INDUCTION OF LABOURModerator:Asst Prof. Dr. B.K. BorahSpeaker:Dr. Nancy Anitha
What is Induction of Labour?• Induction of labor is the artificialinitiation of labour mechanism priorto its spontaneous o...
Mechanism of initiation of labor
Mechanism (continued)
Endocrinology of labor
Time, place & preparation• Time of induction: Preferably early morning• Place of induction: where facility forintervention...
Indications of Induction oflabor
Indications for induction oflabor
Contraindications of induction oflabor• Contracted pelvis and CPD• Malpresentations• Previous classical caesarean section ...
Factors to assess prior toinductionMaternal To confirm theindication Exclude thecontraindicatn Assess Bishopscore Ass...
Modified Bishop’s ScoreFavourable score->6 Best score-8
hygroscopic dilators, osmotic dilators (Laminaria japonicum), Foleycatheters, double balloon devices, and extraamniotic sa...
• Misoprostol (a prostaglandin E1 analogue) has several potentialadvantages: it is stable at room temperature, it is relat...
Membrane sweeping• Its possible only if thecervix has ripened to allowthe passage of one finger.• Insertion of a glovedfin...
Amniotomy• AROMstretching of the cervix & separationof the membranes  release of Prostaglandins• Depends on the state of...
AmniotomyCONTRAINDICATIONS:1.IUD2.HIVHAZARDS:1.Cord prolapse2.Amnionitis3.Amniotic fluidembolism4. Abruptio placentae
Prostaglandins• Chemistry:PG is a carboxylicacid synthetised fromarachidonic acid.• Source: menstrual fluid,endometrium, d...
Mechanism of action• It causes change in themyometrial cell membpermeablity and alterationin the membrane boundcalcium• It...
ProstaglandinsPGE1MisoprostolPGE2Dinoprostone(Cerviprime)
How to give Misoprostol?• Dose of 25 micro gram every 4hrly to amaximum of 6 doses can be givenintravaginally• Dose of 50m...
Oral Vs vaginal MisoprostolORAL• Less effectivewhen comparedto vaginal PG• Chance of fetaldistress is lessVAGINAL• More ef...
Dinoprostone• Vaginal gel 0.5mg can be givenintracervically.• It can be repeated after 6 hrs for 3 – 4doses if required• V...
Misoprostol Vs Dinoprostone• Cheap & costeffective• Stable at room temp• Easy to administer• Costly• Need refrigeration
Advantages Disadvantages• Misoprostol is Cheapand has long half life• It is stable at roomtemp• Induction-deliveryinterval...
Contraindications of PGs• Bronchial asthma• Pulmonary disease• Previous uterine scar isrelativelycontraindicated
Oxytocin• It’s a nanopeptidesynthetised in the supraoptic and paraventricularnuclei of the hypothalamus.• Half life of 3-4...
Mode of Action1.It acts throgh the receptor and voltagegated calcium channelmyometrialcontraction2.It stimulates amniotic...
How to give?Maximum dose of oxytocin 5IU in 500ml offluid at the rate of 40drops /min
Oxytocin Surgical Infusion Pump
Oxytocin (syntocinon) should be usedwith extreme caution in multiparouswomen. Oxytocin (syntocinon) should not bestarted...
Advantages• Cheaper and effective• Easy titrableDisadv:.Needs refrigeration.Effectiveness less with:1. less Bishop scor...
Hazards of oxytocin• Uterine hyperstimulation:(Normal:3 contractions in 10 minseach lasting for 45secs)(>5 contractions in...
When to interrupt?• When there is hyperstimulation ofuterus• Fetal distress• Signs of water intoxication.(Occurswith the m...
Oxytocin Vs Misoprostol• Safe,cheap andeffective• Unstable at roomtemp• Easily titrable• Chance of fetaldistress is less• ...
Failed Induction Of Labor• If Amniotomy is stillimpossible after amaximum no. of doses ofProstaglandins have beengiven or•...
Complications of IOL• UterineHyperstimulation• Uterine rupture• Maternal Upset• Iatrogenic FetalPrematurity• Fetal Distres...
CONCLUSIONduring Induction of Labor,B enefits should be weighed,R isks should be assessed,A lternatives should be consider...
THANK YOU
Induction of labour
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Induction of labour

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Induction of labour

  1. 1. INDUCTION OF LABOURModerator:Asst Prof. Dr. B.K. BorahSpeaker:Dr. Nancy Anitha
  2. 2. What is Induction of Labour?• Induction of labor is the artificialinitiation of labour mechanism priorto its spontaneous onset.
  3. 3. Mechanism of initiation of labor
  4. 4. Mechanism (continued)
  5. 5. Endocrinology of labor
  6. 6. Time, place & preparation• Time of induction: Preferably early morning• Place of induction: where facility forintervention and fetal monitoring is available• Preparation of Patient : Enema may be givento patients prior to induction
  7. 7. Indications of Induction oflabor
  8. 8. Indications for induction oflabor
  9. 9. Contraindications of induction oflabor• Contracted pelvis and CPD• Malpresentations• Previous classical caesarean section &hysterotomy• Uteroplacental factors: unexplainedvaginal bleeding,vasa previa,placentaprevia• Cord presentation,cord prolapse• Active genital herpes infection,HIV• Pelvic tumor
  10. 10. Factors to assess prior toinductionMaternal To confirm theindication Exclude thecontraindicatn Assess Bishopscore Assess pelvicadequacyFetal Ensure fetalgestn age Ensure fetalpresentation Confirm fetalwell being
  11. 11. Modified Bishop’s ScoreFavourable score->6 Best score-8
  12. 12. hygroscopic dilators, osmotic dilators (Laminaria japonicum), Foleycatheters, double balloon devices, and extraamniotic saline infusion.
  13. 13. • Misoprostol (a prostaglandin E1 analogue) has several potentialadvantages: it is stable at room temperature, it is relativelyinexpensive and it can be given via several routes (oral, vaginal,sublingual, buccal). These properties make misoprostol an idealagent for induction of labour, particularly in settings where theuse of prostaglandin E2 is not possible owing to lack ofavailability, facilities for storage, or financial constraints.• Since the use of a powerful uterotonic such as misoprostol canlead to adverse maternal and perinatal effects, it is importantto review the effectiveness and the side-effects of misoprostoluse in cervical priming and induction of labour. This commentaryevaluates three Cochrane reviews that sought to determine theeffectiveness and safety of misoprostol administered orally (3),buccally (sublingually) (4), or vaginally (5) for third-trimestercervical ripening and induction of labour.
  14. 14. Membrane sweeping• Its possible only if thecervix has ripened to allowthe passage of one finger.• Insertion of a glovedfinger through the cervixand it’s rotation againstthe wall of the uterus.• Its strips off the chorionicmembrane from theunderlying deciduareleases PGS• Placenta previa should beexcluded, Accidentalamniotomy is adisadvantage.
  15. 15. Amniotomy• AROMstretching of the cervix & separationof the membranes  release of Prostaglandins• Depends on the state of the cervix and stationof the presenting part• ADV:High success rate and chance to see theamniotic fluid• DIS: cannot be applied in an unfavourablecervix, possibility of cord prolapse
  16. 16. AmniotomyCONTRAINDICATIONS:1.IUD2.HIVHAZARDS:1.Cord prolapse2.Amnionitis3.Amniotic fluidembolism4. Abruptio placentae
  17. 17. Prostaglandins• Chemistry:PG is a carboxylicacid synthetised fromarachidonic acid.• Source: menstrual fluid,endometrium, decidua andamniotic membraneTYPES• PGE1 -amnion• PGE2-amnion• PGF2-decidua and myometrium• PGI2-myometrium
  18. 18. Mechanism of action• It causes change in themyometrial cell membpermeablity and alterationin the membrane boundcalcium• It also sensitises themometrium to the oxytocin• PGE2 has its collagenolyticactivityalter the groundsubstance of cervixcxripening
  19. 19. ProstaglandinsPGE1MisoprostolPGE2Dinoprostone(Cerviprime)
  20. 20. How to give Misoprostol?• Dose of 25 micro gram every 4hrly to amaximum of 6 doses can be givenintravaginally• Dose of 50micro gram every 3hrs to amaximum of 6 doses can be given orally• Dose of 25micro gram every 2hrs canbe given orally• Other routes of administration:1.Buccal2.rectal3.sublingual
  21. 21. Oral Vs vaginal MisoprostolORAL• Less effectivewhen comparedto vaginal PG• Chance of fetaldistress is lessVAGINAL• More effective whencompared to oralroute• Chance of fetaldistress is more
  22. 22. Dinoprostone• Vaginal gel 0.5mg can be givenintracervically.• It can be repeated after 6 hrs for 3 – 4doses if required• Vaginal tab 3 mg can be given inthe posterior fornix followed by3mg after 6-8 hrs to a maximumdose of 6mg• Vaginal pessary releasingdinoprostone 10mg over 24hrs.Itis removed when cx ripening isadequate
  23. 23. Misoprostol Vs Dinoprostone• Cheap & costeffective• Stable at room temp• Easy to administer• Costly• Need refrigeration
  24. 24. Advantages Disadvantages• Misoprostol is Cheapand has long half life• It is stable at roomtemp• Induction-deliveryinterval is short• Failure of induction isless• Powerful oxytoxiceffect irrespectiveof gestation• Side eff: Vomiting,diarrhoea• Bronchospasm• Hyerstimulation ofuterus• Tachysystole• Fetal distress• Rupture uterus
  25. 25. Contraindications of PGs• Bronchial asthma• Pulmonary disease• Previous uterine scar isrelativelycontraindicated
  26. 26. Oxytocin• It’s a nanopeptidesynthetised in the supraoptic and paraventricularnuclei of the hypothalamus.• Half life of 3-4 mins andduration of action 20 mins• Oxytocin is used verycommonly to achieveinduction of labour.• The objective is to produceuterine contractions thateffectively produce cervicalchange and descent of thepresenting part.
  27. 27. Mode of Action1.It acts throgh the receptor and voltagegated calcium channelmyometrialcontraction2.It stimulates amniotic and decidual PGproductionPreparations• Available in ampoules containing 5IU/ml• Buccal tab containing 50IU/ml• Nasal solution containing 40units/mlRoutes of administration:• 1.I.V infusion• Intra muscular• Buccal tablets• Nasal spray
  28. 28. How to give?Maximum dose of oxytocin 5IU in 500ml offluid at the rate of 40drops /min
  29. 29. Oxytocin Surgical Infusion Pump
  30. 30. Oxytocin (syntocinon) should be usedwith extreme caution in multiparouswomen. Oxytocin (syntocinon) should not bestarted for six hours followingadministration of vaginal prostaglandins If a trial of labour is judged safethen Oxytocin may be used. Oxytocin should be used with cautionwith a previous uterine scar. Oxytocin should always be used inconjunction with the partogram once inestablished labour.FACTS
  31. 31. Advantages• Cheaper and effective• Easy titrableDisadv:.Needs refrigeration.Effectiveness less with:1. less Bishop score2.IUD3.lesser weeks ofpregnancy
  32. 32. Hazards of oxytocin• Uterine hyperstimulation:(Normal:3 contractions in 10 minseach lasting for 45secs)(>5 contractions in 10mins eachlasting for 1min)• Water intoxication:It due toanti diuretic action(30-40IU/ml).Manifested byhyponatremia,confusion,comaand CCF• Fetal distress• Uterine rupture• Hypotension
  33. 33. When to interrupt?• When there is hyperstimulation ofuterus• Fetal distress• Signs of water intoxication.(Occurswith the max dose of 100 IU in theinterval of less than 24hrs .clinicallyManifested after 24hrs)
  34. 34. Oxytocin Vs Misoprostol• Safe,cheap andeffective• Unstable at roomtemp• Easily titrable• Chance of fetaldistress is less• More effective nearterm• Less effective withless Bishop scoreand in IUD• Tablet form ischeap& effective• Stable at roomtemp,PGE1-unstable• Not titrable• Chance of fetaldistress is more• Effectiveirrespective ofgestation
  35. 35. Failed Induction Of Labor• If Amniotomy is stillimpossible after amaximum no. of doses ofProstaglandins have beengiven or• If the cervix remainsuneffaced and <3cmdilated after anAmniotomy has beenperformed &• Oxytocin has beenrunning for 6-8hrs withregular contractions• Possible Causes1. Placental Sulfatasedeficiency2. Lack of EssentialCytokines
  36. 36. Complications of IOL• UterineHyperstimulation• Uterine rupture• Maternal Upset• Iatrogenic FetalPrematurity• Fetal Distress• Failed induction
  37. 37. CONCLUSIONduring Induction of Labor,B enefits should be weighed,R isks should be assessed,A lternatives should be considered,N ecessity of intervention adjudged&D ecision should be takenaccordinglyBUT,INJUDICIOUS USE of Labor Inducing agents shouldbe avoided
  38. 38. THANK YOU
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