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transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
transcription factor Ikaros
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transcription factor Ikaros

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transcription factor

transcription factor

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  • 1.  
  • 2.  
  • 3. Introduction
  • 4. Structure <ul><li>N-terminal domain </li></ul><ul><li>Containing different numbers of zinc fingers. </li></ul><ul><li>Exhibit DNA binding activity when it has 3 or more zinc fingers . </li></ul><ul><li>Bind to DNA sites contain the core motif </li></ul><ul><li>GGGA and ZNFs 2,3 </li></ul><ul><li>C -terminal domain </li></ul><ul><li>Oligomerization domain. </li></ul><ul><li>Containing a bipartite transactivation domain and 2 zinc finger motifs. </li></ul><ul><li>Mediate hommo or hetrodimerisation between isoforms and iteract in with other molecules . </li></ul>
  • 5.  
  • 6. Isoforms
  • 7.  
  • 8. ikaros gene expression in human non-lymphoid leukemia cell line
  • 9.  
  • 10. Different roles
  • 11.  
  • 12. Disease associated with ikaros
  • 13. Function of Ikaros <ul><li>Ikaros appears function both as a transcriptional repressor and as an activator through its ability to bind a large number of nuclear factors: </li></ul><ul><li>Histon deacetylase repressor complexses SIN3 , NURD (causes gene inactivation ) </li></ul><ul><li>ATP-dependent chromatin remodeling complexes SW1/SNF (can distrupt histon-DNA –complexes) </li></ul>
  • 14.  
  • 15. <ul><li>TdT gene is initially down-regulated when ikaros dislocates the transcriptional activator Ets-1 from the TdT promotor. </li></ul><ul><li>Down-regulation enhanced by an ikaros –dependent hetrochromatin formation at the TdT locus. </li></ul><ul><li>Ikaros can keep the gene in an inactive state through recruitment of NURD . </li></ul>

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