Obesity- Metabolic alterations, complications and treatment

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Obesity- complications and recent treatment

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Obesity- Metabolic alterations, complications and treatment

  1. 1. SELECTED FOR PUBLICATIONIN STUDENTS CORNERCOMPLICATIONS ANDTREATMENT OFOBESITY Biochemistry For medics www.namrata.co
  2. 2. Presenter Name Presentation DateByB.R-Nabila AubeeluckRoll Number 4
  3. 3. Metabolic alterations in differentSystems and related complicationsPrognosisTreatment –Diet, Exercise,Medication & SurgerySummaryReferences Biochemistry For Medics 3
  4. 4. Co-Morbidities associated withObesity 1.Cardiology Biochemistry For Medics 5
  5. 5. 2.Dermatology Stretch Marks (Striae) Acanthosis nigricans Cellulitis Hirsutism Intetrigo Biochemistry For Medics 6
  6. 6. 3.Endocrinology&Reproductive System  Diabetes Mellitus  Menstrual Disorders  Infertility  Polycystic Ovarian Syndrome Complications of Pregnancy Birth Defects Intrauterine Foetal Death Biochemistry For Medics 7
  7. 7. 4.Gastrointestinal  Gastroesophageal Reflux Disease Due to increased BMI Causes HEARTBURNS  Fatty Liver Due to insulin resistance  Cholelithiasis Low fibre, high cholesterol and starchy food Biochemistry For Medics 8
  8. 8. 6.Neurology Stroke Blockage in blood supply to brain Dementia More visceral fat-> smaller brain volume Meralgia Paresthetica Weight gain->more pressure on lat.cutaneous N of Thigh Migraines Multiple Sclerosis Biochemistry For Medics 9
  9. 9. 7.Oncology  Breast Cancer  Oesophageal Cancer  Liver Cancer  Pancreatic Cancer A recent report estimated that In the United States,14 % of deaths from cancer in men, and 20% of deaths in women were due to overweight and Obesity Biochemistry For Medics 10
  10. 10. 9.MetabolicSyndrome  Hyperinsulinemia  Hyperurecemia Gout  Diabetes  Dyslipidemia Biochemistry For Medics 11
  11. 11. 10.Psychology Depression Self-loathing Strongest in younger and in women Social Stigmatization Less chances of employment, earn less and less likely to get married. Biochemistry For Medics 12
  12. 12. Biochemistry For Medics 14
  13. 13. Prognosis With BMI of 25-28.9,Relative risk of Coronary Heart Disease is 1.72 Increases cardiovascular mortality rate 4 fold Increases cancer-related mortality rate 2 fold In total,severely obese people have 6-12 fold increase in the all-cause mortality rate Biochemistry For Medics 15
  14. 14. Treatment1.Diet DON’T’s DO’s _________________________________________________________ Intake of red and processed Low Calorie diet meat Smaller meals Intake of simple sugars and Increase intake of complex refined carbs carbs and low glycemic Excessive salt intake index foods Excessive intake of fast foods Increase intake of mono and calorie-rich soft drinks and poly saturated fats Intake of saturated fats Increase consumption of Intake of fad diets fresh fruits,veg and low-fat dairy products Drink good quality water Biochemistry For Medics 16
  15. 15. 2.Physical Exercise Muscles consume energy from both fat and glycogen 30 min moderate exercise 5 days a week Must be combined with proper diet for effective weight loss3.Behavioral Modification& Social Support  Psychological Conselling  Support from near and dear ones  Obesity support groups Biochemistry For Medics 17
  16. 16. 4.MedicationsSibutramine -An anorectic Orlistat -Reccomended dose:10 mg/day -Side effects:dry mouth,insomnia,high BP -inhibits pancreatic lipase -Recommended dose:120mg 3 times daily5.Bariatric Surgerygas,cramps -Side effects:Diarrhea,  Gastric Band  Gastric Bypass  Liposuction Biochemistry For Medics 18
  17. 17. SUMMARY Obesity affects almost,if not all,systems of the body Prognosis is usually bad Obesity can be treated! Dieting,Physical activity,Medications,Surgery Biochemistry For Medics 19
  18. 18. References & Acknowledgement World Heath Organisation website NHS website Cancer Network website BBC website The Guardian Wikipedia National Institute for Health and Clinical Excellence website Biochemistry-Harper A case Oriented Approach Towards Biochemistry- Namrata Chhabra Biochemistry department-SSRMC Biochemistry For Medics 20
  19. 19. “Eat to live; Don’t live toeat!” Biochemistry For Medics 21
  20. 20. ` Biochemistry For Medics 22

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