The following slides and audio are taken from a public HIV health and treatments update forum held in Sydney, Australia on 25 November 2008. The slides and audio have been edited for presentation on the web.
The speaker is Bill Whittaker, NAPWA Health, Treatments and Research portfolio co-convenor.
For more presentations from this event, visit the sponsor organisations’ websites:
HIV Treatment and Health Update 25 November 2008 Part 4 New HIV treatment pipeline
* Only for boosting other PIs # Reformulated/redesigned 10/16 antiviral drugs from 1998 either withdrawn, reformulated, redesigned, no longer commonly used in HIV………..
“ The white ones help my immune system but raise my blood pressure. The red ones lower my blood pressure but screw up my stomach. The green ones help my stomach but fuck with my immune system. Then these yellow ones simply ensure an attractive colour combination.”
2008 Experimental HIV Antiviral Drugs Clinical Trials in People RTV like booster Gilead Phase II Enhancer GS 93502 RTV like booster Sequoia Phase I Enhancer SPI-452 Genentech Phase II CD4 TNX-355 Progenics Phase II CCR5 PRO 140 Phase I Aust. Schering Phase I CCR5 SCH532706 Schering Phase III CCR5 Vicriviroc Tobira Phase I CCR5 TBR-652 Gilead Phase II Integrase Elvitegravir Panacos Phase I/II Maturation Beviramat (PA-457) Sequoia Phase I/II Protease I SPI-256 Ardea Phase I/II Non-NRTI RDEA806 Tibotec/JJ Phase III Non-NRTI Rilpivirine (TMC-278) Pfizer Phase I/II Non-NRTI UK-453,061 Idenix Phase I/II Non-NRTI IDX899 Achillion Phase II NRTI Elvucitabine RFS Phase II NRTI Amdoxovir Australian Avexa Phase III NRTI Apricitabine Comment Pharma Clinical Trial progress Target Drug
NEW ARV PIPELINE: Timelines for First Access Beviramat Panacos TNX 355 Genentech NO NEW INFO for some years SO DROP GS1937 Gilead AVX754 Apricitabine Avexa DISCONTINUED Reverset Pharmasset STALLED Racivir Pharmasset TMC-278 Rilpivirine Tibotec APPEARS DISCONTINUED BILR-355 BMS DISCONTINUED INCB9471 Incyte Corp Recently put on hold KP-1461 Koronis Protease Inhibitors NNRTIs (Non Nukes) NRTIs (Nukes) Maturation inhibitor Integrase inhibitors Entry inhibitors 2012 2011 2010 2009 2008 DISCONTINUED GW 640385 Brecanavir GSK