Glutathione levels in the body support normal antioxidant, immune and detoxification function. When glutathione levels drop, susceptibility to illness will rise. A genetic component plays a part in certain individuals.
Genetic Predisposition<br />GPx1 Polymorphisms<br />GPx-1 polymorphism (rs1050450) contributes to tumor susceptibility<br />J Cancer Res Clin Oncol. 2011 Oct;137(10):1553-61<br />prostate cancer , breast cancer, ovarian cancer and lung cancer may be modulated by GPX1 polymorphism and that the combination of genetic factors involved in oxidative response with environmental carcinogens may play an important role in carcinogenesis.<br />Glutathione helps defend the body against damage from cigarette smoking, exposure to radiation, cancer chemotherapy, and toxins such as alcohol. As a detoxifier of heavy metals and drugs; it aids in the treatment of depression, schizophrenia, bipolar and chronic fatigue, blood, immune and liver disorders<br />14<br />
“Treatment with glutathione precursors prevented the MTX-induced ROS production and the increase of paracellular permeability.” <br />Intestinal barrier destruction occurs once glutathione is depleted<br /><ul><li>Cordyceps
Reference Papers:<br />Prog Neuropsychopharmacol Biol Psychiatry. 2011 Apr 29;35(3):784-94. Epub 2010 Jul 4.<br />An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways<br />Significance of Low Plasma Homocysteine Richard S. Lord, Ph.D. and Kara Fitzgerald, N.D.<br />Toxicology and Applied PharmacologyVolume 219, Issues 2-3, March 2007, Pages 181-189 Anticholinesterases Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency<br />Biological Trace Element ResearchVolume 89, Number 2, 105-110, DOI: 10.1385/BTER:89:2:105<br />Download this presentation at http://www.slideshare.net/nancydoreo/glutathione-key-in-wellness-care<br />19<br />Regulation of Neuronal Glutathione SynthesisJ PharmacolSci 108, 227-238 (2008) <br />Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat’s development induce long-term cognitive deficit: relevance to schizophrenia Neurobiology of Disease 15 (2004) 93-105<br />Textbook of Functional Medicine, IFM 2005<br />