Glutathione Key in Wellness Care

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Glutathione levels in the body support normal antioxidant, immune and detoxification function. When glutathione levels drop, susceptibility to illness will rise. A genetic component plays a part in certain individuals.

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  • Inhibits methylation
  • Glutathione Key in Wellness Care

    1. 1. The Glutathione Key<br />Dr. Nancy Doreo, DC<br />1<br />
    2. 2. The Importance of Glutathione<br />Antioxidant<br />Immune System<br />Detoxification<br />2<br />
    3. 3. Master Antioxidant<br />It needs to be ABUNDANT and ACTIVE<br />Major free radical scavenger in the brain<br />3<br />
    4. 4. Environmental Triggers<br />LOCATION<br />STRESSES<br />DIET (gmo, processed)<br />PAST HISTORY<br />NEURO-ENDOCRINE<br />MEDICAL THERAPIES<br />4<br />
    5. 5. Environment<br />Pathogens, drugs, hormones, and toxins are just a few ways that the environment can trigger autoimmunity<br />5<br />
    6. 6. Causes of Autoimmunity<br />GPx1<br />6<br />
    7. 7. Inflammatory Cytokines<br />Inhibit red blood cell growth<br />Activate Microglia<br />Cause pain<br />Cause stiffness<br />Impair intestinal barrier<br />Impair blood brain barrier<br />Wreak chemical havoc with neurotransmitters, hormones, nitric oxide, glutathione<br />7<br />
    8. 8. Some conditions with known glutathione deficiency<br />Heart disease<br />Neurodegenerative<br />ALS, MS, AD, PD<br />Autoimmune diseases<br />Thyroid, AIDS <br />Cancer<br />Brain<br />Schizophrenia, Bipolar<br />ADHD, Autism<br />TBI<br /><ul><li>Drug Damage
    9. 9. Alcohol
    10. 10. Smokers
    11. 11. Low Immune
    12. 12. WBCs low</li></ul>8<br />
    13. 13. Critical Management Points<br />History<br />Exam<br />Labs: in office challenges, blood/saliva/urine<br />Working Diagnosis versus Existing Diagnosis<br />Plan of Action<br />Phases of Plan<br />Follow Up<br />Re-evaluate<br />9<br />
    14. 14. AutoImmunity Reality:<br />Celiac<br />Hashimoto’s<br />Fix?<br />Manages<br />Fluctuates<br />MS<br />Psoriasis<br />Rheumatoid<br />10<br />
    15. 15. Detoxification Pathways <br />Liver Phase 1<br /><ul><li>the cytochrome P450s require several nutrients to function, such as copper, magnesium, zinc and vitamin C</li></ul>Liver Phase 2<br /><ul><li>Glutathione conjugation: Methionine/Cysteine/Glutamate
    16. 16. Amino acid conjugation: cysteine/taurine/glycine/glutamine
    17. 17. Methylation: Folate, B12, Choline, Methionine
    18. 18. Sulfation: sulfur foods, glutathione, taurine
    19. 19. Acetylation: thiamine, pantothenic acid, and vitamin C
    20. 20. Glucuronidation: Magnesium</li></ul>11<br />
    21. 21. Systems Permit Viscous Cycles<br />Mercury Poisons Methionine Synthase<br />Default in GSH and GSSG permit poor detoxification of haptens<br />Virtually every major organ system<br />12<br />
    22. 22. Genomics<br />Glutathione Peroxidase 1 SNP<br />Metalloproteinase SNPs<br />5 MTHFR<br />Others…<br />Genova<br />Genelink<br />Labcorp<br />13<br />
    23. 23. Genetic Predisposition<br />GPx1 Polymorphisms<br />GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility<br />J Cancer Res Clin Oncol. 2011 Oct;137(10):1553-61<br />prostate cancer , breast cancer, ovarian cancer and lung cancer may be modulated by GPX1 polymorphism and that the combination of genetic factors involved in oxidative response with environmental carcinogens may play an important role in carcinogenesis.<br />Glutathione helps defend the body against damage from cigarette smoking, exposure to radiation, cancer chemotherapy, and toxins such as alcohol. As a detoxifier of heavy metals and drugs; it aids in the treatment of depression, schizophrenia, bipolar and chronic fatigue, blood, immune and liver disorders<br />14<br />
    24. 24. “Treatment with glutathione precursors prevented the MTX-induced ROS production and the increase of paracellular permeability.” <br />Intestinal barrier destruction occurs once glutathione is depleted<br /><ul><li>Cordyceps
    25. 25. Centella Asiatica
    26. 26. Silybum Marianum
    27. 27. N-Acetyl-Cysteine
    28. 28. Alpha Lipoic Acid
    29. 29. L-Glutamine
    30. 30. Selenium</li></ul>Support with Glutathione Recycler in Gluten Sensitivity and Cross Reactive Foods<br />15<br />ii<br />
    31. 31. Glutathione Support and Delivery<br />Patient Profile:<br />Autoimmune<br />Oxidative Stress<br />Neurodegenerative<br />Leaky Gut/Brain<br />Energy Depletion<br />Sarcopenia<br />Mental/Emotional<br />Scoliosis<br />16<br />
    32. 32. Let’s Do Some Math:<br />Low GSH + Low Vit D + Stress = illness<br />Low GSH + Toxic Metal Exposure = illness<br />Low GSH + Gluten Intolerance= illness<br />Modifying Processes Rather than Curing Diseases<br /> environmental factors + susceptibility<br /> GSH + 4R Program + Anti-Inflammatory Lifestyle<br />Chapter 23, Textbook of Functional Medicine, page 319 <br />17<br />
    33. 33. So, what are you going to do?<br />Basics that will identify, heal and protect:<br /><ul><li>Test with Labs
    34. 34. Gut Barrier
    35. 35. Glutathione Stores
    36. 36. Anti-Inflammatory Lifestyle
    37. 37. Exercise and Rest Habits
    38. 38. Treatment and Follow Up</li></ul>18<br />
    39. 39. Reference Papers:<br />Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):784-94. Epub 2010 Jul 4.<br />An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways<br />Significance of Low Plasma Homocysteine Richard S. Lord, Ph.D. and Kara Fitzgerald, N.D.<br />Toxicology and Applied PharmacologyVolume 219, Issues 2-3, March 2007, Pages 181-189 Anticholinesterases Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency<br />Biological Trace Element ResearchVolume 89, Number 2, 105-110, DOI: 10.1385/BTER:89:2:105<br />Download this presentation at http://www.slideshare.net/nancydoreo/glutathione-key-in-wellness-care<br />19<br />Regulation of Neuronal Glutathione SynthesisJ PharmacolSci 108, 227-238 (2008) <br />Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat’s development induce long-term cognitive deficit: relevance to schizophrenia Neurobiology of Disease 15 (2004) 93-105<br />Textbook of Functional Medicine, IFM 2005<br />

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