. Tanks.
       Reply 
    Are you sure you want to  Yes  No
    Your message goes here
No Downloads
Views
Total views
15,161
On SlideShare
0
From Embeds
0
Number of Embeds
70
Actions
Shares
0
Downloads
1,397
Comments
4
Likes
47
Embeds 0
No embeds

No notes for slide

Fetal Neurosonogram

  1. 1. Fetal  Nuerosonogram   Professor Hassan Nasrat FRCS, FRCOG The Fetal Medicine Clinic The First Clinic JUCOG January 2013 Sunday, July 28, 13
  2. 2.  Microcephaly Holoprosencephaly Head normal or small  Chiari  Malforma3on ACC  Dia   Anencephaly Occipital Encephalocele Schizencephaly Schizencephaly Circle of Willis Mallformation Vascular   Malforma3ons SOP Pilu Imaging Findings  Herniated brain tissue  „cyst within the cyst“  Ventriculomegaly 7080%  Microcephaly 25%  Polyhydramnios  Oligohydramnios  Encephalocele PF-­‐Fluid-­‐Cyst CAVE:  Associated with multiple syndroms ( Meckel- Gruber ) Hydrance halus , T 21 Ventriculomegaly Hemimegalencephaly Arachnoid  cyst Hydranecphaly Yong seok et a 2 Sunday, July 28, 13
  3. 3. Congenital  CNS  Anomalies o Incidence  in  longtem  studies  about  1  % o  Only  minimal  identified  at  birth   o  Screening  Increases  The  Number  Of   Referred  Cases  For  Evaluation  Of  Suspected   CNS  Anomalies.   o The  CNS  sonographic  appearance  changes   throughout  pregnancy     Sunday, July 28, 13
  4. 4. Learning  Objec3ves ✤ Embryonic  development  of  the  CNS   in  relation  to  sonographic  findings ✤ Standard   Sonographic   Examination   of  the  CNS   ✤ Fetal   Neurosonography   and   the     Role  of  3  D     (systemic  approach  to   examination  of  the  Posterior  Fossa) 4 Sunday, July 28, 13
  5. 5. Embryology of the CNS Sunday, July 28, 13
  6. 6. At   5th   Week   The   Cells   Destined   To   Form   The   Notochord   Infiltrate   Into   The  Embryonic  Disc.   I t   I n d u c e s   T h e   Overlying   Embryonic   Tissue   To  Thicken  And   Ultimately   Fold   Over   And   Fuse   As   The   The   Fusion   Starts   In   Neural  Tube.   The   Midtrunk   Of   The   E m b r y o   A n d   Subsequently   Extends   To   The   Cranial   And   Caudal  Ends   Neural  Crest Neural  Groove Neural  Plate Sunday, July 28, 13 Ectoderm Neural  Tube
  7. 7. Prosencephalon Mesencephalon Rhombencephalon 7 Sunday, July 28, 13
  8. 8. Three orthogonal images and thick slice of three-dimensional reconstructed image (lower right) of normal brain at 8 the end of 8 weeks of gestation. The development of premature ventricular system is seen. Sunday, July 28, 13
  9. 9. Prosencephalon Mesencephalon Three orthogonal images and thick slice of three-dimensional reconstructed image (lower right) of normal brain at 8 the end of 8 weeks of gestation. The development of premature ventricular system is seen. Sunday, July 28, 13
  10. 10. Normal brain development on the mid-sagittal section between 8 and 12 weeks of gestation). Note the remarkable changing of premature brain 9 appearance. Sunday, July 28, 13
  11. 11. AJR:166, AJR:166, Changing  Ultrasound  appearance  of  the   The  Posterior  Fossa  throughout  gesta3on   SONOGRAPHIC February 1996 February 1996 AJR:166, February 1996 ANATOMY SONOGRAPHIC ANATOMY SONOGRAPHIC OF DEVELOPING 433 CEREBELLUM OF DEVELOPING CEREBELLUM ANATOMY OF DEVELOPING CEREBELLUM 433 433 10 C Sunday, C Fig. C C July 28, 13 D 13.-Drawings depicting some relevant features D DD of fetal cerebellar development.
  12. 12. The vermis develops superiorly to inferiorly. Hypoplasia or developmental arrest results in varying size deficits of the inferior portion, leaving a relatively square defect that communicates with the fourth ventricle and separates the lower cerebellar hemispheres. 11 Sunday, July 28, 13
  13. 13. C D Fig. 13.-Drawings depicting some relevant features of fetal cerebellar development. A, Axial drawing of developing cerebellum at 5 weeks’ gestational age shows that developing cerebellar hemispheres have not yet grown toward midline and thatfourth ventricle is covered only byfourth ventricular roof,which is onlytwo cell layers thickatthis stage of development. B, Sagittal drawing of developing cerebellum at 10 weeks’ gestational age shows small cerebellum located rostrally over fourth ventricle, with caudal fourth ventricle being covered only by thin fourth ventricular roof. C, Sagittal drawing at 16 weeks’ gestational age shows further caudal growth of cerebellum ening 0, of caudal Sagfttal fourth drawing ventricular roof. at 17 weeks’ gestational age shows cerebellum We have shown that the sonognaphic appearance of normal cemebellar development can resemble pathology early in the second trimester. Our findings indicate that the mature relationships of the posterior fossa structures are not established until at least 18 weeks’ gestational age; therefore, the Sunday, July 28, 13 diagnosis prenatal sonographic of Dandy-Walker complex and vermis covering 4. Achinon entire R, Tadmor ten of pregnancy: and vermis over fourth fourth 0. Screening tnansvaginal ventrIcle, teno thic and with thick- ventricle. for fetal anomalies versus transabdominal 1991 1:186-191 during the first tnimesUltra- sonography. sound Obstet Gynecol 5. Nicolaides KH, Azan G, Byrne D, Mansur C, Marks K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. BMJ 1992:304:867-869 6. Bronshtein M, Blumenfeld I, Kohn J, Blumenfeld Z. Detection ofcleft lip by early 12
  14. 14. of posteriorB, Next caudal image identifies fetus. fossa in 13- to 14-week-old called in stea fourth ventricular roof joining cerebellar hemispheres acquisition Vermis fetus. A, Vermis isand separating identified between cerebellar hemispheres rostrally (arrow). age of posteriorfossacaudally in (arrow) fourth ventricle and cisterna magna. but not B, Next caudal image identifies fourth ventricular roof joining cerebellar hemispheres fetus. Vermis is identified (arrow) and separating fourth ventricle and cisterna magna. but not caudally at this s Effect  of  Gesta=onal  age  (Posterior  Fossa) Fig. 7.-Axial Fig. 7.-A and tenor fossa tenor fossa in 16-weekA and A and B, Caudally, thickto enoug thick enough be v and sagittal and sagittal (B) planes axial sagittal sonograms of posterior fossa in 16-week-old fetus fourth ventricular roof is visualized in both planes (arrow) 13 Sunday, July 28, 13
  15. 15. gure 1 Transvaginal scan of a 14-week fetus. (a) Oblique-1 (sagittal) section: the fetus is facing left. The choroid plexus fills the antrum ure 1 Transvaginal The of aa14-week appear Oblique-1 but are normal; (b)the fetus facing left. The choroid plexus fills the antrum Transvaginal scan of 14-week fetus. (a) Oblique-1 (sagittal) section: a Frontal-2 (coronal) The choroid plexus fills the horns ure 1lateral ventricle. scan anterior hornsfetus. (a)prominent, (sagittal) section: the fetus isis facing left. section through the anterior antrum the thelateral ventricle. The anterior horns appear normal for this are normal;age; ahowever, this same sonographic picture at anterior horn he lateral ventricle. The anterior horns appear prominent, but are normal; (b) a Frontal-2 (coronal) section through the 20 weeks or the lateral ventricles. The anterior horns are prominent, but gestational (b) Frontal-2 (coronal) section through the anterior horns the is consistent with ventriculomegaly or hydrocephalus this gestational age; however, this same sonographic picture 20 weeks or he lateral ventricles. The anterior horns are normal for ore lateral ventricles. The anterior horns are normal for this gestational age; however, this same sonographic picture atat 20 weeks o re is consistent with ventriculomegaly or hydrocephalus re is consistent with ventriculomegaly or hydrocephalus Effect  Of  Scanning  Level  (Posterior  Fossa) Higher Still gure 2Lower-most Section (horizontal) views through the posterior fossa. (a) This is the lower-most section (see insert). The Three serial, almost axial Somewhat Higher ure ermis2 Three serial, almost axial (horizontal) views through fourth ventriclefossa. (a) a widethe this gestational age, normal) median gure2 appears to be open (arrow) and communicates with the the posterior fossa. (a) This isis (at lower-most section (see insert). The Three serial, almost axial (horizontal) views through the posterior through This the lower-most section (see insert). Th mis appears to be open (arrow)and communicates with rightfourth ventricle the cerebellar (at this gestational age, normal) median perture (foramenbeopen (arrow) (b) somewhat higher,withthe fourth left sides ofthrough a widehemispheres appear closer to eachmedia rmis appears to of Magendie); and communicates the the and ventricle through a wide (at this gestational age, normal) other rture (foramen of Magendie); (b) somewhat higher, rrow); (foramenof Magendie); (b) defect’ is seen and theright and left sides appears as a discrete No ‘vermiancloser to each othe (c) higher still, Appears To entity. C, appear ertureThe Vermisno ‘vermian somewhat higher, the fourth and left sides of the cerebellar hemispherescerebellum Defect’other right ventricle (4) of the cerebellar hemispheres appear closer to each Thethefourth ventricle (4) appears asas a discrete entity. C, cerebellum Right And Left Sides a discrete entity. C, cerebellum row); (c) higher still, no ‘vermian defect’ is seen and the fourth ventricle (4) appears row); (c) higher still, (arrow) And is seen and Be Open no ‘vermian defect’ Is Seen And The Of The Cerebellar Communicates With The eduncular cistern (cisterna magna) and theHemispheres its closest anatomic structures, namely the cavum septi fourth ventriFourth Ventricle (4) Appear its closestand the pericallosal artery, follow acavum septi anatomic structures, namely the well-known duncular ucistern(cisterna magna) land week,fourthventricistern (cisterna n t r i c e the fourth‘normal’ pellucidi anatomic structures, namely As cavum sep e. Later, r t h its closest the duncularafter the 16th postmenstrual the this ventriFo Ve magna) and Closer Appears A pellucidi and the pericallosal artery, reach a developmenLater, after the 16th postmenstrualand developmentTo Each Other thepericallosal artery, follow a a well-know week, this ‘normal’ developmental timetable. They do not follow well-known pen space narrows as postmenstrual week, this ‘normal’ of pellucidi and . Later, after the 16th the growth Through A giving en vermis narrows Wide growth and development of (arrow); tal stage that allows for Discrete reach a developmene space narrows as the rise to and development of developmental timetable. They do notEntity. a developmen developmental timetable. sonographic imaging until postThey do not reach en space progress,as the growth the median aperture oramen progress, giving rise to the median aperture e vermis of Magendie) (Figureto the median aperture vermis progress, giving rise 2). Again, this normal ramen of Magendie) be interpretedAgain, this normal onographic finding may (Figure 2). Again, this normal ramen of Magendie) (Figure 2). by those unfamiliar Sunday, finding may nographic July 28, 13 be interpreted by those unfamiliar tal stage that allows for To search for their presence before 14 menstrual that allows forsonographic imaging until posttal stage weeks 18–19. sonographic imaging until pos menstrual weeks 18–19. To search for their presence before they reach weeks 18–19. To search fordevelopment would menstrual this critical stage in their their presence befor they reach this critical stage in their development would
  16. 16. Effect  of  Gesta=onal  age  (Lateral  Ventricles) 15 Sunday, July 28, 13
  17. 17. The fetal cerebellum Pitfalls in diagnosis Hypoplasia Or Dysplasia Should Not Be Diagnosed Prior To 18 Weeks, Before Vermian Development Is Complete. An Abnormally Steep Scanning Angle May Mimic A Prominent Cleft Between The Lower Portions Of The Cerebellar Hemispheres. 16 Sunday, July 28, 13
  18. 18. Conclusion •TheCNS   displays   remarkable   embryological   and   developmental   changes  throughout  gestation. •Standard  Approach  of  examination  and   evaluation   of   the   CNS   Should   Be   Followed 17 Sunday, July 28, 13
  19. 19. Standard Sonographic Examination of the FEtal CNS 18 Sunday, July 28, 13
  20. 20. Sunday, July 28, 13
  21. 21. Sonography  of  the  CNS Basic  Examination “Neurosongram” Sunday, July 28, 13
  22. 22. Planes  of  Basic  Examina3on Axial  Planes Sunday, July 28, 13 Sagibal  Planes
  23. 23. Axial  Planes Sunday, July 28, 13
  24. 24. Axial  Planes a:  Transventricular Sunday, July 28, 13
  25. 25. Axial  Planes a:  Transventricular b:  Transthalamic   Sunday, July 28, 13
  26. 26. Axial  Planes a:  Transventricular b:  Transthalamic   C:  Transcerebeller   Sunday, July 28, 13
  27. 27. The  Transventricular  plane Sunday, July 28, 13
  28. 28. The  Transventricular  plane Frontal  hones Sunday, July 28, 13
  29. 29. The  Transventricular  plane Frontal  hones Atrium Sunday, July 28, 13
  30. 30. The  Transventricular  plane Frontal  hones Atrium Sunday, July 28, 13 Choroid   Plexus
  31. 31. The  Transventricular  plane Cavum  Sep3  Pellucidi Frontal  hones Atrium Sunday, July 28, 13 Choroid   Plexus
  32. 32. The  Transthalamic    Plane Sunday, July 28, 13
  33. 33. The  Transthalamic    Plane Thalami Sunday, July 28, 13
  34. 34. The  Transthalamic    Plane Thalami Hyppocamas   Gyrus Sunday, July 28, 13
  35. 35. The  Transcerebeller    plane T T Sunday, July 28, 13
  36. 36. The  Transcerebeller    plane T T Cavum  Sep3  Pellucidi Sunday, July 28, 13
  37. 37. The  Transcerebeller    plane Frontal  hones T T Cavum  Sep3  Pellucidi Sunday, July 28, 13
  38. 38. The  Transcerebeller    plane Cerebellum Frontal  hones T T Cavum  Sep3  Pellucidi Sunday, July 28, 13
  39. 39. The  Transcerebeller    plane Cerebellar  vermis Cerebellum Frontal  hones T T Cavum  Sep3  Pellucidi Sunday, July 28, 13
  40. 40. The  Transcerebeller    plane Cerebellar  vermis Cerebellum Frontal  hones T T Cavum  Sep3  Pellucidi Sunday, July 28, 13 Cistrerna  Magna 2-­‐10  mm
  41. 41. Sagibal  Planes     Sunday, July 28, 13
  42. 42. Sagibal  Planes     A:  The  Midsagittal   Plan Sunday, July 28, 13
  43. 43. Sagibal  Planes     b:  Parasgittal  plane A:  The  Midsagittal   Plan Sunday, July 28, 13
  44. 44. Mid  SagiGal  Plane   Corpus  Callosum Cavum  Sep3  Pellucidi Cerebellum 4th  V 27 Sunday, July 28, 13
  45. 45. Mid  SagiGal  Plane   27 Sunday, July 28, 13
  46. 46. The  Corpus  Callosum 28 Sunday, July 28, 13
  47. 47. The  Corpus  Callosum Lateral  Ventricles Splenium Corpus  Callosum Thalamus hypothalamus Third  Ventricle Pituitary Fourth  ventricle midbrain 28 Sunday, July 28, 13
  48. 48. Para-­‐SagiGal  Plane   29 Sunday, July 28, 13
  49. 49. Basic Examniation Checklist Head + Neck Midline & Falx Cavum septi pellucidi Lateral cerebral ventricls Choroid Plexus Cerebellum Cisterna magna 30 Sunday, July 28, 13
  50. 50. Main  Abnormali3es  can  be   Suspected  on  Basic  Planes 31 Sunday, July 28, 13
  51. 51.  Holoprosencephaly Microcephaly Head normal or small  Chiari  Malforma3on ACC  Dia   Anencephaly Occipital Encephalocele Schizencephaly Schizencephaly Circle of Willis Mallformation Vascular   Malforma3ons SOP Pilu Imaging Findings  Herniated brain tissue  „cyst within the cyst“  Ventriculomegaly 7080%  Microcephaly 25%  Polyhydramnios  Oligohydramnios  Encephalocele PF-­‐Fluid-­‐Cyst CAVE:  Associated with multiple syndroms ( Meckel- Gruber ) Hydrance halus , T 21 Ventriculomegaly Hemimegalencephaly Arachnoid  cyst Hydranecphaly Yong seok et a 32 Sunday, July 28, 13
  52. 52.  Holoprosencephaly Microcephaly Head normal or small  Chiari  Malforma3on ACC  Dia   Anencephaly Occipital Encephalocele Schizencephaly Schizencephaly Circle of Willis Mallformation Vascular   Malforma3ons SOP Pilu Imaging Findings  Herniated brain tissue  „cyst within the cyst“  Ventriculomegaly 7080%  Microcephaly 25%  Polyhydramnios  Oligohydramnios  Encephalocele PF-­‐Fluid-­‐Cyst CAVE:  Associated with multiple syndroms ( Meckel- Gruber ) Hydrance halus , T 21 Ventriculomegaly Hemimegalencephaly Arachnoid  cyst Hydranecphaly Yong seok et a 32 Sunday, July 28, 13
  53. 53.  Holoprosencephaly Microcephaly Head normal or small  Chiari  Malforma3on ACC  Dia   Anencephaly Occipital Encephalocele Schizencephaly Schizencephaly Circle of Willis Mallformation Vascular   Malforma3ons SOP Pilu Imaging Findings  Herniated brain tissue  „cyst within the cyst“  Ventriculomegaly 7080%  Microcephaly 25%  Polyhydramnios  Oligohydramnios  Encephalocele PF-­‐Fluid-­‐Cyst CAVE:  Associated with multiple syndroms ( Meckel- Gruber ) Hydrance halus , T 21 Ventriculomegaly Hemimegalencephaly Arachnoid  cyst Hydranecphaly Yong seok et a 32 Sunday, July 28, 13
  54. 54.  Holoprosencephaly Microcephaly Head normal or small  Chiari  Malforma3on ACC  Dia   Anencephaly Occipital Encephalocele Schizencephaly Schizencephaly Circle of Willis Mallformation Vascular   Malforma3ons SOP Pilu Imaging Findings  Herniated brain tissue  „cyst within the cyst“  Ventriculomegaly 7080%  Microcephaly 25%  Polyhydramnios  Oligohydramnios  Encephalocele PF-­‐Fluid-­‐Cyst CAVE:  Associated with multiple syndroms ( Meckel- Gruber ) Hydrance halus , T 21 Ventriculomegaly Hemimegalencephaly Arachnoid  cyst Hydranecphaly Yong seok et a 32 Sunday, July 28, 13
  55. 55. •Ventriculomegaly  (hydrocephalus) •Absent  Cavum  Septum  Pellucidum •Agenesis  of  the  Corpus  Callosum •Fluid  Collection  in  the  posterior  fossa 33 Sunday, July 28, 13
  56. 56. Ventriculomegaly  (hydrocephalus) Mild  10  –  15  mm Low  Risk   mean  =  6-­‐8   mm Severe  >  15  mm   High  Risk   (<  10  mm  is  normal).    Independent   of  gesta7onal  age   Sunday, July 28, 13
  57. 57. Pathogenesis:  Ventriculomegaly Lee  Lateral  Ventricle Right  Lateral  Ventricle Foramen  of  Monro   Aqueduct  of  Sylvius 4th    Ventricle 3rd    Ventricle Cisterna  Magna 35 Sunday, July 28, 13
  58. 58. Absent  CSP •Square  Shaped,  Interrupts  and  Fills  The  Space  Between  The  Frontal  Horns •The  CSP:  Becomes  Visible  At  16    Weeks,  Obliterate  Near  Term Sunday, July 28, 13
  59. 59. Absent  CSP Cavum  Sep3  Pellucidi •Square  Shaped,  Interrupts  and  Fills  The  Space  Between  The  Frontal  Horns •The  CSP:  Becomes  Visible  At  16    Weeks,  Obliterate  Near  Term Sunday, July 28, 13
  60. 60. Absent  CSP A   rare   finding   usually   discovered   Postnatally   in   children  evaluated  for  developmental  delay. Associated  with  various  brain  malformations: agenesis  of  the  corpus  callosum Holoprosencephaly. Setpo-­‐optic  dysplasia. Secondary  to  disruptive  process:  Hydrocephalus,   Chiari  II  malformation,  hydranecephaly.   Sunday, July 28, 13
  61. 61. Agenesis  of  the  Corpus  Callosum     38 Sunday, July 28, 13
  62. 62. 21-­‐week  Fetus  With  Par=al  Agenesis  Of  The  Corpus  Callosum Only   The   Rostrum   (1),   Genu   (2)   And   Body   (3)   Are   Visible;   The   Splenium   Is   Missing.  The  Corpus  Callosum  Is  Short  Posteriorly  And  Does  Not   Seem   To   Overlay   The  Quadrigeminal  Plate Sunday, July 28, 13
  63. 63. Outcome  of  fetal  ACC  Va r i e s   b e t we e n   co m p l e te l y   a sy m p to m a 3 c   appearance  and  severe  neurologic  problems  50   –   100   %   of   isolated   cases   will   have   normal   neurological   development   at   3-­‐11   years   but   Poor   prognosis  with  associated  anomalies   Progressive  decline  in  intellect  over  the  years   Most  need  special  educa3on   Long-­‐term  follow-­‐up  of  children  with  prenatally  diagnosed  agenesis  of  corpus  callosum  (ACC)   J.  H.  Stupin  et  al,  USOG,  32,  2008 Sunday, July 28, 13
  64. 64. Fluid  Collec3on  in  the  Posterior  Fossa 41 Sunday, July 28, 13
  65. 65. Fluid  Collec3on  in  the  Posterior  Fossa •Megacisterna Magna 41 Sunday, July 28, 13
  66. 66. Fluid  Collec3on  in  the  Posterior  Fossa •Megacisterna Magna •Blak’s Pouch Cyst 41 Sunday, July 28, 13
  67. 67. Fluid  Collec3on  in  the  Posterior  Fossa •Megacisterna Magna •D-W Malformation &DW- Variant •Blak’s Pouch Cyst 41 Sunday, July 28, 13
  68. 68. Fluid  Collec3on  in  the  Posterior  Fossa •Megacisterna Magna •Blak’s Pouch Cyst •D-W Malformation &DW- Variant •Arachnoid Cyst 41 Sunday, July 28, 13
  69. 69. Anomalies Of The Meninges •Megacisterna Magna •Blak’s Pouch Cyst Anomalies Cerebellum •D-W Malformation &DW- Variant •Arachnoid Cyst 42 Sunday, July 28, 13
  70. 70. Mega–Cisterna Magna An Enlargement Of The Cisterna Magna Beyond 10 Mm With Intact Vermis 43 Sunday, July 28, 13
  71. 71. Pathogenesis: Mega Cisterna Magna Lateral  Ventricle Third   Ventricle Cerebral  Aqueduct Choriod  Plexus Fourth  Ventricle 44 Sunday, July 28, 13
  72. 72. Pathogenesis: Mega Cisterna Magna The Foramina Of Lateral  Ventricle Luschka And Magendie Fenestrate Delayed Third   Ventricle Cerebral  Aqueduct Choriod  Plexus Fourth  Ventricle 44 Sunday, July 28, 13
  73. 73. Prognosis: • Isolated Cases: (97%-100%) Are Normal. • If Not Isolated: Only 11% Have Normal Outcome. Nonisolated Cases Have VM, Congenital Infection, Or Karyotype Abnormalities. A Large Cisterna Magna Require Careful Search For Other Abnormalities. 45 Sunday, July 28, 13
  74. 74. Blake’s Pouch Cyst 46 Sunday, July 28, 13
  75. 75. Pathogenesis: Blake’s Pouch Cyst Nonfenestration of the foramina of Luschka and Lateral  Ventricle Magendie leads to dilatation of the fourth ventricle and and elevation of the vermis away from the brain stem. Third   Ventricle Cerebral  Aqueduct Choriod  Plexus Fourth  Ventricle There is no communication between the cyst and the subarachnoid space 47 Sunday, July 28, 13
  76. 76. Pathogenesis: Blake’s Pouch Cyst Nonfenestration of the foramina of Luschka and Lateral  Ventricle Magendie leads to dilatation of the fourth ventricle and and elevation of the vermis away from the brain stem. Third   Ventricle Cerebral  Aqueduct Choriod  Plexus Fourth  Ventricle There is no communication between the cyst and the subarachnoid space 47 Sunday, July 28, 13
  77. 77. Dandy-Walker Malformation A Spectrum Of Anomalies Of The Posterior Fossa. • Dandy-Walker Malformation: ✦Increase Of The Posterior Fossa, ✦Complete Or Partially Agenesis Of The Cerebellar Vermis, ✦A Tentorium Elevation • Variant Of Dandy-Walker: ✦Hypoplasia Of The Cerebellar Vermis In Different Degrees With Or Without Increase Of The Posterior Fossa. 48 Sunday, July 28, 13
  78. 78. ctions Dandy-Walker Malformation Elevated tentorium and high position of the torcula Small, rotated, raised, or absent vermis Cystic dilation of the fourth ventricle communicating with a posterior fossa fluid space 49 Sunday, July 28, 13
  79. 79. The Prognosis : Better In Isolated DWS. Karyotype Abnormalities In About 15%. Neonatal Mortality: 12% To 55%. Neonatal Morbidity: •Intelligence Is Normal In About 40% •Borderline In 20% •Subnormal In 40%. 50 Sunday, July 28, 13
  80. 80. igure 2 2 Blake’s Pouch Cyst the torcular Herophili (arrows) inferred the Dandy–Walker Malformation Figure The position ofof torcular Herophili (arrows) is is inferre The position Normal The Torcular Is Found In A The Torcular Is n ultrasound by the direction ofof the tentorium DisplacedIn In (a) th tentorium cerebelli. Higher Position, At About The Same Level on ultrasound by the direction the Than Usual, Indicating That Thisthe cerebelli. (a) As The found Insertion Of The orcular isSitefound in normal position, A at about the same level as torcular is OfOnin a Posterior position, about the same level as a normal Is at Neck Muscles The he site ofof insertion of the neck muscles on the posterior skull; thi insertion of the neck muscles on the posterior skull; this Skull the site 51 a Blake’s13pouch cyst. In (b) the torcular is displaced higher than is a Blake’s pouch cyst. In (b) the torcular is displaced higher than Sunday, July 28,
  81. 81. Arachnoid Cysts • Are Benign, Noncommunicating Fluid Collections Within Arachnoid Membranes. • Location: Intracranially And In The Spinal Canal. • Order Of Frequency Are The Sylvian Fissure Or Temporal Fossa, Posterior Fossa, Over The Cerebral Convexity, And Midline Supratentorial, • Most Appear Stable And Require No Surgical Treatment. Occasionally They Interfere With CSF Circulation And Require Decompression. Sunday, July 28, 13
  82. 82. The Differential Diagnosis Depends On The Location. In The Posterior Fossa: DandyWalker Malformation, Inferior Vermian Hypoplasia, Mega–cisterna Magna, And Blake’s Pouch Cysts. Supratentorial Cysts: Cavum Veli Interpositi, Aneurysm Of Vein Of Galen, Hemorrhage, And Cystic Tumors. 53 Sunday, July 28, 13
  83. 83. Prenatal diagnosis and outcome of fetal posterior fossa fluid collections G. GANDOLFI COLLEONI et al, Ultrasound Obstet Gynecol 2012; 39: 625–631 54 Sunday, July 28, 13
  84. 84. 105 Fetuses Blake’s Pouch Cyst N = 32 Arachnoid Cyst N=1 Megacisterna Magna N = 27 Cerebellar Hypoplasia N=2 Sonographic diagnoses were accurate in 88% Sunday, July 28, 13 Dandy – Walker Malformation N=26 Vermian Hypoplasia N=17 55
  85. 85. ✦ Isolated Cases Of Blake’s Pouch Cyst And Megacisterna Magna Have An Excellent Prognosis, With A High Probability Of Intrauterine Resolution And Normal Intellectual Development In Almost All Cases. ✦ Dandy – Walker Malformation And Vermian Hypoplasia, Even When They Appear Isolated Antenatally, Are Associated With An Abnormal Outcome In Half Of Cases. 56 Sunday, July 28, 13
  86. 86. Conclusion •Black’s   Pouch   Cyst,   DW   Malformation,   and   Mega-­‐Cisterna   Magna   Can   give   Similar   Sonographic  features.     •However  the  prognosis  is  greatly  varialbe. •Careful  Neurosonographic  assessment  using  3   D  or  Fetal  MRI  is  often  Needed 57 Sunday, July 28, 13
  87. 87. Technical Guideline How do we do it? Practical advice on imaging-based techniques and investigations Three dimensional ultrasound examination of the fetal central nervous system Gianluigi Pilu, Tullio Ghi, Angela Carletti, Maria Segata, Antonella Perolo, Nicola Rizzo From the Department of Obstetrics and Gynecology University of Bologna, Italy Address for correspondence: gianluigi.pilu@unibo.it Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245 Sunday, July 28, 13
  88. 88. 3D   ultrasound   is   a   data   set   that   contains   a   large   number   o f   2 D   p l a n e s   ( B -­‐ m o d e   images).   e.g.   If   the   page   of   a   book   is   one   2D   plane,   then   the   book   itself  is  the  en3re  data  set.   The   3   D   probe   acquire   the   data   by   moving   a   B   mode   transducer   within   a   housing  like  a  hand  held  Japanese  fan  . Sunday, July 28, 13
  89. 89. Pyramid  Of  Volume  Informa=on ✴ “Walking”  through  the   volume   is   similar   to   leafing   through   the   pages   of   a   book   i.e.   walking   through   the   various  2D  planes  that   make   up   the   entire   volume.     ✴ The   Volume   can   be   dissected  in  any  plane,   to   get   “Multiplanar   Imaging”   Sunday, July 28, 13 the   acquired   volume   unlike   the   defined  rectangle   shape   of  a   book   looks  like  a  pyramid  or  triangle   of   volume   informa3on   with   a   broad   base  
  90. 90. 3D volumes of the fetal brain obtained from an axial approach: the ‘start’ scan Cavum septi pellucidi midline Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245 61 Sunday, July 28, 13
  91. 91. midline A C Sunday, July 28, 13 B Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245
  92. 92. midline A C Sunday, July 28, 13 B Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245
  93. 93. midline A B A and B rotated on Z plane until midline is aligned with C plane C Sunday, July 28, 13 Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245
  94. 94. A B Corpus callosum + cavum septi pellucidi Cerebellar vermis C Sunday, July 28, 13 Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245 Acoustic shadow
  95. 95. midline Corpus  callosum Cavum  sep*  pellucidi midline Corpus  callosum  +  cavum  sep*  pellucidi Originally  published  in  Ultrasound Obstet Gynecol 2007; 30: 233–245 Sunday, July 28, 13 64
  96. 96. Angled  Insona3on  of  Posterior  Fossa  to   Visualize  brain  Stem 4v Brain  stem Cerebellar  vermis Originally  published  in  Ultrasound  Obstet  Gynecol  2007;  30:  233–245 Sunday, July 28, 13 65
  97. 97. hemisphere hemisphere tentorium 4v vermis hemisphere hemisphere tentorium vermis vermian fissures 4v Sunday, July 28, 13 Originally published in Ultrasound Obstet Gynecol 2007; 30: 233–245
  98. 98. body atrium Occipital   horn Temporal  horn Sylvian  fissure Originally  published  in  Ultrasound  Obstet  Gynecol  2007;  30:  233–245 Sunday, July 28, 13 67
  99. 99. 68 Sunday, July 28, 13
  100. 100. 69 Sunday, July 28, 13
  101. 101. 70 Sunday, July 28, 13
  102. 102. 71 Sunday, July 28, 13
  103. 103. 72 Sunday, July 28, 13
  104. 104. 73 Sunday, July 28, 13
  105. 105. Agenesis  of  the   corpus  callosum Normal  corpus  callosum 3v Absent  corpus  callosum 3v Par3al  agenesis 3v Originally  published  in  Ultrasound  Obstet  Gynecol  2007;  30:  233–245 Sunday, July 28, 13 74
  106. 106. Normal  Posterior  Fossa  At  Midgesta=on Axial view SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  107. 107. Normal  Posterior  Fossa  At  Midgesta=on Cavum  Sep3   Pellucidi Axial view SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  108. 108. Normal  Posterior  Fossa  At  Midgesta=on Cavum  Sep3   Pellucidi Cerebellar  vermis Axial view SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  109. 109. Normal  Posterior  Fossa  At  Midgesta=on Cisterna  Magna Cavum  Sep3   Pellucidi Cerebellar  vermis Axial view SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  110. 110. Normal  Posterior  Fossa  At  Midgesta=on Cisterna  Magna Cavum  Sep3   Pellucidi Cerebellar  vermis Tentorium Axial view Cisterna  Magna SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  111. 111. Normal  Posterior  Fossa  At  Midgesta=on Cisterna  Magna Cavum  Sep3   Pellucidi Cerebellar  vermis Tentorium Axial view Cisterna  Magna SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  112. 112. Normal  Posterior  Fossa  At  Midgesta=on Cisterna  Magna Cavum  Sep3   Pellucidi Cerebellar  vermis Tentorium Axial view Cisterna  Magna SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  113. 113. Normal  Posterior  Fossa  At  Midgesta=on Cisterna  Magna Cavum  Sep3   Pellucidi Cerebellar  vermis Tentorium Axial view Cisterna  Magna SagiGal  view Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid  Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Sunday, July 28, 13
  114. 114. Applica=on  of  3  D  Imaging  in   Prenatal  diagnosis  of  Fetal   Posterior  Fossa  Fluid  Collec=on 76 Sunday, July 28, 13
  115. 115. Prenatal  diagnosis  and  outcome  of  fetal  posterior  fossa  fluid   Collec=ons Gandolfi  Colleoni  et  al.,  UOG  2012 Brainstem–vermis and brainstem–tentorium angles allow accurate categorization of fetal upward rotation of cerebellar vermis P. VOLPE*, et al Ultrasound Obstet Gynecol 2012; 39: 632–635 77 Sunday, July 28, 13
  116. 116. Categoriza3on  of  posterior  fossa  fluid  collec3ons  (1) Sunday, July 28, 13
  117. 117. Categoriza3on  of  posterior  fossa  fluid  collec3ons  (1) Blake’s  pouch  cyst Upward  rotation  of  an  intact  vermis   with  normal  torcular Findings Megacisterna  magna Cisterna  magna  >10mm  with  intact   and  normally  positioned  cerebellum SagiGal   Axial Sunday, July 28, 13 D-­‐W                                         Upward  rotation  of  the  vermis   (normal  or  hypoplastic)  with elevated  torcular
  118. 118. Axial  View • Transverse Diameter Of The Cerebellum. • The Intactness And Size Of The Vermis. • The Depth Of The Cisterna Magna (10 Mm) Sunday, July 28, 13 79
  119. 119. Cavum  Sep3   Pellucidi The  Tentorium:  Level     The  Vermis:  Shape,  Size,  Fissures Figure 1 Measurement of brainstem–vermis (BV) and brainstem–tento 80 this case Sunday, July 28, 13 after acquisition of an ultrasound volume starting from an axi
  120. 120. Cavum  Sep3   Pellucidi Brainstem-tentorium (BT) angle Brainstem-vermis Figure 1 Measurement of brainstem–vermis (BV) and brainstem–tento (BV) angle 81 this case after acquisition of an ultrasound volume starting from an axi Sunday, July 28, 13
  121. 121. 1 Measurement of brainstem–vermis and and brainstem–tentorium (BT) angles.median view of the of the fetal obtained (in (a) Measurement of brainstem–vermis (BV)(BV) brainstem–tentorium (BT) angles. (a) A(a) A A median viewfetal brain is brain is obta Figure 1 Measurement of brainstem–vermis (BV) and brainstem–tentorium (BT) angles. median view of the fetal brain is obtained e after acquisitionan ultrasound volume starting from from an axial view) and theanatomic landmarks are identified. (b) A (b) ter acquisition of of an ultrasound volume starting an axial axial and the main main anatomic landmarks are identified. lin this case after acquisition of an ultrasound volume starting from anview) view) and the main anatomic landmarks are identified. (b) line i A angentially to dorsal aspect of the brain stem stema and a line is line is drawn tangentially to the contour of thethe cerebellar dorsal aspect of of brain and and a second drawn tangentially to the the ventral contour of of the cerebe gentially to the theto the dorsal aspectthe the brain stemsecondsecond line is drawn tangentially toventralventral contourcerebellar drawn tangentially the interposed angle is the BV BV BV angle; the BT angle (2) is measured between the first line andthird line tangential thethe tentoriu interposed angle (1) (1) is the the angle; the BT (2) is measured between the first first line and a line tangential to to tentorium vermis; the interposed angle (1) isangle; the BT angleangle (2) is measured between theline and a third a third line tangential to the te Measurement Of Brainstem–vermis (BV) Angle (1) And Brainstem–tentorium (BT) In Three Conditions Blake’s Pouch Cyst Cerebellar Vermis Hypoplasi Dandy–Walker Malformation. The Angles Has The Widest Measurement In DA Malformation 82 Figure 2 Measurement of brainstem–vermis (BV) angle (1) and brainstem–tentorium (BT) angle (2) in fetuses with: (a) Blake’s pouch cys Sunday, July 28, 13
  122. 122. Blake’s pouch cyst Dandy–Walker malformation Vermian hypoplasia Dandy–Walker malformation 12 12 7 12 23.0 63.5 34.9 63.5 Brainstem–vermis Angle 2.8 17.6 5.4 17.6 60 40 20 0 0 7.0 15.1 32–52 15.1 51–1 45–66 51–112 Brainstem– Tentorium Angle Normal Normal Blake’s pouch Vermian Dandy–Walker cyst hypoplasia malformation Blake’s pouch Vermian Dandy–Walker cyst hypoplasia malformation Figure 3 Box-and-whisker plot of distribution of brainstem–vermis angle in controls and in fetuses with upward rotation of the cerebellar vermis. Medians of distribution line inside each box, Figure 3 Box-and-whisker plot are indicated by a of brainstem–vermis th th th th angle in25 and 75and in fetuses withlimits and 5 and 95 ofpercentiles controls percentiles by box upward rotation the by lower and upper bars, respectively. Brainstem–tentorium angle (°) Brainstem–tentorium angle (°) Brainstem–vermis angle (°) Brainstem–vermis angle (°) 20 67.2 7.1 80 80 40 42.2 52.1 67.2 80 80 60 19–26 45–112 24–40 45–112 60 60 40 40 20 20 Normal Blake’s pouch cyst Normal Vermian Dandy–Walker hypoplasia malformation Blake’s pouch Vermian Dandy–Walk cyst hypoplasia malformatio Figure 4 Box-and-whisker plot of distribution of brainstem– tentorium angle in controls and in fetuses with upward rotation of the cerebellar vermis. Medians are indicated by a line inside each Figure 4 Box-and-whisker plot of distribution of brainstem– box, 25th and 75th percentiles by box limits and 5th and 95th tentorium angle in controls respectively. percentiles by lower and upper bars,and in fetuses with upward rotation o Box-and-whisker plot of distribution of Box-and-whisker indicated by line inside each of cerebellar vermis. Medians are plot of a distribution box, th and 75th percentiles by box limits and 5th and 95th percentiles 25 cerebellar vermis. Medians are in controls and in brainstem–vermis angle in controls and in thebrainstem– tentorium angleindicated by a line inside each by lower and upper bars, < 18◦ and a BT angle < 45◦ . The BV th had a BV angle respectively. box, 25th and 75th upward rotation limits andcerebellarth fetuses with percentiles by box of (BV) and and 95 the 5 fetuses with upward increased inof theofcerebellar Table 2 Statistical comparison ofupper bars, respectively. angle was significantly rotation each the three percentiles by lower and brainstem–vermis brainstem–tentorium (BT) angles in controls and in fetuses with subgroups of anomalies 3, Table 2), angle vermis. Medians are indicated by a line inside vermis. Medians and (Figure angle <a45◦theThe BV upward rotation of the cerebellar vermis had a increasing with18◦ are indicated by condition. The BV angle < increasing a BT of the line inside . severity each box, 25th and 75th of brainstem–vermis (BV) and Table 2 Statistical comparison percentiles by box limits BT angle 25th and similar pattern, of by box angle was significantly increased percentilesthere was each box, demonstrated a75th in each but the three P (Mann–Whitney U-test) brainstem–tentorium (BT) angles in controls and in fetuses with more of anomalies (Figure (Figure 4, Table 2). subgroups overlapping among groups3, Table 2), the angle th and of the percentiles by lower and upper th cerebellar vermis and upward5 limits and 5th and 95th percentiles by lower Comparison*rotation 95 BV angle BT angle increasing with increasing severity of the condition. The BT and upper S I O N respectively. angle Sdemonstrated a similar pattern, but there was D I C U S bars, more overlapping among groups (Figure 4, Table 2). Our results suggest that measurement of the BV angle discriminates Sunday, July 28, 13 accurately posterior fossa fluid collections bars, respectively. Controls vs Blake’s pouch cyst fetuses Controls vs Dandy–Walker Comparison* fetuses < 0.00000005 (Mann–Whitney U-test) P < 0.000005 < 0.00000005 < 0.00000005 BV angle BT angle
  123. 123. Conclusion Fetal posterior fossa fluid collections associated with upward rotation of the cerebellar vermis range from benign asymptomatic conditions to severe abnormalities associated with neurological impairment. The most frequent of these anomalies, Blake’s pouch cyst, vermian hypoplasia and Dandy– Walker malformation, have a similar sonographic appearance but a very different prognosis 84 Sunday, July 28, 13
  124. 124. In  Summary 85 Sunday, July 28, 13
  125. 125. Examination Of The Posterior Fossa And The Cerebellum Axial View Midsagittal Views 86 Sunday, July 28, 13
  126. 126. Prac3cal  Approach  to  the  DD  of  Posterior  Fossa   Cyst  and  Cys3c  like  Lesions Sunday, July 28, 13
  127. 127. Prac3cal  Approach  to  the  DD  of  Posterior  Fossa   Cyst  and  Cys3c  like  Lesions 1. Is  the  Vermis  Present?Is  the  Vermis  intact? Sunday, July 28, 13
  128. 128. Prac3cal  Approach  to  the  DD  of  Posterior  Fossa   Cyst  and  Cys3c  like  Lesions 1. Is  the  Vermis  Present?Is  the  Vermis  intact? 2. Is  the  Toruclar  in  a  normal  posi3on  (tentorial   Cerebelli)? Sunday, July 28, 13
  129. 129. Prac3cal  Approach  to  the  DD  of  Posterior  Fossa   Cyst  and  Cys3c  like  Lesions 1. Is  the  Vermis  Present?Is  the  Vermis  intact? 2. Is  the  Toruclar  in  a  normal  posi3on  (tentorial   Cerebelli)? 3. What  is  the  shape  of  the  cerebellar  clee? Sunday, July 28, 13
  130. 130. Prac3cal  Approach  to  the  DD  of  Posterior  Fossa   Cyst  and  Cys3c  like  Lesions 1. Is  the  Vermis  Present?Is  the  Vermis  intact? 2. Is  the  Toruclar  in  a  normal  posi3on  (tentorial   Cerebelli)? 3. What  is  the  shape  of  the  cerebellar  clee? 4. Brainstem–vermis (BV) Angle And Brainstem– tentorium (BT) Angle Sunday, July 28, 13
  131. 131. Blacke’s  Pouch  Cyst Cystegacisterna  Magna Ultrasound Obstet Gynecol 2012; 39: 625–631 Published online 14 May 2012 in Wiley Online Library (wileyonlinelibrary.com). DOI: 10.1002/uog.11071 Prenatal diagnosis and outcome of fetal posterior fossa fluid collections G. GANDOLFI COLLEONI*, E. CONTRO*, A. CARLETTI*, T. GHI*, G. CAMPOBASSO†, G. REMBOUSKOS†, G. VOLPE‡, G. PILU* and P. VOLPE† Vermian  Hypoplasia D-­‐W  Malforma3on *Department of Obstetrics and Gynecology, University of Bologna, Bologna, Italy; †Fetal Medicine Unit, Di Venere and Sarcone Hospitals, ASL Bari, Bari, Italy; ‡Department of Obstetrics and Gynecology, University of Bari, Bari, Italy K E Y W O R D S: cerebellar anomalies; Dandy–Walker malformation; fetus; megacisterna magna; prenatal diagnosis; ultrasound ABSTRACT Cerebellar  Hypoplasia Objective To evaluate the accuracy of fetal imaging in differentiating between diagnoses involving posterior fossa fluid collections and to investigate the postnatal outcome of affected infants. Methods This was a retrospective study of fetuses with posterior fossa fluid collections, carried out between 2001 and 2010 in two referral centers for prenatal diagnosis. All fetuses underwent multiplanar neurosonography. Parents were also offered fetal magnetic resonance imaging (MRI) and karyotyping. Prenatal diagnosis was compared with autopsy or postnatal MRI findings and detailed follow-up was attempted by consultation of medical records and interview with parents and pediatricians. fluid collections from mid gestation. Blake’s pouch cyst and megacisterna magna are risk factors for associated anomalies but when isolated have an excellent prognosis, with a high probability of intrauterine resolution and normal intellectual development in almost all cases. Conversely, Dandy–Walker malformation and vermian hypoplasia, even when they appear isolated antenatally, are associated with an abnormal outcome in half of cases. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. Arachinoid  Cyst-­‐Pos  Fossa   INTRODUCTION 88 Fluid collections in the fetal posterior fossa encompass a wide spectrum of different megacisterna magna; Figure 1 Categorization of posterior fossa fluid collections on ultrasound: (a,b) Blake’s pouch cyst; (c,d) entities, ranging from(e,f) vermian Sunday, July 28, 13 During the study period, 105 fetuses were examnormal variants to severe anomalies1 . fossa. hypoplasia; (g,h) Dandy–Walker malformation; (i,j) cerebellar hypoplasia; (k,l) arachnoid cyst of the posterior They may have Results
  132. 132. Normal Megacisterna  magna Blake’s  pouch  cyst tentorium Vermian  hypoplasia Dandy-­‐Walker  malforma3on Originally  published  in  Ultrasound  Obstet  Gynecol  2007;  30:  233–245 Sunday, July 28, 13 89
  133. 133. Take  Home  Message Standard  and  Fetal   Neurosonography 90 Sunday, July 28, 13
  134. 134. 91 Sunday, July 28, 13
  135. 135. ✦ examina3on  of  the  Fetal  CNS  should  be  follow  a   Standard  Protocol 91 Sunday, July 28, 13
  136. 136. ✦ examina3on  of  the  Fetal  CNS  should  be  follow  a   Standard  Protocol ✦ Examina3on   should   include   at   least   three   axial   planes. 91 Sunday, July 28, 13
  137. 137. ✦ examina3on  of  the  Fetal  CNS  should  be  follow  a   Standard  Protocol ✦ Examina3on   should   include   at   least   three   axial   planes. ✦ In   Each   plane   the   defined   landmarks   should   should  be  reported  as  normal  or  suspicious 91 Sunday, July 28, 13
  138. 138. ✦ examina3on  of  the  Fetal  CNS  should  be  follow  a   Standard  Protocol ✦ Examina3on   should   include   at   least   three   axial   planes. ✦ In   Each   plane   the   defined   landmarks   should   should  be  reported  as  normal  or  suspicious ✦ In  the  presence  of  possible  abnormali3es  pa3ent   should   be   referred   for   detailed   neuorsonogram   which  include  mutli-­‐planner  3  D  Sanning. 91 Sunday, July 28, 13
  139. 139. ✦ examina3on  of  the  Fetal  CNS  should  be  follow  a   Standard  Protocol ✦ Examina3on   should   include   at   least   three   axial   planes. ✦ In   Each   plane   the   defined   landmarks   should   should  be  reported  as  normal  or  suspicious ✦ In  the  presence  of  possible  abnormali3es  pa3ent   should   be   referred   for   detailed   neuorsonogram   which  include  mutli-­‐planner  3  D  Sanning. ✦ 3   D   scanning   with   mul3planner   analysis   offers   comparable  analysis  to  fetal  MRI 91 Sunday, July 28, 13
  140. 140. Thanks   92 Sunday, July 28, 13

×