Introduction
Structure <ul><li>N-terminal domain </li></ul><ul><li>Containing different  numbers of zinc   fingers. </li></ul><ul><li>E...
 
Isoforms
 
ikaros gene expression in human non-lymphoid leukemia cell line
 
Different roles
 
Disease associated with ikaros
Function of Ikaros  <ul><li>Ikaros  appears function both as a transcriptional  repressor  and as an  activator  through i...
 
<ul><li>TdT gene  is initially down-regulated when  ikaros  dislocates the transcriptional activator  Ets-1  from the TdT ...
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transcription factor Ikaros

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transcription factor

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transcription factor Ikaros

  1. 3. Introduction
  2. 4. Structure <ul><li>N-terminal domain </li></ul><ul><li>Containing different numbers of zinc fingers. </li></ul><ul><li>Exhibit DNA binding activity when it has 3 or more zinc fingers . </li></ul><ul><li>Bind to DNA sites contain the core motif </li></ul><ul><li>GGGA and ZNFs 2,3 </li></ul><ul><li>C -terminal domain </li></ul><ul><li>Oligomerization domain. </li></ul><ul><li>Containing a bipartite transactivation domain and 2 zinc finger motifs. </li></ul><ul><li>Mediate hommo or hetrodimerisation between isoforms and iteract in with other molecules . </li></ul>
  3. 6. Isoforms
  4. 8. ikaros gene expression in human non-lymphoid leukemia cell line
  5. 10. Different roles
  6. 12. Disease associated with ikaros
  7. 13. Function of Ikaros <ul><li>Ikaros appears function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors: </li></ul><ul><li>Histon deacetylase repressor complexses SIN3 , NURD (causes gene inactivation ) </li></ul><ul><li>ATP-dependent chromatin remodeling complexes SW1/SNF (can distrupt histon-DNA –complexes) </li></ul>
  8. 15. <ul><li>TdT gene is initially down-regulated when ikaros dislocates the transcriptional activator Ets-1 from the TdT promotor. </li></ul><ul><li>Down-regulation enhanced by an ikaros –dependent hetrochromatin formation at the TdT locus. </li></ul><ul><li>Ikaros can keep the gene in an inactive state through recruitment of NURD . </li></ul>

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